Experts and Doctors on caprine arthritis encephalitis virus in United States
Locale: United States
Topic: caprine arthritis encephalitis virus
Herrmann L, Cheevers W, McGuire T, Adams D, Hutton M, Gavin W, et al
. Competitive-inhibition enzyme-linked immunosorbent assay for detection of serum antibodies to caprine arthritis-encephalitis virus: diagnostic tool for successful eradication. Clin Diagn Lab Immunol. 2003;10:267-71 pubmed
..At this cutoff value, there were 0 of 60 false-negative sera (100% sensitivity) and 5 of 140 false-positive sera (96.4% specificity). Additional studies utilized IP-monitored cELISA to establish a CAEV-free herd of 1,640 dairy goats. ..
Hötzel I, Cheevers W. Caprine arthritis-encephalitis virus envelope surface glycoprotein regions interacting with the transmembrane glycoprotein: structural and functional parallels with human immunodeficiency virus type 1 gp120. J Virol. 2003;77:11578-87 pubmed
..Our results indicate structural and functional parallels between CAEV gp135 and HIV-1 gp120 that may be more broadly applicable to the SU of other lentiviruses. ..
Ozyörük F, Cheevers W, Hullinger G, McGuire T, Hutton M, Knowles D. Monoclonal antibodies to conformational epitopes of the surface glycoprotein of caprine arthritis-encephalitis virus: potential application to competitive-inhibition enzyme-linked immunosorbent assay for detecting antibodies in goat sera. Clin Diagn Lab Immunol. 2001;8:44-51 pubmed
..A competitive-inhibition ELISA based on displacement of MAb 74A reactivity has potential applicability for the serologic diagnosis of CAEV infection...
Hotzel I, Cheevers W. Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system. J Virol. 2001;75:7384-91 pubmed
..The results indicate a differential receptor recognition by MVV strains which is unrelated to cytopathic phenotype...
Herrmann L, Cheevers W, Marshall K, McGuire T, Hutton M, Lewis G, et al
. Detection of serum antibodies to ovine progressive pneumonia virus in sheep by using a caprine arthritis-encephalitis virus competitive-inhibition enzyme-linked immunosorbent assay. Clin Diagn Lab Immunol. 2003;10:862-5 pubmed
..5% sensitivity) and 0 of 15 false-positives (100% specificity). We conclude that the CAEV cELISA can be applied to detection of OPPV antibodies in sheep with high sensitivity and specificity...
Herrmann Hoesing L, Broughton Neiswanger L, Gouine K, White S, Mousel M, Lewis G, et al
. Evaluation of a caprine arthritis-encephalitis virus/maedi-visna virus indirect enzyme-linked immunosorbent assay in the serological diagnosis of ovine progressive pneumonia virus in U.S. sheep. Clin Vaccine Immunol. 2010;17:307-10 pubmed publisher
..The sensitivity and the specificity were 86.0% (+ or - 5.8%) and 95.9% (+ or - 2.9%), respectively. The iELISA format and phylogenetic differences based on the MVV gag sequence contribute to the reduced sensitivity...
Knowles D, Evermann J, Shropshire C, VanderSchalie J, Bradway D, Gezon H, et al
. Evaluation of agar gel immunodiffusion serology using caprine and ovine lentiviral antigens for detection of antibody to caprine arthritis-encephalitis virus. J Clin Microbiol. 1994;32:243-5 pubmed
..56. The AGID test with either antigen was 100% specific. The lower sensitivity of the OPPV AGID test in detecting caprine antibody to CAEV indicates that OPPV antigen is of limited value for use in CAEV diagnosis and control programs...
Schoborg R. Analysis of caprine arthritis encephalitis virus (CAEV) temporal gene expression in infected cells. Virus Res. 2002;90:37-46 pubmed
..These data indicate that a temporal shift from viral non-structural to structural gene expression occurs in CAEV infected GSM cells...