Genomes and Genes
Experts and Doctors on mice in Germany
Publications810 found, 100 shown here
- Price M. Members of the Dlx- and Nkx2-gene families are regionally expressed in the developing forebrain. J Neurobiol. 1993;24:1385-99 pubmed
- Stuben G, Thews O, Pottgen C, Stuschke M, Sack H. Tumour oxygenation during fractionated radiotherapy--comparison with size-matched controls. Acta Oncol. 1999;38:209-13 pubmed..5 mm Hg on day 21 and 4.8+/-0.9 mm Hg on day 28 after start of irradiation. From these results it can be concluded that the improvement of oxygenation after fractionated irradiation is not solely the result of a reduced tumour volume...
- Saftig P, Hunziker E, Everts V, Jones S, Boyde A, Wehmeyer O, et al. Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice. Adv Exp Med Biol. 2000;477:293-303 pubmed..Taken together the phenotype of cathepsin K knockout mice underlines the importance of this proteinase in bone remodelling. ..
- Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nat Cell Biol. 2001;3:392-9 pubmed..Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15INK4b messenger RNA in primary cells and are, as a consequence, deficient in immortalization. ..
- Kessels M, Engqvist Goldstein A, Drubin D, Qualmann B. Mammalian Abp1, a signal-responsive F-actin-binding protein, links the actin cytoskeleton to endocytosis via the GTPase dynamin. J Cell Biol. 2001;153:351-66 pubmed
- von Schack D, Casademunt E, Schweigreiter R, Meyer M, Bibel M, Dechant G. Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system. Nat Neurosci. 2001;4:977-8 pubmed
- Hashemolhosseini S, Hadjihannas M, Stolt C, Haas C, Amann K, Wegner M. Restricted expression of mouse GCMa/Gcm1 in kidney and thymus. Mech Dev. 2002;118:175-8 pubmed..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development. ..
- Doreulee N, Sergeeva O, Yanovsky Y, Chepkova A, Selbach O, Gödecke A, et al. Cortico-striatal synaptic plasticity in endothelial nitric oxide synthase deficient mice. Brain Res. 2003;964:159-63 pubmed..Impairment of NO-synthesis thus shifts striatal plasticity towards LTD. This indicates a possible involvement of eNOS from endothelia in neuronal modulation. ..
- Weller K, Foitzik K, Paus R, Syska W, Maurer M. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006;20:2366-8 pubmed..Taken together, our findings indicate that MC activation and histamine release are required for normal cutaneous wound healing. ..
- Fischer M, Reeh P. Sensitization to heat through G-protein-coupled receptor pathways in the isolated sciatic mouse nerve. Eur J Neurosci. 2007;25:3570-5 pubmed..To a surprising degree, peripheral nerve axons resemble peripheral sensory terminals in their common properties of sensory and signal transduction. ..
- Garvalov B, FLYNN K, Neukirchen D, Meyn L, Teusch N, Wu X, et al. Cdc42 regulates cofilin during the establishment of neuronal polarity. J Neurosci. 2007;27:13117-29 pubmed..We conclude that Cdc42 is a key regulator of axon specification, and that cofilin is a physiological downstream effector of Cdc42 in this process. ..
- Seeger G, Gärtner U, Ueberham U, Rohn S, Arendt T. FAD-mutation of APP is associated with a loss of its synaptotrophic activity. Neurobiol Dis. 2009;35:258-63 pubmed publisher..This suggests that not only "too much Abeta" but also "too less functional intact APP" might be relevant for synaptic pathology and degeneration in AD. ..
- Favor J, Bradley A, Conte N, Janik D, Pretsch W, Reitmeir P, et al. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Genetics. 2009;182:1077-88 pubmed publisher..Our results suggest that deletion of Rcn1 directly or indirectly contributes to the eye phenotype in Pax6 contiguous gene deletions. ..
- Rupertus K, Sperling J, Corsten M, Scheuer C, Nickels R, Schilling M, et al. Darbepoetin-alpha enhances hepatectomy-associated stimulation of colorectal liver metastatic growth. Ann Surg. 2010;252:131-41 pubmed publisher..Thus, EPOs may not be used in patients undergoing hepatectomy for malignant tumor resection. ..
- Doering M, Ba L, Lilienthal N, Nicco C, Scherer C, Abbas M, et al. Synthesis and selective anticancer activity of organochalcogen based redox catalysts. J Med Chem. 2010;53:6954-63 pubmed publisher..Overall, the high efficacy and selectivity of (redox) catalytic sensor/effector compounds warrant further, extensive testing toward transfer into the clinical arena. ..
- Lazic D, Alborzi F, Marcuzzi G, Angel P, Hess J, Pfister H, et al. Enhanced StefinA and Sprr2 expression during papilloma formation in HPV8 transgenic mice. J Dermatol Sci. 2011;62:84-90 pubmed publisher..Papilloma growth could be synchronized by a single UVA/B irradiation of the skin, which led to the development of papillomas within three weeks...
- Schnoor M, Lai F, Zarbock A, Kläver R, Polaschegg C, Schulte D, et al. Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med. 2011;208:1721-35 pubmed publisher..Our results represent the first physiological evidence that cortactin is crucial for orchestrating the molecular events leading to proper endothelial barrier function and leukocyte recruitment in vivo. ..
- Vlachos A, Bas Orth C, Schneider G, Deller T. Time-lapse imaging of granule cells in mouse entorhino-hippocampal slice cultures reveals changes in spine stability after entorhinal denervation. J Comp Neurol. 2012;520:1891-902 pubmed publisher..We conclude that biphasic changes in spine loss rate and spine stability but not in the rate of spine formation play a central role in the reorganization of dentate granule cells after entorhinal denervation in vitro. ..
- Lall D, Armbruster A, Ruffert K, Betz H, Eulenburg V. Transport activities and expression patterns of glycine transporters 1 and 2 in the developing murine brain stem and spinal cord. Biochem Biophys Res Commun. 2012;423:661-6 pubmed publisher..These alterations in the activities and expression profiles of the GlyTs suggest that the contributions of GlyT1 and GlyT2 to the regulation of extracellular glycine concentrations at glycinergic synapses changes during development. ..
- Maueröder C, Chaurio R, Platzer S, Munoz L, Berens C. Model systems for rapid and slow induction of apoptosis obtained by inducible expression of pro-apoptotic proteins. Autoimmunity. 2013;46:329-35 pubmed publisher..The human cell lines expressing these suicide switches can serve as cancer models in xeno-transplanted mice, the corresponding murine cell lines allow syngeneic and allogeneic murine cancer models to be established. ..
- GÃ¼lden E, Ihira M, Ohashi A, Reinbeck A, Freudenberg M, Kolb H, et al. Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice. PLoS ONE. 2013;8:e75385 pubmed publisher..We conclude that TLR4 is involved in the progression of the insulitis process thereby controlling the development of insulin-deficient diabetes in NOD mice. ..
- Elamin A, Steinicke S, Oehlmann W, Braun Y, Wanas H, Shuralev E, et al. Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa. PLoS ONE. 2017;12:e0186801 pubmed publisher..aeruginosa. In conclusion, these findings establish a link between cell wall targets and virulence of P. aeruginosa and thus may lead to development of novel drugs for the treatment of P. aeruginosa infection...
- Lammerding Koppel M, Greiner Schröder A, Drews U. Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography. Histochem Cell Biol. 1995;103:301-10 pubmed..A large amount of embryonic muscarinic receptors was found in the remnants of the notochord and in the nucleus pulposus of the developing vertebral column. A function in morphogenesis is discussed of the embryonic muscarinic receptor. ..
- Nakos G, Gossrau R. Light microscopic visualization of semicarbazide-sensitive amine oxidase (benzylamine oxidase) using a cerium method. Folia Histochem Cytobiol. 1994;32:3-10 pubmed
- Shoichet S, Bäumer A, Stamenkovic D, Sauer H, Pfeiffer A, Kahn C, et al. Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro. Hum Mol Genet. 2002;11:815-21 pubmed..These findings expand the understanding of antioxidant properties of frataxin, and tentatively suggest a role in the early induction of cancer. ..
- Schenten D, Gerlach V, Guo C, Velasco Miguel S, Hladik C, White C, et al. DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur J Immunol. 2002;32:3152-60 pubmed..However, pol kappa-deficient embryonic fibroblasts are abnormally sensitive to killing following exposure to ultraviolet (UV) radiation, suggesting a role of pol kappa in translesion DNA synthesis. ..
- Sitek B, Poschmann G, Schmidtke K, Ullmer C, Maskri L, Andriske M, et al. Expression of MUPP1 protein in mouse brain. Brain Res. 2003;970:178-87 pubmed..Our results indicate that MUPP1 immunoreactivity co-localizes with 5-HT(2A) or 5-HT(2C) receptor expression in all regions of the mouse brain, including the choroid plexus where 5-HT(2C) receptors are highly enriched. ..
- Kess D, Peters T, Zamek J, Wickenhauser C, Tawadros S, Loser K, et al. CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis. J Immunol. 2003;171:5697-706 pubmed..This murine inflammatory skin model may also have relevance for human polygenic inflammatory diseases. ..
- Schleger C, Platz S, Deschl U. Development of an in vitro model for vascular injury with human endothelial cells. ALTEX. 2004;21 Suppl 3:12-9 pubmed..In conclusion, for a first ranking of drug candidates, cytotoxicity assays on any of the three cell types used are appropriate. For a more detailed characterisation of individual compounds, functional assays on HUVEC cells are proposed. ..
- Dere E, De Souza Silva M, Spieler R, Lin J, Ohtsu H, Haas H, et al. Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5-HT turnover in histidine decarboxylase-KO mice. Eur J Neurosci. 2004;20:1051-8 pubmed..These results are suggestive of important interactions between neuronal histamine and these site-specific neurotransmitters, which may be related to the behavioural changes found in the HDC-deficient animals. ..
- Zhang L, Kirschstein T, Sommersberg B, Merkens M, Manahan Vaughan D, Elgersma Y, et al. Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. J Neurosci. 2005;25:7697-707 pubmed..Thus, modulation of alphaCaMKII activity via autophosphorylation at Thr305/Thr306 is a key mechanism for metaplasticity that may be of importance in the integration of temporally separated episodes of activity. ..
- Uhmann A, Ferch U, Bauer R, Tauber S, Arziman Z, Chen C, et al. A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing. Int J Oncol. 2005;27:1567-75 pubmed..These latter agents could be effective in treatment of, at least, some tumors associated with loss of PTCH1 function. ..
- Khandoga A, Kessler J, Hanschen M, Khandoga A, Burggraf D, Reichel C, et al. Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver. J Leukoc Biol. 2006;79:1295-305 pubmed..MMP-9 blockade is associated with an attenuation of TNF-alpha release and endothelial CD62P expression, weakly protects from early microvascular/hepatocellular I/R damage, but improves postischemic survival. ..
- Andre E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, et al. Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung. Eur Respir J. 2006;28:275-85 pubmed..In conclusion, these data indicate that inhalation of ultrafine carbon particles triggers a biphasic pro-inflammatory process in the lung, involving the activation of macrophages and the upregulation of immunomodulatory proteins. ..
- Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, et al. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation. 2006;114:1403-9 pubmed..A rapid therapeutic elevation of S1P-containing HDL plasma levels may be beneficial in patients at high risk of acute myocardial ischemia. ..
- Neulen A, Blaudeck N, Zittrich S, Metzler D, Pfitzer G, Stehle R. Mn2+-dependent protein phosphatase 1 enhances protein kinase A-induced Ca2+ desensitisation in skinned murine myocardium. Cardiovasc Res. 2007;74:124-32 pubmed..This can be ascribed to dephosphorylation of PKA-dependent phosphorylation sites. Hence PKA-dependent phosphorylation of sarcomeric proteins persists to a functionally relevant degree after the skinning procedure. ..
- Sasse C, Bignell E, Hasenberg M, Haynes K, Gunzer M, Braus G, et al. Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet Biol. 2008;45:693-704 pubmed publisher..Accordingly, basal expression of the Cross-Pathway Control transcriptional activator appears sufficient to support aspergillosis in this disease model...
- Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth H, Dreano M, et al. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut. 2008;57:655-63 pubmed publisher..The data demonstrate that AS602868-mediated IKK2 inhibition represents a new therapeutic approach to prevent dietary-induced NASH progression. ..
- Brenneis C, Coste O, Schmidt R, Angioni C, Popp L, Nusing R, et al. Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice. J Cell Mol Med. 2008;12:639-48 pubmed publisher..Since the latter prostaglandins serve also as mediators of nociception they may compensate the loss of PGE(2) synthesis in mPGES-1-deficient mice. ..
- Sos M, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, et al. Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest. 2009;119:1727-40 pubmed publisher..Thus, genomically annotated cell-line collections may help translate cancer genomics information into clinical practice by defining critical pathway dependencies amenable to therapeutic inhibition. ..
- Descot A, Hoffmann R, Shaposhnikov D, Reschke M, Ullrich A, Posern G. Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction. Mol Cell. 2009;35:291-304 pubmed publisher..Our results show the existence of negatively acting transcriptional networks between pro- and antiproliferative signaling pathways toward SRF. ..
- Merkel O, Zheng M, Mintzer M, Pavan G, Librizzi D, Maly M, et al. Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems. J Control Release. 2011;153:23-33 pubmed publisher..Non-invasive molecular imaging predicted the in vivo fate of the complexes. Therefore, both techniques effectively promote the rapid development of safe and efficient siRNA formulations that are stable in vivo. ..
- Calderón L, Boehm T. Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A. 2011;108:7517-22 pubmed publisher..Our results reveal the redundant roles of Ccr9, Ccr7, and Cxcr4 for thymic homing and provide a framework to examine the regulation of progenitor homing in the postnatal thymus. ..
- Delebinski C, Jaeger S, Kemnitz Hassanin K, Henze G, Lode H, Seifert G. A new development of triterpene acid-containing extracts from Viscum album L. displays synergistic induction of apoptosis in acute lymphoblastic leukaemia. Cell Prolif. 2012;45:176-87 pubmed publisher..Here for the first time, we have demonstrated that either solubilized triterpene acids or lectins and combinations thereof, induce dose-dependent apoptosis in the ALL cell line NALM-6 via caspase-8 and -9 dependent pathways. ..
- Standfuss C, Pospisil H, Klein A. SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer. BMC Cancer. 2012;12:380 pubmed publisher..We conclude from distinctive fragmentation patterns that conserved as well as individual breakpoints exist which promote tumorigenesis. ..
- Ohlig S, Pickhinke U, Sirko S, Bandari S, Hoffmann D, Dreier R, et al. An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions. J Biol Chem. 2012;287:43708-19 pubmed publisher..Our in vitro findings are supported by the presence of CW-processed Shh in murine brain samples, providing the first in vivo evidence for Shh shedding and subsequent solubilization of N-terminal-truncated proteins. ..
- Groneberg D, Lies B, Konig P, Jäger R, Seidler B, Klein S, et al. Cell-specific deletion of nitric oxide-sensitive guanylyl cyclase reveals a dual pathway for nitrergic neuromuscular transmission in the murine fundus. Gastroenterology. 2013;145:188-196 pubmed publisher..In mice, NO-GC is the only NO receptor to relax the fundus; deletion of NO-GC from the combination of SMCs and ICCs blocks nitrergic signaling. Therefore, ICCs and SMCs jointly mediate the relaxant effect of enteric NO. ..
- Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R. The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol. 2014;204:409-22 pubmed publisher..These results shed new light on the mechanism and regulation of EphB2 activation and provide a model on how Eph signaling translates into graded cellular responses. ..
- Russell R, Ilg M, Lin Q, Wu G, Lechel A, Bergmann W, et al. A Dynamic Role of TBX3 in the Pluripotency Circuitry. Stem Cell Reports. 2015;5:1155-1170 pubmed publisher..Additionally, we show TBX3 to be dispensable for induction and maintenance of naive pluripotency as well as for germ cell development. These data highlight novel facets of TBX3 action in mESCs. ..
- Miosge N, Gotz W, Sasaki T, Chu M, Timpl R, Herken R. The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo. Histochem J. 1996;28:109-16 pubmed..The early embryonic expression of both fibulins indicates specific roles during organ development and, in particular, involvements in the differentiation of heart, skeletal and neuronal structures. ..
- Raabe M, Seedorf U, Hameister H, Ellinghaus P, Assmann G. Structure and chromosomal assignment of the murine sterol carrier protein 2 gene (Scp2) and two related pseudogenes by in situ hybridization. Cytogenet Cell Genet. 1996;73:279-81 pubmed..We found the overall structure of murine Scp2 to be identical to that of the human SCP2 gene. In addition, two Scp2 pseudogenes have been isolated and mapped to chromosomes 3H2-->4 and 9F. ..
- Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stevenin J, et al. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 1996;24:3821-8 pubmed..The interaction between mCBP and splicing factor 9G8 was confirmed in vivo. These results suggest a function of mCBP in RNA metabolism. ..
- Angelotti T, Hofmann F. Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit. FEBS Lett. 1996;397:331-7 pubmed..Smooth muscle-containing tissues expressed alpha2d and alpha2e. Thus, alpha2/delta isoforms are restricted in their tissue expression, suggesting an important functional role for the differentially spliced variants. ..
- Jung M, Mo H, Elson C. Synthesis and biological activity of beta-ionone-derived alcohols for cancer chemoprevention. Anticancer Res. 1998;18:189-92 pubmed..We have found several derivatives which show higher growth inhibitory properties and are promising candidates for further improvement of activity. ..
- Walter W, Scheuer C, Loos M, Reichert T, Maeurer M. H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice. J Biol Chem. 2001;276:11086-91 pubmed..These data suggest that I-A(q) exhibits a high affinity for CLIP since virtually all I-A(q) molecules on T2 cells were found to be associated with CLIP in the absence of both H2-M isoforms. ..
- Graw J, Klopp N, Loster J, Soewarto D, Fuchs H, Becker Follmann J, et al. Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts. Genetics. 2001;157:1313-20 pubmed..Therefore, it is concluded that the novel protein destroys the sensitive cellular structure of the eye lens. ..
- Koedel U, Paul R, Winkler F, Kastenbauer S, Huang P, Pfister H. Lack of endothelial nitric oxide synthase aggravates murine pneumococcal meningitis. J Neuropathol Exp Neurol. 2001;60:1041-50 pubmed..This effect seems to be related to an increased expression of (certain) cytokines/chemokines and adhesion molecules; thus leading to increased meningeal inflammation and, subsequently, to aggravated intracranial complications. ..
- Rückert R, Brandt K, Braun A, Hoymann H, Herz U, Budagian V, et al. Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo. J Immunol. 2005;174:5507-15 pubmed..This phenomenon is not mediated by enhanced numbers of CD4(+)/CD25(+) T cells. These results show that IL-15 is important for the induction of allergen-specific, Th2-differentiated T cells and induction of allergic inflammation in vivo. ..
- Geldmacher A, Skrastina D, Borisova G, Petrovskis I, Kruger D, Pumpens P, et al. A hantavirus nucleocapsid protein segment exposed on hepatitis B virus core particles is highly immunogenic in mice when applied without adjuvants or in the presence of pre-existing anti-core antibodies. Vaccine. 2005;23:3973-83 pubmed..Therefore, chimeric core particles should represent promising vaccine candidates even for anti-core positive humans. ..
- Orinska Z, Maurer M, Mirghomizadeh F, Bulanova E, Metz M, Nashkevich N, et al. IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities. Nat Med. 2007;13:927-34 pubmed..Our results identify an unexpected breach in MC-dependent innate immune defenses against sepsis and suggest that inhibiting intracellular IL-15 in MCs may improve survival from sepsis. ..
- Costa M, Kessaris N, Richardson W, Gotz M, Hedin Pereira C. The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex. J Neurosci. 2007;27:11376-88 pubmed
- Miro X, Zhou X, Boretius S, Michaelis T, Kubisch C, Alvarez Bolado G, et al. Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube. Dis Model Mech. 2009;2:412-8 pubmed publisher..Our work strongly suggests that brain malformations such as CM can result from altered epigenetic regulation of genes involved in cell proliferation in the brain. ..
- Igwe E, Essler S, Al Furoukh N, Dehne N, Brüne B. Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics. BMC Genomics. 2009;10:408 pubmed publisher..Gene analysis profiling corroborated the interplay between NO- and hypoxia-induced signaling. ..
- Söhnchen J, Grosheva M, Kiryakova S, Hübbers C, Sinis N, Skouras E, et al. Recovery of whisking function after manual stimulation of denervated vibrissal muscles requires brain-derived neurotrophic factor and its receptor tyrosine kinase B. Neuroscience. 2010;170:372-80 pubmed publisher..We conclude that BDNF and TRkB are required to mediate the effects of MS on target muscle reinnervation and recovery of whisking function. ..
- Molnar A, Haybaeck J, Lackner C, Strnad P. The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful. Expert Rev Gastroenterol Hepatol. 2011;5:167-77 pubmed publisher..Even after 100 years, the cytoskeleton represents a fascinating but greatly understudied area of NASH biology. ..
- Williams S, Fairless R, Weise J, Kalinke U, Schulz Schaeffer W, Diem R. Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. Am J Pathol. 2011;178:2823-31 pubmed publisher..Conversely, mice lacking PrP(C) demonstrated significantly more neurodegeneration. This suggests that PrP(C) may have a neuroprotective function independent of its role in regulating the immune response. ..
- Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, et al. Caspase-8 regulates TNF-?-induced epithelial necroptosis and terminal ileitis. Nature. 2011;477:335-9 pubmed publisher..Together, our data demonstrate a critical function of caspase-8 in regulating intestinal homeostasis and in protecting IECs from TNF-?-induced necroptotic cell death. ..
- Petric S, Clasen L, van Wessel C, Geduldig N, Ding Z, Schullenberg M, et al. In vivo electrophysiological characterization of TASK-1 deficient mice. Cell Physiol Biochem. 2012;30:523-37 pubmed publisher..The heart rate response after premature ventricular contractions is significantly abolished indicating a diminished baroreceptor reflex in TASK-1(-/-) mice. ..
- Ruf S, Buning C, Schreuder H, Linz W, Hübschle T, Linz D, et al. Inhibition of CatA: an emerging strategy for the treatment of heart failure. Future Med Chem. 2013;5:399-409 pubmed publisher..Pharmacological studies in rodents indicate a remarkable influence of CatA inhibition on cardiovascular disease progression and identify CatA as a promising novel target for the treatment of heart failure. ..
- Å Ä‡epoviÄ‡ T, JokiÄ‡ G, Esther A, Kataranovski D, VukÅ¡a P, ÄedoviÄ‡ S, et al. VKOR variant and sex are the main influencing factors on bromadiolone tolerance of the house mouse (Mus musculus L.). Pest Manag Sci. 2016;72:574-9 pubmed publisher..The tolerance levels of VKOR variants should be determined in further studies in order to evaluate the effectiveness of bromadiolone in sustainable management. ..
- Ghallab A, CelliÃ¨re G, Henkel S, Driesch D, Hoehme S, Hofmann U, et al. Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases. J Hepatol. 2016;64:860-71 pubmed publisher..If successfully translated to patients the GDH-based therapy might provide a less aggressive therapeutic alternative for patients with severe hyperammonemia. ..
- Reder Hilz B, Ullrich M, Ringel M, Hewitt N, Utesch D, Oesch F, et al. Metabolism of propafenone and verapamil by cryopreserved human, rat, mouse and dog hepatocytes: comparison with metabolism in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:408-17 pubmed..All of the relevant interspecies differences known from in vivo experiments were identified after short-term incubation with cryopreserved hepatocytes in suspension. ..
- Wassmann S, Czech T, van Eickels M, Fleming I, Bohm M, Nickenig G. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation. 2004;110:3062-7 pubmed..These results indicate a fundamental role of AT1 receptor activation in atherogenesis. ..
- Lokmic Z, Lämmermann T, Sixt M, Cardell S, Hallmann R, Sorokin L. The extracellular matrix of the spleen as a potential organizer of immune cell compartments. Semin Immunol. 2008;20:4-13 pubmed publisher..This review will address the structural characteristics of the ECM of the murine spleen and its potential role as an organizer of immune cell compartments, with reference to the lymph node where relevant. ..
- Woyda K, Koebrich S, Reiss I, Rudloff S, Pullamsetti S, Rühlmann A, et al. Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia. Eur Respir J. 2009;33:861-70 pubmed publisher..Pharmacological inhibition of phosphodiesterase improved lung alveolarisation in hyperoxia-induced bronchopulmonary dysplasia, and thus may offer a new therapeutic modality in the clinical management of bronchopulmonary dysplasia. ..
- Thyagarajan S, van Wyk M, Lehmann K, Lowel S, Feng G, Wässle H. Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci. 2010;30:8745-58 pubmed publisher..In both strains the residual vision was correlated with the density of cones surviving in the peripheral retina. The expression of ChR2 under the control of the Thy1 promoter in retinal ganglion cells does not rescue vision. ..
- Wick M, Härönen R, Mumberg D, Burger C, Olsen B, Budarf M, et al. Structure of the human TIMP-3 gene and its cell cycle-regulated promoter. Biochem J. 1995;311 ( Pt 2):549-54 pubmed..These results provide an important basis for further investigations addressing the role of TIMP-3 in physiological processes and pathological conditions. ..
- Walther D, Bader M. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol. 2003;66:1673-80 pubmed..In fact, there are two serotonin systems in vertebrates, independently regulated and with distinct functions. ..
- Klein G, Schaefer A, Hilfiker Kleiner D, Oppermann D, Shukla P, Quint A, et al. Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon. Circ Res. 2005;96:748-55 pubmed
- Takahashi S, Leiss M, Moser M, Ohashi T, Kitao T, Heckmann D, et al. The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007;178:167-78 pubmed..Our findings demonstrate that FN contains a novel motif for integrin binding and fibril formation whose activity is controlled by amino acid modification. ..
- Lewin G, Matus M, Basu A, Frebel K, Rohsbach S, Safronenko A, et al. Critical role of transcription factor cyclic AMP response element modulator in beta1-adrenoceptor-mediated cardiac dysfunction. Circulation. 2009;119:79-88 pubmed publisher..The results imply the regulation of genes by CREM as an important mechanism of beta(1)AR-induced cardiac damage in mice. ..
- Putzer P, Breuer P, Gotz W, Gross M, Kubler B, Scharf J, et al. Mouse insulin-like growth factor binding protein-6: expression, purification, characterization and histochemical localization. Mol Cell Endocrinol. 1998;137:69-78 pubmed..No immunopositive staining was observed in lung and liver indicating that sites of synthesis and IGFBP action are different. ..
- Arnold H, Braun T. Genetics of muscle determination and development. Curr Top Dev Biol. 2000;48:129-64 pubmed..Finally, we present recent evidence on genes that play a role in regeneration of muscle in adult organisms. ..
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