Genomes and Genes
Experts and Doctors on species specificity in United States
Locale: United States
Topic: species specificity
Publications381 found, 100 shown here
- Soares M, Chakraborty D, Karim Rumi M, Konno T, Renaud S. Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface. Placenta. 2012;33:233-43 pubmed publisher..The purpose of this review is to provide the requisite background to help move the rat to the forefront in placentation research. ..
- Salipante S, Sengupta D, Rosenthal C, COSTA G, Spangler J, Sims E, et al. Rapid 16S rRNA next-generation sequencing of polymicrobial clinical samples for diagnosis of complex bacterial infections. PLoS ONE. 2013;8:e65226 pubmed publisher..The described method is sufficiently rapid (theoretically compatible with same-day turnaround times) and inexpensive for routine clinical use...
- Ablonczy Z, Higbee D, Grey A, Koutalos Y, Schey K, Crouch R. Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium. Arch Biochem Biophys. 2013;539:196-202 pubmed publisher..These results indicate that A2E metabolism may be altered in the human compared to the murine RPE. ..
- Greaser M, Berri M, Warren C, Mozdziak P. Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension. J Muscle Res Cell Motil. 2002;23:473-82 pubmed
- Raman S, Rathinasabapathi B. beta-alanine N-methyltransferase of Limonium latifolium. cDNA cloning and functional expression of a novel N-methyltransferase implicated in the synthesis of the osmoprotectant beta-alanine betaine. Plant Physiol. 2003;132:1642-51 pubmed..Phylogenetic analyses suggested that beta-Ala NMTase represents a novel family of N-methyltransferases that are evolutionarily related to O-methyltransferases...
- Egerton Warburton L, Ghisalberti E. Isolation and structural identification of a germination inhibitor in fire-recruiters from the California chaparral. J Chem Ecol. 2001;27:371-82 pubmed..Lower activity was detected in the fire-independent species, P. tanacetifolia and P. campanularia. The inhibitory activity was associated with the new sucrose ester, 6-O-linoleyl-alpha-D-glucopyranosyl-beta-D-fructofuranoside...
- May P, REINER A, Ryabinin A. Comparison of the distributions of urocortin-containing and cholinergic neurons in the perioculomotor midbrain of the cat and macaque. J Comp Neurol. 2008;507:1300-16 pubmed publisher..This will allow more effective scientific discourse on the connections and function of groups such as the periculomotor urocortin (pIII(U)) and preganglionic (pIII(PG)) populations. ..
- Moore S, Huntington H. Arctic marine mammals and climate change: impacts and resilience. Ecol Appl. 2008;18:s157-165 pubmed..The means to track and assess Arctic ecosystem change using sentinel marine mammal species are suggested to offer a framework for scientific investigation and responsible resource management. ..
- Rhode W, Roth G, Recio Spinoso A. Response properties of cochlear nucleus neurons in monkeys. Hear Res. 2010;259:1-15 pubmed publisher..In the dorsal cochlear nucleus, too, responses were similar. From these results it is evident that insights gained from non-primate studies can be applied to the peripheral auditory system of primates. ..
- Andes D, Diekema D, Pfaller M, Bohrmuller J, Marchillo K, Lepak A. In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species. Antimicrob Agents Chemother. 2010;54:2497-506 pubmed publisher..albicans (mean, 20) for each echinocandin. The results suggest that current susceptibility breakpoints and the consideration of organism species in these determinations should be reexplored. ..
- Estrada D, De Guzman R. Structural characterization of the Crimean-Congo hemorrhagic fever virus Gn tail provides insight into virus assembly. J Biol Chem. 2011;286:21678-86 pubmed publisher..Our results provide insight into a likely role of the CCHF virus Gn zinc fingers in Nairovirus assembly. ..
- Satler J, Carstens B, Hedin M. Multilocus species delimitation in a complex of morphologically conserved trapdoor spiders (mygalomorphae, antrodiaetidae, aliatypus). Syst Biol. 2013;62:805-23 pubmed publisher..and Aliatypus starretti, sp. nov.). This study helps to clarify species limits in a genetically fragmented group and provides a framework for identifying and defining the cryptic lineage diversity that prevails in many organismal groups...
- Stephenson N, Das A, Condit R, Russo S, Baker P, Beckman N, et al. Rate of tree carbon accumulation increases continuously with tree size. Nature. 2014;507:90-3 pubmed publisher..Our results resolve conflicting assumptions about the nature of tree growth, inform efforts to undertand and model forest carbon dynamics, and have additional implications for theories of resource allocation and plant senescence. ..
- Edwards M, Liu G, Mire C, Sureshchandra S, Luthra P, Yen B, et al. Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins. Cell Rep. 2016;14:1632-1640 pubmed publisher..Our studies reveal functional differences in EBOV versus MARV VP35 RNA binding that result in unexpected differences in the host response to deadly viral pathogens. ..
- George H, Marchand P, Murphy K, Wiswall B, Dowling R, Giannaras J, et al. Recombinant human 92-kDa type IV collagenase/gelatinase from baculovirus-infected insect cells: expression, purification, and characterization. Protein Expr Purif. 1997;10:154-61 pubmed..The recombinant enzyme provides a useful source of protein for a variety of biochemical and biophysical studies aimed at elucidating the structure and function of human MMP9. ..
- Vazquez Cooz I, Meyer R. A differential staining method to identify lignified and unlignified tissues. Biotech Histochem. 2002;77:277-82 pubmed..Ethyl alcohol solutions of these dyes provide an effective and reliable method to distinguish lignified and unlignified tissues. ..
- Tanaka Y, Slitt A, Leazer T, Maher J, Klaassen C. Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun. 2005;326:181-7 pubmed..Male-predominant expression of Bcrp in rat kidney appears to be due to the suppressive effect of estradiol, and male-predominant expression of Bcrp in mouse liver appears to be due to the inductive effect of testosterone...
- Calvi B, Byrnes B, Kolpakas A. Conservation of epigenetic regulation, ORC binding and developmental timing of DNA replication origins in the genus Drosophila. Genetics. 2007;177:1291-301 pubmed..Our findings suggest that conserved developmental mechanisms integrate egg chamber morphogenesis with cell cycle modifications and the epigenetic regulation of origins. ..
- Senchina D, Shah N, Doty D, Sanderson C, Hallam J. Herbal supplements and athlete immune function--what's proven, disproven, and unproven?. Exerc Immunol Rev. 2009;15:66-106 pubmed..Fifth and finally, we evaluate the current knowledge on herbal supplements and athlete immune function, identify gaps and limitations in knowledge, and advance several possible options for future research. ..
- Coffee L, Hanson B, Luttrell M, Swayne D, Senne D, Goekjian V, et al. Avian paramyxoviruses in shorebirds and gulls. J Wildl Dis. 2010;46:481-7 pubmed..The higher prevalence of APMV in Ruddy Turnstones mirrors results observed for avian influenza viruses in shorebirds and may suggest similar modes of transmission...
- Sadowitz B, Roy S, Gatto L, Habashi N, Nieman G. Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment. Expert Rev Anti Infect Ther. 2011;9:1169-78 pubmed publisher..Conversely, a treatment strategy based on the appropriate use of mechanical ventilation affects lung physiology on a breath-to-breath basis and has the potential to treat, and even prevent, the ALI/ARDS associated with sepsis. ..
- Baizer J, Weinstock N, Witelson S, Sherwood C, Hof P. The nucleus pararaphales in the human, chimpanzee, and macaque monkey. Brain Struct Funct. 2013;218:389-403 pubmed publisher..These results suggest that the "PRa" in the human may not be the same structure as the flocculus-projecting cell group described in the macaque. The PRa, like the arcuate nucleus, therefore may be unique to humans. ..
- Vicente J, Stewart A, Song B, Hill R, Wright J. Biodiversity of Actinomycetes associated with Caribbean sponges and their potential for natural product discovery. Mar Biotechnol (NY). 2013;15:413-24 pubmed publisher..strain isolated in this study from the Caribbean sponge Agelas sceptrum. ..
- Dewsbury D. The comparative psychology of monogamy. Nebr Symp Motiv. 1987;35:1-50 pubmed..abstract truncated at 400 words) ..
- Lee S, Nicholls R, Jong M, Fukai K, Spritz R. Organization and sequence of the human P gene and identification of a new family of transport proteins. Genomics. 1995;26:354-63 pubmed..These results provide the basis for analyses of patients with OCA2 and may point toward eventual pharmacologic treatment of this and related disorders of pigmentation...
- Randazzo F, Seeger M, Huss C, Sweeney M, Cecil J, Kaufman T. Structural changes in the antennapedia complex of Drosophila pseudoobscura. Genetics. 1993;134:319-30 pubmed..These observations and others suggest that the complex is not absolutely rigid but that selective pressures have maintained this organization of genes for some functional reason that remains elusive...
- Ansaldi M, Marolt D, Stebe T, Mandic Mulec I, Dubnau D. Specific activation of the Bacillus quorum-sensing systems by isoprenylated pheromone variants. Mol Microbiol. 2002;44:1561-73 pubmed..These results give new insights into peptidemediated quorum-sensing signalling in Gram-positive bacteria and emphasize the role of isoprenylation in bacterial signal transduction. ..
- Hempen P, Phillips K, Conway P, Sandoval K, Schneeman T, Wu H, et al. Transcriptional regulation of the human polymeric Ig receptor gene: analysis of basal promoter elements. J Immunol. 2002;169:1912-21 pubmed..These findings suggest that cooperative binding of multiple transcription factors regulates basal activity of the human PIGR promoter. ..
- Hsu Y, Hou Q, Cymbalyuk E, Youle R. Generation and characterization of species-specific anti-Bcl-X(L) monoclonal antibodies. Hybrid Hybridomics. 2003;22:91-5 pubmed..These results suggest that these antibodies can serve as important tools for the detection and purification of endogenous and ectopically expressed human and murine Bcl-X(L). ..
- Ernest S, Hosack A, O Brien W, Rosenblatt D, Nadeau J. Homocysteine levels in A/J and C57BL/6J mice: genetic, diet, gender, and parental effects. Physiol Genomics. 2005;21:404-10 pubmed..Finally, gene-diet interactions affected heritability of mean tHcy levels. These studies showed that each of these factors contributes to tHcy levels and provided important clues to understanding homocysteine homeostasis in humans. ..
- Alam S, Ain R, Konno T, Ho Chen J, Soares M. The rat prolactin gene family locus: species-specific gene family expansion. Mamm Genome. 2006;17:858-77 pubmed..Elucidation of the rat PRL gene family locus provides tools for studying the genetics and biology of the rat PRL family and new insights into species-specific gene family expansion. ..
- Michalak P, Malone J, Lee I, Hoshino D, Ma D. Gene expression polymorphism in Drosophila populations. Mol Ecol. 2007;16:1179-89 pubmed..melanogaster/races/strains and predicted to be translational-inactive in Cosmopolitan due to a major deletion, was found to be up-regulated in Zimbabwe and down-regulated, but still expressed, in Cosmopolitan. ..
- Zheng Q, Ding D, Yu H, Salvi R, Johnson K. A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice. Neurobiol Aging. 2009;30:1693-705 pubmed publisher..Spiral ganglion neurons, cells of the stria vascularis, and vestibular hair cell densities, however, appeared normal in 20-week-old A/J mice. ..
- Callahan C, Castanha E, Fox K, Fox A. The Bacillus cereus containing sub-branch most closely related to Bacillus anthracis, have single amino acid substitutions in small acid-soluble proteins, while remaining sub-branches are more variable. Mol Cell Probes. 2008;22:207-11 pubmed publisher..Double substitutions occurred in both N and C termini. Of the pneumonia-causing strains, one exhibited a single amino acid substitution, while the other two exhibited a two amino acid substitution. ..
- Dumont B, White M, Steffy B, Wiltshire T, Payseur B. Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps. Genome Res. 2011;21:114-25 pubmed publisher..musculus. Our findings reveal considerable variation in the megabase-scale recombination landscape among recently diverged taxa and underscore the continued importance of genetic linkage maps in the post-genome era. ..
- Becker E, Petruno S, Marler C. A comparison of scent marking between a monogamous and promiscuous species of peromyscus: pair bonded males do not advertise to novel females. PLoS ONE. 2012;7:e32002 pubmed publisher..Our data suggest that communication through scent-marking can diverge significantly between species based on mating system and that there are physiological mechanisms that can inhibit responsiveness of males to female cues...
- Mantooth K, Hadziabdic D, Boggess S, Windham M, Miller S, Cai G, et al. Confirmation of independent introductions of an exotic plant pathogen of Cornus species, Discula destructiva, on the east and west coasts of North America. PLoS ONE. 2017;12:e0180345 pubmed publisher..These primers may be useful for investigating the genetic diversity and population structure of these Discula species. ..
- Solomons J, Zimmerly E, Burns S, Krishnamurthy N, Swan M, Krings S, et al. The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. J Mol Biol. 2004;342:847-60 pubmed..The structure with G6P also explains the specificity of PGI for glucose 6-phosphate over mannose 6-isomerase (M6P). To isomerize M6P to F6P requires a rotation of its C2-C3 bond but in PGI this is sterically blocked by Gln511. ..
- Ritchey J, Payton M, Eberle R. Clinicopathological characterization of monkey B virus (Cercopithecine herpesvirus 1) infection in mice. J Comp Pathol. 2005;132:202-17 pubmed..Viral antigen was detected immunohistochemically in the lesions. The results indicated an ascending encephalomyelitis syndrome similar to that produced by BV in man. ..
- Chan D, Anderson A. Towards species-specific antifolates. Curr Med Chem. 2006;13:377-98 pubmed..Specifically, advances in developing inhibitors against Pneumocystis jirovecii and Plasmodium falciparum, the causative agents in pneumocystis pneumonia and malaria, respectively, will be presented. ..
- Wellehan J, Johnson A, Childress A, Harr K, Isaza R. Six novel gammaherpesviruses of Afrotheria provide insight into the early divergence of the Gammaherpesvirinae. Vet Microbiol. 2008;127:249-57 pubmed..These viruses may have codiverged with their host species. Phylogenetic analysis of these novel herpesviruses suggests that two separate groups of gammaherpesviruses may have codiverged with the Afrotheria...
- Antonious G, Bomford M, Vincelli P. Screening Brassica species for glucosinolate content. J Environ Sci Health B. 2009;44:311-6 pubmed publisher..We concluded that environmental stress on growing plants can increase the concentration of GSLs, ascorbic acid, and total phenols in Brassica shoots, but does not increase yields of these phytochemicals per unit area. ..
- Estevo C, Nagy Reis M, Nichols J. When habitat matters: Habitat preferences can modulate co-occurrence patterns of similar sympatric species. PLoS ONE. 2017;12:e0179489 pubmed publisher..Occupancy models can be a valuable tool in such modeling. ..
- Becker Rudzik M, Young D, Marrs B. Sequence of the indoleglycerol phosphate synthase (trpC) gene from Rhodobacter capsulatus. J Bacteriol. 1992;174:5482-4 pubmed..Normalized alignment scores comparing the trpC gene of R. capsulatus with the trpC genes of other bacterial species are reported. An unexpected degree of similarity to the trpC gene of Bacillus subtilis was found. ..
- Craig R, Jabs E, Zhou P, Kozopas K, Hawkins A, Rochelle J, et al. Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. Genomics. 1994;23:457-63 pubmed..MCL1 is thus a candidate gene for involvement in cancer. ..
- Elgren T, Orville A, Kelly K, Lipscomb J, Ohlendorf D, Que L. Crystal structure and resonance Raman studies of protocatechuate 3,4-dioxygenase complexed with 3,4-dihydroxyphenylacetate. Biochemistry. 1997;36:11504-13 pubmed publisher..PCA complex based solely on direct modeling of the 2Fo - Fc electron density and suggests that this is the conformation required for catalysis...
- Buck K, Hood H. Genetic association of a GABA(A) receptor gamma2 subunit variant with severity of acute physiological dependence on alcohol. Mamm Genome. 1998;9:975-8 pubmed..This is the first report that QTL mapping for an alcohol-related trait has successfully led to the identification of a polymorphic candidate gene product that is genetically associated with the trait. ..
- Wittkopp P, Williams B, Selegue J, Carroll S. Drosophila pigmentation evolution: divergent genotypes underlying convergent phenotypes. Proc Natl Acad Sci U S A. 2003;100:1808-13 pubmed publisher..These findings bear upon understanding classic models of melanism and mimicry...
- Herzog R. Immune responses to AAV capsid: are mice not humans after all?. Mol Ther. 2007;15:649-50 pubmed
- Lewellyn E, Loeb D. Base pairing between cis-acting sequences contributes to template switching during plus-strand DNA synthesis in human hepatitis B virus. J Virol. 2007;81:6207-15 pubmed..Finally, we did not identify predicted base pairing between h5E and the hM region, indicating a possible difference between HBV and DHBV. The significance of these similarities and differences between HBV and DHBV will be discussed. ..
- Samuels J, Meachen J, Sakai S. Postcranial morphology and the locomotor habits of living and extinct carnivorans. J Morphol. 2013;274:121-46 pubmed publisher..Results are used to infer the locomotor habits of extinct carnivorans, including members of several extinct families, and also 12 species from the Pleistocene of Rancho La Brea...
- Chapman M, Mandel J, Burke J. Sequence validation of candidates for selectively important genes in sunflower. PLoS ONE. 2013;8:e71941 pubmed publisher..This result confirms a possible strategy for streamlining the search for adaptively-important loci process by pre-screening the derived population to identify the strongest candidates before sequencing them in the ancestral population. ..
- Renne R, Gideon K, Miller R, Mellick P, Grumbein S. Histologic methods and interspecies variations in the laryngeal histology of F344/N rats and B6C3F1 mice. Toxicol Pathol. 1992;20:44-51 pubmed..Routine use of these methods for preparation and microscopic examination of sections of the larynx has revealed some variations in normal laryngeal anatomy between Fischer 344 (F344/N) rats and B6C3F1 mice. ..
- Cronn R, Small R, Haselkorn T, Wendel J. Cryptic repeated genomic recombination during speciation in Gossypium gossypioides. Evolution. 2003;57:2475-89 pubmed..Gossypium gossypioides provides a striking example of the previously unsuspected chimeric nature of some plant genomes and the resulting phylogenetic complexity produced by multiple historical reticulation events...
- Harris R, Wilk D, Bevins C, Munson R, Bakaletz L. Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. J Biol Chem. 2004;279:20250-6 pubmed..Continued study of this and other APs will allow us to determine their role in bacterial colonization of the upper airway as well as how viruses might contribute to the pathogenesis of OM by modulating AP expression...
- Kameda T, Thomson J. Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript. Stem Cells. 2005;23:1535-40 pubmed..The lack of ERas expression in human ES cells suggests that they could have significantly different tumorigenic properties than mouse ES cells. ..
- Post E, Pedersen C, Wilmers C, Forchhammer M. Phenological sequences reveal aggregate life history response to climatic warming. Ecology. 2008;89:363-70 pubmed..Such insight may be compromised by considering changes in individual phenological events in isolation. ..
- Pangule R, Brooks S, Dinu C, Bale S, Salmon S, Zhu G, et al. Antistaphylococcal nanocomposite films based on enzyme-nanotube conjugates. ACS Nano. 2010;4:3993-4000 pubmed publisher..Polymer and paint films containing such antimicrobial conjugates, in particular, could be advantageous to prevent risk of staphylococcal-specific infection and biofouling. ..
- Singer M, Farkas T, Skorik C, Mooney K. Tritrophic interactions at a community level: effects of host plant species quality on bird predation of caterpillars. Am Nat. 2012;179:363-74 pubmed publisher..These results highlight the interrelatedness of plant-herbivore and herbivore-carnivore interactions and thus the importance of a tritrophic perspective. ..
- McLennan M, Hasegawa H, Bardi M, Huffman M. Gastrointestinal parasite infections and self-medication in wild chimpanzees surviving in degraded forest fragments within an agricultural landscape mosaic in Uganda. PLoS ONE. 2017;12:e0180431 pubmed publisher..g. rhabditoid and strongyle nematodes), underscoring the importance of identifying and reducing risks of pathogen exchange in shared landscapes. ..
- Rubinelli P, Kim S, Park S, Roto S, Nealon N, Ryan E, et al. Differential effects of rice bran cultivars to limit Salmonella Typhimurium in chicken cecal in vitro incubations and impact on the cecal microbiome and metabolome. PLoS ONE. 2017;12:e0185002 pubmed publisher..In addition, Calrose rice bran inclusion leads to changes in cecal microbiological composition and metabolite profile...
- Singh N, Berger F. Evolution of a mammalian promoter through changes in patterns of transcription factor binding. J Mol Evol. 1998;46:639-48 pubmed..The results are discussed in terms of a model involving a dynamic equilibrium between states of binding site occupancy, the nature of which can be modified during evolution. ..
- Flory S, Clay K. Non-native grass invasion suppresses forest succession. Oecologia. 2010;164:1029-38 pubmed publisher..Suppression of tree regeneration by Microstegium invasions may slow the rate of forest succession and alter tree species composition. ..
- Hostetler C, Anacker A, Loftis J, Ryabinin A. Social housing and alcohol drinking in male-female pairs of prairie voles (Microtus ochrogaster). Psychopharmacology (Berl). 2012;224:121-32 pubmed publisher..Social influences on alcohol self-administration in prairie voles differ based on the sex of a social partner, consistent with human drinking behavior. ..
- Jenkins J, Thompson F, Faaborg J. Species-specific variation in nesting and postfledging resource selection for two forest breeding migrant songbirds. PLoS ONE. 2017;12:e0179524 pubmed publisher..We recommend that postfledging habitat selection be considered in future conservation efforts dealing with Neotropical migrants and other forest breeding songbirds. ..
- Cali A, Weiss L, Takvorian P. A review of the development of two types of human skeletal muscle infections from microsporidia associated with pathology in invertebrates and cold-blooded vertebrates. Folia Parasitol (Praha). 2005;52:51-61 pubmed..The morphological data presented here demonstrate these relationships. Additionally, water, as a link that connects microsporidial spores in the environment to potential host organisms, is diagrammatically presented...
- Drost M. Advanced reproductive technology in the water buffalo. Theriogenology. 2007;68:450-3 pubmed..Preliminary successes with nucleus transfer of Bubalus bubalis fetal and adult somatic nuclei into enucleated bovine oocytes and subsequent development to the blastocyst stage have been reported. ..
- Baker Herman T, Bavis R, Dahlberg J, Mitchell A, Wilkerson J, Golder F, et al. Differential expression of respiratory long-term facilitation among inbred rat strains. Respir Physiol Neurobiol. 2010;170:260-7 pubmed publisher..BN had higher 5-HT(7) and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF. ..
- Yoder J, Benoit J, Lacagnin M, Hobbs H. Increased cave dwelling reduces the ability of cave crickets to resist dehydration. J Comp Physiol B. 2011;181:595-601 pubmed publisher..We conclude that increasing water loss rates associated with increasing troglomorphic adaptation in cave crickets is a side effect of extended residence in stable moist cave environments. ..
- Laney A, Hassan M, Tzanetakis I. An integrated badnavirus is prevalent in fig germplasm. Phytopathology. 2012;102:1182-9 pubmed publisher..Forty-four isolates were used in a study evaluating the population structure of the virus in the United States. Evidence that FBV-1 is integrated in the fig genome is presented and discussed...
- Dettman R, Turner F, Hoyle H, Raff E. Embryonic expression of the divergent Drosophila beta3-tubulin isoform is required for larval behavior. Genetics. 2001;158:253-63 pubmed..Our data provide a link between the microtubule cytoskeleton in embryogenesis and the behavioral phenotype manifested as defective proprioreception at the larval stage. ..
- Zipper L, Mulcahy R. Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells. Toxicol Sci. 2003;73:124-34 pubmed
- Zhu M, Whigan D, Chang S, Dockens R. Disposition and metabolism of [14C]brasofensine in rats, monkeys, and humans. Drug Metab Dispos. 2008;36:24-35 pubmed..These primary metabolites and glucuronides of demethyl brasofensine (M1 and M2) were major circulating metabolites in humans and were also observed in rat and monkey plasma. ..
- Li C, Hazzard C, Florova G, Reynolds K. High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain. Metab Eng. 2009;11:319-27 pubmed publisher..3 g/l), and demonstrate the potential utility of S. cinnamonensis strains as heterologous hosts for high level expression of a variety of polyketide synthase derived products. ..
- Wang Z, Hamilton Brehm S, Lochner A, Elkins J, Morrell Falvey J. Mathematical modeling of hydrolysate diffusion and utilization in cellulolytic biofilms of the extreme thermophile Caldicellulosiruptor obsidiansis. Bioresour Technol. 2011;102:3155-62 pubmed publisher..The factors determining the rate-limiting step of cellulolytic biofilm growth are also analyzed and discussed. ..
- O Bleness M, Searles V, Varki A, Gagneux P, Sikela J. Evolution of genetic and genomic features unique to the human lineage. Nat Rev Genet. 2012;13:853-66 pubmed publisher..Finally, we discuss the remaining challenges, such as the incomplete nature of current genome sequence assemblies and difficulties in linking human-specific genomic changes to human-specific phenotypic traits. ..
- Santana S, Alfaro J, Noonan A, Alfaro M. Adaptive response to sociality and ecology drives the diversification of facial colour patterns in catarrhines. Nat Commun. 2013;4:2765 pubmed publisher..Thus, both sociality and ecology have played a role in producing the highest diversity of faces within mammals. ..
- Satoh M, Weintraub J, Yoshida H, Shaheen V, Richards H, Shaw M, et al. Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus. J Immunol. 2000;165:1036-43 pubmed..The data strongly support the idea that different subsets of autoantibodies are regulated differentially by cytokine stimulation and/or Fas signaling. ..
- Pan Z, Zhang H, Hague L, Lee J, Lutz C, Tian B. An intronic polyadenylation site in human and mouse CstF-77 genes suggests an evolutionarily conserved regulatory mechanism. Gene. 2006;366:325-34 pubmed..This finding indicates that vertebrates may employ a similar alternative polyadenylation mechanism to modulate CstF-77, highlighting the importance of the regulation of CstF-77 in various species. ..
- Baer C, Phillips N, Ostrow D, Avalos A, Blanton D, Boggs A, et al. Cumulative effects of spontaneous mutations for fitness in Caenorhabditis: role of genotype, environment and stress. Genetics. 2006;174:1387-95 pubmed..We find little evidence that mutational properties differ depending on environmental conditions and mutational correlations between environments are close to those expected if effects were identical in both environments. ..
- Heo S, Nannapaneni R, Story R, Johnson M. Characterization of new hybridoma clones producing monoclonal antibodies reactive against both live and heat-killed Listeria monocytogenes. J Food Sci. 2007;72:M008-15 pubmed..MAbs 22D10 and 24F6--in combination with species-specific MAb EM-7G1--should be useful candidates for use in an ELISA sandwich assays for detecting L. monocytogenes in RTE meat and poultry products...
- Melillo A, Bakshi C, Melendez J. Francisella tularensis antioxidants harness reactive oxygen species to restrict macrophage signaling and cytokine production. J Biol Chem. 2010;285:27553-60 pubmed publisher..Together, these findings suggest a novel role for bacterial antioxidants in restricting macrophage activation through their ability to preserve phosphatases that temper kinase signaling and proinflammatory cytokine production...
- Kijimoto T, Andrews J, Moczek A. Programed cell death shapes the expression of horns within and between species of horned beetles. Evol Dev. 2010;12:449-58 pubmed publisher..More generally, our results illustrate that secondary, differential loss of structures during development can be a powerful mechanism for generating considerable morphological diversity both within and between species. ..
- Kitajima K, Llorens A, Stefanescu C, Timchenko M, Lucas P, Wright S. How cellulose-based leaf toughness and lamina density contribute to long leaf lifespans of shade-tolerant species. New Phytol. 2012;195:640-52 pubmed publisher..In conclusion, cellulose and lamina density jointly enhance leaf fracture toughness, and these carbon-based physical traits, rather than phenolic-based defence, explain species differences in herbivory, leaf lifespan and shade survival. ..