Center For Aging

Summary

Principal Investigator: John Morris
Abstract: [unreadable] DESCRIPTION (provided by applicant): This proposal for an academic career leadership award for John C. Morris will establish the Center for Aging at Washington University. The Center will provide academic and administrative leadership to foster the development and implementation of activities that foster productive aging. Productive aging is closely allied with the concept of successful aging and broadly encompasses the goal of growing old with good health, vitality, and engagement. The University-wide Center will promote research, education, and service initiatives to enable older adults to remain healthy, active, independent, and contributing for as long as possible. The imperative for a Center for Aging is to meet the challenge of effectively integrating into society the growing and vigorous older adult segment of the population. Washington University is particularly well positioned to meet this challenge. There is a strong base of ongoing, high-quality research on aging, especially in three of the University's eight schools: Social Work, Arts and Sciences (Department of Psychology), and Medicine. The Center will enhance: ongoing research relevant to aging and enable new investigators to acquire research skills, mentoring, and experience; will generate new ideas and promote new lines of interdisciplinary and collaborative research, and it will serve as a local, regional, and national resource for aging research in general and productive aging in particular. The award will permit implementation and achievement of the inaugural specific aims of the Center: create a pilot project program to encourage innovative aging-related proposals by junior investigators and more senior investigators who are new to aging; attract junior faculty, postdoctoral fellows, and graduate and undergraduate students to the field of aging by means of awards for proposal development; and provide travel stipends to attend scientific conferences pertinent to aging, and other educational experiences. Dr. Morris is firmly committed to accomplishing these aims and, with this award and with outstanding institutional support, to establishing a preeminent Center for Aging at Washington University.
Funding Period: 2002-09-15 - 2008-07-31
more information: NIH RePORT

Top Publications

  1. ncbi Differences in vision between clinic and home and the effect of lighting in older adults with and without glaucoma
    Anjali M Bhorade
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
    JAMA Ophthalmol 131:1554-62. 2013
  2. pmc Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 20:1780-6. 2012
  3. pmc Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
    Curr Biol 21:835-40. 2011
  4. pmc In-Home Occupational Performance Evaluation (I-HOPE)
    Susan L Stark
    Program in Occupational Therapy, Washington University School of Medicine, Campus Box 8505, St Louis, MO 63108, USA
    Am J Occup Ther 64:580-9. 2010
  5. pmc Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 19:312-8. 2011
  6. pmc Client-centred home modifications improve daily activity performance of older adults
    Susan Stark
    Washington University School of Medicine, St Louis, MO 63108, USA
    Can J Occup Ther 76:235-45. 2009
  7. pmc Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease
    Laurent Seugnet
    Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 32:984-92. 2009
  8. pmc Identifying sleep regulatory genes using a Drosophila model of insomnia
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:7148-57. 2009
  9. pmc Motor-vehicle crash history and licensing outcomes for older drivers reported as medically impaired in Missouri
    Thomas M Meuser
    University of Missouri St Louis, Gerontology Program, School of Social Work, 133 134 Bellerive Hall, 1 University Blvd, St Louis, MO 63121, USA
    Accid Anal Prev 41:246-52. 2009
  10. pmc Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila melanogaster
    L Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 8:377-89. 2009

Scientific Experts

  • D T Villareal
  • Susan Stark
  • John Morris
  • Thomas M Meuser
  • Laurent Seugnet
  • Laura Gottschalk
  • Paul J Shaw
  • Yasuko Suzuki
  • Anjali M Bhorade
  • L Seugnet
  • Jamie Kambarian
  • Monica S Perlmutter
  • Melike Pekmezci
  • Brad Wilson
  • Sidney Chang
  • MAE GORDON
  • Gabriel Merlin
  • Stephen P Duntley
  • R Stidd
  • Sarah I Gimbel
  • Jeff Donlea
  • P J Shaw
  • Matthew Thimgan
  • Y Suzuki
  • James E Galvin
  • Steve P Duntley

Detail Information

Publications15

  1. ncbi Differences in vision between clinic and home and the effect of lighting in older adults with and without glaucoma
    Anjali M Bhorade
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
    JAMA Ophthalmol 131:1554-62. 2013
    ..Patients often report greater visual difficulties at home than expected from vision testing in the clinic. Such discordance may be owing to worse vision in the home than measured in clinic...
  2. pmc Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 20:1780-6. 2012
    ..Thus, the loss of muscle mass must be mediated predominately by adverse effects of dietary calorie restriction on muscle proteolysis...
  3. pmc Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
    Curr Biol 21:835-40. 2011
    ..These data highlight the emerging role of neuron-glia interactions in regulating both sleep and learning impairments associated with sleep loss...
  4. pmc In-Home Occupational Performance Evaluation (I-HOPE)
    Susan L Stark
    Program in Occupational Therapy, Washington University School of Medicine, Campus Box 8505, St Louis, MO 63108, USA
    Am J Occup Ther 64:580-9. 2010
    ..We describe the development and preliminary psychometric properties of an assessment to quantify the magnitude of an environmental barrier's influence on occupational performance...
  5. pmc Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 19:312-8. 2011
    ....
  6. pmc Client-centred home modifications improve daily activity performance of older adults
    Susan Stark
    Washington University School of Medicine, St Louis, MO 63108, USA
    Can J Occup Ther 76:235-45. 2009
    ..Remaining at home is a high priority for many older adults, but the capacity to "age in place" often is threatened by environmental barriers...
  7. pmc Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease
    Laurent Seugnet
    Washington University School of Medicine, St Louis, MO 63110, USA
    Sleep 32:984-92. 2009
    ..Thus we investigated the long-term consequences of sleep deprivation on shortterm memory using a Drosophila model of Parkinson disease...
  8. pmc Identifying sleep regulatory genes using a Drosophila model of insomnia
    Laurent Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:7148-57. 2009
    ..Together, these data indicate that the ins-l flies are a useful tool that can be used to identify molecules important for sleep regulation and may provide insights into both the causes and long-term consequences of insomnia...
  9. pmc Motor-vehicle crash history and licensing outcomes for older drivers reported as medically impaired in Missouri
    Thomas M Meuser
    University of Missouri St Louis, Gerontology Program, School of Social Work, 133 134 Bellerive Hall, 1 University Blvd, St Louis, MO 63121, USA
    Accid Anal Prev 41:246-52. 2009
    ..Of the 4,100 reported individuals, 144 (3.5%) retained a driver's license after the process...
  10. pmc Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila melanogaster
    L Seugnet
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Brain Behav 8:377-89. 2009
    ..These data indicate that APS is a simple and effective assay that can be used to evaluate fly models of human conditions associated with cognitive deficits...
  11. pmc Weight loss therapy improves pancreatic endocrine function in obese older adults
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 16:1349-54. 2008
    ..Obesity and aging increase the risk of type 2 diabetes (T2D). We evaluated whether weight loss therapy improves pancreatic endocrine function and insulin sensitivity in obese older adults...
  12. pmc Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, 4488 Forest Park Boulevard, St Louis, MO 63108, USA
    J Clin Endocrinol Metab 93:2181-7. 2008
    ..Although weight loss and exercise ameliorates frailty and improves cardiac risk factors in obese older adults, the long-term effect of lifestyle intervention on bone metabolism and mass is unknown...
  13. ncbi Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
    Dennis T Villareal
    Geriatrics and Nutritional Science and the Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Clin Nutr 84:1317-23. 2006
    ..Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown...
  14. ncbi Effect of weight loss and exercise on frailty in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Intern Med 166:860-6. 2006
    ..However, appropriate treatment for obese older persons is unknown. We evaluated the effects of weight loss and exercise therapy on physical function and body composition in obese older persons...
  15. ncbi Dementia update 2005
    John C Morris
    Department of Neurology and the Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Alzheimer Dis Assoc Disord 19:100-17. 2005