UCLA Alzheimer's Disease Research Center

Summary

Principal Investigator: David B Teplow
Abstract: The UCLA Alzheimer's Disease Research Center (ADRC) supports cutting edge research in an environment that mentors junior investigators;attracts numerous researchers;hosts a pilot project program that allows investigators to gamer preliminary data for more advanced studies;collaborates with the National Alzheimer's Coordination Center (NACC) as well as other Alzheimer disease (AD) related investigators locally, nationally and internationally;extends AD research to women and minorities;and works closely with community and advocacy groups including the Alzheimer's Association. The UCLA ADRC is comprised of 6 cores and proposes 3 projects in this renewal application. Cores include: Administrative, Clinical, Data Management and Statistics, Neuropathology, Recruitment and Education, and Neuroimaging and Biomarkers. The three projects include an investigation of MRI techniques applicable to clinical trials and population studies (Project 1;Liana Apostolova;Junior Investigator), a study of the comparative information to be gained from FDDNP and Pittsburg Compound B molecular imaging and their relationship to CSF and plasma biomarkers (Project 2;Gary Small);and a study of antibodies that inhibit amyloid 6 and tau aggregation and may represent novel interventions in AD (Project 3;David Eisenberg). The Theme of the UCLA ADRC is The Therapeutic Imperative, emphasizing the urgency of developing new treatments for AD. Resource use, core organization, project selection, collaboration, and educational activities are prioritized according to their integration with the Center theme. Clinical Core is following 120 patients;Recruitment and Education Core sponsored lectures reaching 20,000 participants;Neuropathology Core performed autopsies on Center patients who died, and non-Center patients to augment tissue distribution. This application has a major emphasis on biomarkers as a key aspect of advancing new therapies for AD. A familial AD cohort is included in this renewal application and a new minority site (Harbor View Medical Center) has been added. Innovations in advancing research are proposed in each Core of this proposal. Each core has responded to criticisms and recommendations from the 2008 review in this renewal application.
Funding Period: 1999-04-05 - 2015-03-31
more information: NIH RePORT

Top Publications

  1. pmc Resting-state fMRI can reliably map neural networks in children
    Moriah E Thomason
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, USA
    Neuroimage 55:165-75. 2011
  2. ncbi Biomarkers in Alzheimer's disease drug development
    Jeffrey L Cummings
    Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic Neurological Institute, Las Vegas, NV, USA
    Alzheimers Dement 7:e13-44. 2011
  3. pmc [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 43:565-75. 2011
  4. ncbi Quantification issues in arterial spin labeling perfusion magnetic resonance imaging
    Wen Chau Wu
    Graduate Institute of Oncology and Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan
    Top Magn Reson Imaging 21:65-73. 2010
  5. pmc Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome
    Linda D Nelson
    Department of Psychiatry and Biobehavioral Sciences, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles 90024, USA
    Arch Neurol 68:768-74. 2011
  6. pmc Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: data from the Osteoarthritis Initiative
    Hussain Z Tameem
    Biomedical Engineering Department, University of California, Los Angeles, California, USA
    J Magn Reson Imaging 34:372-83. 2011
  7. pmc Staging Alzheimer's disease progression with multimodality neuroimaging
    Michael Ewers
    Department of Radiology, University of California at San Francisco, San Francisco, USA
    Prog Neurobiol 95:535-46. 2011
  8. pmc Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search
    J L Stein
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
    Mol Psychiatry 16:927-37, 881. 2011
  9. pmc Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Neurol 68:488-97. 2011
  10. pmc Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    Adam C Naj
    The John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA
    Nat Genet 43:436-41. 2011

Research Grants

  1. Massachusetts Alzheimer's Disease Research Center
    Bradley T Hyman; Fiscal Year: 2013
  2. Alzheimer's Disease Research Center
    Oscar L Lopez; Fiscal Year: 2013

Detail Information

Publications382 found, 100 shown here

  1. pmc Resting-state fMRI can reliably map neural networks in children
    Moriah E Thomason
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI 48202, USA
    Neuroimage 55:165-75. 2011
    ..Resting-state connectivity is therefore a reliable method for assessing large-scale brain networks in children...
  2. ncbi Biomarkers in Alzheimer's disease drug development
    Jeffrey L Cummings
    Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic Neurological Institute, Las Vegas, NV, USA
    Alzheimers Dement 7:e13-44. 2011
    ..Fit-for-purpose biomarkers are increasingly available to guide AD drug development decisions...
  3. pmc [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 43:565-75. 2011
    ..These results corroborate previous analyses of [F-18]FDDNP PET imaging in clinical populations...
  4. ncbi Quantification issues in arterial spin labeling perfusion magnetic resonance imaging
    Wen Chau Wu
    Graduate Institute of Oncology and Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan
    Top Magn Reson Imaging 21:65-73. 2010
    ..Finally, an optimal imaging protocol including in vivo measurements of several critical parameters was recommended for clinical ASL studies...
  5. pmc Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome
    Linda D Nelson
    Department of Psychiatry and Biobehavioral Sciences, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles 90024, USA
    Arch Neurol 68:768-74. 2011
    ..For reference, [(18)F]FDDNP binding values and patterns were compared with those from patients with Alzheimer disease and cognitively intact control participants...
  6. pmc Initial results on development and application of statistical atlas of femoral cartilage in osteoarthritis to determine sex differences in structure: data from the Osteoarthritis Initiative
    Hussain Z Tameem
    Biomedical Engineering Department, University of California, Los Angeles, California, USA
    J Magn Reson Imaging 34:372-83. 2011
    ..To create an average atlas of knee femoral cartilage morphology, to apply the atlas for quantitative assessment of osteoarthritis (OA), and to study localized sex differences...
  7. pmc Staging Alzheimer's disease progression with multimodality neuroimaging
    Michael Ewers
    Department of Radiology, University of California at San Francisco, San Francisco, USA
    Prog Neurobiol 95:535-46. 2011
    ..This will be important in designing effective treatments that target specific underlying disease AD mechanisms...
  8. pmc Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search
    J L Stein
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
    Mol Psychiatry 16:927-37, 881. 2011
    ..Searching across both samples offers a rigorous way to screen for genes consistently influencing brain structure at different stages of life. Variants identified here may be relevant to common disorders affecting the caudate...
  9. pmc Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration
    Alice S Chen-Plotkin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Neurol 68:488-97. 2011
    ..To assess the relative frequency of unique mutations and their associated characteristics in 97 individuals with mutations in progranulin (GRN), an important cause of frontotemporal lobar degeneration (FTLD)...
  10. pmc Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    Adam C Naj
    The John P Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA
    Nat Genet 43:436-41. 2011
    ..3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility...
  11. ncbi Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer's disease
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Loma Linda, CA, USA
    J Alzheimers Dis 24:137-49. 2011
    ..Together, these findings demonstrate that CAA is a significant variable affecting transition metals in AD...
  12. ncbi Diffusion imaging, white matter, and psychopathology
    Moriah E Thomason
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48202 3897, USA
    Annu Rev Clin Psychol 7:63-85. 2011
    ..Here we review brain changes that have been studied with DTI over the human lifespan and findings in a variety of neuropsychiatric disorders. We also suggest future areas where DTI is likely to have significant impact...
  13. pmc Investigation of cortical thickness abnormalities in lithium-free adults with bipolar I disorder using cortical pattern matching
    Lara C Foland-Ross
    Laboratory of Neuroimaging, Department of Neurology, Ahmanson Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, USA
    Am J Psychiatry 168:530-9. 2011
    ..The authors used MRI in conjunction with cortical pattern matching methods to assess cortical thickness abnormalities in euthymic bipolar patients who were not receiving lithium treatment...
  14. ncbi Microglia - insights into immune system structure, function, and reactivity in the central nervous system
    Martin Wirenfeldt
    Department of Pathology and Laboratory Medicine Neuropathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Histol Histopathol 26:519-30. 2011
    ..Here, we describe some of the latest findings in microglial biology and discuss the potential for using microglia in therapeutic interventions...
  15. pmc High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease
    Sophie Sokolow
    UCLA School of Nursing, Los Angeles, CA 90095, USA
    Cell Calcium 49:208-16. 2011
    ..Taken together, these data indicate that NCX isoforms are selectively regulated in pathological terminals, suggesting different roles of each NCX isoform in Alzheimer's disease terminals...
  16. pmc Global and regional putamen volume loss in patients with heart failure
    Rajesh Kumar
    Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, 90095 1763, USA
    Eur J Heart Fail 13:651-5. 2011
    ..Our aim was to evaluate global and regional putamen volume differences in HF over control subjects...
  17. pmc Double vision: pigment genes do more than just color
    Surendra S Ambegaokar
    Department of Neurology, University of Texas Medical Branch, Galveston, TX, USA
    Fly (Austin) 5:206-9. 2011
    ..186, p. 435-42). Here we discuss further possible effects of mini-white and evidence for autophagy as a mediator of white enhancement of tau toxicity...
  18. pmc Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study
    Yalin Wang
    School of Computing, Informatics, and Decision Systems Engineering, Arizona State University, Tempe, AZ 85281, USA
    Neuroimage 56:1993-2010. 2011
    ..It may be applied to analyze other brain subcortical structures including the caudate nucleus and putamen. This publically available software may boost power for morphometric studies of subcortical structures in the brain...
  19. pmc Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment
    Liana Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Neurobiol Aging 33:2113-24. 2012
    ..Hippocampal atrophy and lateral ventricular enlargement show promise as structural biomarkers for PD...
  20. pmc Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people
    Markus Donix
    Center for Cognitive Neurosciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 20:565-73. 2012
    ..Our aim was to determine the influence of APOE genotype and family history status on cognitive performance in healthy individuals...
  21. pmc Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
    Lara C Foland-Ross
    Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuroimage 59:738-44. 2012
    ..Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest...
  22. pmc Increased cortical expression of FK506 binding protein-51 in HIV-associated neurocognitive disorders
    Virawudh Soontornniyomkij
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Neurovirol 18:313-22. 2012
    ..The further increased FKBP51 expression might lead to maladaptive stress response and HAND...
  23. pmc An update on the diagnosis and management of dementing conditions
    Marwan Maalouf
    Department of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ, USA
    Rev Neurol Dis 8:e68-87. 2011
    ....
  24. pmc Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases
    Valery Filippov
    Loma Linda University, Department of Basic Science, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    J Alzheimers Dis 29:537-47. 2012
    ..Such findings suggest these genes as attractive candidates both for diagnostic purposes and for intervening in neurodegenerative processes...
  25. pmc National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
    Bradley T Hyman
    Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA
    Alzheimers Dement 8:1-13. 2012
    ....
  26. pmc Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions
    Grace J Lee
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, USA
    Biol Psychiatry 71:814-21. 2012
    ..Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI...
  27. pmc Prediction of cognitive decline by positron emission tomography of brain amyloid and tau
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Arch Neurol 69:215-22. 2012
    ..To determine whether 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) brain regional values in individuals without dementia predict and correlate with future cognitive change...
  28. pmc Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia
    David A Merrill
    Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA
    Int Psychogeriatr 24:1076-84. 2012
    ..Here we investigate whether degree of self-reported memory impairment is associated with FDDNP-PET binding levels in persons without dementia...
  29. pmc Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 26:17-27. 2012
    ..Aging affects both the hippocampus and lateral ventricles independent of AD pathology, and should be included as covariate in all structural, hippocampal, and ventricular analyses when possible...
  30. pmc Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research at UCLA, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 33:1-5. 2012
    ..Changes in cerebrospinal fluid (CSF) levels of 42-amino-acid β-amyloid (Aβ(42)), total tau protein (t-tau) and phosphorylated tau at residue 181 (p-tau(181)) during this state are incompletely characterized...
  31. pmc Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, 10911 Weyburn Ave, Ste 200, Los Angeles, CA 90095, USA
    Arch Neurol 69:96-104. 2012
    ..To identify cerebrospinal fluid (CSF) protein changes in persons who will develop familial Alzheimer disease (FAD) due to PSEN1 and APP mutations, using unbiased proteomics...
  32. pmc Isolation of synaptic terminals from Alzheimer's disease cortex
    Sophie Sokolow
    UCLA School of Nursing, Los Angeles, California 90095, USA
    Cytometry A 81:248-54. 2012
    ..These results confirm co-localization of Aβ and p-tau within individual synaptic terminals and provide proof of concept for the utility of flow sorting synaptosomes...
  33. pmc Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease
    Luis D Medina
    SDSU UCSD Joint Doctoral Program in Clinical Psychology, San Diego, Calif, USA MedinaL rohan sdsu edu
    Dement Geriatr Cogn Disord 32:188-92. 2011
    ..This study explored the relationship between familial AD (FAD) mutation status, apolipoprotein E (APOE) genotype, and p-density...
  34. pmc Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex
    Sophie Sokolow
    UCLA School of Nursing, Los Angeles, CA 90095, USA
    Neurobiol Dis 45:381-7. 2012
    ..These data represent the first evidence of high levels of Aβ in excitatory boutons in AD cortex and support the hypothesis that Aβ may play a role in modulating glutamate transmission in AD terminals...
  35. pmc Brain surface conformal parameterization with the Ricci flow
    Yalin Wang
    Laboratory of Neuro Imaging, School of Medicine, University of California, Los Angeles, CA 90095 USA
    IEEE Trans Med Imaging 31:251-64. 2012
    ..The results show our algorithm's power to detect subtle group differences in cortical surfaces...
  36. pmc Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
    Surendra S Ambegaokar
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, MRB 10 138, Galveston, TX 77555, USA
    Hum Mol Genet 20:4947-77. 2011
    ..These findings suggest therapeutic targets other than mitigation of tau phosphorylation...
  37. pmc Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease
    Liana G Apostolova
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, UCLA School of Medicine, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 32:118-25. 2011
    ..Both familial and sporadic Alzheimer's disease (AD) result in progressive cortical and subcortical atrophy. Familial autosomal dominant AD (FAD) allows us to study AD brain changes presymptomatically...
  38. pmc Protein binding in patients with late-life depression
    Anand Kumar
    Department of Psychiatry, University of Illinois at Chicago, USA
    Arch Gen Psychiatry 68:1143-50. 2011
    ..Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap...
  39. pmc National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
    Thomas J Montine
    Department of Pathology, University of Washington School of Medicine, Box 359791, Seattle, WA 98104, USA
    Acta Neuropathol 123:1-11. 2012
    ..Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations...
  40. pmc Brain network local interconnectivity loss in aging APOE-4 allele carriers
    Jesse A Brown
    Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:20760-5. 2011
    ..05). This genotype-specific pattern of structural connectivity change with age thus appears related to changes in gross cortical structure and cognition, potentially affecting the rate and/or spatial distribution of AD-related pathology...
  41. pmc Quantification of arterial cerebral blood volume using multiphase-balanced SSFP-based ASL
    Lirong Yan
    Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
    Magn Reson Med 68:130-9. 2012
    ..The proposed multiphase bSSFP-based arterial spin labeling technique may allow separation of cerebral blood volume of different vascular compartments for functional MRI studies and clinical evaluation of the cerebral vasculature...
  42. pmc Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Clin Exp Neuropsychol 33:1059-68. 2011
    ..These results have implications for the neurobiology of the cognitive changes associated with brain aging...
  43. pmc Family history and APOE-4 genetic risk in Alzheimer's disease
    Markus Donix
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, 01307 Dresden, Germany
    Neuropsychol Rev 22:298-309. 2012
    ..There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice...
  44. pmc Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy
    Parham Moftakhar
    Department of Radiology and Biomedical Imaging, UCSF Medical Center, San Francisco, CA, USA
    J Neuropathol Exp Neurol 69:1201-9. 2010
    ..Both enhanced AQP4 expression and its unique staining pattern suggest that these proteins may be important in the impaired water transport observed in AD and CAA...
  45. pmc Insensitivity of visual assessment of hippocampal atrophy in familial Alzheimer's disease
    John Matthew Ringman
    UCLA Department of Neurology, Mary S Easton Center for Alzheimer s Disease Research, UCLA, 10911 Weyburn Ave, 200 Los Angeles, CA 90095 7226, USA
    J Neurol 257:839-42. 2010
    ..Our results suggest that radiologists' ability to detect HA in persons in whom the diagnosis of incipient AD is certain is sub-optimal and quantitative MRI techniques or other biological markers of the disease are needed...
  46. pmc Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Neuroimage 51:488-99. 2010
    ..After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution...
  47. pmc Mary S. Easton Center of Alzheimer's Disease Research at UCLA: advancing the therapeutic imperative
    Jeffrey L Cummings
    Department of Neurology, The Mary S Easton Center for Alzheimer s Disease Research at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Alzheimers Dis 19:375-88. 2010
    ..The Center supports excellent senior 3 investigators and serves as an incubator for new scientists, agents, models, technologies and concepts that will significantly influence the future of AD treatment and AD research...
  48. pmc Off-label medication use in frontotemporal dementia
    - Bei Hu
    Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Alzheimers Dis Other Demen 25:128-33. 2010
    ..We sought to determine the most commonly used drugs used to treat behavioral variant FTD (bvFTD) in specialized dementia clinics...
  49. pmc 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA
    Hum Brain Mapp 31:786-97. 2010
    ..Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2-3 involvement becomes more evident as the disease progresses...
  50. pmc Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
    Vivianna M Van Deerlin
    1 Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA 2 These authors contributed equally to this work
    Nat Genet 42:234-9. 2010
    ..TMEM106B variants also contribute to genetic risk for FTLD-TDP in individuals with mutations in GRN. Our data implicate variants in TMEM106B as a strong risk factor for FTLD-TDP, suggesting an underlying pathogenic mechanism...
  51. pmc The emotional brain: combining insights from patients and basic science
    Howard J Rosen
    Department of Neurology, University of California, Memory and Aging Center, 350 Parnassus Ave, Suite 905, Box 1207, San Francisco, CA 94143 1207, USA
    Neurocase 15:173-81. 2009
    ..A thorough understanding of emotional dysfunction in neurological disease will require a sophisticated approach to studying emotion, which takes into account these various processes and links them to neuroanatomical changes...
  52. pmc Lossless online ensemble learning (LOEL) and its application to subcortical segmentation
    Jonathan H Morra
    Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA, USA
    Med Image Comput Comput Assist Interv 12:432-40. 2009
    ....
  53. pmc Genetic influences on brain asymmetry: a DTI study of 374 twins and siblings
    Neda Jahanshad
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Neuroimage 52:455-69. 2010
    ..These maps identify heritable DTI-derived features, and may empower genome-wide searches for genetic polymorphisms that influence brain asymmetry...
  54. pmc Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization
    R C Petersen
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 74:201-9. 2010
    ..Neuroimaging measures and chemical biomarkers may be important indices of clinical progression in normal aging and mild cognitive impairment (MCI) and need to be evaluated longitudinally...
  55. pmc Astrocytes: biology and pathology
    Michael V Sofroniew
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1763, USA
    Acta Neuropathol 119:7-35. 2010
    ....
  56. pmc Reduced hippocampal CA2, CA3, and dentate gyrus activity in asymptomatic people at genetic risk for Alzheimer's disease
    Nanthia A Suthana
    Center for Cognitive Neurosciences, Semel Institute, University of California, Los Angeles, CA 90095 7039, USA
    Neuroimage 53:1077-84. 2010
    ....
  57. pmc Persistence of neuropsychological testing deficits in mild cognitive impairment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 28:168-78. 2009
    ....
  58. pmc Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy
    Virawudh Soontornniyomkij
    Department of Pathology, Laboratory Medicine Neuropathology, David Geffen School of Medicine, University of California, Los Angeles, Calif 92093 0603, USA
    Brain Pathol 20:459-67. 2010
    ..76, sum of ranks 331) in the MCAA group (P = 0.008, two-tailed Mann-Whitney U-test). Frequent old microinfarcts in demented individuals with severe CAA may contribute a vascular component to the cognitive impairment in these patients...
  59. ncbi Defining and labeling disease-modifying treatments for Alzheimer's disease
    Jeffrey L Cummings
    Mary S Easton Center for Alzheimer s Disease Research at UCLA, Departments of Neurology and Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Alzheimers Dement 5:406-18. 2009
    ..Prevention claims will depend heavily on biomarker outcomes...
  60. pmc Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry
    April J Ho
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    Hum Brain Mapp 31:499-514. 2010
    ..Overall, 1.5 and 3 T scans did not significantly differ in their power to detect neurodegenerative changes over a year. Hum Brain Mapp, 2010. (c) 2009 Wiley-Liss, Inc...
  61. pmc Alzheimer's disease neuropathologic changes in semantic dementia
    Tiffany W Chow
    Rotman Research Institute and Division of Neurology, Baycrest, Toronto, ON, Canada
    Neurocase 16:15-22. 2010
    ..This case series examines retrospectively which clinical parameters might have pointed to the neuropathological diagnosis of AD...
  62. pmc Multivariate tensor-based morphometry on surfaces: application to mapping ventricular abnormalities in HIV/AIDS
    Yalin Wang
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
    Neuroimage 49:2141-57. 2010
    ..The resulting analysis pipeline may improve the power of surface-based morphometry studies of the brain...
  63. pmc Cortical event-related potentials in preclinical familial Alzheimer disease
    E J Golob
    Department of Psychology, 3067 Percival Stern Hall, Tulane University, New Orleans, LA 70118, USA
    Neurology 73:1649-55. 2009
    ..To define changes in cortical function in persons inheriting familial Alzheimer disease (FAD) mutations before the onset of cognitive decline...
  64. pmc Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study
    Matthew Schrag
    Neurosurgery Center for Research, Training and Education, Loma Linda University, Coleman Pavilion, Suite 11113, 11175 Campus St, Loma Linda, CA 92350, USA
    Acta Neuropathol 119:291-302. 2010
    ..Correlation of imaging findings to tissue pathology in our cases indicates that a variety of CAA-related pathologies produce MR-identified signal voids and further supports the use of SWI as a biomarker for this disease...
  65. ncbi Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease
    Michelle G Tan
    Dementia Research Laboratory, Department of Clinical Research, Singapore General Hospital, Outram Road, Singapore
    J Neurosci Res 88:1157-69. 2010
    ..The current study aims to add to the growing body of knowledge relating to gene changes in AD and provide further insights into pathogenic mechanisms and potential targets of pharmacotherapy...
  66. pmc Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, California, USA
    Mov Disord 25:687-95. 2010
    ..Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement...
  67. pmc Integrating ADNI results into Alzheimer's disease drug development programs
    Jeffrey L Cummings
    Mary S Easton Center for Alzheimer s Disease Research at UCLA, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, United States
    Neurobiol Aging 31:1481-92. 2010
    ....
  68. pmc Synapse loss in dementias
    Ryan Clare
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1732, USA
    J Neurosci Res 88:2083-90. 2010
    ..Here we demonstrate a significant loss of synaptophysin density within the temporal lobe of frontotemporal dementia (FTD) patients...
  69. pmc Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA
    Cereb Cortex 21:877-83. 2011
    ..Our findings of increased fMRI activation associated with APOE genotype but not with FAD mutations suggest that APOE exerts an effect on the BOLD signal that is not readily explained as a compensatory phenomenon...
  70. pmc Subtle deficits in instrumental activities of daily living in subtypes of mild cognitive impairment
    Edmond Teng
    Neurobehavior Unit, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Dement Geriatr Cogn Disord 30:189-97. 2010
    ..We explored the relationship between these factors by comparing instrumental activities of daily living (IADLs) among cognitive subtypes of MCI and examining associations between IADL and neuropsychological indices...
  71. ncbi A nonconservative Lagrangian framework for statistical fluid registration-SAFIRA
    Caroline C Brun
    Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA 90095, USA
    IEEE Trans Med Imaging 30:184-202. 2011
    ..This suggests the advantages of this approach for large-scale neuroimaging studies...
  72. pmc The use of profanity during letter fluency tasks in frontotemporal dementia and Alzheimer disease
    John M Ringman
    UCLA Department of Neurology, Easton Center for Alzheimer s Disease Research at UCLA, Los Angeles, CA 90095 7226, USA
    Cogn Behav Neurol 23:159-64. 2010
    ..To assess whether the production of profanity during letter fluency testing distinguishes frontotemporal dementia (FTD) and Alzheimer disease (AD) patients...
  73. pmc Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
    John P Andrawis
    Pritzker School of Medicine, University of Chicago, Chicago, IL, USA
    Neurobiol Aging 33:856-66. 2012
    ..ApoE4 showed an independent effect on hippocampal atrophy in MCI and AD and in the pooled sample...
  74. pmc Heritability of different forms of memory in the Late Onset Alzheimer's Disease Family Study
    Robert S Wilson
    Rush Alzheimer s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
    J Alzheimers Dis 23:249-55. 2011
    ..This suggests that genetic analyses of memory endophenotypes may help to identify genetic variants associated with AD...
  75. pmc The link between callosal thickness and intelligence in healthy children and adolescents
    Eileen Luders
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, USA
    Neuroimage 54:1823-30. 2011
    ..Sex effects on links between callosal thickness and intelligence during childhood and adolescence are present but appear rather weak in general...
  76. pmc Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29
    Ming Chang Chiang
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
    Neuroimage 54:2308-17. 2011
    ..Genes affect fiber integrity, but their effects vary with age, sex, SES and IQ. Gene-environment interactions are vital to consider in the search for specific genetic polymorphisms that affect brain integrity and connectivity...
  77. pmc Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, UCLA Department of Neurology, Los Angeles, CA, United States
    Neurosci Lett 487:287-92. 2011
    ..We describe biochemical, imaging, and neuropathological changes in a pedigree with a novel PSEN1 mutation. This allows us to validate the pathogenicity of this mutation and the indices used to assess AD...
  78. pmc The development of the corpus callosum in the healthy human brain
    Eileen Luders
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 7334, USA
    J Neurosci 30:10985-90. 2010
    ....
  79. pmc Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes
    Gyungah Jun
    Department of Medicine, Boston University, USA
    Arch Neurol 67:1473-84. 2010
    ..To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes...
  80. pmc High-definition characterization of cerebral β-amyloid angiopathy in Alzheimer's disease
    Virawudh Soontornniyomkij
    Department of Pathology and Laboratory Medicine Neuropathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Hum Pathol 41:1601-8. 2010
    ....
  81. pmc "Fantastic thinking" in pathologically proven Pick disease
    Sarah A Kremen
    Neurobehavior Unit, Department of Neurology, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Cogn Behav Neurol 23:130-4. 2010
    ..Reports of false beliefs may be a unique feature of behavioral variant frontotemporal dementia (bvFTD) but the nature of these experiences is unclear...
  82. pmc 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Neurobiol Aging 31:1284-303. 2010
    ..p-tau(181) showed stronger correlation in ApoE4 carriers, while t-tau showed stronger correlation in ApoE4 noncarriers. Of the 3 PIB measures the precuneal SUVR showed strongest associations with hippocampal atrophy...
  83. pmc Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism
    Markus Donix
    David Geffen School of Medicine at UCLA, Center for Cognitive Neurosciences, Semel Institute, Los Angeles, CA 90095, USA
    Neuroimage 53:37-43. 2010
    ..This finding is consistent with the hypothesis that carrying the APOE-4 allele renders subjects at a higher risk for developing Alzheimer's disease...
  84. pmc Neurodegenerative models in Drosophila: polyglutamine disorders, Parkinson disease, and amyotrophic lateral sclerosis
    Surendra S Ambegaokar
    Department of Neurology and George P and Cynthia Woods Mitchell Center for Neurodegenerative Disease, University of Texas Medical Branch, Galveston, TX, USA
    Neurobiol Dis 40:29-39. 2010
    ....
  85. pmc The effect of formalin fixation on the levels of brain transition metals in archived samples
    Matthew Schrag
    Neurosurgery Center for Research, Loma Linda University, 11175 Campus Street, Coleman Pavilion Suite 11113, Loma Linda, CA 92350, USA
    Biometals 23:1123-7. 2010
    ..These results indicate that transition metal data obtained from fixed tissue may be heavily distorted and care should be taken in interpreting this data...
  86. pmc Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster
    Surendra S Ambegaokar
    Neuroscience Interdepartmental Ph D Program, Brain Research Institute, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, and Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genetics 186:435-42. 2010
    ..Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205...
  87. pmc Utility of the functional activities questionnaire for distinguishing mild cognitive impairment from very mild Alzheimer disease
    Edmond Teng
    Neurobehavior Unit Geriatric Research Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System Departments of Neurology Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA Department of Neurology, Mayo Clinic
    Alzheimer Dis Assoc Disord 24:348-53. 2010
    ..005) were the FAQ items of greatest diagnostic utility. These data suggest that the FAQ exhibits adequate sensitivity and specificity when used as a standardized assessment of instrumental ADLs in the diagnosis of AD versus MCI. ..
  88. pmc Telephone assessment of cognitive function in the late-onset Alzheimer's disease family study
    Robert S Wilson
    Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Neurol 67:855-61. 2010
    ..Administration of cognitive test batteries by telephone has been shown to be a valid and cost-effective means of assessing cognition, but it remains relatively uncommon in epidemiological research...
  89. pmc Family history of Alzheimer's disease and hippocampal structure in healthy people
    Markus Donix
    Center for Cognitive Neurosciences, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California Los Angeles, Semel Institute, Los Angeles, CA 90095, USA
    Am J Psychiatry 167:1399-406. 2010
    ..The authors investigated the influence of APOE-4 genotype and family history risks on cortical thickness in medial temporal lobe subregions among volunteers without cognitive impairment...
  90. pmc Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    J Alzheimers Dis 23:433-42. 2011
    ..Possession of the ε4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits...
  91. pmc Assessment of dementia risk in aging adults using both FDG-PET and FDDNP-PET imaging
    L M Ercoli
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA
    Int J Geriatr Psychiatry 27:1017-27. 2012
    ..In this follow-up investigation, we compared 2-deoxy-2-[F-18]fluoro- d-glucose (FDG)-PET cerebral metabolic patterns in the three FDDNP-PET binding subgroups...
  92. pmc Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci
    Patrick Holton
    Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
    Ann Hum Genet 77:85-105. 2013
    ..Although these results are mainly negative, they allow us to start defining more realistic alternative approaches to determine the role of all the genetic loci involved in Alzheimer's disease...
  93. pmc Amyloid-β positron emission tomography imaging probes: a critical review
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    J Alzheimers Dis 36:613-31. 2013
    ....
  94. pmc Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
    C Reitz
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY, USA
    Transl Psychiatry 3:e256. 2013
    ..More importantly, the results indicate that variants within these genes have epistatic effects on AD risk...
  95. pmc Ventricular enlargement and its clinical correlates in the imaging cohort from the ADCS MCI donepezil/vitamin E study
    Liana G Apostolova
    Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 27:174-81. 2013
    ..After correction for baseline hippocampal volume, decline in ADL showed a significant association with right frontal horn enlargement. Executive decline was associated with right frontal and left temporal horn enlargement...
  96. pmc Spatial-temporal atlas of human fetal brain development during the early second trimester
    Jinfeng Zhan
    Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 44 Wen Hua Xi Road, 250012 Jinan, Shandong, China
    Neuroimage 82:115-26. 2013
    ..These week-by-week fetal brain atlases can be used as reference in in vivo studies, and may facilitate the quantification of fetal brain development across space and time...

Research Grants30

  1. Massachusetts Alzheimer's Disease Research Center
    Bradley T Hyman; Fiscal Year: 2013
    ..Going forward, the MADRC will continue to expand its clinical and neuropathological resources, its innovative training and scientific programs directed toward AD research. ..
  2. Alzheimer's Disease Research Center
    Oscar L Lopez; Fiscal Year: 2013
    ..Alzheimer's centers such as the one in Pittsburgh play a critical role in the nation's struggle to: 1) care for those currently afflicted;2) improve diagnosis and treatment;and 3) find a means of prevention. ..