Meningioma: Risk Factors and Quality of Life
Principal Investigator: JOSEPH LEO WIEMELS
Abstract: = No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.
Funding Period: ----------------2006 - ---------------2011-
more information: NIH RePORT
- Specific genes expressed in association with progesterone receptors in meningiomaElizabeth B Claus
Department of Neurosurgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
Cancer Res 68:314-22. 2008..These findings suggest that PR status may be a clinical marker for genetic subgroups of meningioma and warrant further examination in a larger data set...
- Endogenous and exogenous hormone exposure and the risk of meningioma in menJoellen M Schildkraut
Department of Community and Family Medicine, Cancer Prevention, Detection and Control Research Program
J Neurosurg 120:820-6. 2014..Hormonally related risk factors have long been postulated to be associated with meningioma risk, but no examination of these factors has been undertaken in males...
- Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma riskSeung Tae Lee
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Int J Cancer 134:2199-210. 2014..Anti-VZV reactions may also be a biomarker of effective CNS immunosurveillance owing to the tropism of the virus. ..
- Assessment of autoantibodies to meningioma in a population-based studyJoseph L Wiemels
Department of Epidemiology and Biostatistics, School of Medicine, Helen Diller Cancer Research Building, University of California, San Francisco, 1450 3rd Street, MC 0520, San Francisco, CA 94158, USA
Am J Epidemiol 177:75-83. 2013..1, 11 (P(trend) = 0.006)). These results indicate that men with meningioma commonly react with a serologic antimeningioma response; if supported by further research, this finding suggests a distinctive etiology for meningioma in men...
- Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in femalesElizabeth B Claus
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Neurosurg 118:649-56. 2013..The 2-fold higher incidence of meningioma in women compared with men has long suggested a role for hormonally mediated risk factors, but specific mechanisms remain elusive...
- Cigarette smoking and risk of meningioma: the effect of genderElizabeth B Claus
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Cancer Epidemiol Biomarkers Prev 21:943-50. 2012..We examined the effect of gender on the association between cigarette smoking and risk of intracranial meningioma in a large population-based, case-control study...
- Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controlsJoseph L Wiemels
Department of Neurosurgery and Epidemiology and Biostatistics, University of California at San Francisco School of Medicine, San Francisco, CA 94158, USA
Int J Cancer 129:1932-9. 2011..As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted...
- Exogenous hormone use and meningioma risk: what do we tell our patients?Elizabeth B Claus
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
Cancer 110:471-6. 2007....
- Family and personal medical history and risk of meningiomaElizabeth B Claus
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
J Neurosurg 115:1072-7. 2011..The authors undertook a case-control study to examine the relationship between family and personal medical history and meningioma risk...
- Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control studyJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
Cancer Epidemiol Biomarkers Prev 20:2377-83. 2011....
- History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemiaGisele M Vasconcelos
Programa de Hematologia e Oncologia Pediátricas, Centro de Pesquisa, Instituto Nacional de Cancer, Rio de Janeiro, Brazil
Epigenetics 6:1436-43. 2011..Infections may impact childhood leukemia by altering DNA methylation patterns and specific key genes in susceptible cells; these changes may be retained even after the clearance of infection...
- Profound deficit of IL10 at birth in children who develop childhood acute lymphoblastic leukemiaJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143 0520, USA
Cancer Epidemiol Biomarkers Prev 20:1736-40. 2011..The current study examines the association between neonatal cytokine profiles, a proxy measure for a child's prenatal immune development, and childhood ALL...
- Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control studyPaige M Bracci
School of Medicine, University of California San Francisco, San Francisco, CA 94118 1944, USA
Cancer 118:5384-94. 2012..Autoantibodies to tumor-associated antigens (TAAs) can be present months to years before diagnosis and hold promise as biomarkers for early detection...
- Treatment and survival of patients with nonmalignant intracranial meningioma: results from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Clinical articleKevin S Cahill
Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Neurosurg 115:259-67. 2011..The authors conducted a study to determine population-based estimates of survival following the diagnosis and treatment of nonmalignant intracranial meningioma in the US in the modern era...
- Epidemiology and etiology of meningiomaJoseph Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Research Building, MC 0520, San Francisco, CA 94158, USA
J Neurooncol 99:307-14. 2010..In this review, we highlight current knowledge about meningioma epidemiology and etiology and suggest future research directions...
- Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult gliomaMi Zhou
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
Cancer Res 70:7534-42. 2010..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis...