PIF4

Summary

Gene Symbol: PIF4
Description: phytochrome interacting factor 4
Alias: AtPIF4, MFL8.13, MFL8_13, SRL2, phytochrome interacting factor 4, phytochrome interacting factor 4
Species: thale cress
Products:     PIF4

Top Publications

  1. Soy J, Leivar P, González Schain N, Sentandreu M, Prat S, Quail P, et al. Phytochrome-imposed oscillations in PIF3 protein abundance regulate hypocotyl growth under diurnal light/dark conditions in Arabidopsis. Plant J. 2012;71:390-401 pubmed publisher
    ..that this behavior involves the action of the growth-promoting bHLH factors PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) and PHYTOCHROME-INTERACTING FACTOR 5 (PIF5) at the end of the night, through a coincidence mechanism that combines ..
  2. Lorrain S, Allen T, Duek P, Whitelam G, Fankhauser C. Phytochrome-mediated inhibition of shade avoidance involves degradation of growth-promoting bHLH transcription factors. Plant J. 2008;53:312-23 pubmed
    ..Here we show that PIF4 and PIF5 act early in the phytochrome signaling pathways to promote the shade-avoidance response...
  3. Casson S, Franklin K, Gray J, Grierson C, Whitelam G, Hetherington A. phytochrome B and PIF4 regulate stomatal development in response to light quantity. Curr Biol. 2009;19:229-34 pubmed publisher
    ..dominated by phytochrome B and also identify a role for the transcription factor, PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) [7]...
  4. Yamashino T, Matsushika A, Fujimori T, Sato S, Kato T, Tabata S, et al. A Link between circadian-controlled bHLH factors and the APRR1/TOC1 quintet in Arabidopsis thaliana. Plant Cell Physiol. 2003;44:619-29 pubmed
    ..The results of extensive analyses of such bHLH factors (namely, HFR1, PIL2, PIF4, PIL5 and PIL6) in wild-type and APRR1-overexressing (APRR1-ox) transgenic lines provided us with several new ..
  5. Nozue K, Harmer S, Maloof J. Genomic analysis of circadian clock-, light-, and growth-correlated genes reveals PHYTOCHROME-INTERACTING FACTOR5 as a modulator of auxin signaling in Arabidopsis. Plant Physiol. 2011;156:357-72 pubmed publisher
    ..We previously found that two basic loop-helix-loop transcription factors, PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and PIF5, integrate light and circadian clock signaling to generate rhythmic plant growth in Arabidopsis (..
  6. de Lucas M, Davière J, Rodríguez Falcón M, Pontin M, Iglesias Pedraz J, Lorrain S, et al. A molecular framework for light and gibberellin control of cell elongation. Nature. 2008;451:480-4 pubmed publisher
    ..report on the central role of the Arabidopsis thaliana nuclear transcription factor PIF4 (encoded by PHYTOCHROME INTERACTING FACTOR 4) in the positive control of genes mediating cell elongation and show that this factor is negatively ..
  7. Nomoto Y, Nomoto Y, Kubozono S, Miyachi M, Yamashino T, Nakamichi N, et al. A circadian clock- and PIF4-mediated double coincidence mechanism is implicated in the thermosensitive photoperiodic control of plant architectures in Arabidopsis thaliana. Plant Cell Physiol. 2012;53:1965-73 pubmed publisher
    ..The clock-controlled PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) encoding a basic helix-loop-helix (bHLH) transcription factor plays crucial roles in this regulation...
  8. Lorrain S, Trevisan M, Pradervand S, Fankhauser C. Phytochrome interacting factors 4 and 5 redundantly limit seedling de-etiolation in continuous far-red light. Plant J. 2009;60:449-61 pubmed publisher
    ..Here we investigated the involvement of PIF4 and PIF5 in phyA signaling, and found that they redundantly control de-etiolation in FR light...
  9. Oh E, Zhu J, Wang Z. Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses. Nat Cell Biol. 2012;14:802-9 pubmed publisher
    ..that direct interaction between the dark- and heat-activated transcription factor phytochrome-interacting factor 4 (PIF4) and the BR-activated transcription factor BZR1 integrates the hormonal and environmental signals...
  10. Kumar S, Lucyshyn D, Jaeger K, Alós E, Alvey E, Harberd N, et al. Transcription factor PIF4 controls the thermosensory activation of flowering. Nature. 2012;484:242-245 pubmed publisher
    ..mechanism by which increasing temperature causes the bHLH transcription factor PHYTOCHROME INTERACTING FACTOR4 (PIF4) to activate FT...

Detail Information

Publications59

  1. Soy J, Leivar P, González Schain N, Sentandreu M, Prat S, Quail P, et al. Phytochrome-imposed oscillations in PIF3 protein abundance regulate hypocotyl growth under diurnal light/dark conditions in Arabidopsis. Plant J. 2012;71:390-401 pubmed publisher
    ..that this behavior involves the action of the growth-promoting bHLH factors PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) and PHYTOCHROME-INTERACTING FACTOR 5 (PIF5) at the end of the night, through a coincidence mechanism that combines ..
  2. Lorrain S, Allen T, Duek P, Whitelam G, Fankhauser C. Phytochrome-mediated inhibition of shade avoidance involves degradation of growth-promoting bHLH transcription factors. Plant J. 2008;53:312-23 pubmed
    ..Here we show that PIF4 and PIF5 act early in the phytochrome signaling pathways to promote the shade-avoidance response...
  3. Casson S, Franklin K, Gray J, Grierson C, Whitelam G, Hetherington A. phytochrome B and PIF4 regulate stomatal development in response to light quantity. Curr Biol. 2009;19:229-34 pubmed publisher
    ..dominated by phytochrome B and also identify a role for the transcription factor, PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) [7]...
  4. Yamashino T, Matsushika A, Fujimori T, Sato S, Kato T, Tabata S, et al. A Link between circadian-controlled bHLH factors and the APRR1/TOC1 quintet in Arabidopsis thaliana. Plant Cell Physiol. 2003;44:619-29 pubmed
    ..The results of extensive analyses of such bHLH factors (namely, HFR1, PIL2, PIF4, PIL5 and PIL6) in wild-type and APRR1-overexressing (APRR1-ox) transgenic lines provided us with several new ..
  5. Nozue K, Harmer S, Maloof J. Genomic analysis of circadian clock-, light-, and growth-correlated genes reveals PHYTOCHROME-INTERACTING FACTOR5 as a modulator of auxin signaling in Arabidopsis. Plant Physiol. 2011;156:357-72 pubmed publisher
    ..We previously found that two basic loop-helix-loop transcription factors, PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and PIF5, integrate light and circadian clock signaling to generate rhythmic plant growth in Arabidopsis (..
  6. de Lucas M, Davière J, Rodríguez Falcón M, Pontin M, Iglesias Pedraz J, Lorrain S, et al. A molecular framework for light and gibberellin control of cell elongation. Nature. 2008;451:480-4 pubmed publisher
    ..report on the central role of the Arabidopsis thaliana nuclear transcription factor PIF4 (encoded by PHYTOCHROME INTERACTING FACTOR 4) in the positive control of genes mediating cell elongation and show that this factor is negatively ..
  7. Nomoto Y, Nomoto Y, Kubozono S, Miyachi M, Yamashino T, Nakamichi N, et al. A circadian clock- and PIF4-mediated double coincidence mechanism is implicated in the thermosensitive photoperiodic control of plant architectures in Arabidopsis thaliana. Plant Cell Physiol. 2012;53:1965-73 pubmed publisher
    ..The clock-controlled PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) encoding a basic helix-loop-helix (bHLH) transcription factor plays crucial roles in this regulation...
  8. Lorrain S, Trevisan M, Pradervand S, Fankhauser C. Phytochrome interacting factors 4 and 5 redundantly limit seedling de-etiolation in continuous far-red light. Plant J. 2009;60:449-61 pubmed publisher
    ..Here we investigated the involvement of PIF4 and PIF5 in phyA signaling, and found that they redundantly control de-etiolation in FR light...
  9. Oh E, Zhu J, Wang Z. Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses. Nat Cell Biol. 2012;14:802-9 pubmed publisher
    ..that direct interaction between the dark- and heat-activated transcription factor phytochrome-interacting factor 4 (PIF4) and the BR-activated transcription factor BZR1 integrates the hormonal and environmental signals...
  10. Kumar S, Lucyshyn D, Jaeger K, Alós E, Alvey E, Harberd N, et al. Transcription factor PIF4 controls the thermosensory activation of flowering. Nature. 2012;484:242-245 pubmed publisher
    ..mechanism by which increasing temperature causes the bHLH transcription factor PHYTOCHROME INTERACTING FACTOR4 (PIF4) to activate FT...
  11. Koini M, Alvey L, Allen T, Tilley C, Harberd N, Whitelam G, et al. High temperature-mediated adaptations in plant architecture require the bHLH transcription factor PIF4. Curr Biol. 2009;19:408-13 pubmed publisher
    ..temperature-induced architectural adaptations are mediated through the bHLH transcriptional regulator PHYTOCHROME INTERACTING FACTOR 4 (PIF4)...
  12. Brock M, Maloof J, Weinig C. Genes underlying quantitative variation in ecologically important traits: PIF4 (phytochrome interacting factor 4) is associated with variation in internode length, flowering time, and fruit set in Arabidopsis thaliana. Mol Ecol. 2010;19:1187-99 pubmed publisher
    ..analyses of local linkage disequilibrium (LD) to evaluate the potentially causal effects of molecular variation at PIF4 (PHYTOCROME INTERACTING FACTOR 4) on ecologically important traits in Arabidopsis thaliana...
  13. Leivar P, Monte E, Al Sady B, Carle C, Storer A, Alonso J, et al. The Arabidopsis phytochrome-interacting factor PIF7, together with PIF3 and PIF4, regulates responses to prolonged red light by modulating phyB levels. Plant Cell. 2008;20:337-52 pubmed publisher
    ..Examination of pif3, pif4, and pif7 double mutant combinations shows that their moderate hypersensitivity to extended red light is additive...
  14. Franklin K, Lee S, Patel D, Kumar S, Spartz A, Gu C, et al. Phytochrome-interacting factor 4 (PIF4) regulates auxin biosynthesis at high temperature. Proc Natl Acad Sci U S A. 2011;108:20231-5 pubmed publisher
    ..A basic helix-loop-helix transcription factor, PHYTOCHROME-INTERACTING FACTOR 4 (PIF4), is also required for hypocotyl elongation in response to high temperature...
  15. Hornitschek P, Kohnen M, Lorrain S, Rougemont J, Ljung K, Lopez Vidriero I, et al. Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling. Plant J. 2012;71:699-711 pubmed publisher
    ..of the SAS occurs in part with phyB, which controls protein abundance of phytochrome-interacting factors 4 and 5 (PIF4 and PIF5) directly...
  16. Huq E, Quail P. PIF4, a phytochrome-interacting bHLH factor, functions as a negative regulator of phytochrome B signaling in Arabidopsis. EMBO J. 2002;21:2441-50 pubmed
    ..Here, we report the identification of a new mutant Arabidopsis locus, srl2 (short under red-light 2), which confers selective hypersensitivity to continuous red, but not far-red, light...
  17. Huq E, Al Sady B, Hudson M, Kim C, Apel K, Quail P. Phytochrome-interacting factor 1 is a critical bHLH regulator of chlorophyll biosynthesis. Science. 2004;305:1937-41 pubmed
  18. Sakuraba Y, Jeong J, Kang M, Kim J, Paek N, Choi G. Phytochrome-interacting transcription factors PIF4 and PIF5 induce leaf senescence in Arabidopsis. Nat Commun. 2014;5:4636 pubmed publisher
    ..Here, we show that in Arabidopsis, dark-induced senescence requires phytochrome-interacting transcription factors PIF4 and PIF5 (PIF4/PIF5)...
  19. Sun J, Qi L, Li Y, Chu J, Li C. PIF4-mediated activation of YUCCA8 expression integrates temperature into the auxin pathway in regulating arabidopsis hypocotyl growth. PLoS Genet. 2012;8:e1002594 pubmed publisher
    ..It has been shown that the transcriptional regulator phytochrome-interacting factor 4 (PIF4) and the phytohormone auxin are involved in the regulation of high temperature-induced hypocotyl elongation in ..
  20. Kunihiro A, Yamashino T, Nakamichi N, Niwa Y, Nakanishi H, Mizuno T. Phytochrome-interacting factor 4 and 5 (PIF4 and PIF5) activate the homeobox ATHB2 and auxin-inducible IAA29 genes in the coincidence mechanism underlying photoperiodic control of plant growth of Arabidopsis thaliana. Plant Cell Physiol. 2011;52:1315-29 pubmed publisher
    ..In this mechanism, phytochromes (mainly phyB) and the PHYTOCHROME-INTERACTING FACTOR4 (PIF4) and PIF5, encoding phytochrome-interacting basic helix-loop-helix (bHLH) transcription factors, play crucial roles...
  21. Hornitschek P, Lorrain S, Zoete V, Michielin O, Fankhauser C. Inhibition of the shade avoidance response by formation of non-DNA binding bHLH heterodimers. EMBO J. 2009;28:3893-902 pubmed publisher
    ..The phytochrome-interacting factors 4 and 5 (PIF4 and PIF5) are stabilized in the shade and are required for a full SAS, whereas the related bHLH factor HFR1 (long ..
  22. Qiu Y, Li M, Pasoreck E, Long L, Shi Y, Galvão R, et al. HEMERA Couples the Proteolysis and Transcriptional Activity of PHYTOCHROME INTERACTING FACTORs in Arabidopsis Photomorphogenesis. Plant Cell. 2015;27:1409-27 pubmed publisher
  23. Huang M, Hu Y, Liu X, Li Y, Hou X. Arabidopsis LEAFY COTYLEDON1 Mediates Postembryonic Development via Interacting with PHYTOCHROME-INTERACTING FACTOR4. Plant Cell. 2015;27:3099-111 pubmed publisher
    ..Furthermore, we show that LEC1 interacts with PHYTOCHROME-INTERACTING FACTOR4 (PIF4), a major transcription modulator in postgermination development, to interdependently regulate hypocotyl elongation-..
  24. Nomoto Y, Nomoto Y, Kubozono S, Yamashino T, Nakamichi N, Mizuno T. Circadian clock- and PIF4-controlled plant growth: a coincidence mechanism directly integrates a hormone signaling network into the photoperiodic control of plant architectures in Arabidopsis thaliana. Plant Cell Physiol. 2012;53:1950-64 pubmed publisher
    ..This diurnal and photoperiodic control of plant growth is best explained by the accumulation of the PIF4 protein at the end of the night-time specifically under SDs, due to coincidence between the internal (circadian ..
  25. Ito S, Matsushika A, Yamada H, Sato S, Kato T, Tabata S, et al. Characterization of the APRR9 pseudo-response regulator belonging to the APRR1/TOC1 quintet in Arabidopsis thaliana. Plant Cell Physiol. 2003;44:1237-45 pubmed
    ..These results are discussed within the context of a current consistent model of the Arabidopsis circadian oscillator. ..
  26. Bernardo García S, de Lucas M, Martinez C, Espinosa Ruiz A, Davière J, Prat S. BR-dependent phosphorylation modulates PIF4 transcriptional activity and shapes diurnal hypocotyl growth. Genes Dev. 2014;28:1681-94 pubmed publisher
    ..Here we show that the light-regulated PIF4 (phytochrome-interacting factor 4) factor is a phosphorylation target of the BR signaling kinase BRASSINOSTEROID-..
  27. Pedmale U, Huang S, Zander M, Cole B, Hetzel J, Ljung K, et al. Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light. Cell. 2016;164:233-245 pubmed publisher
    ..diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5...
  28. Pacín M, Semmoloni M, Legris M, Finlayson S, Casal J. Convergence of CONSTITUTIVE PHOTOMORPHOGENESIS 1 and PHYTOCHROME INTERACTING FACTOR signalling during shade avoidance. New Phytol. 2016;211:967-79 pubmed publisher
    ..we analysed: the transcriptome and the auxin levels of cop1 and phytochrome interacting factor 1 (pif1) pif3 pif4 pif5 (pifq) mutants; the dynamics of ELONGATED HYPOCOTYL 5 (HY5) and LONG HYPOCOTYL IN FAR-RED (HFR1) proteins; and ..
  29. Khanna R, Huq E, Kikis E, Al Sady B, Lanzatella C, Quail P. A novel molecular recognition motif necessary for targeting photoactivated phytochrome signaling to specific basic helix-loop-helix transcription factors. Plant Cell. 2004;16:3033-44 pubmed
    ..Transgenic expression of the native APB-containing AtbHLH protein, PIF4, in a pif4 null mutant, rescued the photoresponse defect in this mutant, whereas mutated PIF4 constructs with site-..
  30. Kang X, Zhou Y, Sun X, Ni M. HYPERSENSITIVE TO RED AND BLUE 1 and its C-terminal regulatory function control FLOWERING LOCUS T expression. Plant J. 2007;52:937-48 pubmed
    ..displayed hyposensitive de-etiolation phenotypes, and the expression of these phenotypes requires the action of PIF4. The double mutant of hrb1/cry2 showed a flowering phenotype and an FT expression pattern similar to hrb1 under ..
  31. Geilen K, Böhmer M. Dynamic subnuclear relocalisation of WRKY40 in response to Abscisic acid in Arabidopsis thaliana. Sci Rep. 2015;5:13369 pubmed publisher
    ..Here we show that WRKY18 and WRKY40, but not WRKY60, co-localise with PIF3, PIF4 and PHYB to Phytochrome B-containing nuclear bodies (PNBs)...
  32. Song Y, Yang C, Gao S, Zhang W, Li L, Kuai B. Age-triggered and dark-induced leaf senescence require the bHLH transcription factors PIF3, 4, and 5. Mol Plant. 2014;7:1776-87 pubmed publisher
    ..Consistently, loss-of-function of PIF4 attenuated dark-induced transcriptional changes associated with chloroplast deterioration and reactive oxygen ..
  33. Wang L, Wu L, Greaves I, Zhu A, Dennis E, Peacock W. PIF4-controlled auxin pathway contributes to hybrid vigor in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2017;114:E3555-E3562 pubmed publisher
    ..of transcriptomes indicated that increased expression of the transcription factor PHYTOCHROME-INTERACTING FACTOR (PIF4) may contribute to hybrid vigor by targeting the auxin biosynthesis gene YUCCA8 and the auxin signaling gene ..
  34. Nieto C, López Salmerón V, Davière J, Prat S. ELF3-PIF4 interaction regulates plant growth independently of the Evening Complex. Curr Biol. 2015;25:187-193 pubmed publisher
    ..the control of Arabidopsis hypocotyl elongation by regulating rhythmic expression of the bHLH factors PHYTOCHROME INTERACTING FACTOR 4 and 5 (PIF4 and 5)...
  35. Choi H, Oh E. PIF4 Integrates Multiple Environmental and Hormonal Signals for Plant Growth Regulation in Arabidopsis. Mol Cells. 2016;39:587-93 pubmed publisher
    ..Recently, increasing evidence has shown that a bHLH transcription factor PIF4 plays a major role in the multiple signal integration for plant growth regulation...
  36. Hao Y, Oh E, Choi G, Liang Z, Wang Z. Interactions between HLH and bHLH factors modulate light-regulated plant development. Mol Plant. 2012;5:688-97 pubmed publisher
    ..Here, we show that light signal stabilizes PAR1 protein and PAR1 interacts with PIF4 and inhibits PIF4-mediated gene activation...
  37. Raschke A, Ibañez C, Ullrich K, Anwer M, Becker S, Glöckner A, et al. Natural variants of ELF3 affect thermomorphogenesis by transcriptionally modulating PIF4-dependent auxin response genes. BMC Plant Biol. 2015;15:197 pubmed publisher
    ..While PHYTOCHROME-INTERACTING FACTOR4 (PIF4) has been identified as a major ambient temperature signaling hub, its upstream regulation seems complex and is ..
  38. Bu Q, Castillon A, Chen F, Zhu L, Huq E. Dimerization and blue light regulation of PIF1 interacting bHLH proteins in Arabidopsis. Plant Mol Biol. 2011;77:501-11 pubmed publisher
    ..Taken together, these data suggest a combinatorial control of photomorphogenesis by bHLH proteins in response to light in Arabidopsis. ..
  39. Thines B, Youn Y, Duarte M, Harmon F. The time of day effects of warm temperature on flowering time involve PIF4 and PIF5. J Exp Bot. 2014;65:1141-51 pubmed publisher
    ..Flowering in each condition relied to varying degrees on the activity of CO , FT , PIF4 , and PIF5 , as well as the action of unknown genes...
  40. Kim K, Shin J, Lee S, Kweon H, Maloof J, Choi G. Phytochromes inhibit hypocotyl negative gravitropism by regulating the development of endodermal amyloplasts through phytochrome-interacting factors. Proc Natl Acad Sci U S A. 2011;108:1729-34 pubmed publisher
    ..inhibit hypocotyl negative gravitropism by inhibiting four phytochrome-interacting factors (PIF1, PIF3, PIF4, PIF5), as shown by hypocotyl agravitropism of dark-grown pif1 pif3 pif4 pif5 quadruple mutants...
  41. Sun J, Qi L, Li Y, Zhai Q, Li C. PIF4 and PIF5 transcription factors link blue light and auxin to regulate the phototropic response in Arabidopsis. Plant Cell. 2013;25:2102-14 pubmed publisher
    ..Here, we report that phytochrome interacting factoR4 (PIF4) and PIF5 act downstream of the BL sensor phototropin1 (PHOT1) to negatively modulate phototropism in Arabidopsis...
  42. Press M, Lanctot A, Queitsch C. PIF4 and ELF3 Act Independently in Arabidopsis thaliana Thermoresponsive Flowering. PLoS ONE. 2016;11:e0161791 pubmed publisher
    ..A particularly important stimulus is temperature. Previous work has identified the interplay of PIF4 and ELF3 as a central circuit underlying thermal responses in Arabidopsis thaliana...
  43. Ma D, Li X, Guo Y, Chu J, Fang S, Yan C, et al. Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light. Proc Natl Acad Sci U S A. 2016;113:224-9 pubmed publisher
    ..Furthermore, CRY1 interacts directly with PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) in a blue light-dependent manner to repress the transcription activity of PIF4...
  44. Soy J, Leivar P, Monte E. PIF1 promotes phytochrome-regulated growth under photoperiodic conditions in Arabidopsis together with PIF3, PIF4, and PIF5. J Exp Bot. 2014;65:2925-36 pubmed publisher
    ..evidence indicates that this behaviour involves the action of PHYTOCHROME-INTERACTING FACTOR 3 (PIF3) together with PIF4 and PIF5, through direct regulation of growth-related genes at dawn coinciding with a PIF3 accumulation peak ..
  45. Liu G, Gao S, Tian H, Wu W, Robert H, Ding Z. Local Transcriptional Control of YUCCA Regulates Auxin Promoted Root-Growth Inhibition in Response to Aluminium Stress in Arabidopsis. PLoS Genet. 2016;12:e1006360 pubmed publisher
    ..Furthermore, we demonstrated that PHYTOCHROME INTERACTING FACTOR4 (PIF4) functions as a transcriptional activator for YUC5/8/9...
  46. Dong J, Tang D, Gao Z, Yu R, Li K, He H, et al. Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark. Plant Cell. 2014;26:3630-45 pubmed publisher
  47. Jégu T, Veluchamy A, Ramirez Prado J, Rizzi Paillet C, Perez M, Lhomme A, et al. The Arabidopsis SWI/SNF protein BAF60 mediates seedling growth control by modulating DNA accessibility. Genome Biol. 2017;18:114 pubmed publisher
    ..genes, opposing in cis the promoting effect of the photomorphogenic and thermomorphogenic regulator Phytochrome Interacting Factor 4 (PIF4) on hypocotyl elongation...
  48. Lee H, Jung J, Cortés Llorca L, Kim S, Lee S, Baldwin I, et al. FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis. Nat Commun. 2014;5:5473 pubmed publisher
    ..In Arabidopsis, the basic helix-loop-helix transcription factor Phytochrome-Interacting Factor 4 (PIF4) regulates temperature-induced adaptive responses by modulating auxin biosynthesis...
  49. Gallego Bartolome J, Minguet E, Marín J, Prat S, Blázquez M, Alabadi D. Transcriptional diversification and functional conservation between DELLA proteins in Arabidopsis. Mol Biol Evol. 2010;27:1247-56 pubmed publisher
    ..Furthermore, both DELLA proteins display equivalent abilities to interact with PIF4 and with other bHLH transcription factors with a reported role in the control of cell growth and seed germination...
  50. Gangappa S, Kumar S. DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms. Cell Rep. 2017;18:344-351 pubmed publisher
    Plant growth and development are defined by environmental cues. The transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is the central signaling hub that integrates environmental cues, including light and temperature, to regulate ..
  51. Kang X, Ni M. Arabidopsis SHORT HYPOCOTYL UNDER BLUE1 contains SPX and EXS domains and acts in cryptochrome signaling. Plant Cell. 2006;18:921-34 pubmed
    ..Consistent with this, overexpression of SHB1 enhanced the expression of PHYTOCHROME-INTERACTING FACTOR4 (PIF4) under red light...
  52. Di D, Wu L, Zhang L, An C, Zhang T, Luo P, et al. Functional roles of Arabidopsis CKRC2/YUCCA8 gene and the involvement of PIF4 in the regulation of auxin biosynthesis by cytokinin. Sci Rep. 2016;6:36866 pubmed publisher
    ..transcription of both CKRC1/TAA and CKRC2/YUC8 can be induced by CK and that the phytochrome-interacting factor 4 (PIF4) is required for this upregulation...
  53. Yamashino T, Kitayama M, Mizuno T. Transcription of ST2A encoding a sulfotransferase family protein that is involved in jasmonic acid metabolism is controlled according to the circadian clock- and PIF4/PIF5-mediated external coincidence mechanism in Arabidopsis thaliana. Biosci Biotechnol Biochem. 2013;77:2454-60 pubmed
    ..In this regulation, phytochrome interacting transcriptional factors, PIF4 and PIF5, are activated at the end of night under short photoperiod or high temperature conditions, due to the ..
  54. Oh E, Zhu J, Bai M, Arenhart R, Sun Y, Wang Z. Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl. elife. 2014;3: pubmed publisher
    ..interactions demonstrate that the auxin-response factor ARF6, the light/temperature-regulated transcription factor PIF4, and the brassinosteroid-signaling transcription factor BZR1, interact with each other and cooperatively regulate ..
  55. Toledo Ortiz G, Huq E, Quail P. The Arabidopsis basic/helix-loop-helix transcription factor family. Plant Cell. 2003;15:1749-70 pubmed
    ..and in vitro binding assays that two related phytochrome-interacting members in the Arabidopsis family, PIF3 and PIF4, can form both homodimers and heterodimers and that all three dimeric configurations can bind specifically to the G-..
  56. Kim J, Lee H, Jung J, Lee S, Park C. HOS1 Facilitates the Phytochrome B-Mediated Inhibition of PIF4 Function during Hypocotyl Growth in Arabidopsis. Mol Plant. 2017;10:274-284 pubmed publisher
    ..ligase or affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTERACTING FACTOR 4 (PIF4), a key transcription factor that promotes hypocotyl growth...
  57. Liu Z, Zhang Y, Wang J, Li P, Zhao C, Chen Y, et al. Phytochrome-interacting factors PIF4 and PIF5 negatively regulate anthocyanin biosynthesis under red light in Arabidopsis seedlings. Plant Sci. 2015;238:64-72 pubmed publisher
    ..Red light effectively increased anthocyanin accumulation in wild-type Col-0, whereas the effects were enhanced in pif4 and pif5 mutants but impaired in overexpression lines PIF4OX and PIF5OX, indicating that PIF4 and PIF5 are both ..
  58. Kunihiro A, Yamashino T, Mizuno T. PHYTOCHROME-INTERACTING FACTORS PIF4 and PIF5 are implicated in the regulation of hypocotyl elongation in response to blue light in Arabidopsis thaliana. Biosci Biotechnol Biochem. 2010;74:2538-41 pubmed
    ..is regulated in response to light conditions through circadian clock-controlled PHYTOCHROME-INTERACTING FACTORs PIF4 and PIF5...
  59. Wei Z, Yuan T, Tarkowska D, Kim J, Nam H, Novak O, et al. Brassinosteroid Biosynthesis Is Modulated via a Transcription Factor Cascade of COG1, PIF4, and PIF5. Plant Physiol. 2017;174:1260-1273 pubmed publisher
    ..Two basic helix-loop-helix transcription factors, PIF4 and PIF5, were found to be transcriptionally up-regulated in cog1-3D Genetic analysis indicated ..