Experts and Doctors on animals in Germany


Locale: Germany
Topic: animals

Top Publications

  1. Zörnig M, Busch G, Beneke R, Gulbins E, Lang F, Ma A, et al. Survival and death of prelymphomatous B-cells from N-myc/bcl-2 double transgenic mice correlates with the regulation of intracellular Ca2+ fluxes. Oncogene. 1995;11:2165-74 pubmed
    ..We hypothesize therefore that the regulation of intracellular Ca2+ concentrations represent one important parameter in the oncogenic cooperation between bcl-2 and N-myc. ..
  2. Gaubatz S, Imhof A, Dosch R, Werner O, Mitchell P, Buettner R, et al. Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J. 1995;14:1508-19 pubmed
    ..Taken together, our data suggest that AP-2 acts as a negative regulator of transactivation by Myc. ..
  3. Wischmeyer E, Nolte E, Klocke R, Jockusch H, Brinkmeier H. Development of electrical myotonia in the ADR mouse: role of chloride conductance in myotubes and neonatal animals. Neuromuscul Disord. 1993;3:267-74 pubmed
    ..We conclude that the low Cl(-)-conductance of myotubes influences excitability but is not controlled by the adr/Clc-1 gene.(ABSTRACT TRUNCATED AT 250 WORDS)..
  4. Miller B, Nusse M. Analysis of micronuclei induced by 2-chlorobenzylidene malonitrile (CS) using fluorescence in situ hybridization with telomeric and centromeric DNA probes, and flow cytometry. Mutagenesis. 1993;8:35-41 pubmed
    ..By sorting MN with distinct DNA content and hybridization of the sorted MN with the centromeric probe, regions in the MN distribution containing mainly MN with single whole chromosomes could be demonstrated. ..
  5. Janke A, Gemmell N, Feldmaier Fuchs G, von Haeseler A, P bo S. The mitochondrial genome of a monotreme--the platypus (Ornithorhynchus anatinus). J Mol Evol. 1996;42:153-9 pubmed
    ..When the protein-coding sequences are used to reconstruct a phylogeny of mammals, the data suggest that monotremes and marsupials are sister groups and thus that placental mammals represent the most ancient divergence among mammals...
  6. Schwarz A, Grabbe S, Grosse Heitmeyer K, Roters B, Riemann H, Luger T, et al. Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system. J Immunol. 1998;160:4262-70 pubmed
    ..The ability of IL-12 to break established tolerance may be due to the prevention of DC death induced by T suppressor cells. ..
  7. Hiendleder S, Lewalski H, Wassmuth R, Janke A. The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotype. J Mol Evol. 1998;47:441-8 pubmed
    ..indicus and B. taurus cattle. Datings based on complete mtDNAs suggest that the bovine and ovine lineages diverged about 30 million years before present. This dating is considerably earlier than that proposed previously. ..
  8. Becker M, Matzner M, Gerisch G. Drainin required for membrane fusion of the contractile vacuole in Dictyostelium is the prototype of a protein family also represented in man. EMBO J. 1999;18:3305-16 pubmed
    ..We suggest that drainin acts in a signaling cascade that couples a volume-sensing device in the vacuolar membrane to the membrane fusion machinery. ..
  9. Volff J, Korting C, Sweeney K, Schartl M. The non-LTR retrotransposon Rex3 from the fish Xiphophorus is widespread among teleosts. Mol Biol Evol. 1999;16:1427-38 pubmed
    ..This wide distribution and occasional association with coding sequences may confer on Rex3 a predisposition to play a role in genome evolution in teleosts. ..

More Information

Publications1091 found, 100 shown here

  1. Janig W, Habler H. Neurophysiological analysis of target-related sympathetic pathways--from animal to human: similarities and differences. Acta Physiol Scand. 2003;177:255-74 pubmed
  2. Piso P, Aselmann H, von Wasielewski R, Dahlke M, Klempnauer J, Schlitt H. Prevention of peritoneal carcinomatosis from human gastric cancer cells by adjuvant-type intraperitoneal immunotherapy in a SCID mouse model. Eur Surg Res. 2003;35:470-6 pubmed
    ..We analyzed the effect of intraperitoneal immunotherapy in an animal model mimicking locoregional dissemination of tumor cells during resection of advanced tumors...
  3. Mittler G, Stühler T, Santolin L, Uhlmann T, Kremmer E, Lottspeich F, et al. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J. 2003;22:6494-504 pubmed
    ..Despite many known targets of VP16, ARC92/ACID1 appears to impose a critical control on transcription activation by VP16 in mammalian cells. ..
  4. Assmann G, Gotto A. HDL cholesterol and protective factors in atherosclerosis. Circulation. 2004;109:III8-14 pubmed
    ..However, HDL-C should be considered as part of the patient's overall profile of established risk factors in determining treatment strategies...
  5. Kania G, Corbeil D, Fuchs J, Tarasov K, Blyszczuk P, Huttner W, et al. Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells. 2005;23:791-804 pubmed
    ..In conclusion, we present the somatic stem cell marker prominin-1 as a new parameter to define ES-derived committed and early progenitor cells. ..
  6. Zoremba N, Homola A, Rossaint R, Sykova E. Brain metabolism and extracellular space diffusion parameters during and after transient global hypoxia in the rat cortex. Exp Neurol. 2007;203:34-41 pubmed
    ..g., mitochondria) may tolerate prolonged hypoxic periods and recover to prehypoxic values. ..
  7. Kupfer L, Eiden M, Buschmann A, Groschup M. Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine/murine and bovine/murine prion protein chimeras. Biochim Biophys Acta. 2007;1772:704-13 pubmed
    ..We therefore postulate that the efficiency of the conversion of chimeric PrP(C) depends on the amino acid sequence as well as on prion strain specific effects. ..
  8. Knör S, Modlinger A, Poethko T, Schottelius M, Wester H, Kessler H. Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds. Chemistry. 2007;13:6082-90 pubmed
    ..Initial biodistribution studies in mice with the radiometalated compound demonstrated the applicability of the described DOTA conjugation. ..
  9. Wimmers K, Ngu N, Jennen D, Tesfaye D, Murani E, Schellander K, et al. Relationship between myosin heavy chain isoform expression and muscling in several diverse pig breeds. J Anim Sci. 2008;86:795-803 pubmed
    ..The study demonstrates that MyHC IIb fibers are the most prominent in pigs having large LM area and implies that MyHC IIb is the determining fiber contributing to the differentiation of large and small loin eye muscle area in the pig. ..
  10. Schmitto J, Ortmann P, Wachter R, Hintze E, Popov A, Kolat P, et al. Chronic heart failure induced by multiple sequential coronary microembolization in sheep. Int J Artif Organs. 2008;31:348-53 pubmed
    ..We aimed to establish a stable and reproducible animal model of chronic heart failure in sheep...
  11. Aly A, Edrada Ebel R, Indriani I, Wray V, Muller W, Totzke F, et al. Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. J Nat Prod. 2008;71:972-80 pubmed publisher
    ..senegalense, thereby indicating that the production of natural products by the endophyte proceeds also under in situ conditions within the plant host...
  12. Girzalsky W, Platta H, Erdmann R. Protein transport across the peroxisomal membrane. Biol Chem. 2009;390:745-51 pubmed publisher
    ..In this brief review, we will summarize our current knowledge on the import of soluble proteins into the peroxisomal matrix...
  13. Schulz I, Baumann O, Samereier M, Zoglmeier C, Gräf R. Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres. Eur J Cell Biol. 2009;88:621-38 pubmed publisher
    ..FRAP analysis revealed at least two populations of Sun1, with an immobile fraction associated with the centrosome, and a mobile fraction in the nuclear envelope. ..
  14. Klein U, Nigg E. SUMO-dependent regulation of centrin-2. J Cell Sci. 2009;122:3312-21 pubmed publisher
    ..These data show that the nucleocytoplasmic shuttling of centrin-2 depends on the SUMO system and indicates that localization of centrin-2 within the nucleus depends on its ability to bind to the XPC protein. ..
  15. Lommel M, Cirak S, Willer T, Hermann R, Uyanik G, van Bokhoven H, et al. Correlation of enzyme activity and clinical phenotype in POMT1-associated dystroglycanopathies. Neurology. 2010;74:157-64 pubmed publisher
    ..Characterization of the POMT1 substrate protein alpha-dystroglycan and POMT in vitro mannosyltransferase activity shows that the severity of the clinical phenotype of the patients analyzed is inversely correlated with POMT activity. ..
  16. Krieglstein J, Kewitz T, Kirchhefer U, Hofnagel O, Weissen Plenz G, Reinbold M, et al. Damage of guinea pig heart and arteries by a trioleate-enriched diet and of cultured cardiomyocytes by oleic acid. PLoS ONE. 2010;5:e9561 pubmed publisher
    ..The diet used with 24% (wt/wt) glycerol trioleate is not comparable to human diets. The detrimental role of MUFAs for guinea pig heart tissue in vivo is shown for the first time. Whether it is true for humans remains to be shown. ..
  17. Nyakatura J, Petrovitch A, Fischer M. Limb kinematics during locomotion in the two-toed sloth (Choloepus didactylus, Xenarthra) and its implications for the evolution of the sloth locomotor apparatus. Zoology (Jena). 2010;113:221-34 pubmed publisher
    ..The observed kinematic patterns of two-toed sloths improve our understanding of the convergent evolution of quadrupedal suspensory posture and locomotion in the two extant sloth lineages...
  18. Ba L, Döring M, Jamier V, Jacob C. Tellurium: an element with great biological potency and potential. Org Biomol Chem. 2010;8:4203-16 pubmed publisher
  19. Gatzioufas Z, Stupp T, Moschos M, Kopsidas K, Charalambous P, Thanos S. Effect of botulinum toxin A on the intraocular pressure and the retina in an animal model. Cutan Ocul Toxicol. 2013;32:107-11 pubmed publisher
    ..However, temporary rise of IOP may possibly occur in the immediate postoperative period due to a volume-effect. ..
  20. Weadick C, Chang B. Complex patterns of divergence among green-sensitive (RH2a) African cichlid opsins revealed by Clade model analyses. BMC Evol Biol. 2012;12:206 pubmed publisher
    ..Our results thus bear both on studies of cichlid visual system evolution and on studies of gene family evolution in general. ..
  21. Geiger T, Velic A, Macek B, Lundberg E, Kampf C, Nagaraj N, et al. Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse. Mol Cell Proteomics. 2013;12:1709-22 pubmed publisher
    ..Our data will be useful to the broad scientific community as an initial atlas of protein expression of a mammalian species. ..
  22. Ohno S, Drummen G, Kuroda M. Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems. Int J Mol Sci. 2016;17:172 pubmed publisher
    ..This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems. ..
  23. Stone S, Jamison S, Yue Y, Durose W, Schmidt Ullrich R, Lin W. NF-κB Activation Protects Oligodendrocytes against Inflammation. J Neurosci. 2017;37:9332-9344 pubmed publisher
    ..The results presented in this study represent the first demonstration that NF-κB activation acts cell autonomously to protect oligodendrocytes against inflammation in animal models of MS. ..
  24. Kreuz S, Joubert E, Waldmann K, Ternes W. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside. Nutr Res. 2008;28:690-701 pubmed publisher
    ..No metabolites or aspalathin were found in plasma samples. The identification of the metabolites in vivo enables investigations to determine the biological potential of rooibos extracts...
  25. Schurmann A, Brauers A, Massmann S, Becker W, Joost H. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J Biol Chem. 1995;270:28982-8 pubmed
    ..It is suggested that RagA and RagB are the mammalian homologues of Gtr1 and that they represent a novel subfamily of Ras-homologous GTP binding proteins. ..
  26. Lehmann M, Korge G. The fork head product directly specifies the tissue-specific hormone responsiveness of the Drosophila Sgs-4 gene. EMBO J. 1996;15:4825-34 pubmed
    ..Aside from being involved in the control of decisions during embryonic development, fkh thus participates directly in the control of specialized functions of differentiated cells at later stages of development. ..
  27. Agianian B, Leonard K, Bonte E, van Der Zandt H, Becker P, Tucker P. The glutamine-rich domain of the Drosophila GAGA factor is necessary for amyloid fibre formation in vitro, but not for chromatin remodelling. J Mol Biol. 1999;285:527-44 pubmed
    ..Consequently, neither the N-terminal domain nor the C-terminal glutamine-rich regions of the GAGA factor are necessary for chromatin remodelling in vitro. ..
  28. Buhler D, Raker V, Luhrmann R, Fischer U. Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy. Hum Mol Genet. 1999;8:2351-7 pubmed
    ..Thus, our data show that SMN is an essential U snRNP assembly factor and establish a direct correlation between defects in the biogenesis of U snRNPs and SMA. ..
  29. Polic B, Kunkel D, Scheffold A, Rajewsky K. How alpha beta T cells deal with induced TCR alpha ablation. Proc Natl Acad Sci U S A. 2001;98:8744-9 pubmed
  30. Blatt J, Roces F. Haemolymph sugar levels in foraging honeybees (Apis mellifera carnica): dependence on metabolic rate and in vivo measurement of maximal rates of trehalose synthesis. J Exp Biol. 2001;204:2709-16 pubmed
  31. Thumfart J, Meyers G. Rabbit hemorrhagic disease virus: identification of a cleavage site in the viral polyprotein that is not processed by the known calicivirus protease. Virology. 2002;304:352-63 pubmed
    ..Expression of a polyprotein fragment lacking the viral protease revealed that the newly identified site is not cleaved by the RHDV protease but by an unknown proteolytic activity...
  32. Petersen W, Varoga D, Zantop T, Hassenpflug J, Mentlein R, Pufe T. Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts. J Orthop Res. 2004;22:847-53 pubmed
    ..These results demonstrate that mechanical factors are involved in the regulation of VEGF expression in tendon tissue. ..
  33. Bartling B, Hofmann H, Weigle B, Silber R, Simm A. Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma. Carcinogenesis. 2005;26:293-301 pubmed
    ..Thus, down-regulation of RAGE may be considered as a critical step in tissue reorganization and the formation of lung tumours. ..
  34. Orth J, Lang S, Taniguchi M, Aktories K. Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13. J Biol Chem. 2005;280:36701-7 pubmed
    ..The data show that YM-254890 is able to block PMT activation of Galpha(q) and indicate that, in addition to Galpha(q), the Galpha(12/13) G proteins are targets of PMT. ..
  35. Bamberg S, Kolesnikova L, Möller P, Klenk H, Becker S. VP24 of Marburg virus influences formation of infectious particles. J Virol. 2005;79:13421-33 pubmed
    ..It is presumed that VP24 is necessary for the formation of transport-competent nucleocapsids and/or the interaction between the nucleocapsids and the budding sites at the plasma membrane. ..
  36. Navdaev A, Heitmann V, Desantana Evangelista K, Morgelin M, Wegener J, Eble J. The C-terminus of the gamma 2 chain but not of the beta 3 chain of laminin-332 is indirectly but indispensably necessary for integrin-mediated cell reactions. Exp Cell Res. 2008;314:489-97 pubmed
  37. Post H, Gutberlet J, Wiche R, Aumüller G, Wilhelm B. The localization of PMCA1b in epithelial cells and aposomes of the rat coagulating gland is influenced by androgens. Prostate. 2008;68:1076-85 pubmed publisher
    ..We showed for the first time that PMCA isoform 1b is released via aposomes of the epithelial cells of the rat coagulating gland and that the localization of PMCA1b in the epithelial cells is influenced by androgens. ..
  38. Kirchhoff C, Osterhoff C, Samalecos A. HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Reproduction. 2008;136:235-45 pubmed publisher
    ..Comparable immunostaining patterns were observed in human and mouse; however, a specific feature of the human ductuli efferentes was an intense HE6/GPR64-related labelling of crypt-like grooves or furrows of hitherto unknown function. ..
  39. Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature. 2008;453:481-8 pubmed publisher
    ..Because Rpn13 is also the proteasomal receptor for Uch37, a deubiquitinating enzyme, our findings suggest a coupling of chain recognition and disassembly at the proteasome. ..
  40. Becker D, Woltersdorf R, Boldt W, Schmitz S, Braam U, Schmalzing G, et al. The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity. J Biol Chem. 2008;283:25725-34 pubmed publisher
    ..Together, these results identify the tail extension as a regulatory gating module, potentially making P2X(7) channel gating sensitive to intracellular regulation. ..
  41. Frey B, Munoz L, Pausch F, Sieber R, Franz S, Brachvogel B, et al. The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype. J Cell Mol Med. 2009;13:1391-9 pubmed publisher
    ..These data demonstrate that endogenous Anx A5 influences the phagocytosis of necrotic cells, modulates the immune response towards allogeneic cells and acts as an inflammatory protein. ..
  42. Schmidt S, Richter M, Montag D, Sartorius T, Gawlik V, Hennige A, et al. Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice. Am J Physiol Endocrinol Metab. 2008;295:E1084-94 pubmed publisher
    ..Taken together, our data indicate that, in contrast to Slc2a1, a single allele of Slc2a3 is sufficient for maintenance of neuronal energy supply, motor abilities, learning and memory, and feeding behavior. ..
  43. Eisinger D, Ammer H. Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells. J Biol Chem. 2009;284:34819-28 pubmed publisher
    ..These results demonstrate that agonist-specific differences in the temporal and spatial pattern of c-Src activation determine the kinetics of DOR-mediated regulation of ERK1/2 signaling. ..
  44. Nguyen D, Wagner Britz L, Maia S, Steffen P, Wagner C, Kaestner L, et al. Regulation of phosphatidylserine exposure in red blood cells. Cell Physiol Biochem. 2011;28:847-56 pubmed publisher
    ..In sheep RBCs, only the latter mechanism occurs suggesting absence of scramblase activity. ..
  45. Rizk A, Herdtweck S, Offinger J, Meyer H, Zaghloul A, Rehage J. The use of xylazine hydrochloride in an analgesic protocol for claw treatment of lame dairy cows in lateral recumbency on a surgical tipping table. Vet J. 2012;192:193-8 pubmed publisher
    ..The use of a low dose of xylazine in the analgesic protocol for the treatment of lame cows in LR alleviates stress and potentiates the analgesic effects of LA. ..
  46. Kunzelmann S, Forstemann K. Reversible perturbations of gene regulation after genome editing in Drosophila cells. PLoS ONE. 2017;12:e0180135 pubmed publisher
  47. Schwarz S, Kehrenberg C, Doublet B, Cloeckaert A. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev. 2004;28:519-42 pubmed
  48. Li Y, Werner H, Püschel A. Rheb and mTOR regulate neuronal polarity through Rap1B. J Biol Chem. 2008;283:33784-92 pubmed publisher
    ..These results indicate that the mTOR pathway is required to counteract the Smurf2-initiated degradation of Rap1B during the establishment of neuronal polarity. ..
  49. Wickström S, Lange A, Montanez E, Fassler R. The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!. EMBO J. 2010;29:281-91 pubmed publisher
    ..This review focuses on the recent advances made towards understanding the specialized roles this complex and its individual components have acquired during evolution. ..
  50. Papanas N, Vinik A, Ziegler D. Neuropathy in prediabetes: does the clock start ticking early?. Nat Rev Endocrinol. 2011;7:682-90 pubmed publisher
    ..This Review summarizes the current evidence on the association between prediabetes and neuropathy...
  51. Kronstein R, Seebach J, Grossklaus S, Minten C, Engelhardt B, Drab M, et al. Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovasc Res. 2012;93:130-40 pubmed publisher
    ..Our results highlight the pivotal role of caveolin-1 in VE-cadherin-mediated cell adhesion via catenins and, in turn, in barrier function regulation. ..
  52. Salpietro V, Lin W, Delle Vedove A, Storbeck M, Liu Y, Efthymiou S, et al. Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome. Ann Neurol. 2017;81:597-603 pubmed publisher
    ..Taken together, our findings highlight VAMP1 homozygous mutations as a cause of presynaptic CMS. Ann Neurol 2017;81:597-603. ..
  53. Baum C, Eckert H, Stockschlader M, Just U, Hegewisch Becker S, Hildinger M, et al. Improved retroviral vectors for hematopoietic stem cell protection and in vivo selection. J Hematother. 1996;5:323-9 pubmed
  54. Jewgenow K, Fickel J. Sequential expression of zona pellucida protein genes during the oogenesis of domestic cats. Biol Reprod. 1999;60:522-6 pubmed
    ..We therefore assume a sequential synthesis of zona proteins in the cat ovary. ..
  55. Wirth M, Paap F, Fischle W, Wenzel D, Agafonov D, Samatov T, et al. HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line. Mol Cell Biol. 2009;29:3700-9 pubmed publisher
    ..Overall, our data indicate that SIR-2.1 and HIS-24 contribute to the propagation of a specialized chromatin state at the subtelomeric regions and elsewhere in the genome. ..
  56. Wedemeyer N, Lengeling A, Ronsiek M, Korthaus D, Baer K, Wuttke M, et al. YAC contigs of the Rab1 and wobbler (wr) spinal muscular atrophy gene region on proximal mouse chromosome 11 and of the homologous region on human chromosome 2p. Genomics. 1996;32:447-54 pubmed
    ..The conservation between the mouse Rab1 and human RAB1 regions will be helpful in identifying candidate genes for the wobbler spinal muscular atrophy and in clarifying a possible relationship between wr and LMGMD2B. ..
  57. Pfeifer A, Aszodi A, Seidler U, Ruth P, Hofmann F, Fassler R. Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science. 1996;274:2082-6 pubmed
    ..The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes. ..
  58. Cohn R, Mayer U, Saher G, Herrmann R, van Der Flier A, Sonnenberg A, et al. Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle. J Neurol Sci. 1999;163:140-52 pubmed
  59. Truyen U. Emergence and recent evolution of canine parvovirus. Vet Microbiol. 1999;69:47-50 pubmed
    ..The recent evolution of CPV, namely the emergence of new antigenic types, their biological properties and global distribution are also discussed...
  60. Patzak D, Zhuchenko O, Lee C, Wehnert M. Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein. Hum Genet. 1999;105:506-12 pubmed
    ..Thus, a novel human gene encoding a small muscular protein that maps to Xp22.1 (SMPX) has been identified and structurally characterized as a basis for further functional analysis. ..
  61. Rupp H, Vetter R. Sarcoplasmic reticulum function and carnitine palmitoyltransferase-1 inhibition during progression of heart failure. Br J Pharmacol. 2000;131:1748-56 pubmed
    ..05). Etomoxir represents a candidate approach for prevention of heart failure by inducing a hypertrophy proportional increase in SR Ca(2+) uptake rate. ..
  62. Conrad S, Viertelhaus A, Orzechowski A, Hoogstraate J, Gjellan K, Schrenk D, et al. Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1. Toxicology. 2001;156:81-91 pubmed
    ..The knowledge of the tissue distribution pattern of these transporters will aid to interpret pharmacokinetic and toxicokinetic data gained from dog studies and to extrapolate them to humans...
  63. Endres M, Fan G, Meisel A, Dirnagl U, Jaenisch R. Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons. Neuroreport. 2001;12:3763-6 pubmed
    ..In conclusion, we demonstrate that reduced levels of Dnmt1, but not its absence, in post-mitotic neurons protect from ischemic brain injury. ..
  64. Schafer T, Scheuer C, Roemer K, Menger M, Vollmar B. Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death. FASEB J. 2003;17:660-7 pubmed
    ..This indicates that p53 mediates, at least in part, LPS-associated apoptosis and contributes to inflammatory endotoxic tissue injury through leukocyte activation and intraorgan sequestration. ..
  65. Urbach R, Schnabel R, Technau G. The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in Drosophila. Development. 2003;130:3589-606 pubmed
  66. Cooper T, Wagenfeld A, Cornwall G, Hsia N, Chu S, Orgebin Crist M, et al. Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice. Biol Reprod. 2003;69:1750-62 pubmed
    ..The changes in these genes could affect sperm function by modifying the composition of epididymal fluid and explain the infertility of the KO males. These genes may be targets for a posttesticular contraceptive. ..
  67. Wilde C, Vogelsgesang M, Aktories K. Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization. Biochemistry. 2003;42:9694-702 pubmed
    ..This fusion toxin caused rounding up of Vero cells comparable to the effects of Rho-inactivating toxins. ..
  68. Marxen J, Nimtz M, Becker W, Mann K. The major soluble 19.6 kDa protein of the organic shell matrix of the freshwater snail Biomphalaria glabrata is an N-glycosylated dermatopontin. Biochim Biophys Acta. 2003;1650:92-8 pubmed
  69. Eick S, Pfister W, Stürzebecher U, Jarema S, Stürzebecher J. Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains. Acta Biochim Pol. 2003;50:725-34 pubmed
    ..gingivalis were observed further in vitro tests concerning immunomodulatory effects should be done before these substances are used for therapy in clinically controlled studies. ..
  70. Breitenlechner C, Gassel M, Hidaka H, Kinzel V, Huber R, Engh R, et al. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure. 2003;11:1595-607 pubmed
    ..Further, a second H-1152P binding site potentially points toward PKA regulatory domain interaction modulators. ..
  71. Anders H, Vielhauer V, Eis V, Linde Y, Kretzler M, Perez de Lema G, et al. Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J. 2004;18:534-6 pubmed
    ..We conclude that TLR9 activation triggers disease activity of systemic autoimmunity, for example, lupus nephritis, and that adaptive and innate immune mechanisms contribute to the CpG-DNA-induced progression of lupus nephritis. ..
  72. Gekle M, Völker K, Mildenberger S, Freudinger R, Shull G, Wiemann M. NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo. Am J Physiol Renal Physiol. 2004;287:F469-73 pubmed
    ..Thus a reduction in NHE3 activity or abundance causes tubular proteinuria. These data show that NHE3 supports proximal tubular RME of filtered proteins in vivo. ..
  73. Schrank S, José H, Moreira R, Schröder H. Elucidation of the behavior of tannery wastewater under advanced oxidation conditions. Chemosphere. 2004;56:411-23 pubmed
    ..Daphnia magna toxicity testing performed in parallel proved a decrease in toxicity after AOP treatment of the tannery wastewater. ..
  74. Trun W, Kiderlen A, Kolodziej H. Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (Eps 7630). Phytomedicine. 2006;13:570-5 pubmed
  75. Donoso Mantke O, Kallies R, Niklasson B, Nitsche A, Niedrig M. A new quantitative real-time reverse transcriptase PCR assay and melting curve analysis for detection and genotyping of Ljungan virus strains. J Virol Methods. 2007;141:71-7 pubmed
    ..These new methods provide useful tools to investigate the putative role of LV as a pathogen in both rodents and humans...
  76. Skripuletz T, Schmiedl A, Schade J, Bedoui S, Glaab T, Pabst R, et al. Dose-dependent recruitment of CD25+ and CD26+ T cells in a novel F344 rat model of asthma. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1564-71 pubmed
    ..Thereby, we found a dose-dependent recruitment of cellular markers of allergic asthma including the activated CD4(+)/CD25(+)/CD26(+) T cell subpopulation, which has not been described in asthma yet. ..
  77. Heitmann V, Wegener J. Monitoring cell adhesion by piezoresonators: impact of increasing oscillation amplitudes. Anal Chem. 2007;79:3392-400 pubmed
    ..Moreover, the experimental data prove that the normal QCM readout with oscillation amplitudes smaller than 1 nm is, indeed, non-invasive with respect to mammalian cells. ..
  78. Lechel A, Holstege H, Begus Y, Schienke A, Kamino K, Lehmann U, et al. Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease. Gastroenterology. 2007;132:1465-75 pubmed
    ..The function of telomerase during in vivo hepatocarcinogenesis has not been studied in this genetic context...
  79. Rotte C, Walz B, Baumann O. Morphological and functional characterization of the thoracic portion of blowfly salivary glands. Arthropod Struct Dev. 2008;37:372-82 pubmed publisher
  80. Schröder U, Muller T, Schreiber R, Stolle A, Zuschratter W, Balschun D, et al. The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice. Neuroscience. 2008;157:385-95 pubmed publisher
    ..Drug- and vehicle-treated groups showed comparable performance at day 5. Our data support a role for mGluR1 in LTP and in the acquisition of spatial memory. ..
  81. Stumpf I, Bazwinsky I, Peschke E. Modulation of the cGMP signaling pathway by melatonin in pancreatic beta-cells. J Pineal Res. 2009;46:140-7 pubmed publisher
    ..In addition, it was demonstrated that melatonin is involved in modulation of CNG channel mRNA. ..
  82. Anastasov N, Bonzheim I, Rudelius M, Klier M, Dau T, Angermeier D, et al. C/EBP? expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway. Haematologica. 2010;95:760-7 pubmed publisher
    ..These findings reveal the convergence of STAT3 and ERK1/2 signaling pathways activated by NPM-ALK in mediating the regulation of C/EBPbeta expression, a transcription factor central to NPM-ALK transformation. ..
  83. Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, et al. Control of TMEM16A by INO-4995 and other inositolphosphates. Br J Pharmacol. 2013;168:253-65 pubmed publisher
    ..These data indicate that TMEM16A is the target for INO-4995, although the mode of action appears different for overexpressed and endogenous channels. INO-4995 may be useful for the treatment of CF lung disease. ..
  84. Hauptmann V, Weichert N, Menzel M, Knoch D, Paege N, Scheller J, et al. Native-sized spider silk proteins synthesized in planta via intein-based multimerization. Transgenic Res. 2013;22:369-77 pubmed publisher
    ..The resulting multimeric structures form microfibers, thereby demonstrating their great potential as a biomaterial. ..
  85. Osigus H, Eitel M, Bernt M, Donath A, Schierwater B. Mitogenomics at the base of Metazoa. Mol Phylogenet Evol. 2013;69:339-51 pubmed publisher
    ..The results of our analyses illustrate the value of mitogenomics and support previously known topologies between animal phyla but also identify several problematic taxa, which are sensitive to long branch artifacts or missing data...
  86. Senger S, Kollmar O, Menger M, Rupertus K. Darbepoetin-α Promotes Cell Proliferation in Established Extrahepatic Colorectal Tumors after Major Hepatectomy. Eur Surg Res. 2016;56:49-60 pubmed publisher
    ..Thus, DPO may not be recommended to stimulate regeneration of the remnant liver after major hepatectomy for colorectal liver metastasis. ..
  87. Kues T, Dickmanns A, Luhrmann R, Peters R, Kubitscheck U. High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking. Proc Natl Acad Sci U S A. 2001;98:12021-6 pubmed
    ..The results substantiate the view that nuclear speckles are not rigid structures but highly dynamic domains characterized by a rapid turnover of U1 snRNPs and other splicing factors. ..
  88. Stock C, Schilling T, Schwab A, Eder C. Lysophosphatidylcholine stimulates IL-1beta release from microglia via a P2X7 receptor-independent mechanism. J Immunol. 2006;177:8560-8 pubmed
    ..In summary, these data indicate that the activity of nonselective cation channels and Ca(2+)-activated K(+) channels is required for optimal IL-1beta release from LPC-stimulated microglia. ..
  89. Zaehres H, Kogler G, Arauzo Bravo M, Bleidissel M, Santourlidis S, Weinhold S, et al. Induction of pluripotency in human cord blood unrestricted somatic stem cells. Exp Hematol. 2010;38:809-18, 818.e1-2 pubmed publisher
    ..Besides the obvious relevance of a second-generation CB iPS cell bank for pharmacological and toxicological testing, its application for autologous or allogenic regenerative cell transplantation appears feasible. ..
  90. Pfennig T, Herrmann B, Bauer T, Schömig E, Gründemann D. Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2. Biochim Biophys Acta. 2013;1828:491-8 pubmed publisher
    ..Increased glutamate efflux at OAT2 could be the main benefit of benzoate treatment in patients with urea cycle defects. ..
  91. Sedehizade F, Klocke R, Jockusch H. Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies. Muscle Nerve. 1997;20:186-94 pubmed
    ..The patterns of gene expression were characteristic for the type of muscle disease, indicating their possible usefulness for clinical diagnosis. ..
  92. Fernandez Catalan C, Bode W, Huber R, Turk D, Calvete J, Lichte A, et al. Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor. EMBO J. 1998;17:5238-48 pubmed
    ..The lower affinity of TIMP-1 for MT1-MMP compared with TIMP-2 might be explained by a reduced number of favourable interactions. ..