Experts and Doctors on viral envelope proteins in United States

Summary

Locale: United States
Topic: viral envelope proteins

Top Publications

  1. Kim T, Leibfried Rutledge M, First N. Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes. Mol Reprod Dev. 1993;35:105-13 pubmed
    ..coli beta-galactosidase gene under a beta-actin internal promoter. In addition, co-culture of ICM cells with virus-producing cells resulted in differentiation of ICM cells into embryoid bodies expressing the marker genes...
  2. Maeda J, Maeda A, Makino S. Release of coronavirus E protein in membrane vesicles from virus-infected cells and E protein-expressing cells. Virology. 1999;263:265-72 pubmed
    ..These data implied that E protein alone can drive the production and release of coronavirus envelope in the absence of M protein. ..
  3. Husak P, Kuo T, Enquist L. Pseudorabies virus membrane proteins gI and gE facilitate anterograde spread of infection in projection-specific neurons in the rat. J Virol. 2000;74:10975-83 pubmed
    ..Our studies confirm that gI and gE specifically facilitate anterograde spread of infection by affecting intracellular processes in the primary infected neuron such as anterograde transport in axons or egress from axon terminals. ..
  4. Kingham B, Zelnik V, Kopacek J, Majerciak V, Ney E, Schmidt C. The genome of herpesvirus of turkeys: comparative analysis with Marek's disease viruses. J Gen Virol. 2001;82:1123-35 pubmed
    ..By implication, other genes present in this region of MDV-1, but missing in HVT, may play important roles in the different biological properties of the viruses. ..
  5. Melder D, Pankratz V, Federspiel M. Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptor interactions. J Virol. 2003;77:10504-14 pubmed
    ..Alterations in the normally extreme specificity of the ALV(A) glycoproteins for Tva may represent an evolutionary first step toward expanding viral receptor usage in response to inefficient viral entry...
  6. Burkhart M, D Agostino P, Kayman S, Pinter A. Involvement of the C-terminal disulfide-bonded loop of murine leukemia virus SU protein in a postbinding step critical for viral entry. J Virol. 2005;79:7868-76 pubmed
  7. Wang D, Raja N, Trubey C, Juompan L, Luo M, Woraratanadharm J, et al. Development of a cAdVax-based bivalent ebola virus vaccine that induces immune responses against both the Sudan and Zaire species of Ebola virus. J Virol. 2006;80:2738-46 pubmed
    ..This study demonstrates the potential efficacy of a bivalent EBOV vaccine based on a cAdVax vaccine vector design. ..
  8. Boehme K, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol. 2006;177:7094-102 pubmed
    ..This study further elucidates the importance and potency of envelope gp as a class of molecules displaying pathogen-associated molecular patterns that are recognized with immediate kinetics by TLRs in permissive cells. ..
  9. Estrada D, Boudreaux D, Zhong D, St Jeor S, De Guzman R. The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers. J Biol Chem. 2009;284:8654-60 pubmed publisher
    ..We discuss the implication of the hantaviral G1 zinc fingers in viral assembly and host-pathogen interaction...

More Information

Publications119 found, 100 shown here

  1. Aubert M, Yoon M, Sloan D, Spear P, Jerome K. The virological synapse facilitates herpes simplex virus entry into T cells. J Virol. 2009;83:6171-83 pubmed publisher
    ..Targeting of the VS might allow selective immunopotentiation during infections with HSV or other nonlymphotropic viruses. ..
  2. Weible A, Schwarcz L, Wickersham I, Deblander L, Wu H, Callaway E, et al. Transgenic targeting of recombinant rabies virus reveals monosynaptic connectivity of specific neurons. J Neurosci. 2010;30:16509-13 pubmed publisher
    ..Such neuron-specific transgenic complementation of recombinant rabies virus holds great promise for obtaining cellular-resolution wiring diagrams of the mammalian CNS. ..
  3. Eksioglu E, Zhu H, Bayouth L, Bess J, Liu H, Nelson D, et al. Characterization of HCV interactions with Toll-like receptors and RIG-I in liver cells. PLoS ONE. 2011;6:e21186 pubmed publisher
    ..This work represents a novel mechanism of viral pathogenesis for HCV and demonstrates the role of PRRs in viral infection. ..
  4. Subathra M, Qureshi A, Luberto C. Sphingomyelin synthases regulate protein trafficking and secretion. PLoS ONE. 2011;6:e23644 pubmed publisher
  5. Hegde S, Hankey P, Paulson R. Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53. Stem Cells. 2012;30:121-30 pubmed publisher
    ..Surprisingly, mutation of p53 is not observed in LSCs. These data establish a new model for Friend virus-induced erythroleukemia and demonstrate the utility of Friend virus as a model system to study LSC self-renewal. ..
  6. Miller E, Chandran K. Filovirus entry into cells - new insights. Curr Opin Virol. 2012;2:206-14 pubmed publisher
    ..Membrane fusion delivers the viral nucleocapsid core into the cytoplasm, which is the site of filovirus replication. This review summarizes our understanding of the filovirus entry mechanism, with emphasis on recent findings...
  7. Skinner A, Chakkaramakkil Verghese S, Kurre P. Cell-cell transmission of VSV-G pseudotyped lentivector particles. PLoS ONE. 2013;8:e74925 pubmed publisher
    ..These studies suggest that cell-surface attachment stabilizes particles and alters neutralization kinetics. Our experiments provide novel insight into the underexplored cell-cell transmission of pseudotyped particles. ..
  8. Martin E, Chirivella M, Co J, Santiago G, Gubler D, Muñoz Jordán J, et al. Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence. Virus Res. 2016;213:23-31 pubmed publisher
    ..This study confirms that DENVs evolve through rapid lineage turnover driven in part by natural selection and genetic drift. ..
  9. Finkelstein L, Ney P, Liu Q, Paulson R, Correll P. Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Oncogene. 2002;21:3562-70 pubmed
    ..These data clearly demonstrate a requirement for signaling through Sf-Stk in the Epo-independent expansion of Friend virus-infected cells, and suggest a pivotal role for Grb2 in this response. ..
  10. Lavillette D, Marin M, Ruggieri A, Mallet F, Cosset F, Kabat D. The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. J Virol. 2002;76:6442-52 pubmed
    ..The recognition of ASCT1 and ASCT2 despite this divergence of their sequences strongly suggests that the use of both receptors has been highly advantageous for survival and evolution of the HERV-W family of retroviruses. ..
  11. Wang D, Hevey M, Juompan L, Trubey C, Raja N, Deitz S, et al. Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges. Virology. 2006;353:324-32 pubmed
    ..Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV...
  12. Liu J, Ye X, Jia J, Zhu R, Wang L, Chen C, et al. Serological Evaluation of Immunity to the Varicella-Zoster Virus Based on a Novel Competitive Enzyme-Linked Immunosorbent Assay. Sci Rep. 2016;6:20577 pubmed publisher
    ..The established competitive sandwich ELISA could be used as a rapid and high-throughput method for evaluating immunity to VZV. ..
  13. Ricotti S, Garcia M, Veaute C, Bailat A, Lucca E, Cook R, et al. Serologically silent, occult equine infectious anemia virus (EIAV) infections in horses. Vet Microbiol. 2016;187:41-49 pubmed publisher
  14. Aubert M, Chen Z, Lang R, Dang C, Fowler C, Sloan D, et al. The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation. J Virol. 2008;82:617-29 pubmed
    ..Thus, HSV gJ is a multifunctional protein, modulating other cellular processes in addition to inhibition of apoptosis. ..
  15. Kong B, Foster L, Foster D. Species-specific deletion of the viral attachment glycoprotein of avian metapneumovirus. Virus Res. 2008;132:114-21 pubmed publisher
    ..The lack of viral gene deletions suggests that avian cell propagated AMPV will provide a better alternative host for live recombinant vaccine development based on a reverse genetics system...
  16. Hussein I, Cheng E, Ganaie S, Werle M, Sheema S, Haque A, et al. Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells. J Virol. 2012;86:7520-9 pubmed publisher
  17. Lu Z, Zhang J, Huang C, Go Y, Faaberg K, Rowland R, et al. Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome virus do not change the cellular tropism of equine arteritis virus. Virology. 2012;432:99-109 pubmed publisher
    ..2012)...
  18. Rabaa M, Klungthong C, Yoon I, Holmes E, Chinnawirotpisan P, Thaisomboonsuk B, et al. Frequent in-migration and highly focal transmission of dengue viruses among children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis. 2013;7:e1990 pubmed publisher
  19. Ryckman B, Chase M, Johnson D. HCMV gH/gL/UL128-131 interferes with virus entry into epithelial cells: evidence for cell type-specific receptors. Proc Natl Acad Sci U S A. 2008;105:14118-23 pubmed publisher
    ..We concluded that epithelial cells express gH/gL/UL128-131 receptors that mediate HCMV entry. Fibroblasts either lack the gH/gL/UL128-131 receptors, the receptors are more numerous, or fibroblasts express other functional receptors. ..
  20. Pardi N, Hogan M, Pelc R, Muramatsu H, Andersen H, Demaso C, et al. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature. 2017;543:248-251 pubmed publisher
    ..These data demonstrate that nucleoside-modified mRNA-LNP elicits rapid and durable protective immunity and therefore represents a new and promising vaccine candidate for the global fight against ZIKV. ..
  21. Hoatlin M, Kozak S, Lilly F, Chakraborti A, Kozak C, Kabat D. Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene. Proc Natl Acad Sci U S A. 1990;87:9985-9 pubmed
    ..These results have important implications for understanding signal transduction by EpoR and the role of host genetic variation in controlling susceptibility to an oncogenic protein...
  22. Chowdhury S, Lee B, Ozkul A, Weiss M. Bovine herpesvirus 5 glycoprotein E is important for neuroinvasiveness and neurovirulence in the olfactory pathway of the rabbit. J Virol. 2000;74:2094-106 pubmed
    ..However, BHV-5 gE is not required for initial viral entry into olfactory pathway. ..
  23. Liu C, Cook F, Cook S, Craigo J, Even D, Issel C, et al. The determination of in vivo envelope-specific cell-mediated immune responses in equine infectious anemia virus-infected ponies. Vet Immunol Immunopathol. 2012;148:302-10 pubmed publisher
    ..These results demonstrate a novel method for detecting in vivo cell-mediated immune responses to EIAV-specific peptides that is readily applicable to other host/pathogen systems...
  24. Eroglu E, Tiwari P, Waffo A, Miller M, Vig K, Dennis V, et al. A nonviral pHEMA+chitosan nanosphere-mediated high-efficiency gene delivery system. Int J Nanomedicine. 2013;8:1403-15 pubmed publisher
    ..In this study, we report, for the first time, the application of the PCNSs as a nanovehicle for gene delivery in vitro and in vivo. ..
  25. Philipp Staheli J, Marquardt T, Thouless M, Bruce A, Grant R, Tsai C, et al. Genetic variability of the envelope gene of Type D simian retrovirus-2 (SRV-2) subtypes associated with SAIDS-related retroperitoneal fibromatosis in different macaque species. Virol J. 2006;3:11 pubmed
  26. Nanbo A, Imai M, Watanabe S, Noda T, Takahashi K, Neumann G, et al. Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog. 2010;6:e1001121 pubmed publisher
    ..These findings provide new insights into the lifecycle of Ebolavirus and may aid in the development of therapeutics for Ebolavirus infection. ..
  27. Nanbo A, Watanabe S, Halfmann P, Kawaoka Y. The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells. Sci Rep. 2013;3:1206 pubmed publisher
    ..Newly synthesized negative-sense RNA was distributed inside the inclusions, whereas positive-sense RNA was distributed both inside and outside. These findings provide useful insights into Ebola virus replication. ..
  28. Shirako Y, Niklasson B, Dalrymple J, Strauss E, Strauss J. Structure of the Ockelbo virus genome and its relationship to other Sindbis viruses. Virology. 1991;182:753-64 pubmed
    ..The Indian and Australian strains form a distinct branch of the evolutionary tree and differ from prototypic AR339 Sindbis virus in 17% of the nucleotides sequenced...
  29. Lazo A, Bailer R, Blakeslee J, Yanagihara R, Stevens V, Kramer L, et al. Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates. Arch Virol. 1995;140:307-23 pubmed
    ..These differences in immunoreactivity may have important implications for serologic diagnosis, as well as epidemiological and vaccine studies of STLV-I infection...
  30. Al Mubarak A, Simon J, Coats C, Okemba J, Burton M, Chowdhury S. Glycoprotein E (gE) specified by bovine herpesvirus type 5 (BHV-5) enables trans-neuronal virus spread and neurovirulence without being a structural component of enveloped virions. Virology. 2007;365:398-409 pubmed
    ..Collectively, the results suggest that gE functions in transsynaptic transmission of BHV-5 and neurovirulence without being a structural component of the virion particle...
  31. Ramanathan M, Kuo Y, Selling B, Li Q, Sardesai N, Kim J, et al. Development of a novel DNA SynCon tetravalent dengue vaccine that elicits immune responses against four serotypes. Vaccine. 2009;27:6444-53 pubmed publisher
    ..This is the first SynCon DNA vaccine that provides tetravalent immunity against all four serotypes of dengue virus. ..
  32. Janaka S, Gregory D, Johnson M. Retrovirus glycoprotein functionality requires proper alignment of the ectodomain and the membrane-proximal cytoplasmic tail. J Virol. 2013;87:12805-13 pubmed publisher
    ..We hypothesize that the CTD forms a coiled-coil that disrupts the protein's functionality if it is not in phase with the trimer interface of the ectodomain...
  33. Wille P, Wisner T, RYCKMAN B, Johnson D. Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein. MBio. 2013;4:e00332-13 pubmed publisher
    ..In contrast, virus particles lacking gH/gL could not enter cells expressing gH/gL. Our study supports the hypothesis that gB is the fusion protein and gH/gL acts upstream of gB to bind receptors and then activate gB for fusion...
  34. Khalil M, Sommer M, Arvin A, Hay J, Ruyechan W. Cellular transcription factor YY1 mediates the varicella-zoster virus (VZV) IE62 transcriptional activation. Virology. 2014;449:244-53 pubmed publisher
    ..This work suggests a novel role for the cellular factor YY1 in VZV replication through the mediation of IE62 activation of viral gene expression. ..
  35. Kuo L, Masters P. The small envelope protein E is not essential for murine coronavirus replication. J Virol. 2003;77:4597-608 pubmed
    ..The properties of this mutant provide further support for the importance of E protein in MHV replication, but surprisingly, they also show that E protein is not essential. ..
  36. Leisenfelder S, Kinchington P, Moffat J. Cyclin-dependent kinase 1/cyclin B1 phosphorylates varicella-zoster virus IE62 and is incorporated into virions. J Virol. 2008;82:12116-25 pubmed publisher
    ..Thus, IE62 is a substrate for CDK1/cyclin B1, and virions could deliver the active cellular kinase to nondividing cells that normally do not express it...
  37. Weber J, Weberova J, Carobene M, Mirza M, Martinez Picado J, Kazanjian P, et al. Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. J Virol Methods. 2006;136:102-17 pubmed
  38. Mahalingam R, Traina Dorge V, Wellish M, deHaro E, Golive A, Messaoudi I, et al. Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaques. J Virol. 2010;84:12454-7 pubmed publisher
    ..Virus transcription and the detection of open reading frame (ORF) 63 protein in the cytoplasm of neurons were comparable. Thus, a 30-h delay after death did not affect varicella-zoster virus expression in latently infected ganglia...
  39. Hughes A, Friedman R. Evolutionary diversification of protein-coding genes of hantaviruses. Mol Biol Evol. 2000;17:1558-68 pubmed
  40. Loiacono C, Taus N, Mitchell W. The herpes simplex virus type 1 ICP0 promoter is activated by viral reactivation stimuli in trigeminal ganglia neurons of transgenic mice. J Neurovirol. 2003;9:336-45 pubmed
    ..It further suggests the possibility that activation of ICP0 gene expression by neuronal transcription factors may be important in reactivation of HSV-1 in neurons. ..
  41. Butchi N, Jones C, Perez S, Doster A, Chowdhury S. Envelope protein Us9 is required for the anterograde transport of bovine herpesvirus type 1 from trigeminal ganglia to nose and eye upon reactivation. J Neurovirol. 2007;13:384-8 pubmed publisher
    ..Therefore, Us9 is essential for reactivation of the virus in the TG and anterograde axonal transport from TG to nose and eye...
  42. Yamamoto S, Eletsky A, Szyperski T, Hay J, Ruyechan W. Analysis of the varicella-zoster virus IE62 N-terminal acidic transactivating domain and its interaction with the human mediator complex. J Virol. 2009;83:6300-5 pubmed publisher
    ..Two-dimensional nuclear magnetic resonance spectroscopy revealed that the TAD is intrinsically unstructured. Our studies suggest that transactivation may involve the TAD adopting a defined structure upon binding MED25. ..
  43. Whitman S, Smith E, Dutch R. Differential rates of protein folding and cellular trafficking for the Hendra virus F and G proteins: implications for F-G complex formation. J Virol. 2009;83:8998-9001 pubmed publisher
    ..These results suggest that the critical F-G interactions occur only after the initial steps of synthesis and cellular transport...
  44. Pati S, Novak Z, Purser M, Arora N, Mach M, Britt W, et al. Strain-specific neutralizing antibody responses against human cytomegalovirus envelope glycoprotein N. Clin Vaccine Immunol. 2012;19:909-13 pubmed publisher
    ..The findings demonstrate that HCMV gN elicits strain-specific neutralizing antibody responses and that broader anti-gN neutralizing activity may provide some protection from reinfection with a different virus strain. ..
  45. Dick J, Hilterbrand A, Strawsine L, Upton J, Bard A. Enzymatically enhanced collisions on ultramicroelectrodes for specific and rapid detection of individual viruses. Proc Natl Acad Sci U S A. 2016;113:6403-8 pubmed publisher
    ..We further apply this method to the detection of MCMV in urine of infected mice. The method provides for a selective, rapid, and sensitive detection technique based on electrochemical collisions. ..
  46. Tailor C, Kabat D. Variable regions A and B in the envelope glycoproteins of feline leukemia virus subgroup B and amphotropic murine leukemia virus interact with discrete receptor domains. J Virol. 1997;71:9383-91 pubmed
    ..We propose a common two-step mechanism for interaction between retroviral envelope glycoproteins and cell surface receptors...
  47. Whitfield A, Ullman D, German T. Tomato spotted wilt virus glycoprotein G(C) is cleaved at acidic pH. Virus Res. 2005;110:183-6 pubmed
    ..Like studies with other members of the Bunyaviridae, this study is the first step towards characterizing the nature of cell entry by TSWV. ..
  48. Klyachkin Y, Geraghty R. Mutagenic analysis of herpes simplex virus type 1 glycoprotein L reveals the importance of an arginine-rich region for function. Virology. 2008;374:23-32 pubmed publisher
    ..Substitution of Arg158 with Lys restored function in gH trafficking and cell fusion but not virus entry. These results indicate that an arginine-rich region of gL is critical for function...
  49. Ammayappan A, Peng K, Russell S. Characteristics of oncolytic vesicular stomatitis virus displaying tumor-targeting ligands. J Virol. 2013;87:13543-55 pubmed publisher
    ..This study provides a rational foundation for the future development of fully retargeted oncolytic VSVs. ..
  50. Al Mubarak A, Zhou Y, Chowdhury S. A glycine-rich bovine herpesvirus 5 (BHV-5) gE-specific epitope within the ectodomain is important for BHV-5 neurovirulence. J Virol. 2004;78:4806-16 pubmed
  51. Moffat J, Mo C, Cheng J, Sommer M, Zerboni L, Stamatis S, et al. Functions of the C-terminal domain of varicella-zoster virus glycoprotein E in viral replication in vitro and skin and T-cell tropism in vivo. J Virol. 2004;78:12406-15 pubmed
  52. Aubert M, Krantz E, Jerome K. Herpes simplex virus genes Us3, Us5, and Us12 differentially regulate cytotoxic T lymphocyte-induced cytotoxicity. Viral Immunol. 2006;19:391-408 pubmed publisher
    ..Taken together, these results suggest that HSV evasion of cellular immunity is multifacterial and complex, and relies on the partially redundant activities of various individual HSV proteins...
  53. Chen Z, Wang Y, Ratia K, Mesecar A, Wilkinson K, Baker S. Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. J Virol. 2007;81:6007-18 pubmed publisher
  54. Koelle D, Magaret A, McClurkan C, Remington M, Warren T, Teofilovici F, et al. Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects. Clin Vaccine Immunol. 2008;15:773-82 pubmed publisher
    ..Modifications of the dose, adjuvant, route, schedule, or HSV antigen may be required to improve responses. ..
  55. Dosch S, Mahajan S, Collins A. SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-kappaB pathway in human monocyte macrophages in vitro. Virus Res. 2009;142:19-27 pubmed publisher
    ..The results further suggested that released or secreted S protein could activate blood monocytes through recognition by toll-like receptor (TLR)2 ligand...
  56. de Silva S, Planelles V, Wu L. Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4+ T-cells and dendritic cells. PLoS ONE. 2012;7:e35385 pubmed publisher
    ..Taken together, our results suggest that Vpr has differential effects on single-cycle and spreading HIV-1 infections, which are dependent on the permissiveness of the target cell. ..
  57. Presley J, Polo J, Johnston R, Brown D. Proteolytic processing of the Sindbis virus membrane protein precursor PE2 is nonessential for growth in vertebrate cells but is required for efficient growth in invertebrate cells. J Virol. 1991;65:1905-9 pubmed
    ..The nucleotide sequences of two such variants were determined. These variants contained point mutations that restored PE2 cleavage, indicating a genetic linkage between failure to cleave PE2 and failure to grow in mosquito cells. ..
  58. Hoatlin M, Kabat D. Host-range control of a retroviral disease: Friend erythroleukemia. Trends Microbiol. 1995;3:51-7 pubmed
    ..Some of these genes limit helper-virus replication, target-cell (erythroblast) pools or immune responses. At least one host gene appears to block the viral oncoprotein...
  59. Jones J, Risser R. Cell fusion induced by the murine leukemia virus envelope glycoprotein. J Virol. 1993;67:67-74 pubmed
    ..Analysis of the effect of these mutations confirmed that this region is a fusion domain...
  60. Klyachkin Y, Stoops K, Geraghty R. Herpes simplex virus type 1 glycoprotein L mutants that fail to promote trafficking of glycoprotein H and fail to function in fusion can induce binding of glycoprotein L-dependent anti-glycoprotein H antibodies. J Gen Virol. 2006;87:759-67 pubmed publisher
    ..If the acquisition of 53S and LP11 binding to gH reflects a gL-induced conformational change, such a change is not sufficient to mediate trafficking of the gH-gL heterodimer...
  61. Wang D, Schmaljohn A, Raja N, Trubey C, Juompan L, Luo M, et al. De novo syntheses of Marburg virus antigens from adenovirus vectors induce potent humoral and cellular immune responses. Vaccine. 2006;24:2975-86 pubmed
    ..These promising results indicate that a cAdVax-based vaccine could be effective for induction of both humoral and cell-mediated immune responses to multiple strains of the Marburg virus...
  62. Wisner T, Wright C, Kato A, Kawaguchi Y, Mou F, Baines J, et al. Herpesvirus gB-induced fusion between the virion envelope and outer nuclear membrane during virus egress is regulated by the viral US3 kinase. J Virol. 2009;83:3115-26 pubmed publisher
    ..By this packaging, US3 might be brought close to the gB CT tail, leading to phosphorylation and triggering fusion between the virion envelope and the outer NM. ..
  63. Chen Y, Honeychurch K, Yang G, Byrd C, Harver C, Hruby D, et al. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Virol J. 2009;6:44 pubmed publisher
    ..These results suggest that p37 localizes to the LE and interacts with proteins associated with LE-derived transport vesicle biogenesis to facilitate assembly of extracellular forms of virus...
  64. Trobridge G, Wu R, Hansen M, Ironside C, Watts K, Olsen P, et al. Cocal-pseudotyped lentiviral vectors resist inactivation by human serum and efficiently transduce primate hematopoietic repopulating cells. Mol Ther. 2010;18:725-33 pubmed publisher
    ..These studies establish the potential of cocal-pseudotyped lentiviral vectors for a variety of scientific and therapeutic gene transfer applications, including in vivo gene delivery and hematopoietic stem cell (HSC) gene therapy. ..
  65. He S, Ni S, Hegde S, Wang X, Sharda D, August A, et al. Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk. J Virol. 2010;84:2223-35 pubmed publisher
  66. Feire A, Roy R, Manley K, Compton T. The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. J Virol. 2010;84:10026-37 pubmed publisher
    ..The strong conservation of the DLD across beta- and gammaherpesviruses suggests that integrin recognition and utilization may be a more broadly conserved feature throughout the Herpesviridae. ..
  67. Pandrea I, Parrish N, Raehtz K, Gaufin T, Barbian H, Ma D, et al. Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites. J Virol. 2012;86:4158-68 pubmed publisher
  68. Jupille H, Medina Rivera M, Hawman D, Oko L, Morrison T. A tyrosine-to-histidine switch at position 18 of the Ross River virus E2 glycoprotein is a determinant of virus fitness in disparate hosts. J Virol. 2013;87:5970-84 pubmed publisher
    ..Taken together, these findings suggest that a tyrosine-to-histidine switch at E2 position 18 functions as a regulator of RRV fitness in vertebrate and invertebrate cells. ..
  69. Acciani M, Alston J, Zhao G, Reynolds H, Ali A, Xu B, et al. Mutational Analysis of Lassa Virus Glycoprotein Highlights Regions Required for Alpha-Dystroglycan Utilization. J Virol. 2017;91: pubmed publisher
    ..Our results highlight a region within the Lassa virus GP1 protein that interacts with the cellular receptor alpha-dystroglycan. This information may be used for future development of new Lassa virus antivirals. ..
  70. White H, Roeder D, Lam T, Green W. Major and minor Kb-restricted epitopes encoded by the endogenous ecotropic murine leukemia virus AKR623 that are recognized by anti-AKR/Gross MuLV CTL. Viral Immunol. 1994;7:51-9 pubmed
    ..The identification and characterization of these additional epitopes allow for a better understanding of both the CTL response against GCSA+ tumor cells and the dysfunctional CTL response against EMV-14 and AK7...
  71. Kim V, Green W. The role of proximal and distal sequence variations in the presentation of an immunodominant CTL epitope encoded by the ecotropic AK7 MuLV. Virology. 1997;236:221-33 pubmed
    ..Interestingly, our data indicate that the enhancer region derived from AK7 negatively influences the presentation of KSPWFTTL in the context of a recombinant AKR623 virus...
  72. Holmen S, Federspiel M. Selection of a subgroup A avian leukosis virus [ALV(A)] envelope resistant to soluble ALV(A) surface glycoprotein. Virology. 2000;273:364-73 pubmed
    ..This virus had a six-amino-acid deletion in the subgroup A hr1 that altered receptor usage. This approach may identify regions of SU that play a critical role in receptor specificity...
  73. Holmen S, Melder D, Federspiel M. Identification of key residues in subgroup A avian leukosis virus envelope determining receptor binding affinity and infectivity of cells expressing chicken or quail Tva receptor. J Virol. 2001;75:726-37 pubmed
    ..We also conclude from these results that, at least for the wild-type and variant ALV(A)s tested, the receptor binding affinity was directly related to infection efficiency...
  74. Oomens A, Megaw A, Wertz G. Infectivity of a human respiratory syncytial virus lacking the SH, G, and F proteins is efficiently mediated by the vesicular stomatitis virus G protein. J Virol. 2003;77:3785-98 pubmed
    ..This is the first report of the recovery of an infectious HRSV lacking a fusion protein of the Paramyxoviridae family and of manipulation of the HRSV entry pathway via incorporation of a nonparamyxoviral transmembrane glycoprotein. ..
  75. Alonso M, Rodríguez Saint Jean S, Perez Prieto S. Virulence of infectious hematopoietic necrosis virus and Infectious pancreatic necrosis virus coinfection in rainbow trout ( Oncorhynchus mykiss) and nucleotide sequence analysis of the IHNV glycoprotein gene. Arch Virol. 2003;148:1507-21 pubmed
    ..S46 and compared with other sequences available in the GenBank. Changes found were not located in the antigenic domains of the glycoprotein and were considered not significant...
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    ..The use of a background subtraction method for the IgM ELISA eliminated all 15 false-positive results, giving a specificity of 100% for the Focus IgM ELISA. ..
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    ..a. 22-44 and 351-357) artificially linked together by glycine, exhibited a potent antiviral activity with IC50 of about 0.1 microM. This novel peptide is a promising candidate as a therapeutic agent against this deadly emerging pathogen. ..
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