Genomes and Genes
Experts and Doctors on amino acid sequence in United States
Locale: United States
Topic: amino acid sequence
Publications677 found, 100 shown here
- Hershey H, Schwartz L, Gale J, Abell L. Cloning and functional expression of the small subunit of acetolactate synthase from Nicotiana plumbaginifolia. Plant Mol Biol. 1999;40:795-806 pubmed..These results are consistent with those observed for the bacterial enzyme in similar experiments and represent the first functional demonstration of the existence of a SSU for plant ALS. ..
- Hicar M, Liu Y, Allen C, Wu L. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. Genomics. 2001;71:89-100 pubmed
- Liang F, Jacobs M, Philipp M. C-terminal invariable domain of VlsE may not serve as target for protective immune response against Borrelia burgdorferi. Infect Immun. 2001;69:1337-43 pubmed..We concluded that the C-terminal invariable domain was exposed at the antigen's surface but not at the surface of either cultured or in vivo spirochetes and thus cannot elicit protection against B. burgdorferi infection. ..
- Caldwell S, Hill K, Cooper A. Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi. J Biol Chem. 2001;276:23296-303 pubmed
- Yahr T, Wickner W. Functional reconstitution of bacterial Tat translocation in vitro. EMBO J. 2001;20:2472-9 pubmed..The development of an in vitro translocation assay is a prerequisite for further biochemical investigations of the mechanism of translocation, substrate recognition and translocase structure. ..
- Morgan K, Gangopadhyay S. Invited review: cross-bridge regulation by thin filament-associated proteins. J Appl Physiol (1985). 2001;91:953-62 pubmed
- Jones C, Ray M, Strobel H. Transcriptional analysis of the xylose ABC transport operons in the thermophilic anaerobe Thermoanaerobacter ethanolicus. Curr Microbiol. 2002;45:54-62 pubmed..T. ethanolicus is unique in possessing a triumvirate of xylose transport and catabolism operons and, given its extensive hemicellulolytic capabilities, may have evolved to constitutively express xyl genes...
- Sangwan I, O Brian M. Identification of a soybean protein that interacts with GAGA element dinucleotide repeat DNA. Plant Physiol. 2002;129:1788-94 pubmed publisher..Homologs of GBP were found in other dicots and in the monocot rice (Oryza sativa), as well. We suggest that interaction between GAGA elements and GBP-like proteins is a regulatory feature in plants...
- Zhang Y, Pohlmann E, Roberts G. Identification of critical residues in GlnB for its activation of NifA activity in the photosynthetic bacterium Rhodospirillum rubrum. Proc Natl Acad Sci U S A. 2004;101:2782-7 pubmed..Finally, the results show that the level of P(II) accumulation is also an important factor for NifA activation...
- Colosi D, Martin D, More K, Lalande M. Genomic organization and allelic expression of UBE3A in chicken. Gene. 2006;383:93-8 pubmed..Biallelic expression of UBE3A is observed in embryonic chicken brain and limb, indicating that UBE3A is not subject to genomic imprinting in chicken. ..
- Wang H, Zhang Y, Cheng Y, Zhou Y, King D, Taylor J, et al. Experimental validation of predicted mammalian erythroid cis-regulatory modules. Genome Res. 2006;16:1480-92 pubmed..Genome-wide predictions based on RP and a large set of well-defined transcription factor binding sites are available through servers at http://www.bx.psu.edu/. ..
- De La Fuente J, Ruybal P, Mtshali M, Naranjo V, Shuqing L, Mangold A, et al. Analysis of world strains of Anaplasma marginale using major surface protein 1a repeat sequences. Vet Microbiol. 2007;119:382-90 pubmed..marginale strains from various geographic locations worldwide. These results contribute to the understanding of the genetic diversity and evolution of A. marginale and tick-pathogen interactions...
- DiRusso C, Darwis D, Obermeyer T, Black P. Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim Biophys Acta. 2008;1781:135-43 pubmed publisher..A 73 amino acid segment common to FATP1 and FATP4 and between the ATP/AMP and FATP/VLACS motifs was identified by studying the chimeras, which is hypothesized to contribute to the transport function. ..
- Rabbitts B, Ciotti M, Miller N, Kramer M, Lawrenson A, Levitte S, et al. glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis. Genetics. 2008;180:857-71 pubmed publisher..Our studies identify GLO-3 as a novel player in the formation of lysosome-related organelles. ..
- Liu W, Zhao R, McFarland C, KIEFT J, Niedzwiecka A, Jankowska Anyszka M, et al. Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem. 2009;284:31336-49 pubmed publisher..Overall the NMR and isothermal titration calorimetry data suggest the importance of intrinsic conformational flexibility in the schistosome eIF4E that enables binding to m(2,2,7)G cap. ..
- Ungewitter E, Scrable H. Delta40p53 controls the switch from pluripotency to differentiation by regulating IGF signaling in ESCs. Genes Dev. 2010;24:2408-19 pubmed publisher..We propose that this is the primary function of ?40p53 in cells of the early embryo and stem cells, which are the only normal cells in which this isoform is expressed. ..
- Zhang J, Guy M, Norman H, Chen Y, Xu Q, Dong X, et al. Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure. J Proteome Res. 2011;10:4054-65 pubmed publisher..This study represents the first clinical application of top-down MS-based quantitative proteomics for biomarker discovery from tissues, highlighting the potential of PTMs as disease biomarkers. ..
- Seo J, Kwon S, Rao A. Molecular dissection of Flock house virus protein B2 reveals that electrostatic interactions between N-terminal domains of B2 monomers are critical for dimerization. Virology. 2012;432:296-305 pubmed publisher..Taken together, our data provide evidence that both monomeric and dimeric B2 proteins function in different modes to suppress RNA silencing. ..
- Sobczak K, Wheeler T, Wang W, Thornton C. RNA interference targeting CUG repeats in a mouse model of myotonic dystrophy. Mol Ther. 2013;21:380-7 pubmed publisher..These data suggest that the expanded CUG repeats are a potential target for allele-selective RNA interference...
- Moroz N, Novak S, Azevedo R, Colpan M, Uversky V, Gregorio C, et al. Alteration of tropomyosin-binding properties of tropomodulin-1 affects its capping ability and localization in skeletal myocytes. J Biol Chem. 2013;288:4899-907 pubmed publisher..This indicates a direct correlation between TM-binding and the actin-capping abilities of Tmod. Our data confirmed the hypothesis that assembly of Tmod at the pointed-end of the actin filament depends on its TM-binding affinity. ..
- Shi J, Yang X, Ballew B, Rotunno M, Calista D, Fargnoli M, et al. Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma. Nat Genet. 2014;46:482-6 pubmed publisher..We also identified two rare recurrent POT1 variants in US and French familial melanoma cases. Our findings suggest that POT1 is a major susceptibility gene for familial melanoma in several populations. ..
- Coppola J, Bryant S, Koda T, Conway D, Barbacid M. Mechanism of activation of the vav protooncogene. Cell Growth Differ. 1991;2:95-105 pubmed..These structural similarities, along with its expression pattern, suggest that the vav protooncogene codes for a new type of signal-transducing molecule that may play an important role in controlling hematopoiesis. ..
- Collier C, Johnson J. The Escherichia coli K-12 metJ193 allele contains a point mutation which alters the hydrophobic pocket responsible for in vitro binding of S-adenosylmethionine: effects on cell growth and induction of met regulon expression. J Bacteriol. 1990;172:3918-24 pubmed..coli metF transcription unit. These results confirm the importance of the leucine 56 residue for the structure and function in vivo of the wild-type MetJ protein. ..
- Doyle G, Betz N, Leeds P, Fleisig A, Prokipcak R, Ross J. The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. Nucleic Acids Res. 1998;26:5036-44 pubmed..Recombinant mouse CRD-BP binds specifically to c- myc CRD RNA in vitro and reacts with antibody against human CRD-BP. Most of the CRD-BP in the cell is cytoplasmic and co-sediments with ribosomal subunits. ..
- Preston K, Radomski C, Venezia R. The cassettes and 3' conserved segment of an integron from Klebsiella oxytoca plasmid pACM1. Plasmid. 1999;42:104-14 pubmed
- Lin X, Mattjus P, Pike H, Windebank A, Brown R. Cloning and expression of glycolipid transfer protein from bovine and porcine brain. J Biol Chem. 2000;275:5104-10 pubmed..Reverse transcriptase-PCR analyses of mRNA levels supported the Northern blot results. ..
- Zhu Y, Johnson T, Myers A, Kanost M. Identification by subtractive suppression hybridization of bacteria-induced genes expressed in Manduca sexta fat body. Insect Biochem Mol Biol. 2003;33:541-59 pubmed..The sequences identified in this M. sexta library reflect our knowledge of insect immune strategies and may facilitate better understanding of insect immune responses. ..
- Sage E, Reed M, Funk S, Truong T, Steadele M, Puolakkainen P, et al. Cleavage of the matricellular protein SPARC by matrix metalloproteinase 3 produces polypeptides that influence angiogenesis. J Biol Chem. 2003;278:37849-57 pubmed..One of these peptides containing KHGK also demonstrated a concentration-dependent effect on angiogenesis. ..
- Huang J, Valluzzi R, Bini E, Vernaglia B, Kaplan D. Cloning, expression, and assembly of sericin-like protein. J Biol Chem. 2003;278:46117-23 pubmed..The glue-like property of sericin is attributed to the hydrogen bonding between serine residues of sericin with serine residues in the fibroin structural components of silk fiber. ..
- Seo J, Yu J. The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans. Eukaryot Cell. 2006;5:400-10 pubmed..Potential differential roles of FadA, Gbetagamma, and FlbA in controlling ST biosynthesis are further discussed. ..
- Dange M, Colman R. Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function. J Biol Chem. 2010;285:20520-5 pubmed publisher..The gammaY135 is also required for catalytic activity and may be involved in proper folding of the enzyme. The corresponding tyrosines in the three dissimilar subunits of NAD-IDH thus have distinctive functions. ..
- Kang M, Fokar M, Abdelmageed H, Allen R. Arabidopsis SAP5 functions as a positive regulator of stress responses and exhibits E3 ubiquitin ligase activity. Plant Mol Biol. 2011;75:451-66 pubmed publisher..These results indicate that AtSAP5 has E3 ligase activity and acts as a positive regulator of stress responses in Arabidopsis. ..
- Harris L, Watkins D, Williams L, Koudelka G. Indirect readout of DNA sequence by p22 repressor: roles of DNA and protein functional groups in modulating DNA conformation. J Mol Biol. 2013;425:133-43 pubmed publisher..These findings suggest that these negatively charged amino acids function to force the P22R-bound DNA into the B' state and therefore play a key role in indirect readout by P22R. ..
- Raina K, Crews C. Targeted protein knockdown using small molecule degraders. Curr Opin Chem Biol. 2017;39:46-53 pubmed publisher..This review briefly summarizes the preclinical development of small molecule-based protein degraders, and describes the recent improvements in the technology that have positioned PROTACs on the cusp of entering the clinic. ..
- Wu L, Genge B, Wuthier R. Association between proteoglycans and matrix vesicles in the extracellular matrix of growth plate cartilage. J Biol Chem. 1991;266:1187-94 pubmed..Thus, strong interactions occur under physiological conditions between MV and both the proteoglycans and collagens, but these take place by different mechanisms. ..
- Fetherston J, Lillard J, Perry R. Analysis of the pesticin receptor from Yersinia pestis: role in iron-deficient growth and possible regulation by its siderophore. J Bacteriol. 1995;177:1824-33 pubmed..HMWP2 likely participates in synthesis of a siderophore which may induce expression of the receptor for pesticin and the siderophore...
- Levenson C, Shay N, Cousins R. Cloning and initial characterization of the promoter region of the rat cysteine-rich intestinal protein gene. Biochem J. 1994;303 ( Pt 3):731-6 pubmed..These experiments provide the initial data required to explore further the regulation of this tissue-specific developmentally regulated Zn(2+)-finger protein. ..
- Sherman M, Dube S, Spicer T, Kane T, Love J, Saksena N, et al. Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I. Cancer Res. 1993;53:6067-73 pubmed..No consistent disease-related changes were observed.(ABSTRACT TRUNCATED AT 400 WORDS)..
- Blanchard R, Cousins R. Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction. Am J Physiol. 1997;272:G972-8 pubmed..These results also suggest a potential mechanism to explain, at least in part, the beneficial effects of zinc supplementation for secretory diarrhea prevalent in many areas of the world...
- Liu W, James C, Frederick L, Alderete B, Jenkins R. PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res. 1997;57:5254-7 pubmed
- Semple Rowland S, Larkin P, Bronson J, Nykamp K, Streit W, Baehr W. Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal. Mol Vis. 1999;5:14 pubmed..The absence of cellular degeneration in the rd pineal gland suggests that GC1 is not critical for pineal cell survival. ..
- Wu G, Mansy S, Wu Sp S, Surerus K, Foster M, Cowan J. Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe. Biochemistry. 2002;41:5024-32 pubmed..Cross-linking of holo ISU1 with holo Fd is consistent with a role for redox chemistry in cluster assembly and may mimic the intramolecular complex already defined in NifU. ..
- Mo X, Dynan W. Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites. Mol Cell Biol. 2002;22:8088-99 pubmed..Tethering of double-strand break repair proteins to defined subnuclear structures may also be advantageous in maintenance of genome stability. ..
- Dougherty M, Boyd J, Downs D. Inhibition of fructose-1,6-bisphosphatase by aminoimidazole carboxamide ribotide prevents growth of Salmonella enterica purH mutants on glycerol. J Biol Chem. 2006;281:33892-9 pubmed..Inhibition of FBP activity by AICAR occurs at physiologically relevant concentrations and may represent a form of regulation of gluconeogenic flux in Salmonella enterica. ..
- Holland N, Nishimiya Y, Tsuda S, SONNICHSEN F. Activity of a two-domain antifreeze protein is not dependent on linker sequence. Biophys J. 2007;92:541-6 pubmed..Nevertheless, the thermal hysteresis activity of the modified protein is indistinguishable from that of native RD3, proving that increased activity of the two-domain antifreeze protein is not dependent on structure of the linker. ..
- Amerik A, Sindhi N, Hochstrasser M. A conserved late endosome-targeting signal required for Doa4 deubiquitylating enzyme function. J Cell Biol. 2006;175:825-35 pubmed..This is the first demonstration of a physiologically important DUB subcellular localization signal and provides a striking example of the functional diversification of DUB paralogues by the evolution of alternative spatial signals. ..
- Cavanagh A, Klocko A, Liu X, Wassarman K. Promoter specificity for 6S RNA regulation of transcription is determined by core promoter sequences and competition for region 4.2 of sigma70. Mol Microbiol. 2008;67:1242-56 pubmed publisher..Region 4.2 binds the -35 element during transcription initiation; therefore we propose one mechanism for 6S RNA regulation of transcription is through competition for binding region 4.2 of sigma70. ..
- Peck R, Shiflett A, Schwartz K, McCann A, Hajduk S, Bangs J. The LAMP-like protein p67 plays an essential role in the lysosome of African trypanosomes. Mol Microbiol. 2008;68:933-46 pubmed publisher..These results indicate p67 plays an essential role in maintenance of normal lysosomal structure and physiology in bloodstream-stage African trypanosomes. ..
- Isackson P, Bennett M, Lichter Konecki U, Willis M, Nyhan W, Sutton V, et al. CPT2 gene mutations resulting in lethal neonatal or severe infantile carnitine palmitoyltransferase II deficiency. Mol Genet Metab. 2008;94:422-7 pubmed publisher..In addition, based on currently available structural, biochemical and clinical data, we have classified all 64 known disease-causing mutations into groups with different predicted phenotypes depending on their CPT2 allelic counterparts. ..
- Lopez Martinez G, Elnitsky M, Benoit J, Lee R, Denlinger D. High resistance to oxidative damage in the Antarctic midge Belgica antarctica, and developmentally linked expression of genes encoding superoxide dismutase, catalase and heat shock proteins. Insect Biochem Mol Biol. 2008;38:796-804 pubmed publisher..Assays to measure oxidative damage (lipid peroxidation TBARS and carbonyl proteins) demonstrated that the Antarctic midge is highly resistant to oxidative stress...
- Aneiros E, Cao L, Papakosta M, Stevens E, Phillips S, Grimm C. The biophysical and molecular basis of TRPV1 proton gating. EMBO J. 2011;30:994-1002 pubmed publisher..We conclude that proton activation and potentiation of TRPV1 are both voltage dependent and that amino acid 660 is essential for proton-mediated gating of TRPV1. ..
- Luo H, Hallen Adams H, Scott Craig J, Walton J. Ribosomal biosynthesis of ?-amanitin in Galerina marginata. Fungal Genet Biol. 2012;49:123-9 pubmed publisher..However, due to the high degree of divergence, the evolutionary relationship between AMA1 in the genera Amanita and Galerina is unclear. ..
- Plowman G, Green J, Neubauer M, Buckley S, McDonald V, Todaro G, et al. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. J Biol Chem. 1992;267:13073-8 pubmed..The broad expression profile of epithelin transcripts, along with the opposing activities of the two mature protein products, implicates these factors as natural mediators of epithelial homeostasis. ..
- Staab J, Elkins M, Earhart C. Nucleotide sequence of the Escherichia coli entE gene. FEMS Microbiol Lett. 1989;50:15-9 pubmed..33. Genetic evidence combined with this and previous sequencing data indicate that the genes entCEB(G)A are transcribed as unit from a promoter upstream of entC. ..
- Dunn T, Koleske A, Lindahl R, Pitot H. Phenobarbital-inducible aldehyde dehydrogenase in the rat. cDNA sequence and regulation of the mRNA by phenobarbital in responsive rats. J Biol Chem. 1989;264:13057-65 pubmed..The strikingly different responses to PB administration between the various mRNA species in each of the genotypes suggest that the regulation of specific gene expression by PB may involve multiple pathways. ..
- Rowley R, Bolen J, Fargnoli J. Molecular cloning of rodent p72Syk. Evidence of alternative mRNA splicing. J Biol Chem. 1995;270:12659-64 pubmed
- Mahan S, McGuire T, Semu S, Bowie M, Jongejan F, Rurangirwa F, et al. Molecular cloning of a gene encoding the immunogenic 21 kDa protein of Cowdria ruminantium. Microbiology. 1994;140 ( Pt 8):2135-42 pubmed..The antigenic conservation of the 21 kDa protein and its immunogenic nature are reasons for further testing of this recombinant protein in subunit diagnostic tests...
- Metz R, Bannister A, Sutherland J, Hagemeier C, O Rourke E, Cook A, et al. c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein. Mol Cell Biol. 1994;14:6021-9 pubmed..Since TBP binding is not exhibited by Fra-1, TBP-mediated activation may be one characteristic that discriminates the function of Fos-related proteins. ..
- Schnepp B, Grumbling G, Donaldson T, Simcox A. Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev. 1996;10:2302-13 pubmed..This combination of domains mirrors those in the vertebrate neuregulins that bind EGFR relatives. ..
- Watanabe R, Wu K, Paul P, Marks D, Kobayashi T, Pittelkow M, et al. Up-regulation of glucosylceramide synthase expression and activity during human keratinocyte differentiation. J Biol Chem. 1998;273:9651-5 pubmed..These results suggest that GCS is up-regulated at the transcriptional level during keratinocyte differentiation and provide the first direct evidence for GCS up-regulation in any cell type. ..
- Chernokalskaya E, Dubell A, Cunningham K, Hanson M, Dompenciel R, Schoenberg D. A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family. RNA. 1998;4:1537-48 pubmed..Finally, we show estrogen induces only a small increase in the amount of PMR-1. This result is consistent with earlier data suggesting estrogen activates mRNA decay through a posttranslational pathway. ..
- Winters D, Ivey D, Maloney T, Johnson M. Characterization by molecular cloning and sequencing of the gene encoding an aminopeptidase from Listeria monocytogenes. Antonie Van Leeuwenhoek. 2000;78:141-51 pubmed..The organization of the locus, designated pep, is presented along with the characterization of the gene products of the pep locus. ..
- Lehoux S, Abe Ji -, Florian J, Berk B. 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange. J Biol Chem. 2001;276:15794-800 pubmed..13 +/- 0.02 versus 0.48 +/- 0.06 mmol of H(+)/min/liter, p < 0.01). These data suggest that 14-3-3 binding to NHE1 participates in serum-stimulated exchanger activation, a new function for 14-3-3. ..
- Gralnick J, Downs D. Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica. Proc Natl Acad Sci U S A. 2001;98:8030-5 pubmed..The data are consistent with a model in which YggX protects protein [Fe-S] clusters from oxidation. ..
- Hunter C, Sung P, Schejter E, Wieschaus E. Conserved domains of the Nullo protein required for cell-surface localization and formation of adherens junctions. Mol Biol Cell. 2002;13:146-57 pubmed..The membrane association of Nullo is required in vivo for its role in basal junction formation and for its ability to block apical junction formation when ectopically expressed during late cellularization. ..
- Vujcic S, Diegelman P, Bacchi C, Kramer D, Porter C. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002;367:665-75 pubmed
- Wozniak M, Desai R, Solski P, Der C, Keely P. ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol. 2003;163:583-95 pubmed
- Pereira S, Huang Y, Bobik E, Kinney A, Stecca K, Packer J, et al. A novel omega3-fatty acid desaturase involved in the biosynthesis of eicosapentaenoic acid. Biochem J. 2004;378:665-71 pubmed
- Nollens H, Jacobson E, Gulland F, Beusse D, Bossart G, Hernandez J, et al. Pathology and preliminary characterization of a parapoxvirus isolated from a California sea lion (Zalophus californianus). J Wildl Dis. 2006;42:23-32 pubmed
- Cheng S, Gallie D. Wheat eukaryotic initiation factor 4B organizes assembly of RNA and eIFiso4G, eIF4A, and poly(A)-binding protein. J Biol Chem. 2006;281:24351-64 pubmed..These results support the notion that eIF4B functions by organizing multiple components of the translation initiation machinery and RNA. ..
- Judelson H. Genomics of the plant pathogenic oomycete Phytophthora: insights into biology and evolution. Adv Genet. 2007;57:97-141 pubmed..A better understanding of these remarkable pathogens should lead to new approaches for managing their diseases. ..
- Pollard A, Onatolu K, Hiller L, Haldar K, Knoll L. Highly polymorphic family of glycosylphosphatidylinositol-anchored surface antigens with evidence of developmental regulation in Toxoplasma gondii. Infect Immun. 2008;76:103-10 pubmed..This group of proteins likely represents a new family of polymorphic GPI-anchored surface antigens that are recognized by the host's immune system and whose expression is regulated during infection. ..
- Cape S, Rehm K, Ma M, Marder E, Li L. Mass spectral comparison of the neuropeptide complement of the stomatogastric ganglion and brain in the adult and embryonic lobster, Homarus americanus. J Neurochem. 2008;105:690-702 pubmed..Collectively, this study expands our current knowledge of the H. americanus neuropeptidome and highlights some intriguing expression differences that occur during development. ..
- Ding X, Richter T, Chen M, Fujii H, Seo Y, Xie M, et al. A rice kinase-protein interaction map. Plant Physiol. 2009;149:1478-92 pubmed publisher..The application of yeast two-hybrid and TAPtag analyses for large-scale plant protein interaction studies is also discussed. ..
- Tian W, Hwang Y, Lu Q, Hwang C. Finger domain mutation affects enzyme activity, DNA replication efficiency, and fidelity of an exonuclease-deficient DNA polymerase of herpes simplex virus type 1. J Virol. 2009;83:7194-201 pubmed publisher..C sites during the polymerization reaction. The implications of the findings are discussed...
- Shoulders M, Satyshur K, Forest K, Raines R. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proc Natl Acad Sci U S A. 2010;107:559-64 pubmed publisher..Thus, preorganization of a main chain by subtle changes to side chains can confer extraordinary conformational stability upon a protein without perturbing its structure. ..
- Walters K, Green J, Surfus J, Yoo S, Huttenlocher A. Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood. 2010;116:2803-11 pubmed publisher..The findings suggest that this transgenic zebrafish model of WHIM syndrome may provide a valuable tool to screen for agents that modify CXCR4-SDF1 retention signals. ..
- Parrott A, Sriram G, Liu Y, Mathews M. Expression of type II chorionic gonadotropin genes supports a role in the male reproductive system. Mol Cell Biol. 2011;31:287-99 pubmed publisher..A novel peptide is encoded by alternatively spliced transcripts. These findings support the view that type II genes evolved in African great apes to function in the male reproductive system. ..
- Bellows Peterson M, Fung H, Floudas C, Kieslich C, Zhang L, Morikis D, et al. De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation. J Med Chem. 2012;55:4159-68 pubmed publisher..The partial agonists also displayed full antagonist activity when tested in a C3aR inhibition assay. In addition, the electrostatic potential profile was shown to potentially discriminate between full agonists and partial agonists. ..
- Wielgus Kutrowska B, Modrak Wójcik A, Dyzma A, Breer K, Zolkiewski M, Bzowska A. Purine nucleoside phosphorylase activity decline is linked to the decay of the trimeric form of the enzyme. Arch Biochem Biophys. 2014;549:40-8 pubmed publisher..These results suggest that the biological role of packing of the PNP monomers into a trimeric structure is to provide the stability of the enzyme since the monomers are not stable in solution. ..
- Jin S, Zhang Z, Dunwell T, Harter M, Wu X, Johnson J, et al. Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration. Cell Rep. 2016;14:493-505 pubmed publisher..Active removal of accumulating 5mC from the TSSs of genes coding for lysosomal proteins by Tet3FL in postmitotic neurons of the brain may be important for preventing neurodegenerative diseases. ..
- Grandy D, Leduc R, Makam H, Flanagan T, Diliberto E, Civelli O, et al. Nucleotide and deduced amino acid sequence of bovine adrenal medulla chromogranin B (secretogranin I). Cell Mol Neurobiol. 1992;12:185-92 pubmed..4. The carboxyl terminus of bovine chromogranin B, including BAM-1745, was found to be the most conserved region of the polypeptide and may identify it as an important functional domain. ..
- Conklin D, McMaster J, Culbertson M, Kung C. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol Cell Biol. 1992;12:3678-88 pubmed..The increased tolerance of strains containing multiple copies of the COT1 gene is probably due to increased compartmentalization or sequestration of the ion within mitochondria. ..
- Shea C, McIntosh M. Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli. Mol Microbiol. 1991;5:1415-28 pubmed..In addition, the transcriptional organization of these genes was examined and primer extension analysis identified a single iron-regulated bidirectional promoter between the P43 gene and the fepDGC operon. ..
- Miller A, Glasel J. Comparative sequence and immunochemical analyses of murine monoclonal anti-morphine antibodies. J Mol Biol. 1989;209:763-78 pubmed..The possible importance of additional contact amino acids, tryptophan, aspartic and/or glutamic acids, is discussed...
- Kelley R. Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene. Genes Dev. 1993;7:948-60 pubmed..A model of D/V axis formation is presented postulating that squid is needed to organize a concentration gradient of a morphogen originating in the germinal vesicle. ..
- Kaprielian Z, Cho K, Hadjiargyrou M, Patterson P. CD9, a major platelet cell surface glycoprotein, is a ROCA antigen and is expressed in the nervous system. J Neurosci. 1995;15:562-73 pubmed..These results provide another example of a cell surface protein expressed by both hematopoietic and neural cells, and suggest a role for CD9 in intercellular signaling in the nervous system. ..
- Schweickart V, Raport C, Godiska R, Byers M, Eddy R, Shows T, et al. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994;23:643-50 pubmed..The mouse EBI1 cDNA has also been isolated and encodes a protein with 86% identity to the human homolog. ..
- Sauer B. Manipulation of transgenes by site-specific recombination: use of Cre recombinase. Methods Enzymol. 1993;225:890-900 pubmed