Experts and Doctors on cell line in United States


Locale: United States
Topic: cell line

Top Publications

  1. Perrino B, Fong Y, Brickey D, Saitoh Y, Ushio Y, Fukunaga K, et al. Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform. J Biol Chem. 1992;267:15965-9 pubmed
    ..The reconstitution of the phosphatase activity of an expressed isoform of calcineurin A by purified B subunit and calmodulin may facilitate comparative studies of the regulation of calcineurin A activity by the B subunit and calmodulin. ..
  2. Hoatlin M, Gomez Lucia E, Lilly F, Beckstead J, Kabat D. Origin and rapid evolution of a novel murine erythroleukemia virus of the spleen focus-forming virus family. J Virol. 1998;72:3602-9 pubmed
    ..Our results suggest that SFFV-related viruses can form in mice by recombination of retroviruses with genomic and helper virus sequences and that these novel viruses then evolve to become increasingly pathogenic...
  3. Tholanikunnel B, Raymond J, Malbon C. Analysis of the AU-rich elements in the 3'-untranslated region of beta 2-adrenergic receptor mRNA by mutagenesis and identification of the homologous AU-rich region from different species. Biochemistry. 1999;38:15564-72 pubmed
    ..Thus, for beta 2-adrenergic receptor, mRNA destabilization likely occurs via conserved AU-rich elements present in the 3'-untranslated regions of receptor mRNAs. ..
  4. Cribbs L, Gomora J, Daud A, Lee J, Perez Reyes E. Molecular cloning and functional expression of Ca(v)3.1c, a T-type calcium channel from human brain. FEBS Lett. 2000;466:54-8 pubmed
    ..The resulting currents were analyzed for their voltage- and time-dependent properties. These properties identify this gene as encoding a T-type Ca(2+) channel. ..
  5. Rininsland F, Helms T, Asaad R, Boehm B, Tary Lehmann M. Granzyme B ELISPOT assay for ex vivo measurements of T cell immunity. J Immunol Methods. 2000;240:143-55 pubmed
    ..The higher resolution and lower labor and material investment should make grB ELISPOT assays an attractive alternative to chromium-release assays in monitoring the clonal sizes of specific CD8 memory cells in vivo. ..
  6. Deng X, Xiao L, Lang W, Gao F, Ruvolo P, May W. Novel role for JNK as a stress-activated Bcl2 kinase. J Biol Chem. 2001;276:23681-8 pubmed
    ..Collectively, these findings indicate a novel role for JNK1 as a SAK and may explain, at least in part, how functional phosphorylation of Bc12 can occur in the absence of growth factor. ..
  7. Wang T, Lafuse W, Zwilling B. NFkappaB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. J Immunol. 2001;167:6924-32 pubmed
    ..Together, these data provide genetic and biochemical evidence for NF-kappaB as well as Sp1 in regulating TLR2 transcription. ..
  8. Vujcic S, Liang P, Diegelman P, Kramer D, Porter C. Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J. 2003;370:19-28 pubmed
  9. Sweat J, Johnson C, Gibbs E. In vitro development and characterization of a manatee bronchial cell line. In Vitro Cell Dev Biol Anim. 2003;39:249-56 pubmed
    ..Cultured manatee bronchial epithelial cells will facilitate future studies to investigate their potential role in pulmonary disease associated with brevetoxicosis after exposure to the red-tide organism, Karenia brevis...

More Information

Publications894 found, 100 shown here

  1. Narayan M, Younis I, D Agostino D, Green P. Functional domain structure of human T-cell leukemia virus type 2 rex. J Virol. 2003;77:12829-40 pubmed
    ..This work thus provides a more detailed functional domain map of Rex-2 and further insight into its regulation of HTLV replication. ..
  2. Reimers M, Hahn M, Tanguay R. Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics. J Biol Chem. 2004;279:38303-12 pubmed
    ..Together these results indicate that class I-like ADH is conserved in zebrafish, albeit with mixed functional properties. ..
  3. Dai M, Lu H. Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem. 2004;279:44475-82 pubmed
    ..We propose that the MDM2-L5-L11-L23 complex functions to inhibit MDM2-mediated p53 ubiquitination and thus activates p53. ..
  4. Yan Y, Yang D, Zarnowska E, Du Z, Werbel B, Valliere C, et al. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells. 2005;23:781-90 pubmed
    ..They may thus provide a renewable source of functional human DA neurons for drug screening and development of sustainable therapeutics for disorders affecting the DA system. ..
  5. Bandyopadhyay B, Li G, Yin H, Kuret J. Tau aggregation and toxicity in a cell culture model of tauopathy. J Biol Chem. 2007;282:16454-64 pubmed
  6. Swiatecka Urban A, Talebian L, Kanno E, Moreau Marquis S, Coutermarsh B, Hansen K, et al. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J Biol Chem. 2007;282:23725-36 pubmed
    ..Taken together, these data indicate that myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. ..
  7. Ligon L, Holzbaur E. Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly. Traffic. 2007;8:808-19 pubmed
  8. Castillo M, Wu X, Dinguirard N, Nyame A, Cummings R, Yoshino T. Surface membrane proteins of Biomphalaria glabrata embryonic cells bind fucosyl determinants on the tegumental surface of Schistosoma mansoni primary sporocysts. J Parasitol. 2007;93:832-40 pubmed
    ..It is concluded that Bge cells have surface protein(s) that may be playing a role in facilitating host cell adhesion to the surface of schistosome primary sporocysts through larval fucosylated glycoconjugates. ..
  9. Xie J, Reverdatto S, Frolov A, Hoffmann R, Burz D, Shekhtman A. Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE). J Biol Chem. 2008;283:27255-69 pubmed publisher
    ..We propose that constitutive oligomerization of RAGE is responsible for recognizing patterns of AGE-modified proteins with affinities less than 100 nm. ..
  10. Jiang J, Parameshwaran K, Seibenhener M, Kang M, Suppiramaniam V, Huganir R, et al. AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus. 2009;19:392-406 pubmed publisher
    ..These findings support a model where p62 interaction and aPKC phosphorylation act together to mediate AMPA receptor trafficking and long-term synaptic plasticity in the hippocampus. ..
  11. Johannessen M, Ramachandran S, Riemer L, Ramos Serrano A, Ruoho A, Jackson M. Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems. Am J Physiol Cell Physiol. 2009;296:C1049-57 pubmed publisher
    ..The modulation of Na(v)1.5 channels by sigma-receptors in the heart suggests an important pathway by which drugs can alter cardiac excitability and rhythmicity. ..
  12. Lehiy C, Martinez O, Passarelli A. Virion-associated viral fibroblast growth factor stimulates cell motility. Virology. 2009;395:152-60 pubmed publisher
    ..Although the function of virion-associated vFGF is not clear, we found that virion-associated vFGF stimulated cell motility and affected virus attachment. ..
  13. Hu G, Wang X, Saunders D, Henderson M, Russell A, Herring B, et al. Modulation of myocardin function by the ubiquitin E3 ligase UBR5. J Biol Chem. 2010;285:11800-9 pubmed publisher
    ..This study reveals an unexpected role for the ubiquitin E3 ligase UBR5 as an activator of smooth muscle differentiation through its ability to stabilize myocardin protein...
  14. Jackson T, Verrier J, Semple Rowland S, Kumar A, Foster T. PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus. J Neurochem. 2010;115:941-55 pubmed publisher
    ..The results provide unique evidence for a divergence in the function of PHLPP1α and PHLPP1β/SCOP, and suggest that PHLPP1α plays a major role in regulating AKT signaling in neurons. ..
  15. Backer M, Backer J, Chinnaiyan P. Targeting the unfolded protein response in cancer therapy. Methods Enzymol. 2011;491:37-56 pubmed publisher
    ..In this chapter, we provide experimental protocols for the assessment of the effects of EGF-SubA on EGFR-positive cancer cells, either alone or in combination with UPR-inducing drugs. ..
  16. Kiedrowski L, Raca G, Laffin J, Nisler B, Leonhard K, McIntire E, et al. DNA methylation assay for X-chromosome inactivation in female human iPS cells. Stem Cell Rev. 2011;7:969-75 pubmed publisher
    ..2. This assay is commonly used in clinical genetic laboratories and we propose that it could be ideal for routine assessment and monitoring of the X-inactivation status in female human iPS cell lines. ..
  17. Richards R, Scholz I, Powers C, Skach W, Fr h K. The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation. J Virol. 2011;85:8766-76 pubmed publisher
    ..These data are consistent with Rh178 blocking protein translation of MHC-I heavy chains at a step prior to the start of translocation, thereby downregulating MHC-I at a very early stage of translation...
  18. Yang M, Wu S, Jia J, May W. JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1. Cell Cycle. 2011;10:2390-9 pubmed
  19. Nagy A, Zane A, Cole S, Severance M, Dutta P, Waldman W. Contrast of the biological activity of negatively and positively charged microwave synthesized CdSe/ZnS quantum dots. Chem Res Toxicol. 2011;24:2176-88 pubmed publisher
    ..This study indicates that the surface charge and aggregation characteristics of QDs change drastically in biological culture conditions and, in turn, influence nanoparticle and cellular interactions. ..
  20. Li X, Stevens P, Liu J, Yang H, Wang W, Wang C, et al. PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. Gastroenterology. 2014;146:1301-12.e1-10 pubmed publisher
    ..In Apc(Min) mice, loss of PHLPP1 promotes tumor progression. ..
  21. Richarson A, Scott D, Zagnitko O, Aza Blanc P, Chang C, Russler Germain D. Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation. elife. 2016;5:e10860 pubmed publisher
    ..The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Scienceand Science Exchange, and the results of the replications will be published by eLife. ..
  22. King B, Hershkowitz D, Eisenhauer P, Weir M, Ziegler C, Russo J, et al. A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). J Virol. 2017;91: pubmed publisher
    ..In so doing, it shows further insight into the interplay between the virus and the host innate immune response and provides an important data set for the field. ..
  23. Tau K, Hefferan T, Waters K, Robinson J, Subramaniam M, Riggs B, et al. Estrogen regulation of a transforming growth factor-beta inducible early gene that inhibits deoxyribonucleic acid synthesis in human osteoblasts. Endocrinology. 1998;139:1346-53 pubmed
    ..It is speculated that TIEG may play a role in the signaling pathway for E2 in inhibiting cell proliferation. ..
  24. Marasco C, Kramer D, Miller J, Porter C, Bacchi C, Rattendi D, et al. Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity. J Med Chem. 2002;45:5112-22 pubmed
    ..Moreover, the acetylated derivative of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine did inhibit HIV-1 growth and infectivity, whereas the parent compound did not. ..
  25. Murphy M, Das P, Nyborg A, Rochette M, Dodson M, Loosbrock N, et al. Overexpression of nicastrin increases Abeta production. FASEB J. 2003;17:1138-40 pubmed
  26. Kuehne M, He L, Jokiel P, Pace C, Fleck M, Maisonneuve I, et al. Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003;46:2716-30 pubmed
    ..The opioid activities were relatively low, and the alpha3beta4 nicotinic acetylcholine receptor activities were found to correlate with in vivo antiaddictive activities. ..
  27. Tse K, Inayat M, Morrow J, DellaPuca R, Hughes N, Gallicchio V. Basic fibroblast growth factor (bFGF) and its receptor expression (bek and flg) In bone marrow stroma of murine AIDS. Virus Res. 2004;101:175-84 pubmed
    ..These results suggest a role for bFGF deficiency in the pathogenesis of MAIDS-related marrow failure...
  28. Fisher J. The alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics. J Physiol. 2004;561:433-48 pubmed
    ..Structural heterogeneity within these transmembrane and intracellular regions can therefore influence the characteristics of the postsynaptic response of GABA(A) receptors with different subunit composition. ..
  29. Finlin B, Mosley A, Crump S, Correll R, Ozcan S, Satin J, et al. Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase. J Biol Chem. 2005;280:41864-71 pubmed
  30. Vickers T, Zhang H, Graham M, Lemonidis K, Zhao C, Dean N. Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide. J Immunol. 2006;176:3652-61 pubmed
  31. Jakymiw A, Ikeda K, Fritzler M, Reeves W, Satoh M, Chan E. Autoimmune targeting of key components of RNA interference. Arthritis Res Ther. 2006;8:R87 pubmed
    ..Together, these results demonstrate an autoimmune response to components of the RNAi pathway which could potentially implicate the involvement of an innate anti-viral response in the pathogenesis of autoantibody production. ..
  32. Bliziotes M, Eshleman A, Burt Pichat B, Zhang X, Hashimoto J, Wiren K, et al. Serotonin transporter and receptor expression in osteocytic MLO-Y4 cells. Bone. 2006;39:1313-21 pubmed
    ..Thus, osteocytes, as well as osteoblasts, are capable of 5-HT synthesis, and express functional receptor and transporter components of the 5-HT signal transduction system. ..
  33. Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed
    ..These observations support that MCPH1 acts early in DNA damage responsive pathways. ..
  34. Xiao R, Tang J, Wang C, Colton C, Tian J, Zhu M. Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem. 2008;283:6162-74 pubmed publisher
    ..We conclude that Ca(2+) inhibits TRPV3 from both the extracellular and intracellular sides. The inhibition is sequentially reduced, appearing as sensitization to repetitive stimulations. ..
  35. Ding H, Dolan P, Johnson G. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem. 2008;106:2119-30 pubmed publisher
    ..These findings establish HDAC6 as a tau-interacting protein and as a potential modulator of tau phosphorylation and accumulation. ..
  36. Wang L, Leonhard Melief C, Haltiwanger R, Apte S. Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan. J Biol Chem. 2009;284:30004-15 pubmed publisher
    ..These data demonstrate that TSR1 from punctin-1 carries C-mannosylation in close proximity to O-linked fucose. Together, these modifications appear to provide a quality control mechanism for punctin-1 secretion. ..
  37. Hardcastle J, Kurozumi K, Dmitrieva N, Sayers M, Ahmad S, Waterman P, et al. Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther. 2010;18:285-94 pubmed publisher
    ..This is the first study to report the antitumor effects of Vstat120 delivery into established tumors and supports the further development of RAMBO as a possible cancer therapy. ..
  38. Chen A, Zhang E, Guan W, Cheng F, Kleiboeker S, Yankee T, et al. The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells. Blood. 2010;115:1070-80 pubmed publisher
    ..Taken together, these results demonstrate that the 11 kDa protein contributes to erythroid progenitor cell death during B19V infection...
  39. O CONNOR C, Pertel T, Gray S, Robia S, Bakowska J, Luban J, et al. p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J Virol. 2010;84:5997-6006 pubmed publisher
    ..p62 may therefore operate to enhance TRIM5alpha-mediated retroviral restriction, contributing to the antiviral state of cells following IFN treatment. ..
  40. Cen B, Mahajan S, Zemskova M, Beharry Z, Lin Y, Cramer S, et al. Regulation of Skp2 levels by the Pim-1 protein kinase. J Biol Chem. 2010;285:29128-37 pubmed publisher
    ..Consistent with these observations, we show that Pim-1 is able to cooperate with Skp2 to signal S phase entry. Our data reveal a novel Pim-1 kinase-dependent signaling pathway that plays a crucial role in cell cycle regulation. ..
  41. Chacko S, Ahmed S, Selvendiran K, Kuppusamy M, Khan M, Kuppusamy P. Hypoxic preconditioning induces the expression of prosurvival and proangiogenic markers in mesenchymal stem cells. Am J Physiol Cell Physiol. 2010;299:C1562-70 pubmed publisher
    ..These results could provide further insights into optimal preparation of MSCs which would greatly influence the effectiveness of cell therapy in vivo. ..
  42. Fichter K, Flajolet M, Greengard P, Vu T. Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. Proc Natl Acad Sci U S A. 2010;107:18658-63 pubmed publisher
    ..Single-molecule imaging of endosomal trafficking will significantly impact the understanding of cellular signaling and provide powerful tools to elucidate the actions of GPCR-targeted therapeutics. ..
  43. Tanos R, Murray I, Smith P, Patterson A, Perdew G. Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver. Toxicol Sci. 2012;129:372-9 pubmed publisher
    ..Based on our results, we can conclude that increased AHR activity represses fatty acid synthesis, suggesting it may be a future therapeutic target. ..
  44. Oki K, Kopf P, Campbell W, Luis Lam M, Yamazaki T, Gomez Sanchez C, et al. Angiotensin II and III metabolism and effects on steroid production in the HAC15 human adrenocortical cell line. Endocrinology. 2013;154:214-21 pubmed publisher
    ..In conclusion, A-II was not converted to A-III in the HAC15 cell and is the more potent stimulator of aldosterone secretion and cortisol of the two. A-III stimulated aldosterone secretion but not cortisol secretion. ..
  45. Chahal J, Gallagher C, Dehart C, Flint S. The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication. J Virol. 2013;87:4432-44 pubmed publisher
  46. Julian M, Shao G, Vangundy Z, Papenfuss T, Crouser E. Mitochondrial transcription factor A, an endogenous danger signal, promotes TNF? release via RAGE- and TLR9-responsive plasmacytoid dendritic cells. PLoS ONE. 2013;8:e72354 pubmed publisher
    ..These findings, and others reported herein, significantly advance our understanding of sterile immune responses triggered by mitochondrial danger signals. ..
  47. Hire R, Hua G, Zhang Q, Mishra R, Adang M. Anopheles gambiae Ag55 cell line as a model for Lysinibacillus sphaericus Bin toxin action. J Invertebr Pathol. 2015;132:105-10 pubmed publisher
    ..Presence of α-glucosidase gene (Agm3) expression in the Ag55 cells was also confirmed. Thus, Ag55 cells constitute an appropriate model system to decipher the mode of Bin action in mosquito larvae. ..
  48. McGee T, Yi H, Allen W, Jacobs A, Rizzo R. Structure-based identification of inhibitors targeting obstruction of the HIVgp41 N-heptad repeat trimer. Bioorg Med Chem Lett. 2017;27:3177-3184 pubmed publisher
  49. Lakritz J, Tyler J, Marsh A, Romesburg Cockrell M, Smith K, Holle J. Tilmicosin reduces lipopolysaccharide-stimulated bovine alveolar macrophage prostaglandin E(2) production via a mechanism involving phospholipases. Vet Ther. 2002;3:7-21 pubmed
    ..Tilmicosin (in vivo and in vitro) appears to reduce the PGE(2) eicosanoid response of LPS-stimulated alveolar macrophages by reducing the in vitro substrate availability without altering in vitro COX-2 mRNA expression...
  50. Ling J, Morley S, Pain V, Marzluff W, Gallie D. The histone 3'-terminal stem-loop-binding protein enhances translation through a functional and physical interaction with eukaryotic initiation factor 4G (eIF4G) and eIF3. Mol Cell Biol. 2002;22:7853-67 pubmed
    ..These data indicate that SLBP stimulates the translation of histone mRNAs through a functional interaction with both the mRNA stem-loop and the 5' cap that is mediated by eIF4G and eIF3. ..
  51. Monroe D, Johnsen S, Subramaniam M, Getz B, Khosla S, Riggs B, et al. Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines. J Endocrinol. 2003;176:349-57 pubmed
    ..These data suggest that the transactivation capacity of various ER isoforms is both SRC species and cell type dependent. ..
  52. Bruno M, West R, Schneeman T, Bresnick E, Kaetzel C. Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene. Mol Immunol. 2004;40:695-708 pubmed
    ..The results of our experiments may shed light on the mechanisms of dysregulated expression of pIgR in inflammatory bowel disease and colorectal cancer, diseases associated with aberrant expression of c-Myc. ..
  53. Song S, Lu Y, Choi Y, Han Y, Tang Q, Zhao G, et al. DNA-dependent PK inhibits adeno-associated virus DNA integration. Proc Natl Acad Sci U S A. 2004;101:2112-6 pubmed
    ..In summary, we have provided evidence that DNA-PK inhibits AAV integration both in vitro and in vivo. ..
  54. Cai L, de Beer M, de Beer F, van der Westhuyzen D. Serum amyloid A is a ligand for scavenger receptor class B type I and inhibits high density lipoprotein binding and selective lipid uptake. J Biol Chem. 2005;280:2954-61 pubmed
  55. Sautin Y, Lu M, Gaugler A, Zhang L, Gluck S. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005;25:575-89 pubmed
  56. Liu S, Shen T, Huynh L, Klisovic M, Rush L, Ford J, et al. Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. Cancer Res. 2005;65:1277-84 pubmed
    ..These results suggest a novel mechanism for gene silencing mediated by RUNX1/MTG8 and support the combination of HDAC and DNMT inhibitors as a novel therapeutic approach for t(8;21) AML. ..
  57. Hwang Y, Leong O, Chen W, Yates M. Comparison of a reporter assay and immunomagnetic separation real-time reverse transcription-PCR for the detection of enteroviruses in seeded environmental water samples. Appl Environ Microbiol. 2007;73:2338-40 pubmed
    ..Both new procedures detected infective viruses in environmental samples at the same level as the plaque assay. ..
  58. Hochreiter R, Ptaschinski C, Kunkel S, Rochford R. Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation. J Gen Virol. 2007;88:1896-905 pubmed
    ..Taken together, these data demonstrate that gamma HV-68 infection of DCs differs depending on the maturation state of the DC. Moreover, the block in DC maturation suggests a possible immunoevasion strategy by gamma HV-68...
  59. Jha A, Cadugan D, Purohit P, Auerbach A. Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. J Gen Physiol. 2007;130:547-58 pubmed
    ..The M2-M3 linker appears to be the key moving part that couples gating motions at the base of the ECD with those in TMD. These interactions are distributed along an approximately 16-A border and involve about a dozen residues...
  60. Price C, Bukka A, Cynamon M, Graham J. Glycine betaine uptake by the ProXVWZ ABC transporter contributes to the ability of Mycobacterium tuberculosis to initiate growth in human macrophages. J Bacteriol. 2008;190:3955-61 pubmed publisher
    ..We then demonstrated that ProXVWZ allows M. tuberculosis to obtain betaine from host macrophages and thereby contributes to early steps in colonizing this niche...
  61. Howie H, Shiflett S, So M. Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim. Infect Immun. 2008;76:2715-21 pubmed publisher
    ..We conclude that Tfp-induced cytoprotection is due in part to ERK-dependent modification and/or downregulation of proapoptotic proteins Bad and Bim. ..
  62. Misch E, Macdonald M, Ranjit C, Sapkota B, Wells R, Siddiqui M, et al. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis. 2008;2:e231 pubmed publisher
    ..Our findings suggest that TLR1 deficiency influences adaptive immunity during leprosy infection to affect clinical manifestations such as nerve damage and disability. ..
  63. Wacker J, Feller D, Tang X, DeFino M, Namkung Y, Lyssand J, et al. Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. J Biol Chem. 2008;283:31068-78 pubmed publisher
    ..Importantly, mutations that disrupt this key hydrophobic interface can manifest as human disease. ..
  64. Minhajuddin M, Bijli K, Fazal F, Sassano A, Nakayama K, Hay N, et al. Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. J Biol Chem. 2009;284:4052-61 pubmed publisher
    ..Thus, these data reveal an important role of PKC-delta and PI3K/Akt pathways in activating mTOR as an endogenous modulator to ensure a tight regulation of NF-kappaB signaling of ICAM-1 expression in endothelial cells. ..
  65. Zhu Y, Wu Y, Kim J, Wang Z, Daaka Y, Nie Z. Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling. J Biol Chem. 2009;284:13489-96 pubmed publisher
    ..Our results indicate that AGAP2 regulates the FAK activity and the focal adhesion disassembly during cell migration. ..
  66. Barnes N, Bartee M, Braiterman L, Gupta A, Ustiyan V, Zuzel V, et al. Cell-specific trafficking suggests a new role for renal ATP7B in the intracellular copper storage. Traffic. 2009;10:767-79 pubmed publisher
    ..We discuss factors that may contribute to cell-specific behavior of ATP7B and propose a role for renal ATP7B in intracellular copper storage. ..
  67. TURNER J, Thomas A, Reeves J, Hantash B. Calcineurin activation by slow calcium release from intracellular stores suppresses protein kinase C regulation of L-type calcium channels in L6 cells. Cell Calcium. 2009;46:242-7 pubmed publisher
    ..This study is the first to demonstrate that the regulation of L-type Ca(2+) channels in a myocyte model involves a balance between the differential Ca(2+) sensitivities and opposing actions of PKC and calcineurin. ..
  68. Howard P, Ransom D, Maurer R. Transcription intermediary factor 1gamma decreases protein expression of the transcriptional cofactor, LIM-domain-binding 1. Biochem Biophys Res Commun. 2010;396:674-8 pubmed publisher
    ..These studies are consistent with a model in which TIF1gamma acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters. ..
  69. Ramabu S, Schneider D, Brayton K, Ueti M, Graça T, Futse J, et al. Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector. Infect Immun. 2011;79:2847-55 pubmed publisher
    ..Selection for divergence in Ank function among Anaplasma and Ehrlichia spp. is supported by both locus and allelic analyses of genes encoding orthologous proteins and their ankyrin motif compositions. ..
  70. Matsumura Y, David L, Skach W. Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell. 2011;22:2797-809 pubmed publisher
    ..Moreover, the degradative outcome of Hsc70 binding appears highly sensitive to the duration of its binding cycle, which is in turn governed by the integrated expression of regulatory cochaperones. ..
  71. Vishnoi N, Flaherty K, Hancock L, Ferreira M, Amin A, Prochasson P. Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes. Biochim Biophys Acta. 2011;1809:557-66 pubmed publisher
    ..This is the first direct demonstration that a separation-of-function mutation exists within the HIR complex. ..
  72. Shi N, Xie W, Chen S. Cell division cycle 7 is a novel regulator of transforming growth factor-?-induced smooth muscle cell differentiation. J Biol Chem. 2012;287:6860-7 pubmed publisher
    ..Likewise, Cdc7 enhances Smad3 binding to SMC marker promoter via supporting Smad3 nuclear retention and physically interacting with Smad3. Taken together, our studies have demonstrated a novel role of Cdc7 in SMC differentiation. ..
  73. Hertz M, Landry D, Willis A, Luo G, Thompson S. Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Mol Cell Biol. 2013;33:1016-26 pubmed publisher
    ..We present a model that explains how RPS25 can be a nexus for multiple alternative translation initiation pathways. ..
  74. Chou S, Ercolani R, Marousek G, Bowlin T. Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance. Antimicrob Agents Chemother. 2013;57:3375-9 pubmed publisher
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