Experts and Doctors on xenopus laevis in Japan


Locale: Japan
Topic: xenopus laevis

Top Publications

  1. Ikeda K, Nagasawa M, Mori H, Araki K, Sakimura K, Watanabe M, et al. Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel. FEBS Lett. 1992;313:34-8 pubmed
    ..The epsilon 4 subunit is thus distinct in functional properties from the epsilon 1, epsilon 2 and epsilon 3 subunits, and contributes further diversity of the NMDA receptor channel. ..
  2. Ohsu T, Amino Y, Nagasaki H, Yamanaka T, Takeshita S, Hatanaka T, et al. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010;285:1016-22 pubmed publisher
    ..This is the first report indicating a distinct function of the CaSR in human taste perception. ..
  3. Kumar S, Iwao M, Yamagishi T, Noda M, Asashima M. Expression of GTP-binding protein gene drg during Xenopus laevis development. Int J Dev Biol. 1993;37:539-46 pubmed
    ..Among the three mRNA species detected by Northern hybridization, two smaller ones show temporally regulated expression patterns during embryonic development. ..
  4. Nakata Y, Fuse T, Yamato K, Asahi M, Nakahira K, Ozoe F, et al. A Single Amino Acid Substitution in the Third Transmembrane Region Has Opposite Impacts on the Selectivity of the Parasiticides Fluralaner and Ivermectin for Ligand-Gated Chloride Channels. Mol Pharmacol. 2017;92:546-555 pubmed publisher
    ..Given the high sequence similarity of TM3, this may hold true more widely for the GluCls and GABACls of other insect species. ..
  5. Kobayashi S, Amikura R, Okada M. Localization of mitochondrial large rRNA in germinal granules and the consequent segregation of germ line. Int J Dev Biol. 1994;38:193-9 pubmed
  6. Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H. Characterization of 3-[125I]iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1. Nucl Med Biol. 2003;30:31-7 pubmed
    ..The level of efflux mediated by hLAT1 was highly stimulated by extracellularly applied L-Leu, suggesting exchange of [(125)I]IMT and L-Leu via hLAT1. ..
  7. Imai Y, Davey J, Kawagishi Kobayashi M, Yamamoto M. Genes encoding farnesyl cysteine carboxyl methyltransferase in Schizosaccharomyces pombe and Xenopus laevis. Mol Cell Biol. 1997;17:1543-51 pubmed
    ..pombe cells. The isolation of a vertebrate gene encoding farnesyl cysteine carboxyl methyltransferase opens the way to in-depth studies of the role of methylation in a large body of proteins, including Ras superfamily proteins. ..
  8. Yaguchi T, Yamamoto S, Nagata T, Kanno T, Tanaka A, Nishizaki T. Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses. Brain Res Mol Brain Res. 2005;133:320-4 pubmed
    ..The role of the number and position of the cis-double bonds in the receptor responses, however, remains an open question. ..
  9. Kondo M, Semba K, Shiokawa K, Yamamoto T. Molecular cloning of Xenopus activin type I receptor and the analysis of its expression during embryogenesis. Biochem Biophys Res Commun. 1996;218:549-55 pubmed

More Information

Publications122 found, 100 shown here

  1. Ishibashi K, Kuwahara M, Kageyama Y, Tohsaka A, Marumo F, Sasaki S. Cloning and functional expression of a second new aquaporin abundantly expressed in testis. Biochem Biophys Res Commun. 1997;237:714-8 pubmed
    ..The unexpected complexity of the presence of two aquaporins in testis may call for the further analysis of the role of aquaporins in the reproduction biology. ..
  2. Fujimoto K, Nakajima K, Yaoita Y. Expression of matrix metalloproteinase genes in regressing or remodeling organs during amphibian metamorphosis. Dev Growth Differ. 2007;49:131-43 pubmed
  3. Ogawara D, Muroya T, Yamauchi K, Iwamoto T, Yagi Y, Yamashita Y, et al. Near-full-length REV3L appears to be a scarce maternal factor in Xenopus laevis eggs that changes qualitatively in early embryonic development. DNA Repair (Amst). 2010;9:90-5 pubmed publisher
    ..These observations indicate the existence of REV3L as a scarce protein, of approximately the full predicted size, whose level may impose severe constraints on the assembly of pol zeta in X. laevis. ..
  4. Tashiro K, Yamada R, Asano M, Hashimoto M, Muramatsu M, Shiokawa K. Expression of mRNA for activin-binding protein (follistatin) during early embryonic development of Xenopus laevis. Biochem Biophys Res Commun. 1991;174:1022-7 pubmed
    ..These results suggest that the follistatin acts also as a regulator of activin in inductive interactions during amphibian embryonic development. ..
  5. Ishibashi K, Sasaki S, Fushimi K, Uchida S, Kuwahara M, Saito H, et al. Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Proc Natl Acad Sci U S A. 1994;91:6269-73 pubmed
    ..In kidney, it was exclusively immunolocalized at the basolateral membrane of collecting duct cells. AQP3 may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. ..
  6. Yamamoto T, Nakayama Y, Tajima T, Abe S, Kawahara A. Cloning of a cDNA for Xenopus prolactin receptor and its metamorphic expression profile. Dev Growth Differ. 2000;42:167-74 pubmed
    ..In the kidney, mRNA expression increased and reached a maximum level at the end of metamorphosis. The results obtained were discussed in relation to metamorphosis. ..
  7. Nakamura M, Honda Z, Matsumoto T, Noma M, Shimizu T. Isolation and properties of platelet-activating factor receptor cDNAs. J Lipid Mediat. 1993;6:163-8 pubmed
  8. Bao H, Ishizuka T, Sakamoto T, Fujimoto K, Uechi T, Kenmochi N, et al. Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy. Nucleic Acids Res. 2017;45:5501-5511 pubmed publisher
    ..The finding provides new insight into the structural behavior of telomere RNA G-quadruplex in living cells. These results open new avenues for the investigation of G-quadruplex structures in vitro and in living cells. ..
  9. Sumida M, Kanamori Y, Kaneda H, Kato Y, Nishioka M, Hasegawa M, et al. Complete nucleotide sequence and gene rearrangement of the mitochondrial genome of the Japanese pond frog Rana nigromaculata. Genes Genet Syst. 2001;76:311-25 pubmed
    ..A quartet-puzzling tree showed that three amphibian species form a monophyletic clade and that the caecilian is a sister group of the monophyletic Anura...
  10. Nakajima K, Yaoita Y. Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis. Dev Dyn. 2003;227:246-55 pubmed
  11. Yoshimoto S, Ito M. A ZZ/ZW-type sex determination in Xenopus laevis. FEBS J. 2011;278:1020-6 pubmed publisher
    ..laevis. Finally, we discuss sex-determining systems and germ-cell development during vertebrate evolution, especially in view of a conserved role of DMRT1 in gonadal masculinization...
  12. Yoshioka H, Ohuchi H, Nohno T, Fujiwara A, Tanda N, Kawakami Y, et al. Regional expression of the Cwnt-4 gene in developing chick central nervous system in relationship to the diencephalic neuromere D2 and a dorsal domain of the spinal cord. Biochem Biophys Res Commun. 1994;203:1581-8 pubmed
    ..Thus, we designated the gene as Cwnt-4 (chick Wnt-4). Our results suggested that Cwnt-4 is involved in segmentation of the forebrain into the neuromere D2 and in differentiation of the dorsal region of the spinal cord. ..
  13. Suzuki K, Yamamoto T, Inoue J. Molecular cloning of cDNA encoding the Xenopus homolog of mammalian RelB. Nucleic Acids Res. 1995;23:4664-9 pubmed
    ..These results raise the possibility that XrelB and Xrel1/XrelA play different roles in the development of X.laevis. ..
  14. Hasebe T, Buchholz D, Shi Y, Ishizuya Oka A. Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine. Stem Cells. 2011;29:154-61 pubmed publisher
  15. Miura R, Shiota K, Noda K, Yagi S, Ogawa T, Takahashi M. Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Biochem J. 1994;299 ( Pt 2):561-7 pubmed
  16. Goto T, Katada T, Kinoshita T, Kubota H. Expression and characterization of Xenopus type I collagen alpha 1 (COL1A1) during embryonic development. Dev Growth Differ. 2000;42:249-56 pubmed
    ..These results suggest that COL1A1 is a major component of the dorsal dermis exposed to the somite in Xenopus embryos, but its expression is not related to the temporal sequence of somite segregation. ..
  17. Sakimura K, Morita T, Kushiya E, Mishina M. Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992;8:267-74 pubmed
    ..Expression of the gamma 2 subunit together with the beta 2 subunit in Xenopus oocytes yields functional glutamate receptor channels selective for kainate. ..
  18. Atsuchi Y, Yamana K, Yatsuki H, Hori K, Ueda S, Shiokawa K. Cloning of a brain-type aldolase cDNA and changes in its mRNA level during oogenesis and early embryogenesis in Xenopus laevis. Biochim Biophys Acta. 1994;1218:153-7 pubmed
    ..The characteristic change in the temporal pattern of expression and the distribution of XALD3 mRNA among different tissues suggest a possibility that brain type aldolase may play some important roles in gametogenesis and in neurulation. ..
  19. Honda J, Ogawa K, Taniguchi K. [Immunohistochemical and morphometric studies on the development of the thyroid, parathyroid and ultimobranchial body in Xenopus laevis Daudin]. Jikken Dobutsu. 1993;42:23-32 pubmed
    ..Calcitonin-immunoreactive cells first appeared in the ultimobranchial body at stage 47/48, showed the most intense reaction at stage 59, and rapidly decreased in number thereafter towards the end of metamorphosis...
  20. Furukawa T, Horikawa S, Terai T, Ogura T, Katayama Y, Hiraoka M. Molecular cloning and characterization of a novel truncated from (ClC-2 beta) of ClC-2 alpha (ClC-2G) in rabbit heart. FEBS Lett. 1995;375:56-62 pubmed
    ..Thus, different RNA processing of the same gene appears to provide two highly homologous PKA-activated Cl- channels with or without responsiveness to cell swelling in rabbit heart. ..
  21. Saito H, Motohashi H, Mukai M, Inui K. Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1. Biochem Biophys Res Commun. 1997;237:577-82 pubmed
    ..This is the first demonstration of cDNA isolation of a regulatory factor which modulates hPEPT1 activity. ..
  22. Quan J, Uchide T, Takizawa S, Adur J, Nara E, Saida K. cDNA cloning and sequence analysis of Xenopus laevis preproendothelin-1. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S256-9 pubmed
    ..This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species. ..
  23. Ariyoshi N, Hiyoshi H, Katagiri C, Abe S. cDNA cloning and expression of Xenopus sperm-specific basic nuclear protein 5 (SP5) gene. Mol Reprod Dev. 1994;37:363-9 pubmed
  24. Tani T, Gram L, Arakawa H, Kikuchi A, Chiba M, Ishii Y, et al. Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats. Pharm Res. 2008;25:1085-91 pubmed
  25. Suzuki K, Tsuchida J, Yamamoto T, Inoue J. Identification and expression of the Xenopus homolog of mammalian p100-NFkappaB2. Gene. 1998;206:1-9 pubmed
    ..These results suggest that Xp100 could be involved in the late-stage development of Xenopus laevis, especially in the maturation of somites. ..
  26. Ochi H, Kawaguchi A, Tanouchi M, Suzuki N, Kumada T, Iwata Y, et al. Co-accumulation of cis-regulatory and coding mutations during the pseudogenization of the Xenopus laevis homoeologs six6.L and six6.S. Dev Biol. 2017;427:84-92 pubmed publisher
    ..We also underscore the value of the allotetraploid genome of X. laevis as a resource for studying latent pathogenic mutations. ..
  27. Tsuneki H, You Y, Toyooka N, Sasaoka T, Nemoto H, Dani J, et al. Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors. Biol Pharm Bull. 2005;28:611-4 pubmed
  28. Mawaribuchi S, Tamura K, Okano S, Takayama S, Yaoita Y, Shiba T, et al. Tumor necrosis factor-alpha attenuates thyroid hormone-induced apoptosis in vascular endothelial cell line XLgoo established from Xenopus tadpole tails. Endocrinology. 2008;149:3379-89 pubmed publisher
    ..These findings suggested that xTNF-alpha could protect vascular endothelial cells from apoptotic cell death induced by T(3) during metamorphosis and thereby participate in the regulation of cell fate. ..
  29. Hasegawa K, Shiraishi T, Kinoshita T. Xoom: a novel oocyte membrane protein maternally expressed and involved in the gastrulation movement of Xenopus embryos. Int J Dev Biol. 1999;43:479-85 pubmed
    ..These results suggest that maternally expressed and membrane-associated Xoom is closely involved in the gastrulation movement through a lithium-inducible signal pathway. ..
  30. Suzuki M, Van Paesschen W, Stalmans I, Horita S, Yamada H, Bergmans B, et al. Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine. Proc Natl Acad Sci U S A. 2010;107:15963-8 pubmed publisher
    ..The immunohistological and functional analyses of these mutants demonstrate that the near total loss of NBCe1 activity in astrocytes can cause migraine potentially through dysregulation of synaptic pH. ..
  31. Mo R, Kato Y, Nonaka M, Nakayama K, Takahashi M. Fourth component of Xenopus laevis complement: cDNA cloning and linkage analysis of the frog MHC. Immunogenetics. 1996;43:360-9 pubmed
    ..These results clearly demonstrate that C3/C4 gene duplication and linkage between the C4 gene and the major histocompatibility complex predate mammalian/amphibian divergence. ..
  32. Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004;279:24246-54 pubmed
  33. Nakamura M, Honda Z, Izumi T, Sakanaka C, Mutoh H, Minami M, et al. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J Biol Chem. 1991;266:20400-5 pubmed
    ..The production of the mRNA was prominently increased when EoL-1 cells were treated with granulocyte macrophage colony stimulating factor, interleukin-5, and n-butyrate. ..
  34. Uchida K, Uchida M, Hanai S, Ozawa Y, Ami Y, Kushida S, et al. Isolation of the poly(ADP-ribose) polymerase-encoding cDNA from Xenopus laevis: phylogenetic conservation of the functional domains. Gene. 1993;137:293-7 pubmed
    ..The first Leu of the putative leucine zipper of D. melanogaster PARP is substituted to Lys in X. laevis PARP. All the Glu residues in the leucine zipper are conserved in these six species. ..
  35. Furutani K, Ohno Y, Inanobe A, Hibino H, Kurachi Y. Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel. Mol Pharmacol. 2009;75:1287-95 pubmed publisher
    ..1 current. This study may represent a possible general approach for the understanding of the mechanism of ligand-protein interactions. ..
  36. Takahashi N, Tochimoto N, Ohmori S, Mamada H, Itoh M, Inamori M, et al. Systematic screening for genes specifically expressed in the anterior neuroectoderm during early Xenopus development. Int J Dev Biol. 2005;49:939-51 pubmed
    ..Interestingly, Semaphorin 6D is expressed in the mesoderm with a dorsoventral gradient, as well as in the ectoderm at the gastrula stage, implying a new role for this protein in development other than in axon guidance. ..
  37. Okuda M, Saito H, Urakami Y, Takano M, Inui K. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun. 1996;224:500-7 pubmed
    ..These findings suggest that OCT2 is responsible for the transport of cationic drugs in the kidney...
  38. Suzuki K, Taniguchi K, Syuto B. Characterization of olfactory receptor organs in Xenopus laevis Daudin. Anat Rec. 1999;255:420-7 pubmed
    ..The characteristics of the epithelia demonstrated in this study should further our understanding of the functional differences between the receptors of water-soluble odorants and of airborne odorants at the molecular level. ..
  39. Matsushima Y, Matsumura K, Ishii S, Inagaki H, Suzuki T, Matsuda Y, et al. Functional domains of chicken mitochondrial transcription factor A for the maintenance of mitochondrial DNA copy number in lymphoma cell line DT40. J Biol Chem. 2003;278:31149-58 pubmed
    ..A series of deletion mutant at the tail region suggested stimulatory and suppressive sequences in this region for the maintenance of mtDNA level. ..
  40. Yamazaki M, Mori H, Araki K, Mori K, Mishina M. Cloning, expression and modulation of a mouse NMDA receptor subunit. FEBS Lett. 1992;300:39-45 pubmed
    ..It has been found that the zeta 1 channel activity is positively modulated by treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA). ..
  41. Ishihara K, Hiraoka M. Gating mechanism of the cloned inward rectifier potassium channel from mouse heart. J Membr Biol. 1994;142:55-64 pubmed
    ..Our results suggest the existence of the intrinsic gating mechanism, accounting for the extent of rectification in the current-voltage relationship in the expressed channel. ..
  42. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, et al. Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 1989;259:37-42 pubmed
    ..mRNAs derived from both the cloned cDNAs, when injected into Xenopus oocytes, direct the formation of functional potassium channels with properties of delayed rectifiers. ..
  43. Nakashima T, Sekiguchi T, Kuraoka A, Fukushima K, Shibata Y, Komiyama S, et al. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol Cell Biol. 1993;13:6367-74 pubmed
    ..The DAD1 protein disappeared in tsBN7 cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggers apoptosis...
  44. Ueki T, Furuno N, Michibata H. A novel vanadium transporter of the Nramp family expressed at the vacuole of vanadium-accumulating cells of the ascidian Ascidia sydneiensis samea. Biochim Biophys Acta. 2011;1810:457-64 pubmed publisher
    ..Vanadium is an essential transition metal in biological systems. Several key proteins related to vanadium accumulation and its physiological function have been isolated, but no vanadium ion transporter has yet been identified...
  45. Imaoka S, Muraguchi T, Kinoshita T. Isolation of Xenopus HIF-prolyl 4-hydroxylase and rescue of a small-eye phenotype caused by Siah2 over-expression. Biochem Biophys Res Commun. 2007;355:419-25 pubmed
    ..Additional over-expression of PHD47 rescued the abnormality caused by xSiah2, suggesting that the level of expression or activity of PHD proteins is important to the maintenance of homeostasis in embryonic development. ..
  46. Kaupp U, Niidome T, Tanabe T, Terada S, Bönigk W, Stuhmer W, et al. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature. 1989;342:762-6 pubmed
    ..Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes. ..
  47. Sakimura K, Bujo H, Kushiya E, Araki K, Yamazaki M, Meguro H, et al. Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990;272:73-80 pubmed
    ..These results suggest that kainate and quisqualate can activate a common glutamate receptor subtype and that glutamate-gated ionic channels are hetero-oligomers of different subunits. ..
  48. Hatada S, Kinoshita M, Takahashi S, Nishihara R, Sakumoto H, Fukui A, et al. An interferon regulatory factor-related gene (xIRF-6) is expressed in the posterior mesoderm during the early development of Xenopus laevis. Gene. 1997;203:183-8 pubmed
    ..The temporally and spatially limited expression of the xIRF-6 gene product may contribute to the transcriptional regulation of specific genes which are necessary for the development of the posterior somites. ..
  49. Misaki N, Mao X, Lin Y, Suga S, Li G, Liu Q, et al. Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release. J Pharmacol Exp Ther. 2007;322:871-8 pubmed
  50. Kato Y, Salter Cid L, Flajnik M, Namikawa C, Sasaki M, Nonaka M. Duplication of the MHC-linked Xenopus complement factor B gene. Immunogenetics. 1995;42:196-203 pubmed
  51. Nakata K, Nagai T, Aruga J, Mikoshiba K. Xenopus Zic family and its role in neural and neural crest development. Mech Dev. 1998;75:43-51 pubmed
    ..Our findings suggest that Zic1 and Zic2 have essentially the same properties as Zic3 and that the Xenopus Zic family may act cooperatively in the initial phase of neural and neural crest development. ..
  52. Morita T, Sakimura K, Kushiya E, Yamazaki M, Meguro H, Araki K, et al. Cloning and functional expression of a cDNA encoding the mouse beta 2 subunit of the kainate-selective glutamate receptor channel. Brain Res Mol Brain Res. 1992;14:143-6 pubmed
    ..The beta 2 subunit has structural characteristics common to the subunits of glutamate-gated ion channels. Expression of the cloned cDNA in Xenopus oocytes yields functional glutamate receptor channels selective for kainate. ..
  53. Tanaka M, Wang D, Kamo T, Igarashi H, Wang Y, Xiang Y, et al. Interaction of EphB2-tyrosine kinase receptor and its ligand conveys dorsalization signal in Xenopus laevis development. Oncogene. 1998;17:1509-16 pubmed
  54. Endo Y, Takahashi M, Nakao M, Saiga H, Sekine H, Matsushita M, et al. Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J Immunol. 1998;161:4924-30 pubmed
    ..Furthermore, the presence of MASP or MASP-like sequences in most vertebrate species suggests that the lectin pathway functions extensively in vertebrates and that its origin is traced back to the invertebrate stage...
  55. Kikuta S, Kikawada T, Hagiwara Komoda Y, Nakashima N, Noda H. Sugar transporter genes of the brown planthopper, Nilaparvata lugens: A facilitated glucose/fructose transporter. Insect Biochem Mol Biol. 2010;40:805-13 pubmed publisher
    ..This showed that NlST6 is a facilitative glucose/fructose transporter that mediates sugar uptake from rice phloem sap in the BPH midgut in a manner similar to NlST1. ..
  56. Semenova I, Gupta D, Usui T, Hayakawa I, Cowan A, Rodionov V. Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules. Mol Biol Cell. 2017;28:1418-1425 pubmed publisher
    ..We conclude that generation of new MT transport tracks by concentration of the leading pigment granules provides a positive feedback loop that enhances delivery of trailing granules to the cell center. ..
  57. Yamamoto M, Shoda A, Minamino N, Matsuo H, Nishimatsu S, Ueno N, et al. Expression of thymosin beta 4 gene during Xenopus laevis embryogenesis. Biochem Biophys Res Commun. 1992;184:93-9 pubmed
    ..Northern blot analysis revealed the mRNA is maternally present at a low level and the transcript becomes abundant after gastrulation, supporting the distribution of the peptide. ..
  58. Shimamoto T, Kohno K, Tanaka K, Okada Y. Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster. Biochem Biophys Res Commun. 1991;181:1231-7 pubmed
    ..These results strongly suggest that the COOH-terminal domain containing a zinc-finger motif plays an important role in the function of these proteins. ..
  59. Hiyoshi H, Uno S, Yokota T, Katagiri C, Nishida H, Takai M, et al. Isolation of cDNA for a Xenopus sperm-specific basic nuclear protein (SP4) and evidence for expression of SP4 mRNA in primary spermatocytes. Exp Cell Res. 1991;194:95-9 pubmed
    ..These size differences were due to differences in the length of the poly(A) tracts because digestion of poly(A) with ribonuclease H resulted in the shortening of mRNA to the same size for three stages. ..
  60. Hayashizaki Y, Hiraoka Y, Endo Y, Miyai K, Matsubara K. Thyroid-stimulating hormone (TSH) deficiency caused by a single base substitution in the CAGYC region of the beta-subunit. EMBO J. 1989;8:2291-6 pubmed
    ..Southern blot hybridization of genomic DNA digested with MaeI showed that the patients were homozygous and their parents were heterozygous for the mutation. This test was also used to examine other family members for the disease. ..
  61. Hatada S, Kinoshita M, Noda M, Asashima M. Identification of a Xenopus glutamine synthetase gene abundantly expressed in the embryonic nervous system but not in adult brain. FEBS Lett. 1995;371:287-92 pubmed
  62. Kawakami H, Tanaka K, Nakayama T, Inoue K, Nakamura S. Cloning and expression of a human glutamate transporter. Biochem Biophys Res Commun. 1994;199:171-6 pubmed
    ..The cDNA sequence predicts a protein of 542 amino acids that is highly homologous to the congeneric proteins from rat and mouse brains. RNA blotting analyses revealed the expression both in the brain and in peripheral tissues. ..
  63. Yamane T, Furukawa T, Horikawa S, Hiraoka M. External pH regulates the slowly activating potassium current IsK expressed in Xenopus oocytes. FEBS Lett. 1993;319:229-32 pubmed
    ..These data suggest that H+ ions bind to the channel with a one-to-one stoichiometry, and this binding site may be located outside of the membrane electric field. ..
  64. Ozawa Y, Uchida K, Uchida M, Ami Y, Kushida S, Okada N, et al. Isolation of cDNAs encoding the catalytic domain of poly(ADP-ribose) polymerase from Xenopus laevis and cherry salmon using heterologous oligonucleotide consensus sequences. Biochem Biophys Res Commun. 1993;193:119-25 pubmed
  65. Mori N, Morishita M, Tsukazaki T, Giam C, Kumatori A, Tanaka Y, et al. Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300. Blood. 2001;97:2137-44 pubmed
    ..The novel function of Tax as a repressor of TGF-beta signaling may contribute to HTLV-I leukemogenesis. (Blood. 2001;97:2137-2144) ..
  66. Uchiyama H, Kobayashi T, Yamashita A, Ohno S, Yabe S. Cloning and characterization of the T-box gene Tbx6 in Xenopus laevis. Dev Growth Differ. 2001;43:657-69 pubmed
    ..These results suggest that Tbx6 is implicated in ventral mesoderm specification but is involved in muscle differentiation when acting together with the dorsalizing factor noggin. ..
  67. Miyazaki H, Kaneko T, Uchida S, Sasaki S, Takei Y. Kidney-specific chloride channel, OmClC-K, predominantly expressed in the diluting segment of freshwater-adapted tilapia kidney. Proc Natl Acad Sci U S A. 2002;99:15782-7 pubmed
    ..The localization of OmClC-K and its induction in hypoosmotic media suggest that OmClC-K is involved in Cl(-) reabsorption in the distal tubule of freshwater-adapted tilapia. ..
  68. Tamura K, Noyama T, Ishizawa Y, Takamatsu N, Shiba T, Ito M. Xenopus death receptor-M1 and -M2, new members of the tumor necrosis factor receptor superfamily, trigger apoptotic signaling by differential mechanisms. J Biol Chem. 2004;279:7629-35 pubmed
    ..Although xDR-M1 and xDR-M2 are very similar to each other, the difference in their death domains may result in diverse signaling, suggesting distinct roles of xDR-M1 and xDR-M2 in cell death or survival. ..
  69. Shibata M, Itoh M, Hikasa H, Taira S, Taira M. Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. Mech Dev. 2005;122:1322-39 pubmed
    ..These data suggest a potential role for Crescent in head formation by regulating a non-canonical Wnt pathway positively in the adjacent posterior mesoderm and negatively in the overlying anterior neuroectoderm. ..
  70. Kondow A, Hitachi K, Ikegame T, Asashima M. Bowline, a novel protein localized to the presomitic mesoderm, interacts with Groucho/TLE in Xenopus. Int J Dev Biol. 2006;50:473-9 pubmed
    ..This study indicates that Bowline is a novel protein interacting with Groucho/TLE and may play a role in somitogenesis in X. laevis. ..
  71. Tamanoue Y, Yamagishi M, Hongo I, Okamoto H. Polypyrimidine tract-binding protein is required for the repression of gene expression by all-trans retinoic acid. Dev Growth Differ. 2010;52:469-79 pubmed publisher
    ..Our results indicate that PTB plays a role in the repression of gene expression by retinoic acid through binding to the TG/CA repeats. ..
  72. Hasebe T, Kajita M, Iwabuchi M, Ohsumi K, Ishizuya Oka A. Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis. Dev Genes Evol. 2011;221:199-208 pubmed publisher
    ..laevis intestine, suggesting the involvement of the lamins in the process of dedifferentiation during amphibian metamorphosis...
  73. Nakajima K, Fujimoto K, Yaoita Y. Regulation of thyroid hormone sensitivity by differential expression of the thyroid hormone receptor during Xenopus metamorphosis. Genes Cells. 2012;17:645-59 pubmed publisher
    ..We propose the positive feedback loop model to amplify the cell's ability to respond to low levels of T4...
  74. Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster D, et al. Kinetic analyses of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. Nucl Med Biol. 2013;40:670-5 pubmed publisher
    ..Anti-FACBC has higher affinity for ASCT2 than for SNAT2, LAT1, or LAT2. The ASCT2-preferential transport of anti-[(18)F]FACBC in cancer cells could be used for more effective prostate cancer imaging. ..
  75. Asano M, Emori Y, Saigo K, Shiokawa K. Isolation and characterization of a Xenopus cDNA which encodes a homeodomain highly homologous to Drosophila Distal-less. J Biol Chem. 1992;267:5044-7 pubmed
    ..Embryo dissection experiment revealed that the transcript is abundant in the anterior region at the neurula stage, suggesting that Xdll may play a role in the establishment of the structures in the anterior part of the embryo. ..
  76. Hirata M, Hayashi Y, Ushikubi F, Yokota Y, Kageyama R, Nakanishi S, et al. Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature. 1991;349:617-20 pubmed
    ..This first report on the molecular structure of an eicosanoid receptor will promote the molecular pharmacology and pathophysiology of these bioactive compounds. ..
  77. Kuno T, Shuntoh H, Takeda T, Ito A, Sakaue M, Hirai M, et al. Activation of type I cyclic AMP-dependent protein kinases is impaired by a point mutation in cyclic AMP binding sites. Eur J Pharmacol. 1989;172:263-71 pubmed
    ..These results suggest that both A and B cyclic AMP binding sites are required for efficient coupling between cyclic AMP binding and activation of the enzyme. ..
  78. Akiba I, Kubo T, Maeda A, Bujo H, Nakai J, Mishina M, et al. Primary structure of porcine muscarinic acetylcholine receptor III and antagonist binding studies. FEBS Lett. 1988;235:257-61 pubmed
    ..The antagonist binding properties of muscarinic acetylcholine receptor III expressed from the cloned DNA in Xenopus oocytes correspond most closely to those of the pharmacologically defined M2 glandular (III) subtype. ..
  79. Sasaki S, Fushimi K, Saito H, Saito F, Uchida S, Ishibashi K, et al. Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct. J Clin Invest. 1994;93:1250-6 pubmed
    ..Chromosomal mapping of the hAQP-CD gene assigned its location to chromosome 12q13. These results could be important for future studies of the pathophysiology of human urinary concentration mechanisms in normal and abnormal states. ..
  80. Nishimatsu S, Koyasu N, Sugaya T, Ohnishi J, Yamagishi T, Murakami K, et al. Isolation and characterization of two alternatively spliced complementary DNAs encoding a Xenopus laevis angiotensin II receptor. Biochim Biophys Acta. 1994;1218:401-7 pubmed
    ..This indicated that the Xenopus heart, unlike that of mammals, plays a major role in the AII-dependent regulation of blood pressure and extracellular fluid volume. ..
  81. Hasegawa S, Kuzuhara T, Horikoshi M. The sequence of a Xenopus laevis TFIID subunit reveals remarkable conservation among vertebrates. Gene. 1995;164:369-70 pubmed
    ..A highly conserved region exists in the central region among these species. In contrast, the C-terminal region has significant homology among vertebrates, whereas the corresponding region of the Dm homologue shows poor homology. ..
  82. Miyamoto K, Tatsumi S, Sonoda T, Yamamoto H, Minami H, Taketani Y, et al. Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression. Biochem J. 1995;305 ( Pt 1):81-5 pubmed
    ..These findings indicate that two high-affinity Na/P(i) cotransporters (NaP(i)-3 and NPT-1) are present in human kidney cortex. ..
  83. Miyamoto K, Tatsumi S, Morimoto A, Minami H, Yamamoto H, Sone K, et al. Characterization of the rabbit intestinal fructose transporter (GLUT5). Biochem J. 1994;303 ( Pt 3):877-83 pubmed
    ..However, biochemical properties of fructose transport in Xenopus oocytes injected with GLUT5 cRNA differed from those in rabbit jejunal vesicles. ..
  84. Okabayashi K, Shoji H, Nakamura T, Hashimoto O, Asashima M, Sugino H. cDNA cloning and expression of the Xenopus laevis vitellogenin receptor. Biochem Biophys Res Commun. 1996;224:406-13 pubmed
    ..6 kb in Xenopus ovary, weak but significant expression was observed in other tissues by RT-PCR analysis. The fact that major expression of the gene occurs in the ovary suggests that it has an important function in this organ. ..
  85. Todo T, Kim S, Hitomi K, Otoshi E, Inui T, Morioka H, et al. Flavin adenine dinucleotide as a chromophore of the Xenopus (6-4)photolyase. Nucleic Acids Res. 1997;25:764-8 pubmed
    ..Here we report isolation of a Xenopus laevis(6-4)photolyase gene and show that the (6-4)photolyase binds non- covalently to stoichiometric amounts of FAD. This is the first indication of FAD as the chromophore of (6-4)photolyase. ..
  86. Shimizu Nishikawa K, Tazawa I, Uchiyama K, Yoshizato K. Expression of helix-loop-helix type negative regulators of differentiation during limb regeneration in urodeles and anurans. Dev Growth Differ. 1999;41:731-43 pubmed
    ..From these results, it was suggested that the blastema redifferentiates earlier in the frog than in the newt, and therefore the timing of redifferentiation of the cartilage is crucial for complete regeneration. ..
  87. Kishi Y, Funakoshi H, Matsumoto K, Nakamura T. Molecular cloning, expression and partial characterization of Xksy, Xenopus member of the Sky family of receptor tyrosine kinases. Gene. 2002;288:29-40 pubmed
    ..And doxycycline pre-treatment eliminated these activities. These findings suggest that Xksy may play an important role in growth, differentiation and the accurate migration of cells during embryogenesis and early neural development. ..
  88. Ishibashi K, Matsuzaki T, Takata K, Imai M. Identification of a new member of type I Na/phosphate co-transporter in the rat kidney. Nephron Physiol. 2003;94:p10-8 pubmed
    ..The electron microscopic studies confirmed this finding. The present study revealed the expression of a new type I Na/P(i) co-transporter at the brush border membrane of the proximal tubules in the kidney. ..
  89. Chan T, Satow R, Kitagawa H, Kato S, Asashima M. Ledgerline, a novel Xenopus laevis gene, regulates differentiation of presomitic mesoderm during somitogenesis. Zoolog Sci. 2006;23:689-97 pubmed
    ..These results strongly suggest that ledgerline is essential for mesodermal RA activity and differentiation of the presomitic mesoderm during Xenopus somitogenesis. ..
  90. Sakamoto T, Oda A, Yamamoto K, Kaneko M, Kikuyama S, Nishikawa A, et al. Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis. Peptides. 2006;27:3347-51 pubmed
    ..PrRP mRNA levels in the developing Xenopus brain peak in early prometamorphosis, different from prolactin levels. PrRP may not be a major prolactin-releasing factor (PRF), at least in adult frogs, as in mammals. ..
  91. Takebayashi Suzuki K, Arita N, Murasaki E, Suzuki A. The Xenopus POU class V transcription factor XOct-25 inhibits ectodermal competence to respond to bone morphogenetic protein-mediated embryonic induction. Mech Dev. 2007;124:840-55 pubmed
  92. Araki N, Umemura M, Miyagi Y, Yabana M, Miki Y, Tamura K, et al. Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension. Hypertension. 2008;51:773-7 pubmed publisher
    ..Such interactions might abnormally increase sodium reabsorption. Taken together, our analyses suggest that the human Nedd4L gene, especially the evolutionarily new isoform I, is a candidate gene for hypertension. ..