Experts and Doctors on gene expression regulation in Shenzhen, Guangdong, China


Locale: Shenzhen, Guangdong, China
Topic: gene expression regulation

Top Publications

  1. Hosokawa K, Kajigaya S, Keyvanfar K, Qiao W, Xie Y, Townsley D, et al. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways. J Immunol. 2017;199:477-488 pubmed publisher
    ..These pathways may be targets for new strategies to modulate T cell immune responses in BM failure. ..
  2. Jiang Y, Xie M, Chen W, Talbot R, Maddox J, Faraut T, et al. The sheep genome illuminates biology of the rumen and lipid metabolism. Science. 2014;344:1168-1173 pubmed publisher
    ..This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals. ..
  3. Zhu Y, Li B, Wu T, Ye L, Zeng Y, Zhang Y. Cell cycle and histone modification genes were decreased in placenta tissue from unexplained early miscarriage. Gene. 2017;636:17-22 pubmed publisher
    ..Further studies and validations are necessary to elucidate the exact roles of these genes in miscarriage pathogenesis, which can develop tools for early detection and management. ..
  4. Ye Y, Li Z, Feng Q, Chen Z, Wu Z, Wang J, et al. Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3. PLoS ONE. 2017;12:e0180896 pubmed publisher
    ..MiR-145-5p was confirmed to target ADD3 by luciferase reporter assay. The downregulation of miR-145 may contribute to liver fibrosis in BA by upregulating the expression of ADD3. ..
  5. Li J, Ma Y, Yuan W, Xiao Y, Liu C, Wang J, et al. FOXA transcriptional factor modulates insect susceptibility to Bacillus thuringiensis Cry1Ac toxin by regulating the expression of toxin-receptor ABCC2 and ABCC3 genes. Insect Biochem Mol Biol. 2017;88:1-11 pubmed publisher
    ..These results demonstrate that FOXA up-regulates expression of the Cry1Ac-toxin receptor ABCC2 and ABCC3 genes, and that lower FOXA expression correlates with tolerance to Cry toxin in cell lines and in lepidopteran larvae. ..
  6. Sun Y, Bao Y, Han W, Song F, Shen X, Zhao J, et al. Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay. Nucleic Acids Res. 2017;45:8524-8540 pubmed publisher
    ..Our combined computational and experimental approach should be useful for elucidating the role of AS-NMD in auto- and cross-regulation by other splicing regulators. ..
  7. Deng Y, Wu A, Li P, Li G, Qin L, Song H, et al. Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair. Cell Rep. 2016;14:2224-2237 pubmed publisher
    ..Taken together, our work provides insights into the mechanism by which Yap1 regulates endochondral ossification, which may help the development of therapeutic treatment for bone regeneration. ..
  8. Yang B, Li L, Xu L, Liu J, Zhang H, Geng X, et al. Histone acetyltransferease p300 modulates TIM4 expression in dendritic cells. Sci Rep. 2016;6:21336 pubmed publisher
    ..CT increases p300 expression to regulate STAT6 levels in DCs. STAT6 mediates the CT-induced TIM4 expression in DCs. In conclusion, p300 and STAT6 mediate the microbial product CT-induced TIM4 expression in DCs. ..
  9. Guo H, Li Y, Luo M, Lin S, Chen J, Ma Q, et al. Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells. Mol Reprod Dev. 2015;82:976-85 pubmed publisher
    ..Moreover, androgen receptor directly binds the androgen-responsive element of the Srsf4 promoter. Taken together, these results demonstrate that Srsf4 is a direct downstream target of the androgen receptor in mouse Sertoli cells. ..

More Information


  1. Tsang W, Shu Y, Kwok P, Zhang F, Lee K, Tang M, et al. CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS ONE. 2013;8:e76153 pubmed publisher
    ..CD146(+) HUCPVCs may serve as a potential autologous cell source for bone regeneration. ..
  2. Mou L, Zhang Q, Wang Y, Zhang Q, Sun L, Li C, et al. Identification of Ube2b as a novel target of androgen receptor in mouse sertoli cells. Biol Reprod. 2013;89:32 pubmed publisher
    ..These results suggest that Ube2b, as a direct AR transcriptional target in Sertoli cells, mediates the function of AR in spermatogenesis by promoting H2A ubiquitylation. ..
  3. Yuan M, Li J, Lv J, Mo X, Yang C, Chen X, et al. Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca²? mobilization. Toxicol Appl Pharmacol. 2012;264:462-9 pubmed publisher
    ..Taken together, our data indicate that PD stabilizes mast cells by suppressing Fc?RI-induced Ca²? mobilization mainly through inhibiting Ca²? entry via CRACs, thus exerting a protective effect against PCA. ..
  4. Peng S, Liu X, Huang S, Li Z, Pan H, Zhen W, et al. The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin. Bone. 2011;49:1290-8 pubmed publisher
    ..We hypothesize that OPG plays an important role in the cross-talk between osteoclasts and osteoblasts in response to Sr treatment...
  5. Meng S, Luo M, Sun H, Yu X, Shen M, Zhang Q, et al. Identification and characterization of Bmi-1-responding element within the human p16 promoter. J Biol Chem. 2010;285:33219-29 pubmed publisher
  6. Chen X, Zhang M, Zhu X, Deng Q, Liu H, Larmonier N, et al. Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. J Infect Dis. 2009;200:399-408 pubmed publisher
    ..These data indicate that direct interaction between M. tuberculosis TLR2 ligands and CD4(+) T cells facilitated local CD4(+) T cell immune responses in patients with tuberculous pleurisy. ..
  7. Dong S, Xiong W, Yuan J, Li J, Liu J, Xu X. MiRNA-146a regulates the maturation and differentiation of vascular smooth muscle cells by targeting NF-?B expression. Mol Med Rep. 2013;8:407-12 pubmed publisher
    ..These results support the conclusion that miR-146a is a novel regulator of VSMC fate and may be a new biomarker or therapeutic target for proliferative cardiovascular disease. ..
  8. Hong X, Zhang X, He X, Huang X, Chen H, Wang Y. [Effect of Astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy]. Zhongguo Zhong Yao Za Zhi. 2008;33:676-80 pubmed
    ..To study the effect of Astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy by cDNA microarray...
  9. Xie W, Li M, Xu N, Lv Q, Huang N, He J, et al. MiR-181a regulates inflammation responses in monocytes and macrophages. PLoS ONE. 2013;8:e58639 pubmed publisher
    ..Thus, we provide the first evidence for anti-inflammatory effects of miR-181a mediated at least in part by down-regulating IL1a...
  10. Ying Y, Li L, Cao W, Yan D, Zeng Q, Kong X, et al. The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. FEBS Lett. 2012;586:3674-80 pubmed publisher
    ..Additionally, syntabulin was preferentially phosphorylated by the Epac2 agonist 8-pCPT-2'-O-Me-cAMP, suggesting that syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion. ..
  11. Cheng Y, Gao W, Tang H, Deng J, Wong C, Chan C, et al. ?-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H. Sci Rep. 2016;6:23938 pubmed publisher
    ..Taken together, our work revealed a new intracellular signaling pathway that controls ubiquitination and degradation of the active form of CREB-H transcription factor. ..
  12. Geng X, Qiu S, Yang L, Liu Z, Yang G, Liu J, et al. Allergen-specific immune response suppresses interleukin 10 expression in B cells via increasing micro-RNA-17-92 cluster. Cell Biochem Funct. 2016;34:449-54 pubmed publisher
    ..In conclusion, miR-19a mediates the allergen-specific immune response-decreased IL-10 expression in B cells. ..
  13. Yu B, Shao Y, Yue X, Zhang J, Guan M, Wan J, et al. Copy number variations of Interleukin-12B and T-bet are associated with systemic lupus erythematosus. Rheumatology (Oxford). 2011;50:1201-5 pubmed publisher
    ..The mRNA levels of IL-12B and T-bet in the samples with more than two copies of DNA were significantly higher than those with two copies of DNA. CNVs of IL-12B and T-bet are associated with the risk of SLE. ..
  14. Huang G, Li S, Yang N, Zou Y, Zheng D, Xiao T. Recent progress in circular RNAs in human cancers. Cancer Lett. 2017;404:8-18 pubmed publisher
    ..In this review, we describe briefly the formation and properties of circRNAs, and focus mainly on recent progress in research into their function, regulation, and clinical relevance in different cancers. ..
  15. Liu X, Wang W, Song G, Wei X, Zeng Y, Han P, et al. Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. PLoS ONE. 2017;12:e0182558 pubmed publisher
    ..In conclusion, administration of AS-IV could retard DN progression in type 2 diabetes mice, which might be associated with restoration of the mitochondrial quality control network. ..
  16. Wu Z, Li Y, Huang A, Li M, Zhang X, Wang J, et al. Endoplasmic reticulum stress induced by tunicamycin and antagonistic effect of Tiantai No.1 (1) on mesenchymal stem cells. Chin J Integr Med. 2010;16:41-9 pubmed publisher
    ..05 or P<0.01). This effect showed a dose dependent manner. Tiantai No.1 might attenuate the cell apoptosis induced by ERS injury, and thus protect the neurons against AD. ..