Experts and Doctors on hypoglycemic agents in Nigeria


Locale: Nigeria
Topic: hypoglycemic agents

Top Publications

  1. Ohadoma S, Michael H. Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats. Asian Pac J Trop Med. 2011;4:475-7 pubmed publisher
    ..05) with the highest percentage reduction in blood glucose (64.86%) exhibited by metformin-extract combination. The leaf extract of C. roseus significantly increases the hypoglycemic effect of metformin. ..
  2. Adaramoye O, Amanlou M, Habibi Rezaei M, Pasalar P, Ali M. Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats. Asian Pac J Trop Med. 2012;5:427-33 pubmed publisher
    ..Extract of African mistletoe has anti-diabetic and anti-hyperlipidemic effects in STZ-diabetic rats. AM may find clinical application in the amelioration of diabetes-induced lipid disorders. ..
  3. Akanmu M, Nwabudike N, Ilesanmi O. Analgesic, learning and memory and anxiolytic effects of insulin in mice. Behav Brain Res. 2009;196:237-41 pubmed publisher
    ..p.) had no effect on spatial working memory, however, it had significant spatial working memory impairment at the dose of 2.0IU/kg, i.p. in mice. The study showed that insulin has several neuropharmacological effects at doses used. ..
  4. Gbolade A. Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria. J Ethnopharmacol. 2009;121:135-9 pubmed publisher
    ..The principal antidiabetic plants included Vernonia amygdalina, Bidens pilosa, Carica papaya, Citrus aurantiifolia, Ocimum gratissimum, Momordica charantia and Morinda lucida. Dietary recommendations also accompanied therapy. ..
  5. Eseyin O, Ebong P, Ekpo A, Igboasoiyi A, Oforah E. Hypoglycemic effect of the seed extract of Telfairia occidentalis in rat. Pak J Biol Sci. 2007;10:498-501 pubmed
    ..It could be concluded that the ethanolic extract of the seed of Telfairia occidentalis possesses hypoglycemic effect in alloxan diabetic rats and could be useful in the ethnotherapy of type 2 diabetes. ..
  6. Ottah A, Augustine O, Obiora I, Maxwell E. Antihyperglycemic effects of the methanol leaf extract of Diaphananthe bidens in normoglycemic and streptozotocin-induced hyperglycemic rats. Asian Pac J Trop Med. 2012;5:192-6 pubmed publisher
    ..D. bidens extract possess antihyperglycemic activity which may be mediated through pancreatic and extra-pancreatic pathways, thereby justifying it folkloric use. ..
  7. Adewole S, Ojo S, Adenowo T, Salako A, Naicker T, Ojewole J. Effects of Ficus exasperata vahl. (moraceae) leaf aqueous extract on the renal function of streptozotocin-treated rats. Folia Morphol (Warsz). 2012;71:1-9 pubmed
    ..FEE treatment positively ameliorated the alterations in the biochemical variables in the STZ + FEE-treated rats. In conclusion, our findings suggest that FEE treatment ameliorates STZ-induced nephrotoxicity. ..
  8. Ejike C, Awazie S, Nwangozi P, Godwin C. Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions. J Ethnopharmacol. 2013;149:111-6 pubmed publisher
    ..This is a case of positive synergism, and justifies the use of these plants in ethnopharmacological BG lowering recipes. ..
  9. Sulyman A, Akolade J, Sabiu S, Aladodo R, Muritala H. Antidiabetic potentials of ethanolic extract of Aristolochia ringens (Vahl.) roots. J Ethnopharmacol. 2016;182:122-8 pubmed publisher
    ..These findings revealed that ethanolic extract from A. ringens root possess antihyperglycemic activity and the data established its usage in folkloric decoctions for management of diabetes. ..

More Information


  1. Saba A, Oyagbemi A, Azeez O. Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats. Afr Health Sci. 2010;10:276-82 pubmed
    ..However, the mechanism underlying the antidiabetic and haematinic properties of Parquetina nigrescens remains to be elucidated. ..
  2. Okolo C, Ejere V, Chukwuka C, Ezeigbo I, Nwibo D, Okorie A. HEXANE EXTRACT OF Dacryodes edulis FRUITS POSSESSES ANTI-DIABETIC AND HYPOLIPIDAEMIC POTENTIALS IN ALLOXAN DIABETES OF RATS. Afr J Tradit Complement Altern Med. 2016;13:132-144 pubmed publisher
    ..However no scientific substantiation of their claim and use exist in literature. Hence, the need to evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D. edulis fruit in alloxanised animal model...
  3. Aderibigbe A, Emudianughe T, Lawal B. Evaluation of the antidiabetic action of Mangifera indica in mice. Phytother Res. 2001;15:456-8 pubmed
    ..The results of this study indicate that the aqueous extract of the leaves of Mangifera indica possess hypoglycaemic activity...
  4. Sabiu S, Ajani E, Sunmonu T, Ashafa A. KINETICS OF MODULATORY ROLE OF Cyperus esculentus L. ON THE SPECIFIC ACTIVITY OF KEY CARBOHYDRATE METABOLIZING ENZYMES. Afr J Tradit Complement Altern Med. 2017;14:46-53 pubmed publisher
    ..i>Cyperus esculentus L. is one of the therapeutically implicated botanicals against several degenerative diseases including diabetes mellitus...
  5. Dada O, Akindele A, Morakinyo O, Sofidiya M, Ota D. Hypoglycemic and antioxidant activities of the hydroethanolic leaf extract of Byrsocarpus coccineus Schumach. & Thonn. (Connaraceae). Chin J Nat Med. 2013;11:628-37 pubmed publisher
    ..This study was conducted to investigate the antidiabetic activity of the hydroethanolic leaf extract of B. coccineus in rats...
  6. Olubomehin O, Abo K, Ajaiyeoba E. Alpha-amylase inhibitory activity of two Anthocleista species and in vivo rat model anti-diabetic activities of Anthocleista djalonensis extracts and fractions. J Ethnopharmacol. 2013;146:811-4 pubmed publisher
    ..The need for newer, more effective and less toxic drugs is imperative and the biodiversity of Nigeria has a high potential for drug discovery based on plants used in the ethnomedicine...
  7. Adisa R, Choudhary M, Adewoye E, Olorunsogo O. Hypoglycaemic and biochemical properties of Cnestis ferruginea. Afr J Tradit Complement Altern Med. 2010;7:185-94 pubmed
  8. Adisa R, Choudhary M, Olorunsogo O. Hypoglycemic activity of Buchholzia coriacea (Capparaceae) seeds in streptozotocin-induced diabetic rats and mice. Exp Toxicol Pathol. 2011;63:619-25 pubmed publisher
    ..coriacea seeds contain a potent hypoglycemic and antioxidant agent suggested to be a flavone glycoside concentrated in BFBC which may find clinical application in amelioration of diabetes-induced secondary complications...
  9. Brai B, Odetola A, Agomo P. Hypoglycemic and hypocholesterolemic potential of Persea americana leaf extracts. J Med Food. 2007;10:356-60 pubmed
    ..This could represent a protective mechanism against the development of atherosclerosis...
  10. Adaramoye O, Adeyemi E. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia Kola in streptozotocin-induced diabetes mellitus rats. J Pharm Pharmacol. 2006;58:121-8 pubmed
    ..This study confirms the anti-diabetic and hypolipidaemic effects of KV in STZ-diabetic rats. These observed effects of KV are attributed to two of its fractions, FI and FII, with RF values of 0.48 and 0.71, respectively...