Experts and Doctors on thyroid hormones in Japan


Locale: Japan
Topic: thyroid hormones

Top Publications

  1. Akane H, Shiraki A, Imatanaka N, Akahori Y, Itahashi M, Abe H, et al. Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study. Toxicol Lett. 2014;224:424-32 pubmed publisher
    ..These results suggest that glycidol causes aberrations in adult neurogenesis in the SGZ at the late stage involving the process of neurite extension similar to the developmental exposure study in a standard 28-day toxicity study. ..
  2. Shashni B, Sakharkar K, Nagasaki Y, Sakharkar M. Glycolytic enzymes PGK1 and PKM2 as novel transcriptional targets of PPAR? in breast cancer pathophysiology. J Drug Target. 2013;21:161-74 pubmed publisher
    ..These investigations will help us in understanding the molecular mechanisms by which PPAR? regulates the cellular energy pathway and the use of its ligands in human breast cancer therapeutics. ..
  3. Sarui H, Sano A, Maruyama T, Nakashima K, Takeda N, Yasuda K. Severe graves ophthalmopathy accompanied by HTLV-1-associated uveitis (HAU) and anti-neutrophil cytoplasmic antibody-related vasculitis: a case report and a review of the literature of HAU with Graves disease. Am J Med Sci. 2002;324:109-14 pubmed
    ..Only 2 of 27 cases (except unknown cases) (7.4%) had Graves ophthalmopathy. To the best of our knowledge, there has been no investigation of HAU and Graves ophthalmopathy. ..
  4. Kato K, Murakami H, Isozaki O, Tsushima T, Takano K. Serum concentrations of BNP and ANP in patients with thyrotoxicosis. Endocr J. 2009;56:17-27 pubmed
    ..Thus, the determination of serum BNP levels in thyrotoxic patients is useful for monitoring cardiovascular conditions of HF. ..
  5. Abe T, Suzuki T, Unno M, Tokui T, Ito S. Thyroid hormone transporters: recent advances. Trends Endocrinol Metab. 2002;13:215-20 pubmed
    ..Here, we discuss the classification of thyroid hormone transporters, with emphasis on how they are influenced by their ionic milieu and what their symported organic anions are. ..
  6. Sugiyama S, Shimada N, Miyoshi H, Yamauchi K. Detection of thyroid system-disrupting chemicals using in vitro and in vivo screening assays in Xenopus laevis. Toxicol Sci. 2005;88:367-74 pubmed
    ..It should be noted that chemicals elicited thyroid system-disrupting activity in the luciferase assay did not always interfere with the thyroid system in vivo. ..
  7. Sasaki K, Yoshida A, Nakata Y, Mizote I, Sakata Y, Komuro I. A case of thyroid storm with multiple organ failure effectively treated with plasma exchange. Intern Med. 2011;50:2801-5 pubmed
    ..After therapeutic plasma exchange was carried out, his thyroid hormone level decreased markedly. Consequently, his condition recovered gradually, and he was discharged at day 43...
  8. Matsubara K, Sanoh S, Ohta S, Kitamura S, Sugihara K, Fujimoto N. An improved thyroid hormone reporter assay to determine the thyroid hormone-like activity of amiodarone, bithionol, closantel and rafoxanide. Toxicol Lett. 2012;208:30-5 pubmed publisher
    ..Our improved assay was proved to be a sensitive tool for assessing thyroid hormone-like activity of environmental chemicals...
  9. Hasebe T, Kajita M, Iwabuchi M, Ohsumi K, Ishizuya Oka A. Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis. Dev Genes Evol. 2011;221:199-208 pubmed publisher
    ..laevis intestine, suggesting the involvement of the lamins in the process of dedifferentiation during amphibian metamorphosis...

More Information


  1. Hasebe T, Kajita M, Shi Y, Ishizuya Oka A. Thyroid hormone-up-regulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis. Dev Dyn. 2008;237:3006-15 pubmed publisher
    ..Finally, we demonstrate that Hip binds to the N-terminal fragment of processed Shh in vivo, suggesting that Hip suppresses Shh signaling through sequestering Shh...
  2. Mawaribuchi S, Tamura K, Okano S, Takayama S, Yaoita Y, Shiba T, et al. Tumor necrosis factor-alpha attenuates thyroid hormone-induced apoptosis in vascular endothelial cell line XLgoo established from Xenopus tadpole tails. Endocrinology. 2008;149:3379-89 pubmed publisher
    ..These findings suggested that xTNF-alpha could protect vascular endothelial cells from apoptotic cell death induced by T(3) during metamorphosis and thereby participate in the regulation of cell fate. ..
  3. Ishizuya Oka A, Hasebe T, Shimizu K, Suzuki K, Ueda S. Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling. Dev Dyn. 2006;235:3240-9 pubmed
    ..These results strongly suggest that the Shh/BMP-4 signaling pathway plays key roles in the amphibian intestinal remodeling through epithelial-connective tissue interactions. ..
  4. Kawaguchi M, Iwata S, Kamiya Y, Hayakawa F, Fujii T, Ito J, et al. Thyroid storm associated with probable subclinical hypoadrenocorticism in an elderly woman. Intern Med. 1992;31:1236-8 pubmed
    ..She responded to the administration of intravenous methimazole and oral supersaturated potassium iodide solution...
  5. Kubo Y, Sekiya S, Ohigashi M, Takenaka C, Tamura K, Nada S, et al. ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. Mol Cell Biol. 2005;25:4138-49 pubmed
    ..In addition, Abca5(-)(/)(-) mice also exhibited exophthalmos and collapse of the thyroid gland. Therefore, ABCA5 is a protein related to a lysosomal disease and plays important roles, especially in cardiomyocytes and follicular cells...
  6. Nakajima K, Yaoita Y. Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis. Dev Dyn. 2003;227:246-55 pubmed
  7. Hayashi Y, Ohmori S, Ito T, Seo H. A splicing variant of Steroid Receptor Coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action. Biochem Biophys Res Commun. 1997;236:83-7 pubmed
    ..SRC-1E enhanced thyroid hormone dependent transactivation of reporter gene expression more profoundly than SRC-1 or SRC-1(-Q). Taken together, it was suggested that SRC-1E is the major isoform of SRC-1 to mediate thyroid hormone action. ..
  8. Miura Y, Mori Y, Yamamori I, Tani Y, Murata Y, Yoshimoto M, et al. Sequence of a variant thyroxine-binding globulin (TBG) in a family with partial TBG deficiency in Japanese (TBG-PDJ). Endocr J. 1993;40:127-32 pubmed
    ..The proline to leucine substitution may cause a change in the TBG tertiary structure and result in decreased heat stability, resulting in decreased TBG levels in the affected subjects. ..
  9. Nishii Y, Hashizume K, Ichikawa K, Miyamoto T, Suzuki S, Takeda T, et al. Changes in cytosolic 3,5,3'-tri-iodo-L-thyronine (T3) binding activity during administration of L-thyroxine to thyroidectomized rats: cytosolic T3-binding protein and its activator act as intracellular regulators for nuclear T3 binding. J Endocrinol. 1989;123:99-104 pubmed
  10. Miyajima N, Horiuchi R, Shibuya Y, Fukushige S, Matsubara K, Toyoshima K, et al. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell. 1989;57:31-9 pubmed
    ..Interestingly, the ear-1 gene product showed low, but appreciable, binding to T3, although its authentic ligand remains to be clarified. ..