Northeast Biodefense Center

Summary

Principal Investigator: W Ian Lipkin
Abstract: The Northeast Biodefense Center (NBC) is a consortium of >350 investigators in 28 academic and research institutions (many of them in close proximity to one another in the greater NYC metro area), and 13 US based governmental and international organizations. Over the past 5 years, NBC investigators have demonstrated their commitment to working together across disciplines and institutional boundaries in research and training programs focused on biodefense and emerging infectious diseases as well as emergency preparedness. Evidence of productivity includes >160 publications, 15 invention disclosures, 13 patent applications and 5 licenses for product development. This renewal will comprise 42 investigators and 32 research projects organized into 6 scientific theme areas: Passive Immunotherapeutics (chair: Arturo Casadevall, Einstein);Vaccines (chair: John Rose, Yale);Diagnostics and Pathogen Discovery (chair: Ian Lipkin, Columbia);Therapeutics (chairs: Charles Rice, Rockefeller and Howard Shuman, Columbia,);Innate Immunity (chairs: David Levy, NYU, and Adolfo Garcia-Sastre, Sinai), and Microbial Pathogenesis (chairs: Jorge E. Galan, Yale, and Jorge Benach, Stony Book). Biotechnology and pharmaceutical collaborators are represented in the Diagnostics and Pathogen Discovery (Agilent, Akonni, Cepheid, Xynostics, 454 Life Sciences), Therapeutics (Prosetta, Snowdon), and Passive Immunotherapeutics (Regeneron) themes. These industrial links provide not only intellectual capital and resources but also a path for moving discoveries from NBC laboratories to a larger arena where they can contribute to human health and welfare. Additional strength derives from relationships with national and international public health agencies that provide unique access to insights and clinical materials (such as diagnostic samples and PBMC) that enable work that could not otherwise be pursuec. Core facilities will include Protein Expression, Animal Models, and Proteomics. We will also invest in Developmental Projects (innovative pilot projects) and in Career Development and Training Programs that include individual and group career development awards. As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness.
Funding Period: 2003-09-04 - 2015-02-28
more information: NIH RePORT

Top Publications

  1. pmc Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis
    John B Biggins
    Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, United States
    Org Lett 13:1536-9. 2011
  2. pmc Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques
    Carlos A Sariol
    Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, United States of America
    PLoS ONE 6:e19323. 2011
  3. pmc Characterization of a canine homolog of hepatitis C virus
    Amit Kapoor
    Center for Infection and Immunity, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:11608-13. 2011
  4. pmc The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication
    Kimberly L Carey
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002056. 2011
  5. pmc Optimal irrigation and debridement of infected joint implants: an in vitro methicillin-resistant Staphylococcus aureus biofilm model
    Evan M Schwechter
    Department of Orthopaedic Surgery, Montefiore Medical Center, Bronx, New York 10467, USA
    J Arthroplasty 26:109-13. 2011
  6. pmc Infection of primary neurons mediated by nipah virus envelope proteins: role of host target cells in antiviral action
    Aparna Talekar
    Department of Pediatrics and Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Virol 85:8422-6. 2011
  7. pmc Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york
    Anna Kaltsas
    Albert Einstein College of Medicine, Department of Medicine, Infectious Disease Division, 1300 Morris Park Ave, UL 1223, Bronx, NY 10461, USA
    J Clin Microbiol 49:2992-5. 2011
  8. pmc Longitudinal molecular microbial analysis of influenza-like illness in New York City, May 2009 through May 2010
    Rafal Tokarz
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, USA
    Virol J 8:288. 2011
  9. pmc BRAF mutations in hairy-cell leukemia
    Enrico Tiacci
    Institute of Hematology, University of Perugia, Perugia, Italy
    N Engl J Med 364:2305-15. 2011
  10. pmc Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
    Giulia Fabbri
    Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Exp Med 208:1389-401. 2011

Detail Information

Publications538 found, 100 shown here

  1. pmc Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis
    John B Biggins
    Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, United States
    Org Lett 13:1536-9. 2011
    ..The isolation and characterization of burkholdacs A and B, two new acyldepsitripeptide histone deacetylase inhibitors produced by B. thailandensis overexpressing the TF bhcM, is reported...
  2. pmc Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques
    Carlos A Sariol
    Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, United States of America
    PLoS ONE 6:e19323. 2011
    ..This study aimed to determine the role of increased TLR3- and TLR7/8-mediated innate signaling after Dengue infection of rhesus macaques in vivo to evaluate its impact on disease and anti-DENV immune responses...
  3. pmc Characterization of a canine homolog of hepatitis C virus
    Amit Kapoor
    Center for Infection and Immunity, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:11608-13. 2011
    ..The discovery of CHV may provide new insights into the origin and evolution of HCV and a tractable model system with which to probe the pathogenesis, prevention, and treatment of diseases caused by hepacivirus infection...
  4. pmc The Coxiella burnetii Dot/Icm system delivers a unique repertoire of type IV effectors into host cells and is required for intracellular replication
    Kimberly L Carey
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002056. 2011
    ..burnetii to successfully establish a niche inside mammalian cells that supports intracellular replication...
  5. pmc Optimal irrigation and debridement of infected joint implants: an in vitro methicillin-resistant Staphylococcus aureus biofilm model
    Evan M Schwechter
    Department of Orthopaedic Surgery, Montefiore Medical Center, Bronx, New York 10467, USA
    J Arthroplasty 26:109-13. 2011
    ....
  6. pmc Infection of primary neurons mediated by nipah virus envelope proteins: role of host target cells in antiviral action
    Aparna Talekar
    Department of Pediatrics and Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Virol 85:8422-6. 2011
    ..These results highlight the advantage of evaluating antiviral potency in cells relevant to natural host target tissue...
  7. pmc Frequency of panton-valentine leukocidin-producing methicillin-sensitive Staphylococcus strains in patients with complicated skin and soft tissue infection in bronx, new york
    Anna Kaltsas
    Albert Einstein College of Medicine, Department of Medicine, Infectious Disease Division, 1300 Morris Park Ave, UL 1223, Bronx, NY 10461, USA
    J Clin Microbiol 49:2992-5. 2011
    ..aureus (MRSA) and MSSA SSTIs were comparable. In multivariable analysis, the presence of lukF-PV remained a significant predictor for incision and drainage among MSSA strains...
  8. pmc Longitudinal molecular microbial analysis of influenza-like illness in New York City, May 2009 through May 2010
    Rafal Tokarz
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, USA
    Virol J 8:288. 2011
    ....
  9. pmc BRAF mutations in hairy-cell leukemia
    Enrico Tiacci
    Institute of Hematology, University of Perugia, Perugia, Italy
    N Engl J Med 364:2305-15. 2011
    ..Hairy-cell leukemia (HCL) is a well-defined clinicopathological entity whose underlying genetic lesion is still obscure...
  10. pmc Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation
    Giulia Fabbri
    Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    J Exp Med 208:1389-401. 2011
    ..These results provide initial data on the complexity of the CLL coding genome and identify a dysregulated pathway of diagnostic and therapeutic relevance...
  11. ncbi An enzymatic assay for detection of viral entry
    Donna M Tscherne
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
    Curr Protoc Cell Biol . 2011
    ..This straightforward assay has broad application for studying the entry steps of enveloped viruses, especially those that require high levels of biosafety containment...
  12. pmc Discovering disease associations by integrating electronic clinical data and medical literature
    Antony B Holmes
    Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 6:e21132. 2011
    ..In particular, we report a statistically significant association between Kawasaki disease and diagnosis of autistic disorder...
  13. pmc Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors
    Nadine Dalrymple
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Rm 126, Stony Brook, NY 11794 5222, USA
    J Virol 85:9478-85. 2011
    ....
  14. pmc Bocavirus episome in infected human tissue contains non-identical termini
    Amit Kapoor
    Center for Infection and Immunity, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e21362. 2011
    ..Moreover, we identified the HBoV genomic terminal sequences that will be helpful in developing reverse genetic systems for these widely prevalent parvoviruses...
  15. pmc A reassortment-incompetent live attenuated influenza virus vaccine for protection against pandemic virus strains
    Rong Hai
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029 6574, USA
    J Virol 85:6832-43. 2011
    ..Overall, our data indicate that the chimeric live-attenuated influenza B viruses expressing the modified influenza A hemagglutinin are effective LAIVs...
  16. pmc A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages
    Ying Zheng
    Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Pathog 7:e1002026. 2011
    ..This pro-inflammatory form of apoptosis may represent an early innate immune response to highly virulent pathogens such as Y. pestis KIM that have evolved an enhanced ability to inhibit host signaling pathways...
  17. pmc Programming the magnitude and persistence of antibody responses with innate immunity
    Sudhir Pai Kasturi
    Emory Vaccine Center, Emory University, Atlanta, Georgia 30329, USA
    Nature 470:543-7. 2011
    ..Immunization protected completely against lethal avian and swine influenza virus strains in mice, and induced robust immunity against pandemic H1N1 influenza in rhesus macaques...
  18. pmc Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice
    Rafael Prados-Rosales
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 121:1471-83. 2011
    ..These findings may open up new horizons for understanding the pathogenesis of tuberculosis and developing vaccines...
  19. pmc Keratinocytes are cell targets of West Nile virus in vivo
    Pei Yin Lim
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Virol 85:5197-201. 2011
    ..In addition, primary keratinocytes produced infectious virus in vitro. In conclusion, keratinocytes are cell targets of WNV in vivo and may play an important role in pathogenesis...
  20. pmc The C-terminal 42 residues of the Tula virus Gn protein regulate interferon induction
    Valery Matthys
    Department of Molecular Genetics and Microbiology, Stony Brook University, Life Sciences Room 126, Stony Brook, NY 11794 5222, USA
    J Virol 85:4752-60. 2011
    ..Thus, in addition to IFN regulation, hantaviruses contain discrete virulence determinants which permit them to be human pathogens...
  21. pmc Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    Laura Pasqualucci
    Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nature 471:189-95. 2011
    ..These results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin's lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms...
  22. pmc Synthetic protocells interact with viral nanomachinery and inactivate pathogenic human virus
    Matteo Porotto
    Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 6:e16874. 2011
    ..The use of protocells that interact with, but do not accumulate, viruses may provide significant advantages over current antiviral drugs, and this general approach may have wide potential for antiviral development...
  23. pmc Novel picornavirus in Turkey poults with hepatitis, California, USA
    Kirsi S Honkavuori
    Columbia University, New York, New York, USA
    Emerg Infect Dis 17:480-7. 2011
    ..Molecular, anatomic, and immunologic evidence suggests that TVH is caused by a novel picornavirus, tentatively named turkey hepatitis virus...
  24. pmc Genomic and phylogenetic characterization of Leanyer virus, a novel orthobunyavirus isolated in northern Australia
    Nazir Savji
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Gen Virol 92:1676-87. 2011
    ..Genetic and serological characterization confirmed its antigenic distance from other orthobunyaviruses, including to its closest genetic neighbours, the Simbu group viruses, suggesting that it may represent a new antigenic complex...
  25. pmc Differential recognition of viral RNA by RIG-I
    Alina Baum
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA
    Virulence 2:166-9. 2011
    ..In influenza virus infected cells RIG-I also preferentially associated with DI RNAs as well as with the shorter genomic segments...
  26. pmc Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis
    Hans Heinrich Hoffmann
    Department of Microbiology, Department of Medicine, and Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 108:5777-82. 2011
    ..Based on these findings, it is proposed that A3 acts by depleting pyrimidine pools, which are crucial for efficient virus replication...
  27. pmc Rapid molecular strategy for orbivirus detection and characterization
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Clin Microbiol 49:2314-7. 2011
    ..Phylogenetic assignment is achieved by automated Web-based sequence analysis of amplification products...
  28. ncbi Mucosal vaccines for biodefense
    N J Mantis
    Division of Infectious Diseases, Wadsworth Center, NYDOH, 120 New Scotland Ave, Albany, NY 12208, USA
    Curr Top Microbiol Immunol 354:181-95. 2012
    ..For others, however, the respiratory or gastrointestinal mucosa is the primary tissue associated with pathogenesis, and therefore, the tissue for which countermeasures must be developed...
  29. pmc Oncolytic specificity of Newcastle disease virus is mediated by selectivity for apoptosis-resistant cells
    Mena Mansour
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Virol 85:6015-23. 2011
    ..Overall, these findings propose a new mechanism for cancer cell specificity for NDV, making it an attractive anticancer agent for chemoresistant tumors with enhanced antiapoptotic activity...
  30. pmc A diverse range of gene products are effectors of the type I interferon antiviral response
    John W Schoggins
    Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10065, USA
    Nature 472:481-5. 2011
    ..Several ISGs, including ADAR, FAM46C, LY6E and MCOLN2, enhanced the replication of certain viruses, highlighting another layer of complexity in the highly pleiotropic type I interferon system...
  31. pmc Genetic characterization of K13965, a strain of Oak Vale virus from Western Australia
    Phenix lan Quan
    Center for Infection and Immunity, Columbia University, New York, NY 10032, USA
    Virus Res 160:206-13. 2011
    ..Phylogenetic analysis of N and L sequences indicated genetic relationship to a recently proposed Sandjima virus clade, although the Oak Vale virus sequences form a branch separate from the African members of that group...
  32. pmc Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites
    Zhiyang Feng
    Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:12629-34. 2011
    ..The large-scale functional screening of eDNA clones should be a productive strategy for generating structurally previously uncharacterized chemical entities for use in future drug development efforts...
  33. pmc Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies
    Sanae Sasaki
    Department of Immunology and Microbiology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 121:3109-19. 2011
    ..They also suggest that exposure history affects the cross-reactivity of vaccination-induced antibodies...
  34. pmc A homing endonuclease and the 50-nt ribosomal bypass sequence of phage T4 constitute a mobile DNA cassette
    Richard P Bonocora
    Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222, USA
    Proc Natl Acad Sci U S A 108:16351-6. 2011
    ..We present a scenario by which the bypass sequence, which is otherwise a unique genetic element, might have been derived from a degenerate group I intron...
  35. pmc Nonconsensus West Nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo
    Gregory D Ebel
    Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Virol 85:12605-13. 2011
    ..Overall, this work highlights the complex relationships that exist between individual and group phenotypes in RNA viruses and identifies RNA helicase as an attenuation and fitness determinant in WNV...
  36. pmc Targeting B cell responses in universal influenza vaccine design
    Kaval Kaur
    Committee on Immunology, The University of Chicago, Chicago, IL, USA
    Trends Immunol 32:524-31. 2011
    ..Such approaches take us away from the limited range of protection provided by current seasonal influenza vaccines and towards a future with a pan-influenza vaccine capable of providing universal strain coverage...
  37. ncbi New strategies for the development of H5N1 subtype influenza vaccines: progress and challenges
    John Steel
    Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA
    BioDrugs 25:285-98. 2011
    ..Overall, recent advances in experimental vaccines and in vaccine production processes provide the potential to lower mortality and morbidity resulting from influenza infection...
  38. pmc Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis
    Rodrigo Torres
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 6:e25084. 2011
    ..Thus, the results of this molecular study of Y. pestis RipA provide a structural platform for rational inhibitor design, which may lead to a greater understanding of the role of RipA in this unique virulence pathway...
  39. pmc Spring-loaded model revisited: paramyxovirus fusion requires engagement of a receptor binding protein beyond initial triggering of the fusion protein
    Matteo Porotto
    Departments of Pediatrics and of Microbiology and Immunology, Weill Medical College of Cornell University, 515 East 71st Street, 6th Floor, Box 309, New York, NY 10021, USA
    J Virol 85:12867-80. 2011
    ..This model has broad implications for the mechanism of paramyxovirus fusion and for strategies to prevent viral entry...
  40. pmc Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles
    Osvaldo Martinez
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Infect Dis 204:S825-32. 2011
    ..Furthermore, removing the mucin-like domain from immunizing VLPs has modest impact on neutralizing antibody titers in serum...
  41. pmc The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import
    Reed S Shabman
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 204:S904-10. 2011
    ..These data further define the mechanism of hnRNP C1/C2 nuclear import and demonstrate that the impact of EBOV VP24 on nuclear import extends beyond STAT1...
  42. pmc DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function
    Reed S Shabman
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Infect Dis 204:S911-8. 2011
    ..These data suggest that DRBP76, via its association with VP35, exerts an anti-EBOV function...
  43. pmc Ebola virus failure to stimulate plasmacytoid dendritic cell interferon responses correlates with impaired cellular entry
    Lawrence W Leung
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Infect Dis 204:S973-7. 2011
    ..These observations identify a novel means by which Ebola virus can avoid triggering an antiviral response...
  44. pmc ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro
    Jianfeng Dai
    Institute of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, P R China
    Virol J 8:468. 2011
    ..The exact roles of ISG15 in DENV and WNV infections remain unknown. In the current study, we evaluated the relevancies of ISG15 to DENV and WNV infection of a mouse macrophage cell line RAW264.7...
  45. pmc Genomic and antigenic characterization of Jos virus
    Ana Valeria Bussetti
    Center for Infection and Immunity and WHO Collaborating Centre for Diagnostics, Surveillance and Immunotherapeutics for Emerging Infectious and Zoonotic Diseases, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Gen Virol 93:293-8. 2012
    ..Here, we report genetic, ultrastructural and serological evidence that JOSV is an orthomyxovirus distinct from but phylogenetically related to viruses of the genus Thogotovirus...
  46. pmc Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies
    Masanori Terajima
    Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 85:13463-7. 2011
    ....
  47. pmc Filoviral immune evasion mechanisms
    Parameshwaran Ramanan
    Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA
    Viruses 3:1634-49. 2011
    ..The examples also represent distinct mechanisms utilized by filoviral proteins in order to counter immune responses, which results in limited IFN-α/β production and downstream signaling...
  48. pmc The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses
    Natalie Pica
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    J Virol 85:12825-9. 2011
    ..Our data demonstrate the utility of DBA.2 mice for the elucidation of influenza virus pathogenicity determinants and the testing of influenza vaccines...
  49. pmc Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses
    Tonya M Colpitts
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002189. 2011
    ..This work provides an extensive list of targets for controlling flaviviral infection in mosquitoes that may also be used to develop broad preventative and therapeutic measures for multiple flaviviruses...
  50. pmc Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor
    Miguel A Mata
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Chem Biol 7:712-9. 2011
    ..Thus, REDD1 is a new host defense factor, and chemical activation of REDD1 expression represents a potent antiviral intervention strategy...
  51. pmc Innate immune control of West Nile virus infection
    Alvaro Arjona
    Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA
    Cell Microbiol 13:1648-58. 2011
    ..This mini-review summarizes our current understanding of how the innate immune systems of the vector and the mammalian host react to WNV infection and shape its pathogenesis...
  52. pmc Discovery of an orthoreovirus in the aborted fetus of a Steller sea lion (Eumetopias jubatus)
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Gen Virol 92:2558-65. 2011
    ..Phylogenetic analysis revealed similarities between SSRV and orthoreoviruses of birds, bats and other mammals that suggests potential for interspecies transmission...
  53. pmc Premature activation of the paramyxovirus fusion protein before target cell attachment with corruption of the viral fusion machinery
    Shohreh F Farzan
    Department of Pediatrics, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 286:37945-54. 2011
    ..This first evidence that activation of a paramyxovirus F can be specifically induced before the virus contacts its target cell suggests a new strategy with broad implications for the design of antiviral agents...
  54. pmc Analysis of the coding genome of diffuse large B-cell lymphoma
    Laura Pasqualucci
    Institute for Cancer Genetics, Columbia University, New York, New York, USA
    Nat Genet 43:830-7. 2011
    ..These results provide initial data on the complexity of the DLBCL coding genome and identify novel dysregulated pathways underlying its pathogenesis...
  55. pmc An in vivo transfection approach elucidates a role for Aedes aegypti thioester-containing proteins in flaviviral infection
    Gong Cheng
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e22786. 2011
    ..In vivo transfection of AeTEP-1 into Ae. aegypti significantly reduced dengue virus infection, suggesting that the approach can further our understanding of pathogen-mosquito interactions...
  56. pmc Modulation of Rab GTPase function by a protein phosphocholine transferase
    Shaeri Mukherjee
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut, CT 06536, USA
    Nature 477:103-6. 2011
    ..Thus, phosphocholination of Rab GTPases represents a mechanism by which bacterial FIC-domain-containing proteins can alter host-cell functions...
  57. pmc Serological studies confirm the novel astrovirus HMOAstV-C as a highly prevalent human infectious agent
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e22576. 2011
    ..Together these results document human humoral responses to HMOAstV-C and validate LIPS as a facile and effective approach for identifying humoral responses to novel infectious agents...
  58. pmc Type III secretion system-dependent translocation of ectopically expressed Yop effectors into macrophages by intracellular Yersinia pseudotuberculosis
    Yue Zhang
    Center for Infectious Diseases, SUNY Stony Brook, CMM235, Stony Brook, NY 11794 5222, USA
    Infect Immun 79:4322-31. 2011
    ..pseudotuberculosis in macrophages. Collectively, our results suggest that the Ysc T3SS of Y. pseudotuberculosis can function within macrophage phagosomes to translocate Yops into the host cytosol...
  59. pmc Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species
    Mirco Schmolke
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS Pathog 7:e1002186. 2011
    ..Our data could explain why PB1-F2 is conserved in avian influenza virus isolates and only impacts pathogenicity in mammals when containing certain amino acid motifs such as the rare N66S polymorphism...
  60. pmc Characterization of a canine homolog of human Aichivirus
    Amit Kapoor
    Center for Infection and Immunity, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    J Virol 85:11520-5. 2011
    ..The discovery of CKoV provides new insights into the origin and evolution of AiV and the species specificity and pathogenesis of kobuviruses...
  61. ncbi Antigen tissue distribution of Avian bornavirus (ABV) in psittacine birds with natural spontaneous proventricular dilatation disease and ABV genotype 1 infection
    Arno Wunschmann
    University of Minnesota, Department of Veterinary Population Medicine, 1333 Gortner Avenue, St Paul, MN 55108, USA
    J Vet Diagn Invest 23:716-26. 2011
    ..Sequencing and phylogenetic analysis indicated the presence of ABV genotype 1 in all cases. Findings further substantiate a role of ABV in PDD of psittacine bird species...
  62. pmc Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virus
    Kelly K Lee
    Department of Medicinal Chemistry and Biomolecular Structure and Design Program, University ofWashington, Seattle, Washington 98195, USA
    J Biol Chem 286:42141-9. 2011
    ..These results provide proof of concept for an antiviral strategy that is applicable to intracellularly fusing viruses, including known and emerging viral pathogens...
  63. pmc High diversity and ancient common ancestry of lymphocytic choriomeningitis virus
    Cesar G Albarino
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 16:1093-100. 2010
    ..Bayesian analysis estimates the most recent common ancestor to be 1,000-5,000 years old, and this long history is consistent with complex phylogeographic relationships of the extant virus isolates...
  64. pmc TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague
    Jr Shiuan Lin
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Vaccine 29:357-62. 2010
    ..pestis challenge will be an important co-determinant of antibody-mediated defense against pneumonic plague...
  65. pmc Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections
    Joseph N Brown
    Department of Microbiology, Washington National Primate Research Center, Seattle, WA 98195, USA
    J Virol 84:12058-68. 2010
    ..Proteomic results were integrated with previous genomic and pathological analysis to characterize the dynamic nature of the influenza virus infection process...
  66. pmc Andes virus regulation of cellular microRNAs contributes to hantavirus-induced endothelial cell permeability
    Timothy Pepini
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5222, USA
    J Virol 84:11929-36. 2010
    ....
  67. pmc Characterization of Durham virus, a novel rhabdovirus that encodes both a C and SH protein
    A B Allison
    Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States
    Virus Res 155:112-22. 2011
    ....
  68. pmc The mechanism of microcin C resistance provided by the MccF peptidase
    Anton Tikhonov
    Institutes of Molecular Genetics and Gene Biology, Russian Academy of Sciences, Moscow, Russia
    J Biol Chem 285:37944-52. 2010
    ..MccF also cleaves the same bond in nonhydrolyzable aminoacyl sulfamoyl adenosines containing aspartyl, glutamyl, and, to a lesser extent, seryl aminoacyl moieties but is ineffective against other aminoacyl adenylates...
  69. pmc Granada virus: a natural phlebovirus reassortant of the sandfly fever Naples serocomplex with low seroprevalence in humans
    Ximena Collao
    Department of Virology, National Center of Microbiology, Institute of Health Carlos III, Madrid, Spain
    Am J Trop Med Hyg 83:760-5. 2010
    ....
  70. pmc A requirement for FcγR in antibody-mediated bacterial toxin neutralization
    Nareen Abboud
    Department of Microbiology and Immunology, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Exp Med 207:2395-405. 2010
    ..These findings highlight a new parameter for evaluating vaccine responses and the possibility of harnessing optimal FcγR interactions in the design of passive immunization strategies...
  71. pmc NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets
    Bin Zhou
    Wadsworth Center, New York State Department of Health, State University of New York, Albany, NY 12201, United States
    Vaccine 28:8015-25. 2010
    ....
  72. pmc Discovery and characterization of mammalian endogenous parvoviruses
    Amit Kapoor
    Center for Infection and Immunity, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    J Virol 84:12628-35. 2010
    ....
  73. pmc Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein
    Anja Lührmann
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 107:18997-9001. 2010
    ..Thus, emergence of an effector protein that interferes with a proapoptotic signaling pathway directed against intracellular bacteria correlates with adaptation of a pathogen to mammalian hosts...
  74. pmc Cholesterol lipids of Borrelia burgdorferi form lipid rafts and are required for the bactericidal activity of a complement-independent antibody
    Timothy J LaRocca
    Department of Molecular Genetics and Microbiology, and Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794, USA
    Cell Host Microbe 8:331-42. 2010
    ..burgdorferi lipid raft organization may have significant implications in the transmission cycle of the spirochetes which are exposed to a range of temperatures...
  75. pmc Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes
    Taia T Wang
    Department of Microbiology and Medicine, Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 107:18979-84. 2010
    ..These results provide proof of concept for an HA2-based influenza vaccine that could diminish the threat of pandemic influenza disease and generally reduce the significance of influenza viruses as human pathogens...
  76. pmc Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
    Johanna Rivera
    Department of Microbiology and Immunology, Division of Infectious Diseases, The Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:19002-7. 2010
    ..Our observations may have important implications for the design of vaccines, for passive antibody strategies, and provide a previously unexplored system for studying secretory pathways in Gram-positive bacteria...
  77. pmc PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice
    Bin Zhou
    Wadsworth Center, NYSDOH, Griffin Laboratory, 5668 State Farm Road, Slingerlands, NY 12159, USA
    J Virol 85:357-65. 2011
    ..Therefore, future surveillance efforts should include scrutiny of this region of PB2 because of its potential impact on pathogenesis...
  78. pmc A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    Nicolas Manel
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 467:214-7. 2010
    ..The virulence of HIV-1 may be related to evasion of this response, the manipulation of which may be necessary to generate an effective HIV-1 vaccine...
  79. pmc Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I
    Penghua Wang
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 11:912-9. 2010
    ....
  80. pmc Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin
    Stefan M Muehlbauer
    Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA
    Am J Pathol 177:735-43. 2010
    ..Our studies indicate that pharmacological inhibition of NLR signaling and caspase-1 can be used to treat inflammatory diseases...
  81. pmc Identification of GBV-D, a novel GB-like flavivirus from old world frugivorous bats (Pteropus giganteus) in Bangladesh
    Jonathan H Epstein
    Conservation Medicine Program, Wildlife Trust, New York, New York, United States of America
    PLoS Pathog 6:e1000972. 2010
    ..Phylogenetic analysis indicates that this first GBV-like flavivirus reported in bats constitutes a distinct species within the Flaviviridae family and is ancestral to the GBV-A and -C virus clades...
  82. pmc Protection from the 2009 H1N1 pandemic influenza by an antibody from combinatorial survivor-based libraries
    Arun K Kashyap
    Sea Lane Biotechnologies, Menlo Park, California, United States of America
    PLoS Pathog 6:e1000990. 2010
    ..These results demonstrate broad activity of the A06 antibody and its utility as an anti-influenza treatment option, even against newly evolved influenza strains to which there is limited immunity in the general population...
  83. pmc Heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus
    Gustavo Palacios
    Center for Infection and Immunity, Columbia University, New York, New York, United States of America
    PLoS ONE 5:e11487. 2010
    ....
  84. pmc Drug-target residence time: critical information for lead optimization
    Hao Lu
    Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, United States
    Curr Opin Chem Biol 14:467-74. 2010
    ..Consequently, to improve the correlation between the in vitro and in vivo activity of drugs, measurements of drug-target residence time must be incorporated into the drug discovery process...
  85. pmc Use of nucleotide composition analysis to infer hosts for three novel picorna-like viruses
    A Kapoor
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    J Virol 84:10322-8. 2010
    ..As metagenomic analyses of different environments and organisms continue to yield highly divergent viral genomes NCA provides a rapid and robust method to identify their likely cellular hosts...
  86. pmc Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody
    Cheolho Cheong
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10065, USA
    Blood 116:3828-38. 2010
    ....
  87. pmc Identification and characterization of a new bocavirus species in gorillas
    Amit Kapoor
    Center for Infection and Immunity, Columbia University, New York, New York, United States of America
    PLoS ONE 5:e11948. 2010
    ..GBoV is the first non-human primate bocavirus identified and provides new insights into the genetic diversity and evolution of this highly prevalent and recently discovered group of parvoviruses...
  88. pmc Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function
    Kathleen C Prins
    Department of Microbiology, Mount Sinai School of Medicine, Box 1124, 1 Gustave L Levy Place, New York, NY 10029, USA
    J Virol 84:10581-91. 2010
    ..Collectively, these results highlight the importance of conserved basic residues from the EBOV VP35 C-terminal IID and validate the VP35 IID as a potential therapeutic target...
  89. pmc A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes
    Gong Cheng
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 142:714-25. 2010
    ..During the mosquito blood-feeding process, WNV infection was blocked in vivo with mosGCTL-1 antibodies. A molecular understanding of flaviviral-arthropod interactions may lead to strategies to control viral dissemination in nature...
  90. pmc Microbe hunting
    W Ian Lipkin
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
    Microbiol Mol Biol Rev 74:363-77. 2010
    ..These refinements are working constructs that will continue to evolve in light of new technologies, new models, and new insights. What will endure is the excitement of the chase. Happy hunting!..
  91. ncbi Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague
    Yoonkyung Do
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, NY 10065 6399, USA
    Eur J Immunol 40:2791-6. 2010
    ..Therefore, LcrV targeting to DC elicits combined humoral and cellular immunity, and for the first time with this approach, also induces protection in a mouse model for a human pathogen...
  92. ncbi Genetic analysis of West Nile virus containing a complete 3'CSI RNA deletion
    Bo Zhang
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
    Virology 408:138-45. 2010
    ..These results demonstrate, for the first time, that a flavivirus without 3'CSI could restore genome cyclization and viral replication through enhancement of the 5'UAR/3'UAR and 5'DAR/3'DAR interactions...
  93. pmc In vitro and in vivo studies identify important features of dengue virus pr-E protein interactions
    Aihua Zheng
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Pathog 6:e1001157. 2010
    ..The sequence conservation of key residues involved in the flavivirus pr-E interaction suggests that this protein-protein interface may be a useful target for broad-spectrum inhibitors...

Research Grants30

  1. Pacific NorthWest Regional Center of Excellence (PNWRCE)
    Jay A Nelson; Fiscal Year: 2013
    ..pseudomallei host pathogen response during both the septicemic as well as the intracellular phases of the disease. ..
  2. Southeast Regional Centers of Excellence for Biodefense &Emerging Infectious Di
    Philip Frederick Sparling; Fiscal Year: 2013
    ..SERCEB brings new investigators to the biodefense effort through a combination of educational programs, support of innovative new projects, and the synergistic interactions among its world-class investigators. ..
  3. New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Dennis L Kasper; Fiscal Year: 2013
    ..NERCE will also continue its Developmental Projects program and Career Development in Biodefense program in an effort to initiate new research efforts and to attract new investigators to this field. ..
  4. Middle Atlantic Regional Center for Excellence for Biodefense and Emerging Infect
    MYRON MAX LEVINE; Fiscal Year: 2013
    ..abstract_text> ..