Expanding Excellence in Developmental Biology in Oklahoma
Principal Investigator: Linda F Thompson
Abstract: DESCRIPTION (provided by applicant): This COBRE, Expanding Excellence in Developmental Biology in Oklahoma, will support five extremely talented, well-trained, newly-hired Junior Investigators working in diverse areas of Developmental Biology. Dr. Hui-Ying Lim comes to us from the Burnham Institute. She will investigate the regulation of cardiac development and function by reactive oxygen species in Drosophila. Dr. Lorin Olson arrived at OMRF after post-doctoral studies at Mt. Sinai. He will study the role of PDGF receptors in fibrosis using genetically engineered mice as model systems. Dr. Roberto Pezza trained at the NIH. He will investigate molecular mechanisms of DNA strand invasion during homologous recombination in meiosis using purified proteins, cell lines, and murine models. Dr. Chris Sansam came to OMRF recently from MIT. He will study mechanisms of DNA repair during mitosis, both during normal development and also after chemotherapy, using cell lines and zebrafish. Dr. Weidong Wang came from iPierian, a biotech company in California. He will develop methods to produce human pancreatic beta cells from induced pluripotent stem cells for treatment of patients with type 1 diabetes. Each Junior Investigator will be assigned two or three mentors, one of whom will be their Program Head. They will also receive feedback and mentoring from an outstanding External Advisory Committee comprised of Drs. Max Cooper (Chair), Nicholas Dysan, Eric Olson, and Patricia Hunt, The Junior Investigators will be supported by four Cores: an Administrative Core, a Bioinformatics and Pathways Core, a Flow Cytometry Core, and an Imaging Core. A monthly seminar series will be initiated to facilitate interactions among the Junior Investigators who are united by common scientific interests, experimental approaches, and bioinformatics challenges. The establishment of this COBRE will promote the careers of these young scientists, encourage multidisciplinary research in Developmental Biology, and build infrastructure that will benefit OMRF and the entire scientific enterprise of the state of Oklahoma.
Funding Period: 2013-03-01 - 2018-02-28
more information: NIH RePORT
- Genome instability and embryonic developmental defects in RMI1 deficient miceMichel F Guiraldelli
Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
DNA Repair (Amst) 12:835-43. 2013..Our results demonstrate the importance of RMI1 in maintaining genome integrity and normal embryonic development. ..
- The dual role of HOP2 in mammalian meiotic homologous recombinationRoberto J Pezza
Oklahoma Medical Research Foundation, Oklahoma City, 73104 OK, USA, Department of Cell Biology, Oklahoma University Health Science Center, Oklahoma City, 73126 OK, USA, Genetics and Biochemistry Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, 20892 MD, USA, Institute of Molecular Genetics of the Russian Academy of Sciences, 123182 Moscow, Russia, Biomedical Research Center, National Institute of Aging, Baltimore, 21224 MA, USA and Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, 19102 PA, USA
Nucleic Acids Res 42:2346-57. 2014..We propose that HOP2 may act as a recombinase with specific functions in meiosis. ..
- Epigenomic elements enriched in the promoters of autoimmunity susceptibility genesMikhail G Dozmorov
Oklahoma Medical Research Foundation Arthritis and Clinical Immunology Research Program Oklahoma City, OK USA
Epigenetics 9:276-85. 2014..Our analysis suggests common and disease-specific epigenomic elements that may define novel therapeutic targets for controlling aberrant activation of autoimmune susceptibility genes. ..
- Experimental validation of 5 in-silico predicted glioma biomarkersRheal A Towner
Corresponding author Rheal A Towner, PhD, Director, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 USA
Neuro Oncol 15:1625-34. 2013....
- Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairingWeixing Zhao
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Institute of Biochemical Sciences, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan, Cell Cycle and Cancer Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA, Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA and Ministry of Education Key Laboratory of Protein Science, Tsinghua Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
Nucleic Acids Res 42:906-17. 2014..A model of the Hop2-Mnd1-DMC1-ssDNA ensemble is proposed to explain how it mediates homologous DNA pairing in meiotic recombination. ..
- Couples, pairs, and clusters: mechanisms and implications of centromere associations in meiosisDavid Obeso
Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
Chromosoma 123:43-55. 2014..Recent work in yeast, Drosophila, and mice suggest that centromere pairing is a previously unappreciated, general meiotic feature that may promote meiotic segregation fidelity of the exchange and non-exchange chromosomes. ..
- Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndromeChristopher J Lessard
1 Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA 2 Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
Nat Genet 45:1284-92. 2013..These results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome...
- ROS regulate cardiac function via a distinct paracrine mechanismHui Ying Lim
Development, Aging and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA Free Radical Biology and Aging Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA Electronic address
Cell Rep 7:35-44. 2014..Our results provide evidence for a previously unrecognized role of ROS in mediating PC/CM interactions that significantly modulates heart function...
- Center for Neuroplasticity at the University of Puerto RicoSteven N Treistman; Fiscal Year: 2013..This UPR COBRE Center should define pathways and benchmarks for basic and translational research across the UPR system for the next decades. ..