Experts and Doctors on carbonic anhydrases in Denmark
Topic: carbonic anhydrases
Aamand R, Dalsgaard T, Jensen F, Simonsen U, Roepstorff A, Fago A. Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation. Am J Physiol Heart Circ Physiol. 2009;297:H2068-74 pubmed publisher
..The CA-mediated NO production may be important to the correlation between blood flow and metabolic activity in tissues, as occurring for instance in active areas of the brain. ..
Knudsen B, Miyamoto M, Laipis P, Silverman D. Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases. Genetics. 2003;164:1261-9 pubmed
..As illustrated by the CAs, these LRTs, in combination with other biological evidence, offer a powerful and cost-effective approach for testing hypotheses, making predictions, and designing experiments in protein functional studies. ..
Larsen M, Thingholm T, Jensen O, Roepstorff P, Jørgensen T. Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns. Mol Cell Proteomics. 2005;4:873-86 pubmed
..A putative mechanism for this intriguing effect is presented. ..
Nordsmark M, Eriksen J, Gebski V, Alsner J, Horsman M, Overgaard J. Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients. Radiother Oncol. 2007;83:389-97 pubmed
..High plasma osteopontin, high HIF-1alpha and high proportion of tumour pO(2)2.5mmHg (HP(2.5)) related significantly with poorer loco-regional control, whereas CA9 and tumour OPN failed to predict local control. ..
Eriksen J, Overgaard J. Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study. Radiother Oncol. 2007;83:383-8 pubmed
..The data suggest that CA IX have no prognostic or predictive potential in patients with cancer in the head and neck treated with conventional radiotherapy and concomitant nimorazole. ..
Busk M, Toustrup K, Sørensen B, Alsner J, Horsman M, Jakobsen S, et al
. In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors. BMC Cancer. 2011;11:63 pubmed publisher
..Among tested genes, our study identified CA9, GLUT1 and possibly LOX as highly specific biomarkers of tumor hypoxia in vivo. ..
Rasmussen S, Donskov F, Pedersen J, Wandall H, Buus S, Harndahl M, et al
. Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy. Immunopharmacol Immunotoxicol. 2013;35:487-96 pubmed publisher
..This may have interest in future cancer vaccines, but more studies are needed to elucidate the immunological mechanisms of action in potentially cured patients treated with an immunotherapeutic agent. ..