Micronutrients, stroke and cognition in aging
Principal Investigator: I H Rosenberg
Abstract: A major determinant of the quality of life for elderly individuals is the efficiency of their mental processes. Loss of neurocognitive functioning has been noted in elderly individuals; the severity of this loss ranges from simple memory deficits to profound dementia of the Alzheimer's variety. It is important to discover to what extent such functional decline is preventable and reversible. Specific to this project is the possibility that nutritional factors are important. Since estimates of the incidence of micronutrient deficiency in the elderly is quite large, intervention could significantly reduce the public health burden. The aim of this multidisciplinary study is to determine the prevalence of elevated homocysteine, brain disease, and cognitive decline in the homebound elderly. From 7500 homebound elderly, representative of all registered cases from a specified geographical area, a cohort of 1600 elders will be assessed. The assessment will include dietary history and serum nutrient levels, as well as comprehensive neuropsychological testing. Clinical examination and MRI scans will be performed on a subset of 400 subjects. Known risks for cognitive impairment such as diagnosed depression, anxiety, hypertension, diabetes, atrial fibrillation, medications, APOE, saturated fat intake, and mutations of MTHFR will be measured and included in analyses as covariates and effect modifiers.
Funding Period: 2002-06-15 - 2008-05-31
more information: NIH RePORT
- High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging StudyKatherine L Tucker
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 82:627-35. 2005..It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both...
- Association between linear measurements of corpus callosum and gait in the elderlyHarald Brodoefel
Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Eur Radiol 23:2252-7. 2013..However, such measurements are impracticable in clinical routine. The purpose of this study was to evaluate the association between simple linear measurements of CC thickness with gait...
- Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health StudyXiang Feng
Departmennt of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, China
Asia Pac J Clin Nutr 22:150-9. 2013..We examined the relationship between common variants in IRS1, type 2 diabetes, and related traits including insulin resistance, hyperglycemia and DNA damage in the Boston Puerto Rican Health Study...
- Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adultsDenish Moorthy
Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
J Nutr 142:1554-60. 2012..The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression...
- Diffusion tensor imaging, white matter lesions, the corpus callosum, and gait in the elderlyRefeeque A Bhadelia
Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Stroke 40:3816-20. 2009..Our purpose was to investigate the relationship between the integrity of white matter in the corpus callosum as determined by DTI and quantitative measures of gait in the elderly...
- MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folateChao Qiang Lai
Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 91:1377-86. 2010..The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism...
- Depression and glycemic intake in the homebound elderlyD Mkaya Mwamburi
Department of Public Health and Family Medicine, Tufts University, United States
J Affect Disord 132:94-8. 2011..We aimed to study the relationship between depression and glycemic intake in the elderly, and examine whether antidepressant use modified this relationship...
- The relationship between plasma amyloid-β peptides and the medial temporal lobe in the homebound elderlyXiaoyan Sun
Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, MA, USA
Int J Geriatr Psychiatry 26:593-601. 2011..We thus examined the relationship between plasma Aβ levels and brain volumes...
- Clinical prediction of fall risk and white matter abnormalities: a diffusion tensor imaging studyBang Bon Koo
Departments of Anatomy and Neurobiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Arch Neurol 69:733-8. 2012..The Tinetti scale is a simple clinical tool designed to predict risk of falling by focusing on gait and stance impairment in elderly persons. Gait impairment is also associated with white matter (WM) abnormalities...
- 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home servicesJ S Buell
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
Neurology 74:18-26. 2010..However, no studies have examined the association between vitamin D status, dementia, and cranial MRI indicators of cerebrovascular disease (CVD)...
- Depression and plasma amyloid beta peptides in the elderly with and without the apolipoprotein E4 alleleXiaoyan Sun
Department of Psychiatry, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
Alzheimer Dis Assoc Disord 23:238-44. 2009....
- Validity of estimated dietary eicosapentaenoic acid and docosahexaenoic acid intakes determined by interviewer-administered food frequency questionnaire among older adults with mild-to-moderate cognitive impairment or dementiaLisa N Arsenault
Tufts University, Boston, Massachusetts 02124, USA
Am J Epidemiol 170:95-103. 2009..This frequency was consistently high across all cognitive categories. With interviewer administration, this FFQ seems to be a valid method of assessing dietary EPA + DHA intake in older adults with mild-to-moderate cognitive impairment...
- Vitamin D is associated with cognitive function in elders receiving home health servicesJennifer S Buell
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
J Gerontol A Biol Sci Med Sci 64:888-95. 2009..The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function...
- Albuminuria, cognitive functioning, and white matter hyperintensities in homebound eldersDaniel E Weiner
Division of Nephrology, Tufts Medical Center, Boston, MA 02111, USA
Am J Kidney Dis 53:438-47. 2009..Albuminuria, a kidney marker of microvascular disease, may herald microvascular disease elsewhere, including in the brain...
- Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesisWei Qiao Qiu
Department of Psychiatry, New England Medical Center and Tufts University School of Medicine, 150 Harrison Avenue, Rm 234, Boston, MA 02111, USA
Neurobiol Aging 27:190-8. 2006..Further studies of the role of IDE in the pathogenesis of AD, which may uncover potential treatment target, are much needed...
- Nerve atrophy in severe trigeminal neuralgia: noninvasive confirmation at MR imaging--initial experienceSami H Erbay
Department of Radiology, Tufts New England Medical Center, 750 Washington St, Boston, MA 02467, USA
Radiology 238:689-92. 2006..To retrospectively evaluate the size of the trigeminal nerve on magnetic resonance (MR) images of patients with unilateral trigeminal neuralgia...
- Executive dysfunction in homebound older people with diabetes mellitusWei Qiao Qiu
Friedman School of Nutrition Science and Policy, Department of Psychiatry, Clinical Research Center, Tufts University, Boston, Massachusetts 02111, USA
J Am Geriatr Soc 54:496-501. 2006..To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus...
- The Nutrition, Aging, and Memory in Elders (NAME) study: design and methods for a study of micronutrients and cognitive function in a homebound elderly populationTammy M Scott
Tufts New England Medical Center, Boston, MA 02111, USA
Int J Geriatr Psychiatry 21:519-28. 2006..Understanding mediating factors by which micronutrient status affects cognitive function would contribute to elders' quality of life and their ability to remain in the home...
- Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderlyWei Qiao Qiu
Department of Psychiatry, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Int J Geriatr Psychiatry 22:536-42. 2007..Plasma Amyloid-beta peptide 42 (Abeta42) declines before and soon after the onset of AD, yet the relationship between plasma Abeta42 and depression is unclear...
- The homocysteine hypothesis of depressionMarshal Folstein
Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
Am J Psychiatry 164:861-7. 2007..Longitudinal studies and clinical trials should be designed to challenge the hypothesis...
- Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular diseaseXiaoyan Sun
Department of Psychiatry, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Biol Psychiatry 62:1413-7. 2007..Low plasma amyloid-beta peptide 42 (Abeta42) is associated with depressive symptoms independently of cardiovascular disease (CVD) in the elderly. It is critical to investigate whether antidepressants modify this relationship...
- Amyloid-associated depression: a prodromal depression of Alzheimer disease?Xiaoyan Sun
Department of Psychiatry, Tufts New England Medical Center, Campus Box 1007, 750 Washington St, Boston, MA 02111, USA
Arch Gen Psychiatry 65:542-50. 2008..In a previous study, we reported that depression is also associated with low plasma Abeta(42) levels in the elderly population...
- Vitamin D and neurocognitive dysfunction: preventing "D"ecline?Jennifer S Buell
Friedman School of Nutrition Science and Policy at Tufts University, USA
Mol Aspects Med 29:415-22. 2008..These findings potentially implicate vitamin D in neurocognitive function...