CANCER CENTER SUPPORT GRANT

Summary

Principal Investigator: Nancy E Davidson
Abstract: DESCRIPTION (provided by applicant): This Cancer Center Support Grant application from the University of Pittsburgh Cancer Institute, an NCI-designated Comprehensive Cancer Center, seeks support for years 22-26. The UPCI is organized as a matrix center that integrates cancer research, clinical care, and cancer outreach across the University of Pittsburgh and its affiliated health system, UPMC. The UPCI includes 348 members from 37 academic departments who have come together to work to reduce the burden of cancer through cancer-related basic, translational, clinical, behavioral, epidemiological, prevention and control research. Total annual extramural cancer research funding (direct costs) to UPCI was $109.5 million (peer-reviewed $95M, non-peer-reviewed $14.5M) on October 1, 2009 of which $42.5M was received from the National Cancer Institute. The commitment of UPCI to transdisciplinary cancer research is exemplified by the fact that its members lead three SPORE grants (lung, head and neck, and skin cancers), eight cancer-focused P01s, two Early Detection Research Network grants, and a phase I U01. The impact of the cancer research driven by UPCI and its members can be seen in the more than 4,400 unique publications by UPCI investigators from 2004-2009 of which 45% represent collaborative efforts (17% intra-programmatic, 20% inter-programmatic, and 8% both). The integration of investigators at the main University of Pittsburgh campus with clinicians from a unique clinical care network encompassing about 40 UPMC community cancer centers across Western Pennsylvania has enabled enhanced patient access to clinical trials throughout our catchment area in a highly productive way. In 2008 a total of 11,484 patients were entered in the cancer registry. During that same year 1,158 and 2,508 patients entered interventional and non-interventional clinical trials, respectively. It is noteworthy that in 2008 30% of accruals to interventional trials were to investigator-initiated trials and 40% of accruals to interventional trials took place at UPMC community cancer centers. This renewal application requests support for twelve scientific research Programs, fifteen Shared Facilities, Protocol-Specific Research Support, Protocol Review and Monitoring System, planning and evaluation activities, developmental funds, senior leadership, staff investigators, and administration.
Funding Period: 1997-09-10 - 2015-07-31
more information: NIH RePORT

Top Publications

  1. pmc Crizotinib induces PUMA-dependent apoptosis in colon cancer cells
    Xingnan Zheng
    Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Mol Cancer Ther 12:777-86. 2013
  2. pmc Why can't rodents vomit? A comparative behavioral, anatomical, and physiological study
    Charles C Horn
    Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e60537. 2013
  3. pmc Premetastatic soil and prevention of breast cancer brain metastasis
    Yan Liu
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Neuro Oncol 15:891-903. 2013
  4. pmc ADAR1 is essential for intestinal homeostasis and stem cell maintenance
    W Qiu
    Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Death Dis 4:e599. 2013
  5. pmc Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, U S A
    In Vivo 27:291-7. 2013
  6. pmc The second transmembrane domain of P2X7 contributes to dilated pore formation
    Chengqun Sun
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e61886. 2013
  7. pmc Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors
    Ji Young Song
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cancer Epidemiol 37:518-22. 2013
  8. pmc Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
    Vivian W Y Lui
    Departments of 1Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Discov 3:761-9. 2013
  9. ncbi Interleukin-8 as a modulator of response to bevacizumab in preclinical models of head and neck squamous cell carcinoma
    Rekha Gyanchandani
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Oral Oncol 49:761-70. 2013
  10. pmc LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma
    Brian F Kiesel
    Molecular Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    J Pharm Biomed Anal 81:89-98. 2013

Detail Information

Publications380 found, 100 shown here

  1. pmc Crizotinib induces PUMA-dependent apoptosis in colon cancer cells
    Xingnan Zheng
    Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Mol Cancer Ther 12:777-86. 2013
    ..These findings have important implications for future clinical development of crizotinib...
  2. pmc Why can't rodents vomit? A comparative behavioral, anatomical, and physiological study
    Charles C Horn
    Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e60537. 2013
    ..The implications of these findings for the utility of rodents as models in the area of emesis research are discussed...
  3. pmc Premetastatic soil and prevention of breast cancer brain metastasis
    Yan Liu
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Neuro Oncol 15:891-903. 2013
    ..As therapies for systemic cancer improve and patients survive longer, the risk for brain metastases increases. We evaluated whether immune mechanisms are involved in the development of brain metastasis...
  4. pmc ADAR1 is essential for intestinal homeostasis and stem cell maintenance
    W Qiu
    Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Death Dis 4:e599. 2013
    ..These results support an essential role of ADAR1 and RNA editing in tissue homeostasis and stem cells...
  5. pmc Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, U S A
    In Vivo 27:291-7. 2013
    ..Thoracic irradiation results in an acute inflammatory response, latent period, and late fibrosis. Little is known about the mechanisms involved in triggering late radiation fibrosis...
  6. pmc The second transmembrane domain of P2X7 contributes to dilated pore formation
    Chengqun Sun
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e61886. 2013
    ..Our results demonstrate a critical role for the TM2 domain of P2X7 in receptor function, and provide a structural basis for differences between purinergic receptors...
  7. pmc Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors
    Ji Young Song
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cancer Epidemiol 37:518-22. 2013
    ..To investigate the association between inherited variation in the estrogen receptor beta (ERβ) gene (ESR2) and ERβ lung tumor expression, a phenotype that possibly affects survival differently in men and women...
  8. pmc Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
    Vivian W Y Lui
    Departments of 1Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Discov 3:761-9. 2013
    ..These results suggest that PI3K pathway mutations may serve as predictive biomarkers for treatment selection. ..
  9. ncbi Interleukin-8 as a modulator of response to bevacizumab in preclinical models of head and neck squamous cell carcinoma
    Rekha Gyanchandani
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Oral Oncol 49:761-70. 2013
    ..In this study, we assessed the efficacy of bevacizumab in HNSCC xenograft models to characterize escape mechanisms underlying intrinsic resistance and identify potential biomarkers of drug response...
  10. pmc LC-MS/MS assay for the quantitation of the HDAC inhibitor belinostat and five major metabolites in human plasma
    Brian F Kiesel
    Molecular Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    J Pharm Biomed Anal 81:89-98. 2013
    ....
  11. pmc A phase I trial of isolated hepatic perfusion (IHP) using 5-FU and oxaliplatin in patients with unresectable isolated liver metastases from colorectal cancer
    D Magge
    University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Ann Surg Oncol 20:2180-7. 2013
    ..Isolated hepatic perfusion (IHP) with melphalan is an established approach for patients with unresectable metastatic liver lesions. This study determined the safety and maximum tolerated dose (MTD) of 5-FU with oxaliplatin via IHP...
  12. pmc Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells
    X Song
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Death Dis 4:e577. 2013
    ..This study supports the application of hyperthermia combined with other regimens to treat colorectal hepatic metastases...
  13. pmc Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
    Lívia B Salum
    Laboratorio de Quimica Medicinal e Computacional, IFSC USP, Sao Carlos, SP, Brazil
    Eur J Med Chem 63:501-10. 2013
    ....
  14. pmc A rationally designed A34R mutant oncolytic poxvirus: improved efficacy in peritoneal carcinomatosis
    Pragatheeshwar Thirunavukarasu
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mol Ther 21:1024-33. 2013
    ..Thus, vA34R may be a potent oncolytic virus (OV) for patients with PC, even after prior exposure to vaccinia virus (VV)...
  15. pmc Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients
    Raghvendra M Srivastava
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:1858-72. 2013
    ..However, the role of CD8(+) CTL and FcγR in initiating innate and adaptive immune responses in mAb-treated human patients with cancer is still emerging...
  16. pmc Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity
    Shao Yu Wu
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Nucleic Acids Res 41:4650-9. 2013
    ..The strategy of designing siRNA molecules that incorporate cytotoxic nucleosides represents a potentially novel drug development approach for the treatment of cancer and other human diseases...
  17. pmc Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes
    Josephia R Muindi
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Horm Cancer 4:242-50. 2013
    ..Individuals with these genotypes may require higher D(3) supplementation doses to achieve vitamin D(3) sufficiency...
  18. pmc Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis
    Harrison Brand
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreas 42:836-40. 2013
    ....
  19. pmc Prediction of the Oncotype DX recurrence score: use of pathology-generated equations derived by linear regression analysis
    Molly E Klein
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Mod Pathol 26:658-64. 2013
    ..Conversely, an Oncotype DX result that is dramatically different from what is expected based on standard morphoimmunohistologic variables should be thoroughly investigated...
  20. pmc Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogens
    Berthony Deslouches
    Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 57:2511-21. 2013
    ..The results demonstrate that the rational design of CAPs can lead to a significant reduction in the length and the number of amino acids used in peptide design to achieve optimal potency and selectivity against specific pathogens...
  21. pmc Differential effects of phenethyl isothiocyanate and D,L-sulforaphane on TLR3 signaling
    Jianzhong Zhu
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 190:4400-7. 2013
    ..These results indicate biologically relevant functional differences between two structurally similar ITCs and may provide important insights in therapeutic development of these compounds targeted to specific cancer...
  22. pmc Distinguishing pseudoprogression from progression in high-grade gliomas: a brief review of current clinical practice and demonstration of the potential value of 18F-FDG PET
    Matthew J Oborski
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Nucl Med 38:381-4. 2013
    ..PET showed low tumor uptake indicating stable disease. Follow-up CE-MRI at 3 and 4 months post-RT confirmed stable disease. This case emphasizes the value of 18F-FDG PET when pseudoprogression is clinically suspected...
  23. pmc Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
    Ping Mao
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 110:8644-9. 2013
    ..Inhibition of ALDH1A3-mediated pathways therefore might provide a promising therapeutic approach for a subset of HGGs with the Mes signature...
  24. pmc A phase II trial of dasatinib in patients with metastatic castration-resistant prostate cancer treated previously with chemotherapy
    Przemyslaw W Twardowski
    Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA
    Anticancer Drugs 24:743-53. 2013
    ..The observation of a patient with prolonged, objective, clinically significant benefit warrants molecular profiling to select the appropriate patient population. ..
  25. pmc Inhibitors of C5 complement enhance vaccinia virus oncolysis
    D Magge
    Department of Surgery, University of Pittsburgh School of Medicine and Medical Center, Pittsburgh, PA 15213, USA
    Cancer Gene Ther 20:342-50. 2013
    ..This study suggests that complement inhibition may reduce vaccinia viral neutralization and may be critical to future in vivo work...
  26. pmc TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation
    Quanhong Sun
    Department of Medicine Hematology Oncology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Bone Miner Res 29:90-102. 2014
    ..These results demonstrate that TBK1 plays a critical role in mediating the effects of MVNP on osteoclast differentiation and on the expression of IL-6, a key contributor to the pagetic osteoclast phenotype...
  27. pmc Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells
    Adriana Forero
    Cancer Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 191:1476-85. 2013
    ..Taken together, these results suggest a dual role for IRF4 in regulating ISG induction and KSHV lytic reactivation in primary effusion lymphoma cells. ..
  28. pmc Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negative (knockout) mice
    Michael Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    In Vivo 27:419-30. 2013
    ..We determined whether absence of caspase-1 altered the stress response of hematopoietic and bone marrow stromal cells in vitro...
  29. pmc Metabolic alterations in mammary cancer prevention by withaferin A in a clinically relevant mouse model
    Eun Ryeong Hahm
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Natl Cancer Inst 105:1111-22. 2013
    ..Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model...
  30. pmc The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity
    S H Kook
    Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Cell Death Dis 4:e703. 2013
    ..These data indicate that P2Y14 is a receptor governing in utero tolerance to genotoxic stress that may be pharmacologically targeted to mitigate radiation toxicity in pregnancy. ..
  31. pmc Development of high-content assays for kidney progenitor cell expansion in transgenic zebrafish
    Subramaniam Sanker
    1Department of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, USA
    J Biomol Screen 18:1193-202. 2013
    ....
  32. pmc Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells
    L Chen
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cancer Gene Ther 20:469-77. 2013
    ..Tbet. When taken together, our data support a paradigm for extranodal (cross)priming of therapeutic Type-1 immunity in the TME after intratumoral delivery of mDC.Tbet-based gene therapy...
  33. pmc The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells
    Sungho Kook
    University of Pittsburgh Cancer Institute and Department of Medicine, Division of Hematology and Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 123:3420-35. 2013
    ..These findings provide direct evidence demonstrating a potential role for UDP-glucose in HSPC mobilization and may provide an attractive strategy to improve the yield of stem cells in poor-mobilizing allogeneic or autologous donors. ..
  34. pmc Disturbed sleep and inflammatory cytokines in depressed and nondepressed pregnant women: an exploratory analysis of pregnancy outcomes
    Michele L Okun
    Sleep Medicine Institute and Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Psychosom Med 75:670-81. 2013
    ....
  35. ncbi The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis
    Sergei Boichuk
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Cancer Res 73:5120-9. 2013
    ..Inhibition of this process enhances imatinib-induced apoptosis, which opens the opportunity for future therapeutic interventions to target the DREAM complex for more efficient imatinib responses...
  36. pmc Prevalence of endogenous CD34+ adipose stem cells predicts human fat graft retention in a xenograft model
    Brian J Philips
    Pittsburgh, Pa From the Departments of Plastic Surgery and Bioengineering, University of Pittsburgh the University of Pittsburgh Cancer Institute and the McGowan Institute for Regenerative Medicine
    Plast Reconstr Surg 132:845-58. 2013
    ..The authors' objective was to determine whether biological properties of adipose-derived stem cells present within human fat would correlate with in vivo outcomes of graft volume retention...
  37. pmc Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity
    Anbarasi Kothandapani
    Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, OH 43614, USA, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA and Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Nucleic Acids Res 41:7332-43. 2013
    ....
  38. pmc Dietary chemopreventative benzyl isothiocyanate inhibits breast cancer stem cells in vitro and in vivo
    Su Hyeong Kim
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Prev Res (Phila) 6:782-90. 2013
    ..Ron overexpression resulted in upregulation of bCSC-associated genes Oct-4, SOX-2, and Nanog. In conclusion, the present study indicates that BITC treatment eliminates bCSCs in vitro and in vivo...
  39. pmc 5α-reductase inhibition suppresses testosterone-induced initial regrowth of regressed xenograft prostate tumors in animal models
    Khalid Z Masoodi
    Department of Urology, Hillman Cancer Centre, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
    Endocrinology 154:2296-307. 2013
    ..These results suggest that short off-cycle coupled with 5α-reductase inhibition could maximize suppression of prostate tumor growth and, thus, improve potential survival benefit achieved in combination with IADT. ..
  40. pmc TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells
    Ryan M Stephenson
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer Immunol Immunother 62:1347-57. 2013
    ..We investigated the effects of activating toll-like receptor (TLR)-8 to enhance activity of cetuximab-stimulated, FcγR-bearing cells...
  41. pmc Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer
    Tian Ma
    Departments of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
    Mol Cancer Ther 12:1545-55. 2013
    ..Thus, combining murine and human HDACi trials is a strategy to translate preclinical HDACi treatment outcomes into the clinic. This study uncovered clinically tractable mechanisms to engage in future HDACi trials...
  42. pmc Pathologic and gene expression features of metastatic melanomas to the brain
    Ronald Hamilton
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Cancer 119:2737-46. 2013
    ..The prognosis of metastatic melanomas to the brain (MBM) is variable with prolonged survival in a subset. It is unclear whether MBM differ from extracranial metastases (EcM) and primary melanomas (PrM)...
  43. pmc Biomarker modulation following short-term vorinostat in women with newly diagnosed primary breast cancer
    Vered Stearns
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 19:4008-16. 2013
    ..We evaluated biomarker modulation in breast cancer tissues obtained from women with newly diagnosed invasive disease who received vorinostat and those who did not...
  44. pmc An extensive targeted proteomic analysis of disease-related protein biomarkers in urine from healthy donors
    Brian M Nolen
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e63368. 2013
    ....
  45. pmc Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models
    Sarah Elizabeth Wheeler
    Department of Otolaryngology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
    Head Neck 36:385-92. 2014
    ..Tumor-associated fibroblasts (TAFs) are the largest stromal cellular components of the tumor microenvironment in HNSCC...
  46. pmc Development of a robust cell-based high-throughput screening assay to identify targets of HIV-1 viral protein R dimerization
    Courtney Zych
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Des Devel Ther 7:403-12. 2013
    ..High content imaging was used to screen a library of small molecules for an effect on Vpr dimerization. Among the tested molecules, a few of the small molecules demonstrate an effect on Vpr dimerization in a dose-dependent manner...
  47. pmc Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose)
    Leizhen Wei
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, USA
    J Cell Sci 126:4414-23. 2013
    ..In summary, the dynamic damage response of XRCC1 is regulated in a manner that depends on modifications of polyADP-ribosylation, phosphorylation and ubiquitylation in live cells...
  48. pmc Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest
    Changyou Li
    Department of Medicine, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Cell Cycle 12:923-34. 2013
    ..Collectively, these findings establish that wild-type p53 encoded by HPV-positive HNSCC cells, once liberated from HPV E6, can play important roles in promoting apoptosis and cell cycle arrest...
  49. pmc Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration
    Eun Ryeong Hahm
    Department of Pharmacology and Chemical Biology, and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e44957. 2012
    ..These results indicate that Notch activation is largely dispensable for SFN-mediated inhibition of cell migration, which should be viewed as a therapeutic advantage as Notch activation is frequent in human prostate cancers...
  50. pmc Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair
    Joon Seok Cho
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA
    Stem Cells 31:511-25. 2013
    ..These data provide novel evidence that spontaneous, endogenous DNA damage, if not repaired, promotes progressive attrition of adult stem cells via both cell autonomous and nonautonomous mechanisms...
  51. ncbi Prevention of Barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor in a rat model of gastroesophageal reflux disease
    Michael K Gibson
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg 258:82-8. 2013
    ..We hypothesize that blockade of the Hh pathway with smoothened (Smo) inhibitor can prevent the development of BE/EAC in the Levrat model, in which induced gastroduodenoesophageal reflux (GDER) leads to esophageal carcinogenesis...
  52. pmc The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas
    Chitralekha Bhattacharya
    Department of Pathology, University of Pittsburgh, HCC 1, 46, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Mol Cancer 11:82. 2012
    ..In this report, we present data, which document that the DEAD-box helicase DDX11, which is required for sister chromatid cohesion, is a crucial gatekeeper for melanoma cell survival...
  53. pmc Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
    David C Whitcomb
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Nat Genet 44:1349-54. 2012
    ..These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07)...
  54. pmc Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis
    H A Tawbi
    Department of Medicine Division of Hematology Oncology, School of Medicine, University of Pittsburgh, Pittsburgh 15232, USA
    Ann Oncol 24:1112-9. 2013
    ....
  55. pmc Mesenchymal markers on human adipose stem/progenitor cells
    Ludovic Zimmerlin
    Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cytometry A 83:134-40. 2013
    ..5 ± 1.2)% CD90+]. These data imply a progenitor/progeny relationship between pericytes and SA-ASC, the most mesenchymal of SVF cells. Despite phenotypic and functional similarities to BM-MSC, SA-ASC are distinguished by CD34 expression...
  56. pmc Autophagy is required for IL-2-mediated fibroblast growth
    Rui Kang
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Exp Cell Res 319:556-65. 2013
    ..These findings suggest that autophagy is an important pro-survival regulator for IL-2-induced cell growth in fibroblasts...
  57. pmc CLT1 targets bladder cancer through integrin α5β1 and CLIC3
    Lynn M Knowles
    Department of Urology, University of Pittsburgh School of Medicine, Shadyside Medical Center, Suite G33, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
    Mol Cancer Res 11:194-203. 2013
    ..On the basis of its affinity for bladder tumor tissue and strong antitumor effects, we propose that CLT1 could be useful for targeting bladder cancer...
  58. pmc c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met
    Laura P Stabile
    Departments of Pharmacology and Chemical Biology and Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Cancer Res 19:380-92. 2013
    ..Co-activation of alternative kinases may contribute to erlotinib resistance...
  59. pmc Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice
    Anna Guastafierro
    Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Virol Methods 187:6-14. 2013
    ..Hence, MS-1 is an early passage cell line that provides a useful in vitro model to characterize MCV-positive MCC...
  60. pmc Flow cytometric determination of stem/progenitor content in epithelial tissues: an example from nonsmall lung cancer and normal lung
    Vera S Donnenberg
    Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Cytometry A 83:141-9. 2013
    ..The results of bivariate analysis show a striking similarity between the expression of stem/progenitor markers on lung tumor and adjacent tumor-free lung...
  61. pmc Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo
    Anuradha Sehrawat
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 2 32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Breast Cancer Res Treat 136:429-41. 2012
    ..These results indicate that ZER causes G(2)/M phase cell cycle arrest and Bax/Bak-mediated apoptosis in human breast cancer cells, and retards growth of MDA-MB-231 xenografts in vivo...
  62. pmc The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4
    Yan Zang
    Department of Medicine, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Autophagy 8:1873-4. 2012
    ..Carfilzomib- and oprozomib-induced autophagy acts to promote HNSCC cell survival. Our study indicates that the therapeutic benefit of these promising proteasome inhibitors may be improved by inhibiting MCL1 expression or autophagy...
  63. pmc The mouse lymph node as an ectopic transplantation site for multiple tissues
    Junji Komori
    McGowan Institute for Regenerative Medicine, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nat Biotechnol 30:976-83. 2012
    ..Collectively, these results suggest the practical approach of targeting lymph nodes to restore, maintain or improve tissue and organ functions...
  64. pmc A Phase I clinical trial of the combination of imatinib and paclitaxel in patients with advanced or metastatic solid tumors refractory to standard therapy
    Michael J Pishvaian
    Lombardi Comprehensive Cancer Center, Developmental Therapeutics Program, Washington, DC 20007, USA
    Cancer Chemother Pharmacol 70:843-53. 2012
    ..We conducted a Phase I study of imatinib in combination with paclitaxel in patients with advanced or metastatic solid tumors...
  65. pmc Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress
    Wei Qian
    Department of Pharmacology and Chemical Biology, Hillman Cancer Center Pittsburgh, PA 15213 USA
    J Cell Sci 125:5745-57. 2012
    ..Our findings provide a novel mechanism that contributes to the cellular dysfunction and diseases associated with altered mitochondrial dynamics...
  66. ncbi Myeloid-derived suppressor cells (MDSCs) in gliomas and glioma-development
    Gary Kohanbash
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    Immunol Invest 41:658-79. 2012
    ..The insight gained from these findings may lead to the development of novel immunotherapeutic strategies for gliomas...
  67. pmc Alkylation sensitivity screens reveal a conserved cross-species functionome
    David Svilar
    Departments of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Mol Cancer Res 10:1580-96. 2012
    ..Importantly, these studies provide potential new targets to overcome alkylating agent resistance...
  68. pmc Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neuropathol Exp Neurol 71:948-58. 2012
    ..These findings support the role of BRP-39 expression in limiting immune cell infiltration into the CNS and offer a new target to modulate neuroinflammation...
  69. pmc The role of Bcl-xL in synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia on human colon cancer
    Xinxin Song
    Department of Surgery, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Mol Cancer Res 10:1567-79. 2012
    ..In addition, the multimodality treatment significantly inhibited colorectal cancer xenografts' tumor growth. The successful outcome of this study will support the application of multimodality strategy to colorectal hepatic metastases...
  70. pmc Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines
    Robert A Parise
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cancer Chemother Pharmacol 71:73-83. 2013
    ..The information gained from these experiments will be instrumental in the evaluation of the pharmacology of BEN in ongoing human trials...
  71. pmc Longitudinal bone marrow evaluations for myelodysplasia in patients with myeloma before and after treatment with lenalidomide
    Sara A Monaghan
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Leuk Lymphoma 54:1965-74. 2013
    ..Thus, this study did not reveal rapidly emerging MDS in 39 of 40 patients with MM treated with LEN. The development of MDS in one patient suggests that longer follow-up is needed for all...
  72. pmc Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography
    William A LaFramboise
    University of Pittsburgh, Department of Pathology, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
    BMC Med 10:157. 2012
    ....
  73. pmc Crosstalk between immune cell and oncolytic vaccinia therapy enhances tumor trafficking and antitumor effects
    Padma Sampath
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Mol Ther 21:620-8. 2013
    ..The resulting multicomponent therapy displays the ability for synergistic crosstalk between components, so significantly enhancing tumor trafficking and antitumor effects...
  74. pmc Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
    Seog Young Kim
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cell Signal 25:961-9. 2013
    ..These results suggest that the IL-6-JAK1-STAT3 signal transduction pathway plays an important role in the conversion of non-CSCs into CSCs through regulation of OCT-4 gene expression...
  75. pmc Crosstalk between lysine-specific demethylase 1 (LSD1) and histone deacetylases mediates antineoplastic efficacy of HDAC inhibitors in human breast cancer cells
    Shauna N Vasilatos
    University of Pittsburgh Cancer Institute
    Carcinogenesis 34:1196-207. 2013
    ..Taken together, these results provide novel mechanistic insight into the breast cancer subtype-dependent role of LSD1 in mediating HDAC activity and therapeutic efficacy of HDAC inhibitor...
  76. pmc Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer
    Swati Suryawanshi
    Magee Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Cancer Res 19:1213-24. 2013
    ..We aimed to identify plasma miRNAs that can be used to differentiate patients with endometriosis and ovarian cancer from healthy individuals...
  77. pmc The immune signature of CD8(+)CCR7(+) T cells in the peripheral circulation associates with disease recurrence in patients with HNSCC
    Malgorzata Czystowska
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Cancer Res 19:889-99. 2013
    ..The functional and clinical significance of this imbalance was investigated using peripheral blood of patients with squamous cell carcinoma of the head and neck (HNSCC)...
  78. pmc SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells
    Michael S Leibowitz
    Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Cancer Res 19:798-808. 2013
    ..We investigated whether an overexpressed phosphatase was responsible for basal suppression of pSTAT1 and subsequent APM component-mediated immune escape in HNC cells...
  79. pmc LOH in the HLA class I region at 6p21 is associated with shorter survival in newly diagnosed adult glioblastoma
    Jacky T Yeung
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Cancer Res 19:1816-26. 2013
    ..In this study, we examined the prevalence of these LOH events and their relations with overall survival in GBM...
  80. ncbi Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia
    Ivana Gojo
    University of Maryland Marlene and Stewart Greenebaum Cancer Center UMGCC, Baltimore, MD 21201, USA
    Clin Cancer Res 19:1838-51. 2013
    ....
  81. pmc Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic
    Kumar Chandra-Kuntal
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, 2 32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Breast Cancer Res Treat 138:69-79. 2013
    ..The DATS-mediated induction of heme oxygenase-1 was partially attenuated by overexpression of Mn-SOD. These results provide novel mechanistic insights indicating a critical role for ROS in anticancer effects of DATS...
  82. pmc The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics
    R Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Oncogene 33:567-77. 2014
    ..Moreover, our observations provide a novel mechanism within the tumor microenvironment by which necrosis and inflammation promote tumor progression. ..
  83. pmc Expression of CCL19 from oncolytic vaccinia enhances immunotherapeutic potential while maintaining oncolytic activity
    Jun Li
    Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neoplasia 14:1115-21. 2012
    ..This approach therefore represents a means to increase the safety and therapeutic benefit of oncolytic viruses, used alone or in combination with immune cell therapies...
  84. pmc Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: results from a pilot, randomized, and controlled trial
    Jessica Citronberg
    Department of Epidemiology, Emory University, Atlanta, Georgia, USA
    Cancer Prev Res (Phila) 6:271-81. 2013
    ....
  85. pmc Statistical classification of multivariate flow cytometry data analyzed by manual gating: stem, progenitor, and epithelial marker expression in nonsmall cell lung cancer and normal lung
    Daniel P Normolle
    Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213, USA
    Cytometry A 83:150-60. 2013
    ..We anticipate that the methods described here will be broadly applicable to a variety of multidimensional cytometry problems...
  86. pmc Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiation
    Tuna Toptan
    Cancer Virology Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Virol 87:2744-55. 2013
    ..KSHV overcomes its limited genetic coding capacity by generating alternatively initiated protein isoforms that may have distinct biological functions...
  87. pmc Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs
    Luigi A Nasto
    Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mech Ageing Dev 134:35-42. 2013
    ..Local irradiation of the vertebra in Wt mice elicited a similar reduction in PG. These data demonstrate that genotoxic stress drives degenerative changes associated with IDD...
  88. pmc The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells
    Philip J Vernon
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    J Immunol 190:1372-9. 2013
    ..KCR mice also maintained a significantly less suppressive milieu evidenced by marked decreases in CCL22 in relation to CXCL10 and diminished serum levels of IL-6...
  89. pmc Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells
    Anuradha Sehrawat
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Carcinogenesis 34:864-73. 2013
    ..In conclusion, this study implicates FOXQ1 suppression in BITC-mediated inhibition of EMT in human breast cancer cells...
  90. pmc DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism
    Qian Chen
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Bone Miner Res 28:1214-28. 2013
    ..These results demonstrate that DNA damage drives osteoporosis through an NF-κB-dependent mechanism. Therefore, the NF-κB pathway represents a novel therapeutic target to treat aging-related bone disease...
  91. pmc Regulating cytokine function enhances safety and activity of genetic cancer therapies
    Hannah Chen
    Department of Surgery, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Mol Ther 21:167-74. 2013
    ..As a result of this exogenous regulation of cytokine function, both oncolytic and immune-mediated mechanisms of action were optimized, greatly enhancing therapeutic activity, while toxicity was significantly reduced...
  92. pmc KIT (CD117) expression in a subset of non-small cell lung carcinoma (NSCLC) patients
    Albert D Donnenberg
    Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e52885. 2012
    ..We conclude that NSCLC tumors divide into CD117(low) and CD117(high). Overexpression of CD117 in CD117(high) NSCLC supports exploring KIT as a therapeutic target in this subset of patients...
  93. pmc Antigen choice determines vaccine-induced generation of immunogenic versus tolerogenic dendritic cells that are marked by differential expression of pancreatic enzymes
    Adam M Farkas
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 190:3319-27. 2013
    ..Tg mice. Suppression of the enzymes was dependent on regulatory T cells and on signaling through the IL-10R and correlated with global downregulation of DC immunostimulatory phenotype and function...
  94. pmc Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice
    Laura E Pascal
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e79542. 2013
    ....
  95. pmc Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice
    Hebist Berhane
    a Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213
    Radiat Res 181:76-89. 2014
    ..The absence of the mouse Fancd2 gene product confers radiosensitivity to bone marrow stromal but not hematopoietic progenitor cells. ..
  96. pmc Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response
    Matthew J Sikora
    Authors Affiliations Women s Cancer Research Center Departments of Biomedical Informatics, Pharmacology and Chemical Biology, Biostatistics, Human Genetics, University of Pittsburgh Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania and Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
    Cancer Res 74:1463-74. 2014
    ..Targeting growth factors using FGFR1 inhibitors may block survival pathways required by ILC and reverse tamoxifen resistance...
  97. pmc Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam
    Ronny Kalash
    Professor and Chairman, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5150 Centre Avenue, Rm 533, Pittsburgh, PA 15232, U S A
    In Vivo 28:1-12. 2014
    ..We evaluated the radiobiological effects of stereotactic radiosurgery (SRS) photon beams on survival of C57BL/6NTac mice following total body irradiation...
  98. pmc Delineation of vagal emetic pathways: intragastric copper sulfate-induced emesis and viral tract tracing in musk shrews
    Charles C Horn
    Biobehavioral Medicine in Oncology Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
    Am J Physiol Regul Integr Comp Physiol 306:R341-51. 2014
    ..Furthermore, the current neural tracing data suggest brain stem anatomical circuits that are activated by GI signaling in the musk shrew. ..