Experts and Doctors on blood glucose in Ehime, Japan


Locale: Ehime, Japan
Topic: blood glucose

Top Publications

  1. Kanno H, Iwai M, Inaba S, Senba I, Nakaoka H, Sone H, et al. Improvement of glucose intolerance by combination of pravastatin and olmesartan in type II diabetic KK-A(y) mice. Hypertens Res. 2009;32:706-11 pubmed publisher
    ..The effects seem to be mediated by an increase in insulin sensitivity through the inhibition of oxidative stress. ..
  2. Iwai M, Li H, Chen R, Shiuchi T, Wu L, Min L, et al. Calcium channel blocker azelnidipine reduces glucose intolerance in diabetic mice via different mechanism than angiotensin receptor blocker olmesartan. J Pharmacol Exp Ther. 2006;319:1081-7 pubmed
  3. Mogi M, Tsukuda K, Li J, Iwanami J, Min L, Sakata A, et al. Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan. Neuropharmacology. 2007;53:899-905 pubmed
    ..Our results suggest that olmesartan could be therapeutically effective in preventing the impairment of quality of life in persons on a high-fat and high-salt diet. ..
  4. Ohshima K, Mogi M, Jing F, Iwanami J, Tsukuda K, Min L, et al. Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPAR? activation. PLoS ONE. 2012;7:e48387 pubmed publisher
  5. Hasegawa M, Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, et al. Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice. Diabetes Res Clin Pract. 2002;58:79-85 pubmed
    ..7-fold in control mice, but was reduced to 1.35-fold in IRS-1 (-/-) mice. Thus, PDE3B gene expression may be inversely correlated with a fat cell size, whereas insulin-induced PDE3B activation is mediated through IRS-1. ..
  6. Ogura T, Osawa H, Tang Y, Onuma H, Ochi M, Nishimiya T, et al. Reduction of phosphodiesterase 3B gene expression in peroxisome proliferator-activated receptor gamma (+/-) mice independent of adipocyte size. FEBS Lett. 2003;542:65-8 pubmed
    ..Basal PDE activity tended to be decreased to 70% of wild-type levels, and, similarly, insulin-induced PDE activity was significantly decreased to 70%. Thus, PPAR gamma is required for PDE3B gene expression independent of adipocyte size. ..
  7. Tsujita T, Takaku T. Mechanism of the inhibitory action of chestnut astringent skin extract on carbohydrate absorption. J Nutr Sci Vitaminol (Tokyo). 2008;54:416-21 pubmed
    ..CAS extract prevented increases in body weight and fasting blood glucose concentration. These data suggest that CAS extract has an anti-diabetic function in type 2 diabetic mice that mainly functions through inhibition of alpha-amylase. ..
  8. Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, Takata Y, et al. The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. J Hum Genet. 2010;55:600-4 pubmed publisher
    ..We replicated GCKR rs780094 as a marker of T2DM susceptibility in Japanese subjects. This suggests that GCKR rs780094 is a common variant for T2DM susceptibility in various ethnic groups. ..
  9. Tsujita T, Yamada M, Takaku T, Shintani T, Teramoto K, Sato T. Purification and characterization of polyphenols from chestnut astringent skin. J Agric Food Chem. 2011;59:8646-54 pubmed publisher
    ..Our results suggest CAS contains polyphenols with strong ?-amylase inhibitory activity. The data also suggest CAS polyphenols might be oligomeric proanthocyanidins with gallic acid and ellagic acid...

More Information


  1. Kawamoto R, Kusunoki T, Abe M, Kohara K, Miki T. An association between body mass index and high-sensitivity C-reactive protein concentrations is influenced by age in community-dwelling persons. Ann Clin Biochem. 2013;50:457-64 pubmed publisher
    ..00 mg/L) compared with the normal-weight (BMI <22.0 kg/m(2)), but such an association was not observed in those aged ? 75 years. Adiposity promotes low-grade systemic inflammation in community-dwelling persons aged <75 years. ..
  2. Tsujita T, Takaku T, Suzuki T. Chestnut astringent skin extract, an alpha-amylase inhibitor, retards carbohydrate absorption in rats and humans. J Nutr Sci Vitaminol (Tokyo). 2008;54:82-8 pubmed
    ..These results suggest that CAS extract retards absorption of carbohydrate and reduces post-prandial hyperglycemia. ..
  3. Makino H, Shimizu I, Murao S, Kondo S, Tabara Y, Fujiyama M, et al. A pilot study suggests that the G/G genotype of resistin single nucleotide polymorphism at -420 may be an independent predictor of a reduction in fasting plasma glucose and insulin resistance by pioglitazone in type 2 diabetes. Endocr J. 2009;56:1049-58 pubmed
    ..511, P=0.044). Therefore, this pilot study suggests that the G/G genotype of resistin SNP -420 may be an independent predictor of the reduction of fasting plasma glucose and HOMA-IR by pioglitazone. ..
  4. Min L, Mogi M, Shudou M, Jing F, Tsukuda K, Ohshima K, et al. Peroxisome proliferator-activated receptor-? activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice. Hypertension. 2012;59:1079-88 pubmed publisher
  5. Tsujita T, Shintani T, Sato H. α-Amylase inhibitory activity from nut seed skin polyphenols. 1. Purification and characterization of almond seed skin polyphenols. J Agric Food Chem. 2013;61:4570-6 pubmed publisher
    ..The results suggest almond seed skin contains highly polymerized polyphenols with strong α-amylase inhibitory activity, which retard absorption of carbohydrate. ..
  6. Kawamoto R, Tabara Y, Kohara K, Kusunoki T, Abe M, Miki T. Serum uric acid is more strongly associated with impaired fasting glucose in women than in men from a community-dwelling population. PLoS ONE. 2013;8:e65886 pubmed publisher
    ..005). SUA levels are associated with different categories of impaired fasting glucose in participants from community-dwelling persons, particularly in women. ..