COLLABORATIVE STUDY OF INITIAL GLAUCOMA TREATMENT

Summary

Principal Investigator: P R Lichter
Abstract: Conventional wisdom in the United States in managing patients with newly-diagnosed open angle glaucoma is to institute topical medical therapy. The medical regimen is increased as necessary to achieve an intraocular pressure reduction considered sufficient to preclude progression of optic nerve and visual field damage. If the medical regimen is inadequate, argon laser trabeculoplasty is often tried if there is a reasonable expectation that adequate pressure reduction might be achieved. If such an expectation is not realistic and/or if argon laser trabeculoplasty is tried and fails to control intraocular pressure, incisional filtration surgery is utilized. Recent studies, particularly in Great Britain, suggest that initial treatment for open angle glaucoma is best handled with filtration surgery and that the rationale for such an approach is based on better outcomes of visual function parameters. The proposed clinical trial will randomize patients with newly-diagnosed open angle glaucoma to either a medical regimen or a surgical approach. Assessments will be made of visual function, intraocular pressure, and the quality of life achieved by patients on the medical and surgical regimens. Null hypotheses to be tested include the lack of a difference between the two treatment modalities in terms of preservation of visual function, level of intraocular pressure achieved, and overall life satisfaction experienced. This clinical trial will take place at 11 Clinical Centers and will include the participation of community ophthalmologists to not only assist in recruitment and management of patients, but to improve the generalizability of the trial's results.
Funding Period: 1993-03-05 - 2004-02-29
more information: NIH RePORT

Top Publications

  1. pmc Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss
    Stephanie J Loomis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Ophthalmology 121:508-16. 2014
  2. pmc Genome-wide association study and meta-analysis of intraocular pressure
    A Bilge Ozel
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genet 133:41-57. 2014
  3. pmc Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States
    Louis R Pasquale
    Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 19:1471-81. 2013
  4. pmc Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS)
    Sarwar Zahid
    Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan
    Am J Ophthalmol 155:674-680, 680.e1. 2013
  5. pmc CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 155:342-353.e5. 2013
  6. pmc Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia
    Megan Ulmer
    Duke University Center for Human Genetics, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 53:4468-74. 2012
  7. pmc Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002654. 2012
  8. pmc The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment study
    Philip P Chen
    Department of Ophthalmology, University of Washington, 359608, Seattle, WA 98104 2499, USA
    J Glaucoma 20:211-4. 2011
  9. pmc Contrasting the use of 2 vision-specific quality of life questionnaires in subjects with open-angle glaucoma
    Patricia A Wren
    Department of Wellness, Health Promotion, and Injury Prevention, School of Health Sciences, Oakland University, Rochester, MI 48309, USA
    J Glaucoma 18:403-11. 2009
  10. pmc Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors
    David C Musch
    Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 116:200-7. 2009

Scientific Experts

  • P P Chen
  • Patricia A Wren
  • H D Jampel
  • Louis R Pasquale
  • Paul R Lichter
  • Brian L Yaspan
  • Jae H Kang
  • Yutao Liu
  • Sayoko E Moroi
  • Michael A Hauser
  • Julia E Richards
  • R Rand Allingham
  • David S Friedman
  • Janey L Wiggs
  • Douglas Vollrath
  • Kuldev Singh
  • Kang Zhang
  • Donald L Budenz
  • Joel S Schuman
  • Douglas Gaasterland
  • Gadi Wollstein
  • David C Musch
  • Stephanie J Loomis
  • Robert N Weinreb
  • Donald J Zack
  • Richard K Lee
  • Terry Gaasterland
  • Jonathan L Haines
  • Catherine A McCarty
  • Margaret A Pericak-Vance
  • Tony Realini
  • Megan Ulmer
  • A Bilge Ozel
  • William G Christen
  • JOHN FINGERT
  • Lana Olson
  • Peter Kraft
  • Arthur J Sit
  • MURRAY BRILLIANT
  • Don Zack
  • Sarwar Zahid
  • Jonathan Haines
  • Allison Ashley-Koch
  • Kathleen Scott
  • Wael Abdrabou
  • Elizabeth DelBono
  • Lana M Olson
  • Anthony Realini
  • Margaret Pericak-Vance
  • Leslie M Niziol
  • Jesse Gilbert
  • John Heckenlively
  • Jun Z Li
  • Goncalo Abecasis
  • Kari Branham
  • Jessica N Cooke Bailey
  • Mohammad Othman
  • Caroline M Schmidt
  • Sarah J Garnai
  • Melisa Nika
  • Louis Pasquale
  • Sara Akbari
  • Frank Rozsa
  • Wei Chen
  • Hemant Pawar
  • David M Reed
  • Janey Wiggs
  • Anand Swaroop
  • Doug Gaasterland
  • Douglas J Rhee
  • Cynthia L Grosskreutz
  • William K Scott
  • Teresa C Chen
  • Jessica Cooke Bailey
  • Stephanie Loomis
  • Cathy Laurie
  • Bao J Fan
  • Richard Lee
  • Terri Young
  • Joshua D Stein
  • Andrew Crenshaw
  • Sachiko Yoneyama
  • Frank W Rozsa
  • Paul VanVeldhuisen
  • Wendy Brodeur
  • Manolis Kellis
  • Daniel Mirel
  • Edward H Trager
  • Cathy McCarty
  • Jun Li

Detail Information

Publications11

  1. pmc Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss
    Stephanie J Loomis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Ophthalmology 121:508-16. 2014
    ..The aim of this study was to assess the association between CAV1/CAV2 single nucleotide polymorphisms (SNPs) and POAG in a large case-control dataset and to explore associations by gender and pattern of visual field (VF) loss further...
  2. pmc Genome-wide association study and meta-analysis of intraocular pressure
    A Bilge Ozel
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Genet 133:41-57. 2014
    ..These results confirm the involvement of common variants in multiple genomic regions in regulating IOP and/or glaucoma risk...
  3. pmc Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States
    Louis R Pasquale
    Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 19:1471-81. 2013
    ..We assessed the association between an estrogen metabolism single nucleotide polymorphism (SNP) panel in relation to primary open angle glaucoma (POAG), accounting for gender...
  4. pmc Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS)
    Sarwar Zahid
    Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan
    Am J Ophthalmol 155:674-680, 680.e1. 2013
    ..To report the risk of endophthalmitis and other long-term complications in patients randomized to trabeculectomy in the Collaborative Initial Glaucoma Treatment Study...
  5. pmc CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 155:342-353.e5. 2013
    ....
  6. pmc Genome-wide analysis of central corneal thickness in primary open-angle glaucoma cases in the NEIGHBOR and GLAUGEN consortia
    Megan Ulmer
    Duke University Center for Human Genetics, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 53:4468-74. 2012
    ....
  7. pmc Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002654. 2012
    ..009). These results suggest that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma...
  8. pmc The effect of early posttrabeculectomy intraocular pressure spike in the collaborative initial glaucoma treatment study
    Philip P Chen
    Department of Ophthalmology, University of Washington, 359608, Seattle, WA 98104 2499, USA
    J Glaucoma 20:211-4. 2011
    ..To examine effects of early postoperative intraocular pressure (IOP) spike in patients undergoing primary trabeculectomy in the Collaborative Initial Glaucoma Treatment Study...
  9. pmc Contrasting the use of 2 vision-specific quality of life questionnaires in subjects with open-angle glaucoma
    Patricia A Wren
    Department of Wellness, Health Promotion, and Injury Prevention, School of Health Sciences, Oakland University, Rochester, MI 48309, USA
    J Glaucoma 18:403-11. 2009
    ..To compare 2 vision-specific functional status measures to each other and to clinical parameters in the Collaborative Initial Glaucoma Treatment Study (CIGTS)...
  10. pmc Visual field progression in the Collaborative Initial Glaucoma Treatment Study the impact of treatment and other baseline factors
    David C Musch
    Department of Ophthalmology and Visual Sciences, The University of Michigan, Ann Arbor, Michigan 48105, USA
    Ophthalmology 116:200-7. 2009
    ..To evaluate factors associated with visual field (VF) progression, using all available follow-up through 9 years after treatment initiation, in the Collaborative Initial Glaucoma Treatment Study (CIGTS)...
  11. ncbi Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS)
    Henry D Jampel
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 140:16-22. 2005
    ..To describe the incidence of, and risk factors for, surgical complications reported during and within the first post-operative month after trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS)...