FY

Summary

Gene Symbol: FY
Description: Transducin/WD40 repeat-like superfamily protein
Alias: T6I14.10, T6I14_10, Transducin/WD40 repeat-like superfamily protein
Species: thale cress

Top Publications

  1. Simpson G, Dijkwel P, Quesada V, Henderson I, Dean C. FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition. Cell. 2003;113:777-87 pubmed
    ..FCA contains a WW protein interaction domain that is essential for FCA function. We have identified FY as a protein partner for this domain...
  2. Koornneef M, Hanhart C, van der Veen J. A genetic and physiological analysis of late flowering mutants in Arabidopsis thaliana. Mol Gen Genet. 1991;229:57-66 pubmed
    ..In wild type, vernalization promotes flowering to a small extent. For mutants at the loci fca, fve, fy and fpa, vernalization has a large effect both under LD and short day (SD) conditions, whereas co, gi, fd and fwa ..
  3. Henderson I, Liu F, Drea S, Simpson G, Dean C. An allelic series reveals essential roles for FY in plant development in addition to flowering-time control. Development. 2005;132:3597-607 pubmed publisher
    ..Within this pathway FCA is a plant-specific, nuclear RNA-binding protein, which interacts with FY, a highly conserved eukaryotic polyadenylation factor...
  4. Feng W, Jacob Y, Veley K, Ding L, Yu X, Choe G, et al. Hypomorphic alleles reveal FCA-independent roles for FY in the regulation of FLOWERING LOCUS C. Plant Physiol. 2011;155:1425-34 pubmed publisher
    ..Unexpectedly, we found that a hypomorphic allele of the autonomous pathway gene fy (fy null alleles are embryo lethal) displayed background-specific effects on FLC expression and flowering time; in a ..
  5. Manzano D, Marquardt S, Jones A, Bäurle I, Liu F, Dean C. Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. Proc Natl Acad Sci U S A. 2009;106:8772-7 pubmed publisher
    ..This mechanism needs FCA to interact with an RNA 3' processing/polyadenylation factor (FY/Pfs2p), but the subsequent events leading to chromatin changes are unknown...
  6. Zhao H, Xing D, Li Q. Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies. Plant Physiol. 2009;151:1546-56 pubmed publisher
    ..Interestingly, these two unique plant CPSF components have been associated with embryo development and flowering time controls, both of which involve plant-specific biological processes. ..
  7. Marquardt S, Boss P, Hadfield J, Dean C. Additional targets of the Arabidopsis autonomous pathway members, FCA and FY. J Exp Bot. 2006;57:3379-86 pubmed
    ..One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK...
  8. Herr A, Molnar A, Jones A, Baulcombe D. Defective RNA processing enhances RNA silencing and influences flowering of Arabidopsis. Proc Natl Acad Sci U S A. 2006;103:14994-5001 pubmed
    ..The last two proteins physically associated with the flowering time regulator FY in the 3' end formation complex AtCPSF...
  9. Xing D, Zhao H, Li Q. Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic development. Plant Physiol. 2008;148:2059-69 pubmed publisher
    ..These observations indicate that Arabidopsis CLPS3 might be involved in the processing of pre-mRNAs encoded by a distinct subset of genes that are important in plant development. ..
  10. Budhiraja R, Hermkes R, Muller S, Schmidt J, Colby T, Panigrahi K, et al. Substrates related to chromatin and to RNA-dependent processes are modified by Arabidopsis SUMO isoforms that differ in a conserved residue with influence on desumoylation. Plant Physiol. 2009;149:1529-40 pubmed publisher
    ..The majority of the identified bona fide substrates contain predicted sumoylation sites. A subset of the proteins was expressed in Escherichia coli and could be sumoylated in vitro. ..

Detail Information

Publications13

  1. Simpson G, Dijkwel P, Quesada V, Henderson I, Dean C. FY is an RNA 3' end-processing factor that interacts with FCA to control the Arabidopsis floral transition. Cell. 2003;113:777-87 pubmed
    ..FCA contains a WW protein interaction domain that is essential for FCA function. We have identified FY as a protein partner for this domain...
  2. Koornneef M, Hanhart C, van der Veen J. A genetic and physiological analysis of late flowering mutants in Arabidopsis thaliana. Mol Gen Genet. 1991;229:57-66 pubmed
    ..In wild type, vernalization promotes flowering to a small extent. For mutants at the loci fca, fve, fy and fpa, vernalization has a large effect both under LD and short day (SD) conditions, whereas co, gi, fd and fwa ..
  3. Henderson I, Liu F, Drea S, Simpson G, Dean C. An allelic series reveals essential roles for FY in plant development in addition to flowering-time control. Development. 2005;132:3597-607 pubmed publisher
    ..Within this pathway FCA is a plant-specific, nuclear RNA-binding protein, which interacts with FY, a highly conserved eukaryotic polyadenylation factor...
  4. Feng W, Jacob Y, Veley K, Ding L, Yu X, Choe G, et al. Hypomorphic alleles reveal FCA-independent roles for FY in the regulation of FLOWERING LOCUS C. Plant Physiol. 2011;155:1425-34 pubmed publisher
    ..Unexpectedly, we found that a hypomorphic allele of the autonomous pathway gene fy (fy null alleles are embryo lethal) displayed background-specific effects on FLC expression and flowering time; in a ..
  5. Manzano D, Marquardt S, Jones A, Bäurle I, Liu F, Dean C. Altered interactions within FY/AtCPSF complexes required for Arabidopsis FCA-mediated chromatin silencing. Proc Natl Acad Sci U S A. 2009;106:8772-7 pubmed publisher
    ..This mechanism needs FCA to interact with an RNA 3' processing/polyadenylation factor (FY/Pfs2p), but the subsequent events leading to chromatin changes are unknown...
  6. Zhao H, Xing D, Li Q. Unique features of plant cleavage and polyadenylation specificity factor revealed by proteomic studies. Plant Physiol. 2009;151:1546-56 pubmed publisher
    ..Interestingly, these two unique plant CPSF components have been associated with embryo development and flowering time controls, both of which involve plant-specific biological processes. ..
  7. Marquardt S, Boss P, Hadfield J, Dean C. Additional targets of the Arabidopsis autonomous pathway members, FCA and FY. J Exp Bot. 2006;57:3379-86 pubmed
    ..One of the many pathways that regulate FLC expression is the autonomous promotion pathway composed of FCA, FY, FLD, FPA, FVE, LD, and FLK...
  8. Herr A, Molnar A, Jones A, Baulcombe D. Defective RNA processing enhances RNA silencing and influences flowering of Arabidopsis. Proc Natl Acad Sci U S A. 2006;103:14994-5001 pubmed
    ..The last two proteins physically associated with the flowering time regulator FY in the 3' end formation complex AtCPSF...
  9. Xing D, Zhao H, Li Q. Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic development. Plant Physiol. 2008;148:2059-69 pubmed publisher
    ..These observations indicate that Arabidopsis CLPS3 might be involved in the processing of pre-mRNAs encoded by a distinct subset of genes that are important in plant development. ..
  10. Budhiraja R, Hermkes R, Muller S, Schmidt J, Colby T, Panigrahi K, et al. Substrates related to chromatin and to RNA-dependent processes are modified by Arabidopsis SUMO isoforms that differ in a conserved residue with influence on desumoylation. Plant Physiol. 2009;149:1529-40 pubmed publisher
    ..The majority of the identified bona fide substrates contain predicted sumoylation sites. A subset of the proteins was expressed in Escherichia coli and could be sumoylated in vitro. ..
  11. Xing D, Zhao H, Xu R, Li Q. Arabidopsis PCFS4, a homologue of yeast polyadenylation factor Pcf11p, regulates FCA alternative processing and promotes flowering time. Plant J. 2008;54:899-910 pubmed publisher
    ..Specifically, two autonomous factors in the Arabidopsis thaliana flowering time control pathway, FY and FCA, are required for the alternative polyadenylation of FCA pre-mRNA...
  12. Jang Y, Lee J, Kim J. Abscisic acid does not disrupt either the Arabidopsis FCA-FY interaction or its rice counterpart in vitro. Plant Cell Physiol. 2008;49:1898-901 pubmed publisher
    We examined the effect of (+)-ABA on the in vitro interaction of rice FCA and FY homologs, OsFCA and OsFY. From this analysis, we found no disruption of the OsFCA-OsFY complexes by ABA treatment...
  13. Jiang S, Kumar S, Eu Y, Jami S, Stasolla C, Hill R. The Arabidopsis mutant, fy-1, has an ABA-insensitive germination phenotype. J Exp Bot. 2012;63:2693-703 pubmed publisher
    Arabidopsis FY, a homologue of the yeast RNA 3' processing factor Pfs2p, regulates the autonomous floral transition pathway through its interaction with FCA, an RNA binding protein...