Inflammatory Biomarkers and Colorectal Cancer Risk

Summary

Principal Investigator: G Yang
Abstract: Colorectal cancer (CRC) is a major cause of cancer deaths in the United States and many other countries. Chronic inflammation has been suggested to play a major role in the pathogenesis of CRC. We propose in this application to conduct a nested case-control study within the Shanghai Women's Health Study, a large population-based prospective cohort study, to evaluate the association of CRC risk with measures of several key products of the inflammatory process and with related genetic markers of inflammation. Specifically, we will include 580 incident cases of CRC and their individually matched controls (1 to1 match for biochemical markers and 1 to 3 match for genetic markers). Urine samples collected at baseline will be measured for a major metabolite of prostaglandin E2 (PGE2) using a liquid chromatographic/mass spectrometric assay and F2-isoprostanes using the mass spectrometric method. Baseline blood samples will be measured for soluble tumor necrosis factor-a receptors, interleukin-6, and C-reactive protein. Genomic DNA will be assayed for polymorphisms in genes involved in PGE2 production (PTGS2, PTGES), metabolism (15-PGDH), and signaling (PTGER1-PTGER4). We will perform statistical analyses to evaluate the associations between these biochemical and genetic markers of inflammation and CRC risk and potential interactions of these markers. Given the large sample size, the prospective study design, the availability of comprehensive baseline survey data and biospecimens, as well as the excellent collaborative environment, we believe that this proposed study represents a unique opportunity to evaluate, vigorously and cost-efficiently, the relationship between various markers of inflammation and CRC. Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk.
Funding Period: ----------------2007 - ---------------2011-
more information: NIH RePORT

Top Publications

  1. pmc Soy food intake and circulating levels of inflammatory markers in Chinese women
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    J Acad Nutr Diet 112:996-1004, 1004.e1-4. 2012
  2. pmc Body weight, fat distribution and colorectal cancer risk: a report from cohort studies of 134255 Chinese men and women
    H Li
    Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Int J Obes (Lond) 37:783-9. 2013
  3. pmc Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
    Wei Hua Jia
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 45:191-6. 2013
  4. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
  5. pmc Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 34:279-93. 2013
  6. pmc Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Nutr Cancer 65:625-32. 2013
  7. pmc Nonexercise physical activity and inflammatory and oxidative stress markers in women
    Sheng Hui Wu
    1 Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    J Womens Health (Larchmt) 23:159-67. 2014
  8. pmc Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians
    Ben Zhang
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
    Int J Cancer 135:948-55. 2014
  9. pmc Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk
    Ben Zhang
    Division of Epidemiology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 46:533-42. 2014
  10. pmc Prospective cohort study of soy food intake and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:577-83. 2009

Scientific Experts

  • G Yang
  • Wei Zheng
  • Sheng Hui Wu
  • Xiao Ou Shu
  • Hong Lan Li
  • Yu Tang Gao
  • Bu Tian Ji
  • Yong Bing Xiang
  • Ben Zhang
  • Qiuyin Cai
  • Wei Hua Jia
  • Wanqing Wen
  • Keitaro Matsuo
  • Sun Ha Jee
  • Yi Xin Zeng
  • Wong Ho Chow
  • Xianglan Zhang
  • Dong Hyun Kim
  • Jin Young Jeong
  • Zhi Zhong Pan
  • Satoyo Hosono
  • Zefang Ren
  • Ji Won Park
  • Fumihiko Matsuda
  • Yoon Ok Ahn
  • Jae Hwan Oh
  • Jiajun Shi
  • Jirong Long
  • Aesun Shin
  • Graham Casey
  • Nathaniel Rothman
  • Ulrike Peters
  • Hui Cai
  • Koichi Matsuda
  • Michiaki Kubo
  • Jaeseong Jo
  • Fredrick R Schumacher
  • Martha L Slattery
  • Eun Jung Park
  • Stephen B Gruber
  • Ginger Milne
  • Andrew T Chan
  • Jenny Chang-Claude
  • H Li
  • Lai Fun Thean
  • Yusuke Nakamura
  • Chun Li
  • Min Ho Shin
  • Yan Guo
  • Sun Seog Kweon
  • Hyeong Rok Kim
  • Bingshan Li
  • Peh Yean Cheah
  • Stephanie L Stenzel
  • Sang Hee Cho
  • Soriul Kim
  • Yanfeng Zhang
  • Atsushi Takahashi
  • Yan Liu
  • Jing Ma
  • Mark A Jenkins
  • John L Hopper
  • Edward L Giovannucci
  • Conghui Qu
  • Michael Hoffmeister
  • Cecelia A Laurie
  • Carolyn M Hutter
  • Zhong Liu
  • Lin S Chen
  • Peter T Campbell
  • John A Baron
  • Aaron K Aragaki
  • Sebastien Kury
  • Noralane M Lindor
  • Brent W Zanke
  • Christopher S Carlson
  • Robert E Schoen
  • MARTHA SHRUBSOLE
  • Sonja I Berndt
  • Thomas Rohan
  • Loic Le Marchand
  • Li Hsu
  • Steven Gallinger
  • John D Potter
  • Stephen N Thibodeau
  • Yongbing Xiang
  • Keith R Curtis
  • Andrea Z LaCroix
  • Thomas J Hudson
  • Hermann Brenner

Detail Information

Publications14

  1. pmc Soy food intake and circulating levels of inflammatory markers in Chinese women
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203 1738, USA
    J Acad Nutr Diet 112:996-1004, 1004.e1-4. 2012
    ..Soy and some of its constituents, such as isoflavones, have been shown to affect the inflammatory process in animal studies. The association between soy food intake and inflammatory markers has not been evaluated adequately in humans...
  2. pmc Body weight, fat distribution and colorectal cancer risk: a report from cohort studies of 134255 Chinese men and women
    H Li
    Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Int J Obes (Lond) 37:783-9. 2013
    ..The objective was to evaluate the association of body size and fat distribution with the risk of colorectal cancer (CRC) in Chinese men and women...
  3. pmc Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer
    Wei Hua Jia
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Nat Genet 45:191-6. 2013
    ..This study identified three new CRC susceptibility loci and provides additional insight into the genetics and biology of CRC...
  4. pmc Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis
    Ulrike Peters
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Gastroenterology 144:799-807.e24. 2013
    ..Heritable factors contribute to the development of colorectal cancer. Identifying the genetic loci associated with colorectal tumor formation could elucidate the mechanisms of pathogenesis...
  5. pmc Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Dis Markers 34:279-93. 2013
    ..This study evaluated associations of various anthropometric measures of adiposity with a panel of inflammatory and oxidative stress markers in a relatively lean population of Chinese women...
  6. pmc Soy food consumption and lung cancer risk: a meta-analysis using a common measure across studies
    Sheng Hui Wu
    Division of Epidemiology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203 1738, USA
    Nutr Cancer 65:625-32. 2013
    ..This study suggests a borderline reduction in risk of lung cancer with daily soy protein intake in grams, and a significant inverse association in nonsmokers. ..
  7. pmc Nonexercise physical activity and inflammatory and oxidative stress markers in women
    Sheng Hui Wu
    1 Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee
    J Womens Health (Larchmt) 23:159-67. 2014
    ..Leisure time exercise has been linked to lower circulating levels of inflammatory markers. Few studies have examined the association of nonexercise physical activity with markers of inflammation and oxidative stress...
  8. pmc Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians
    Ben Zhang
    Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN
    Int J Cancer 135:948-55. 2014
    ..This study identifies a new CRC risk variant in the SMAD7 gene, further highlighting the significant role of this gene in the etiology of CRC...
  9. pmc Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk
    Ben Zhang
    Division of Epidemiology, Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Nat Genet 46:533-42. 2014
    ..11, 10q21.1 and 10q24.2. Furthermore, we replicated 22 previously reported CRC-associated loci. Our study provides insights into the genetic basis of CRC and suggests the involvement of new biological pathways. ..
  10. pmc Prospective cohort study of soy food intake and colorectal cancer risk in women
    Gong Yang
    Department of Medicine, Vanderbilt Epidemiology Center and Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203 1738, USA
    Am J Clin Nutr 89:577-83. 2009
    ..Data from epidemiologic studies linking usual soy food intake with colorectal cancer are limited and inconsistent...
  11. pmc Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk
    Gong Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Clin Nutr 91:704-11. 2010
    ..Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates...
  12. pmc Dietary glycemic load and risk of colorectal cancer in Chinese women
    Hong Lan Li
    Shanghai Cancer Institute, Shanghai, China
    Am J Clin Nutr 93:101-7. 2011
    ..This association has not been prospectively evaluated in other populations...
  13. pmc Green tea consumption and colorectal cancer risk: a report from the Shanghai Men's Health Study
    Gong Yang
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, 2525 West End Avenue, Suite 600, IMPH, Nashville, TN 37203, USA
    Carcinogenesis 32:1684-8. 2011
    ..88, 95% CI: 0.78-0.99). No significant association was found among smokers (HR = 0.94, 95% CI: 0.66-1.34). This study suggests that regular consumption of green tea may reduce colorectal cancer risk among non-smokers...