Experts and Doctors on plant extracts in Ehime, Japan


Locale: Ehime, Japan
Topic: plant extracts

Top Publications

  1. Sumiyoshi M, Kimura Y. Enhancing effects of a chromone glycoside, eucryphin, isolated from Astilbe rhizomes on burn wound repair and its mechanism. Phytomedicine. 2010;17:820-9 pubmed publisher
  2. Sumiyoshi M, Kimura Y. Effects of olive leaf extract and its main component oleuroepin on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice. Phytother Res. 2010;24:995-1003 pubmed publisher
  3. Matsuura M, Kimura Y, Nakata K, Baba K, Okuda H. Artery relaxation by chalcones isolated from the roots of Angelica keiskei. Planta Med. 2001;67:230-5 pubmed
  4. Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 2004;70:211-9 pubmed
    ..These results suggest that the antitumor and antimetastatic activities of 4-hydroxyderricin may be modulated by the immune system and the inhibition of angiogenesis. ..
  5. Kimura Y, Sumiyoshi M. Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice. J Ethnopharmacol. 2004;95:447-53 pubmed
    ..Therefore, it is suggested that eleutheroside E may be contributed to the anti-fatigue action, the recovery of the reduction of NK activity and the inhibition of corticosterone elevation induced by swimming stress. ..
  6. Yamada N, Araki H, Yoshimura H. Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors. Psychopharmacology (Berl). 2011;216:589-99 pubmed publisher
  7. Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. J Agric Food Chem. 2013;61:4570-6 pubmed publisher
    ..The results suggest almond seed skin contains highly polymerized polyphenols with strong α-amylase inhibitory activity, which retard absorption of carbohydrate. ..
  8. Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. 2001;131:1409-13 pubmed
    ..From these results, it seems likely that the antitumor activity of ergosterol might be due to direct inhibition of angiogenesis induced by solid tumors. This is the first report of ergosterol as an antiangiogenic substance. ..
  9. Kimura Y, Sumiyoshi M, Tamaki T. Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice. Fitoterapia. 2013;84:163-9 pubmed publisher
    ..zedoaria extract on drunkenness might be due to an active substance, curcumenone, and decreases in the elevation of blood alcohol concentrations through increased liver alcohol dehydrogenase activity...

More Information


  1. Tsujita T, Yamada M, Takaku T, Shintani T, Teramoto K, Sato T. Purification and characterization of polyphenols from chestnut astringent skin. J Agric Food Chem. 2011;59:8646-54 pubmed publisher
    ..Our results suggest CAS contains polyphenols with strong ?-amylase inhibitory activity. The data also suggest CAS polyphenols might be oligomeric proanthocyanidins with gallic acid and ellagic acid...
  2. Kimura Y, Sumiyoshi M. Effects of Swertia japonica extract and its main compound swertiamarin on gastric emptying and gastrointestinal motility in mice. Fitoterapia. 2011;82:827-33 pubmed publisher
    ..These findings suggest that the powder and swertiamarin stimulate gastric emptying and gastrointestinal motility by inhibiting the dopamine D(2) receptor. ..
  3. Kimura Y, Sumiyoshi M. French maritime pine bark (Pinus maritima Lam.) extract (Flavangenol) prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice. Photochem Photobiol. 2010;86:955-63 pubmed publisher
    ..The antiphotoaging and anticarcinogenetic activities of flavangenol may be due to inhibition of the expression of Ki-67, 8-OHdG and VEGF through a scavenging effect on reactive oxygen species. ..
  4. Sumiyoshi M, Kimura Y. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice. Phytomedicine. 2009;16:1137-43 pubmed publisher
    ..Prevention of UVB-induced skin aging by turmeric may be due to the inhibition of increases in MMP-2 expression caused by chronic irradiation. ..
  5. Tsujita T, Takaku T. Mechanism of the inhibitory action of chestnut astringent skin extract on carbohydrate absorption. J Nutr Sci Vitaminol (Tokyo). 2008;54:416-21 pubmed
    ..CAS extract prevented increases in body weight and fasting blood glucose concentration. These data suggest that CAS extract has an anti-diabetic function in type 2 diabetic mice that mainly functions through inhibition of alpha-amylase. ..
  6. Tsujita T, Takaku T, Suzuki T. Chestnut astringent skin extract, an alpha-amylase inhibitor, retards carbohydrate absorption in rats and humans. J Nutr Sci Vitaminol (Tokyo). 2008;54:82-8 pubmed
    ..These results suggest that CAS extract retards absorption of carbohydrate and reduces post-prandial hyperglycemia. ..
  7. Tsujita T, Takaku T. Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark). J Nutr Sci Vitaminol (Tokyo). 2007;53:547-51 pubmed
    ..These results suggest that the segment wall, an edible fraction, from Satsuma mandarin orange might be useful as a functional food, especially as a fat-reducing material...
  8. Han L, Sumiyoshi M, Zheng Y, Okuda H, Kimura Y. Anti-obesity action of Salix matsudana leaves (Part 2). Isolation of anti-obesity effectors from polyphenol fractions of Salix matsudana. Phytother Res. 2003;17:1195-8 pubmed
    ..Furthermore, three flavonoid glucosides enhanced norepinephrine-induced lipolysis in fat cells...
  9. Han L, Sumiyoshi M, Zhang J, Liu M, Zhang X, Zheng Y, et al. Anti-obesity action of Salix matsudana leaves (Part 1). Anti-obesity action by polyphenols of Salix matsudana in high fat-diet treated rodent animals. Phytother Res. 2003;17:1188-94 pubmed