Experts and Doctors on babesia bovis in Obihiro, Hokkaido, Japan
Locale: Obihiro, Hokkaido, Japan
Topic: babesia bovis
Bork S, Okamura M, Matsuo T, Kumar S, Yokoyama N, Igarashi I. Host serum modifies the drug susceptibility of Babesia bovis in vitro. Parasitology. 2005;130:489-92 pubmed
..Therefore, the serum-free culture system is useful for standardizing drug test protocols and understanding the roles of serum factors in the drug test...
Aboulaila M, Sivakumar T, Yokoyama N, Igarashi I. Inhibitory effect of terpene nerolidol on the growth of Babesia parasites. Parasitol Int. 2010;59:278-82 pubmed publisher
..05) inhibited the growth of B. microti at the dosage of 10 and 100mg/kg BW, while the inhibition was low compared with the high doses used. Therefore, nerolidol could not be used as a chemotherapeutic drug for babesiosis...
Bork S, Das S, Okubo K, Yokoyama N, Igarashi I. Effects of protein kinase inhibitors on the in vitro growth of Babesia bovis. Parasitology. 2006;132:775-9 pubmed
..bovis requires, to a certain extent, the phosphorylations mediated by parasite- or host erythrocyte-protein kinases, in particular, for the processes of successful invasion of erythrocytes and intraerythrocytic development...
Aboulaila M, Yokoyama N, Igarashi I. Development and evaluation of a nested PCR based on spherical body protein 2 gene for the diagnosis of Babesia bovis infection. Vet Parasitol. 2010;169:45-50 pubmed publisher
..6% (127/145), while B. bovis RAP-1 gene nPCR detected 37.2% (51/145) of the total samples examined. This nPCR assay provides a good diagnostic tool for the laboratory diagnostic assessment of B. bovis infection in cattle worldwide...
Aboulaila M, Yokoyama N, Igarashi I. Development and evaluation of two nested PCR assays for the detection of Babesia bovis from cattle blood. Vet Parasitol. 2010;172:65-70 pubmed publisher
..The nPCR assay of BV5650 was the most sensitive for the detection of B. bovis from the field samples. The BV5650 nPCR assay provides a good diagnostic tool for laboratory diagnostic assessment of B. bovis infection in cattle worldwide...
Goo Y, Terkawi M, Jia H, Aboge G, Ooka H, Nelson B, et al
. Artesunate, a potential drug for treatment of Babesia infection. Parasitol Int. 2010;59:481-6 pubmed publisher
..microti at doses equal to and greater than 10mg/kg of body weight on days 8-10 post-infection. Taken together, these results suggest that artesunate could be a potential drug against Babesia infection...
Ueno A, Terkawi M, Yokoyama M, Cao S, Aboge G, Aboulaila M, et al
. Farsenyl pyrophosphate synthase is a potential molecular drug target of risedronate in Babesia bovis. Parasitol Int. 2013;62:189-92 pubmed publisher
..02±0.91?M). No regrowth of B. bovis was observed at 10?M of risedronate in the subsequent viability test. These results demonstrate that BbFPPS is the molecular target of risedronate, which could inhibit the in vitro growth of B. bovis. ..
Rizk M, El Sayed S, Aboulaila M, Yokoyama N, Igarashi I. Evaluation of the inhibitory effect of N-acetyl-L-cysteine on Babesia and Theileria parasites. Exp Parasitol. 2017;179:43-48 pubmed publisher
..bovis and B. caballi cultures. These results indicate that N-acetyl-L-cysteine might be used as a drug for the treatment of babesiosis, especially when used in combination with diminazene aceturate. ..
Altangerel K, Sivakumar T, Battsetseg B, Battur B, Ueno A, Igarashi I, et al
. Phylogenetic relationships of Mongolian Babesia bovis isolates based on the merozoite surface antigen (MSA)-1, MSA-2b, and MSA-2c genes. Vet Parasitol. 2012;184:309-16 pubmed publisher
..Our findings indicate that effective preventative and control strategies are essential to control B. bovis infection in Mongolian cattle populations, and suggest that a careful approach must be adopted when using immunization techniques...