Center for the Study of Reproductive Biology and Women's Health
Principal Investigator: Jeffrey W Pollard
Abstract: DESCRIPTION (provided by applicant): The proposed Specialized Cooperative Center Program in Reproductive and Infertility Research (SCCPIR) is focused upon female reproductive biology with Dr. Jeffrey W. Pollard as Principal Investigator. It has evolved out of an institutional supported "Center for the Study of Reproductive Biology and Women's Health" founded in 2003 at the Albert Einstein College of Medicine with Dr. Pollard as Director. This Center drew together disparate strands of research in the female reproduction at the institution to form a distinct group of interactive individuals who have a translational focus. Investigators with this Center have worked for the last four years to develop this submission and in doing so have met regularly to undertake collaborative projects and used institutional funds to support clinical fellowship training relevant to the study of female reproduction. In doing so the PI's of the proposed projects have all published with one another and they have identified several fellows to be brought onto faculty to perform clinical/basic science research. The SCCPIR has four Projects (Projects 1 and 2 being clinical) and an administrative core as follows: Project 1. Dr. Jeffrey Pollard (PI) - Estrogen and Progesterone Regulation of Human Endometrial Cell Proliferation. Project 2. Dr. Nanette Santoro (PI) - Reproductive hormonal alterations in obesity. Project 3. Dr. Anne Etgen (PI) - IGF-I and Neuroendocrine Regulation of Female Reproductive Function. Project 4. Dr. Streamson Chua (PI) - Antagonistic actions of melanocortins and leptin on reproductive competence. A senior investigator leads all of these projects. There is integration amongst the projects through studies on the roles of obesity and nutrition in reproductive biology as well as the relationship between the insulin-like growth factor-1 axis and estrogen action. The PI, Dr. Jeffrey W. Pollard, is an internationally known researcher in reproductive biology having been, amongst other things, Chair of the Reproductive Tract Gordon Conference. He holds several senior administrative appointments in the College of Medicine and is well able to administer the proposed SCCPIR internally and to enable effective interactions with other SCCPIRs.
Funding Period: 2009-06-03 - 2014-12-31
more information: NIH RePORT
- The excitatory peptide kisspeptin restores the luteinizing hormone surge and modulates amino acid neurotransmission in the medial preoptic area of middle-aged ratsGenevieve Neal-Perry
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Endocrinology 150:3699-708. 2009....
- Metabolic correlates of menopause: an updateLauren A Ross
Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, Colorado 80045, USA
Curr Opin Obstet Gynecol 24:402-7. 2012..We will review the most interesting and relevant studies on metabolic correlates of menopause published over the last year...
- Assessment of luteal function in the vervet monkey as a means to develop a model for obesity-related reproductive phenotypeMila C Kundu
Department of Pathology Comparative Medicine, Wake Forest University Primate Center, Winston Salem, North Carolina, USA
Syst Biol Reprod Med 59:74-81. 2013....
- Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistanceGenevieve Marcelin
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 62:2784-95. 2013..Overall, we have identified a loss-of-function mutation in Ube2l6 that contributes to the chromosome 2 obesity quantitative trait locus. ..
- Macrophage biology in development, homeostasis and diseaseThomas A Wynn
Immunopathogenesis Section, Program in Tissue Immunity and Repair and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20877 8003, USA
Nature 496:445-55. 2013..It is essential to understand this diversity because macrophages have emerged as important therapeutic targets in many human diseases...
- Big enough for an aromatase inhibitor? How adiposity affects male fertilitySahar M Stephens
Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado, USA
Semin Reprod Med 31:251-7. 2013..Adequately designed randomized controlled studies are needed to produce evidence-based data on the role of aromatase inhibitors in male subfertility management and evaluate the side-effect profile...
- Mechanism of formation of the major estradiol product ions following collisional activation of the molecular anion in a tandem quadrupole mass spectrometerKerry M Wooding
Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA
J Am Soc Mass Spectrom 24:1451-5. 2013..We propose two fragmentation schemes to explain the CID data and suggest a structure of m/z 183 and m/z 169 consistent with several isotopic variants and high resolution mass spectrometric measurements. ..
- The correlation between self-reported and measured height, weight, and BMI in reproductive age womenLauren W Roth
Division of Reproductive Endocrinology and Infertility, University of Colorado, Denver, Colorado, United States
Maturitas 76:185-8. 2013..Pearson's correlation coefficient for height (0.96, p<0.001), weight (0.99, p<0.001), and BMI (0.99, p<0.001) were high. Reproductive age women accurately reported their height and weight...
- Agouti-related peptide plays a critical role in leptin's effects on female puberty and reproductionSharone Sheffer-Babila
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York
Am J Physiol Endocrinol Metab 305:E1512-20. 2013..These studies suggest that AGRP imposes an inhibitory effect on puberty and that TAC2 neurons may transmit melanocortinergic inhibition of GnRH neurons. ..
- Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus)Sahar M Stephens
Reproductive Endocrinology, University of Colorado Denver, Denver, Colorado, USA
Comp Med 63:432-8. 2013..These findings demonstrate that vervet monkeys are a suitable animal model for evaluating LH pulse dynamics longitudinally in studies of diet-induced obesity. ..
- Insulin-like growth factor-I regulates LH release by modulation of kisspeptin and NMDA-mediated neurotransmission in young and middle-aged female ratsGenevieve Neal-Perry
Department of Obstetrics and Gynecology G N P, J S, Y S, A M E and the Dominick P Purpura Department of Neuroscience G N P, A M E, Albert Einstein College of Medicine, Bronx, New York 10461 and Internal Medicine of Tongji Hospital D Y, Huazhong University of Science and Technology, Wuhan 430030, R P China
Endocrinology 155:1827-37. 2014..These findings indicate that age-related changes in estradiol-regulated responsiveness to excitatory input from glutamate and kisspeptin reflect reduced IGF-Ir signaling. ..
- Evidence of GnRH antagonist escape in obese womenLauren W Roth
Divisions of Reproductive Endocrinology and Infertility L W R, J L, J C, A J P, N S and Basic Reproductive Sciences A P B and Departments of Pharmaceutical Sciences E L B P and Biostatistics and Informatics A A A, University of Colorado, Aurora, Colorado 80045
J Clin Endocrinol Metab 99:E871-5. 2014..Premature luteinization due to inadequate endogenous gonadotropin suppression is a possibility for this higher risk of cancellation...
- Should the ketogenic diet be considered for enhancing fertility?D Kulak
Albert Einstein College of Medicine, Department of Obstetrics and Gynecology, 1300 Morris Park Ave, Bronx, NY 10461, USA
Maturitas 74:10-3. 2013..We explore the data, both clinical and laboratory, for potential fertility enhancing benefits of the ketogenic diet, beyond just caloric restriction or weight loss...
- KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensingSanhita Ray
Department of Developmental and Molecular Biology, Specialized Cooperative Center for the Study of Reproduction and Infertility Research, Albert Einstein College of Medicine, NY 10461, USA
Proc Natl Acad Sci U S A 109:E1334-43. 2012..KLF15 is therefore a downstream physiological mediator of progesterone's cell cycle inhibitory action in the uterine epithelium...
- Middle-aged female rats retain sensitivity to the anorexigenic effect of exogenous estradiolJessica Santollo
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Behav Brain Res 232:159-64. 2012..These data demonstrate that young and middle-aged rats are similarly sensitive to the anorexigenic effect of E2 and that most, but not all feeding-related genes retain sensitivity to E2...
- Age-related LH surge dysfunction correlates with reduced responsiveness of hypothalamic anteroventral periventricular nucleus kisspeptin neurons to estradiol positive feedback in middle-aged ratsMatthew A Lederman
Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neuropharmacology 58:314-20. 2010....
- Leptin receptor modulation of adiposity and fertilityDavelene Israel
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Trends Endocrinol Metab 21:10-6. 2010..In this review we discuss the evidence that supports the concept of networked functions of leptin receptor as it pertains to feeding, substrate utilization and reproduction...
- Genomic profiling of microRNAs and messenger RNAs reveals hormonal regulation in microRNA expression in human endometriumSatu Kuokkanen
Department of Obstetrics and Gynecology and Women s Health, Cooperative Center for the Study of Reproduction and Infertility Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Biol Reprod 82:791-801. 2010..Thus, our findings suggest a role for miRNAs in down-regulating the expression of some cell cycle genes in the secretory-phase endometrial epithelium, thereby suppressing cell proliferation...
- Hypothalamic insulin-like growth factor-I receptors are necessary for hormone-dependent luteinizing hormone surges: implications for female reproductive agingBrigitte J Todd
Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Endocrinology 151:1356-66. 2010....
- The neuroendocrine physiology of female reproductive aging: An updateGenevieve Neal-Perry
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Montefiore Medical Center and Albert Einstein College of Medicine and Yeshiva University, Bronx, NY, USA
Maturitas 67:34-8. 2010..This article provides a brief update on our current understanding of the role of the hypothalamic-pituitary axis in the onset of and transition into female reproductive senescence...
- Determinants of female reproductive senescence: differential roles for the ovary and the neuroendocrine axisErkan Buyuk
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Montefiore Medical Center and Albert Einstein College of Medicine and Yeshiva University, Bronx, New York 10641, USA
Semin Reprod Med 28:370-9. 2010..This article provides a brief update on our current understanding of the physiological and cellular mechanisms that precipitate and/or commit women to transit into reproductive senescence...
- Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal womenAlexander Kucherov
Obstetrics and Gynecology and Women s Health, Division of Reproductive Endocrinology and Infertility, Albert Einstein College of Medicine, Bronx, New York, USA
Fertil Steril 95:2063-6. 2011..To better understand the site and mode of action of aromatase inhibitors...
- Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neuronsLinh Vong
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, EC CLS717, Boston, MA 02215, USA
Neuron 71:142-54. 2011..As POMC neurons prevent obesity, their disinhibition by leptin action on presynaptic GABAergic neurons probably mediates, at least in part, leptin's antiobesity effects...
- Differential effects of hypothalamic IGF-I on gonadotropin releasing hormone neuronal activation during steroid-induced LH surges in young and middle-aged female ratsYan Sun
Department of Obstetrics Gynecology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullmann 1211, Bronx, New York 10461, USA
Endocrinology 152:4276-87. 2011..IGF-I likely exerts its effects by actions on E2-sensitive neurons that are upstream of GnRH neurons and terminals...
- The nitric oxide pathway participates in lordosis behavior induced by central administration of leptinMarcos García-Juárez
Centro de Investigacion en Reproduccion Animal, Universidad Autónoma de Tlaxcala CINVESTAV, Apdo 62, Tlaxcala, Mexico
Neuropeptides 46:49-53. 2012..These data support the hypothesis that the nitric oxide/cGMP/PKG pathway is involved in the facilitation of lordosis by leptin in estrogen-primed female rats...
- Genetic control of ATGL-mediated lipolysis modulates adipose triglyceride stores in leptin-deficient miceGenevieve Marcelin
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Lipid Res 53:964-72. 2012..Marcelin, G., S-M. Liu, X. Li, G. J. Schwartz, and S. Chua...
- Effects of leptin and melanocortin signaling interactions on pubertal development and reproductionDavelene D Israel
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Endocrinology 153:2408-19. 2012..These studies thus establish melanocortin signaling as an important component in the leptin-mediated regulation of GnRH neuron activity, initiation of puberty and fertility...
- Vasoactive intestinal peptide modulation of the steroid-induced LH surge involves kisspeptin signaling in young but not in middle-aged female ratsAlexander S Kauffman
Department of Reproductive Medicine A S K, J K, A R K, University of California, San Diego, La Jolla, California Department of Obstetrics Gynecology and Women s Health Y S, J S, G N P, Albert Einstein College of Medicine, Bronx, New York and Dominick P Purpura Department of Neuroscience G N P, Albert Einstein College of Medicine, Bronx, New York
Endocrinology 155:2222-32. 2014..These data suggest that VIP differentially affects activation of GnRH and kisspeptin neurons of female rats in an age-dependent manner. ..