Experts and Doctors on insulin in New Delhi, NCT, India

Summary

Locale: New Delhi, NCT, India
Topic: insulin

Top Publications

  1. Sehra D, Sehra S, Sehra S. Cardiovascular pleiotropic effects of statins and new onset diabetes: is there a common link: do we need to evaluate the role of KATP channels?. Expert Opin Drug Saf. 2017;16:823-831 pubmed publisher
    ..This disturbs the carbohydrate metabolism and probably leads to diabetes. In our opinion, use of stains should be more judicious and restricted to secondary prevention only. ..
  2. Preet A, Siddiqui M, Taha A, Badhai J, Hussain M, Yadava P, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues. Mol Cell Biochem. 2006;289:137-47 pubmed
    ..In conclusion, the potential of SOV and TSP alone or in low dose combination may be considered as promising approaches for the prevention of diabetic retinopathy and other ocular disorders...
  3. Kumar V, Padhy B. Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats. Biocell. 2011;35:63-9 pubmed
    ..Our study shows that by exhibiting antioxidant and anti-hyperglycemic property the aqueous suspension of dried latex of C. procera affords protection against the complications associated with diabetes. ..
  4. Gulati S, Misra A, Tiwari R, Sharma M, Pandey R, Yadav C. Effect of high-protein meal replacement on weight and cardiometabolic profile in overweight/obese Asian Indians in North India. Br J Nutr. 2017;117:1531-1540 pubmed publisher
    ..These findings show that intervention with HPMR may lead to significant weight loss and improvement in obesity measures, metabolic, lipid and inflammatory parameters and hepatic transaminases in overweight/obese Asian Indians. ..
  5. Singh R, Bansal R, Rathore A, Goel G. Equilibrium Ensembles for Insulin Folding from Bias-Exchange Metadynamics. Biophys J. 2017;112:1571-1585 pubmed publisher
    ..We have also determined stability of monomeric insulin by incubation at a very low concentration to isolate protein-protein interaction effects. ..
  6. Alam P, Beg A, Siddiqi M, Chaturvedi S, Rajpoot R, Ajmal M, et al. Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity. Arch Biochem Biophys. 2017;621:54-62 pubmed publisher
    ..The present data signifies the role of ascorbic acid that can serve as potential molecule in preventing human insulin aggregation and associated pathophysiologies. ..
  7. Ganie M, Khurana M, Nisar S, Shah P, Shah Z, Kulshrestha B, et al. Improved efficacy of low-dose spironolactone and metformin combination than either drug alone in the management of women with polycystic ovary syndrome (PCOS): a six-month, open-label randomized study. J Clin Endocrinol Metab. 2013;98:3599-607 pubmed publisher
    ..To improve the treatment outcomes in women with polycystic ovary syndrome (PCOS), various drugs like glitazones, oral contraceptive pills, or antiandrogens have been combined with metformin...
  8. Biswas S, Tapryal N, Mukherjee R, Kumar R, Mukhopadhyay C. Insulin promotes iron uptake in human hepatic cell by regulating transferrin receptor-1 transcription mediated by hypoxia inducible factor-1. Biochim Biophys Acta. 2013;1832:293-301 pubmed publisher
    ..Transfection of cDNA expressing stable form of HIF-1? reversed the increased TfR1 expression and iron uptake. These results suggest a novel role of insulin in hepatic iron uptake by a HIF-1 dependent transcriptional regulation of TfR1. ..
  9. Sharma A, Bharti S, Goyal S, Arora S, Nepal S, Kishore K, et al. Upregulation of PPAR? by Aegle marmelos ameliorates insulin resistance and ?-cell dysfunction in high fat diet fed-streptozotocin induced type 2 diabetic rats. Phytother Res. 2011;25:1457-65 pubmed publisher
    ..These findings suggest that the protective effect of AMF in type 2 diabetic rats is due to the preservation of ?-cell function and insulin-sensitivity through increased PPAR? expression...

More Information

Publications18

  1. Sivanandan S, Sinha A, Jain V, Lodha R. Management of diabetic ketoacidosis. Indian J Pediatr. 2011;78:576-84 pubmed publisher
    ..Factors precipitating the episode of DKA should be identified and rectified. Following resolution of ketoacidosis, intravenous insulin is transitioned to subcutaneous route, titrating dose to achieve normoglycemia. ..
  2. Kirana H, Srinivasan B. Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats. Indian J Exp Biol. 2010;48:499-502 pubmed
    ..Improved glycogen in peripheral tissue such as skeletal muscle indicates the ability of plant drug to combat insulin resistance of type 2 diabetes...
  3. Batra C, Gupta N, Atwal G, Gupta V. Transient neonatal diabetes due to activating mutation in the ABCC8 gene encoding SUR1. Indian J Pediatr. 2009;76:1169-72 pubmed
    ..Genetic analysis was negative for mutations of KCNJ11, 6q24, Glucokinase and IPF-1 genes. A mutation R1183W was found in the ABCC8 gene encoding SUR1, which was the cause of neonatal diabetes in this case...
  4. Mukhtar H, Ansari S, Ali M, Bhat Z, Naved T. Effect of aqueous extract of Pterocarpus marsupium wood on alloxan-induced diabetic rats. Pharmazie. 2005;60:478-9 pubmed
    ..During both acute and sub-acute tests, the water extract, at an oral dose of 250 mg/kg, showed statistically significant hypoglycemic activity...
  5. Grover J, Vats V, Yadav S. Pterocarpus marsupium extract (Vijayasar) prevented the alteration in metabolic patterns induced in the normal rat by feeding an adequate diet containing fructose as sole carbohydrate. Diabetes Obes Metab. 2005;7:414-20 pubmed
    ..Though several antidiabetic principles (-epicatechin, pterosupin, marsupin and pterostilbene) have been identified in the PM, yet future studies are required to certify their efficacy and safety before clinical scenario...
  6. Sharma A, Bharti S, Kumar R, Krishnamurthy B, Bhatia J, Kumari S, et al. Syzygium cumini ameliorates insulin resistance and ?-cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-? in type 2 diabetic rats. J Pharmacol Sci. 2012;119:205-13 pubmed
    ..Moreover, hepatic tissue demonstrated increased PPAR? and PPAR? protein expressions. Thus, our study demonstrated the beneficial effect of SC seed extract on IR and ?-cell dysfunction in HFD-STZ-induced type 2 diabetic rats. ..
  7. Bhandari U, Kumar V, Khanna N, Panda B. The effect of high-fat diet-induced obesity on cardiovascular toxicity in Wistar albino rats. Hum Exp Toxicol. 2011;30:1313-21 pubmed publisher
    ..This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat induces the obesity in humans. ..
  8. Jyotsna V, Pal S, Kandasamy D, Gamanagatti S, Garg P, Raizada N, et al. Evolving management of insulinoma: Experience at a tertiary care centre. Indian J Med Res. 2016;144:771 pubmed publisher
    ..Our results suggest that patients with insulinoma have a varied presentation. Multiphasic contrast-enhanced MRI/CT scan, EUS and ASVS may be complimentary in pre-operative localization. ..
  9. Mohammad S, Taha A, Bamezai R, Baquer N. Modulation of glucose transporter (GLUT4) by vanadate and Trigonella in alloxan-diabetic rats. Life Sci. 2006;78:820-4 pubmed
    ..The treatment of diabetic rats with combined doses of vanadate and TSP was most effective in the normalization of plasma glucose levels and correction of altered GLUT4 distribution...