ppb1

Summary

Gene Symbol: ppb1
Description: calcium-dependent serine/threonine protein phosphatase calcineurin, catalytic subunit Ppb1
Species: Schizosaccharomyces pombe 972h-

Top Publications

  1. ncbi A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning
    T Yoshida
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    J Cell Sci 107:1725-35. 1994
  2. pmc pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast
    R Sugiura
    Department of Pharmacology, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650, Japan
    EMBO J 17:140-8. 1998
  3. ncbi The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch
    R Sugiura
    Department of Pharmacology, Kobe University School of Medicine, Japan
    Nature 399:479-83. 1999
  4. pmc Transient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeast
    Yan Ma
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 6:e22421. 2011
  5. pmc Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast
    Hirofumi Takada
    Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, 577 8502, Japan
    Mol Biol Cell 18:4794-802. 2007
  6. pmc Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast
    Yan Ma
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 17:5028-37. 2006
  7. pmc Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast
    Lu Deng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 17:4790-800. 2006
  8. ncbi Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast
    Sonoko Hirayama
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 278:18078-84. 2003
  9. ncbi Feedback regulation of MAPK signalling by an RNA-binding protein
    Reiko Sugiura
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nature 424:961-5. 2003
  10. pmc Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast
    Ayako Kita
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 15:2920-31. 2004

Scientific Experts

  • Yan Ma
  • J Ishiguro
  • Reiko Sugiura
  • Takayoshi Kuno
  • Ayako Kita
  • Yabin Lu
  • Hirofumi Takada
  • Susie O Sio
  • Xin Zhou
  • Hisato Shuntoh
  • Mari Higa
  • Eugenia Cisneros-Barroso
  • Jie Qiong Fan
  • Angela Cadou
  • Lu Deng
  • Yue Fang
  • Akira Doi
  • Kazunori Kume
  • Aiko Nishida
  • Shunji Ishiwata
  • Masaaki Fujita
  • Hong Cheng
  • Mai Takeuchi
  • Hideki Tohda
  • Yuko Giga-Hama
  • Sonoko Hirayama
  • Kaoru Takegawa
  • Kanako Hagihara
  • Rie Nagasoko
  • Ryosuke Satoh
  • Yuki Kitai
  • David Giménez-Zaragoza
  • Tula Yance-Chávez
  • Alba Gómez-Hierro
  • Ayako Kito
  • Rosa Aligue
  • James R Paulson
  • Anne Couturier
  • Wurentuya Jaiseng
  • Wugan Gerile
  • Bi Wei Feng
  • Linfeng Xie
  • Yao Yu
  • Cathy Le Goff
  • Xavier Le Goff
  • Yuki Yamada
  • Ji Feng Wang
  • Xiao Long Deng
  • Hong Lv
  • Dai Hirata
  • Takashi Toda
  • Muneyoshi Kanai
  • Takayuki Koyano
  • Takashi Masuko
  • Y Zhang
  • Mitsuhiro Kinoshita
  • Kazuaki Kakehi
  • Mitsuhiro Domae
  • Atsushi Uchida
  • Yuki Yamano
  • Yuta Asayama
  • Naoyuki Kai
  • Yoshiaki Mannse
  • Sayako Moriuchi
  • Masayuki Nishimura
  • Masahiro Suzuki
  • T Toda
  • Atsushi Koike
  • Shiori Iba
  • Tomonori Takami
  • Hidemine Ebina
  • Takafumi Suehiro
  • Hideyuki Mukai
  • Yi He
  • Motoyoshi Sakaue
  • Hiromi Shoji
  • Mistuhiro Yokoyama
  • Kenji Kawagishi
  • Takuya Maeda
  • Tomoko Yada
  • Linxiao Xu
  • Yujie Xia
  • M Yanagida
  • Rena Kawai
  • Wenlian Wu
  • T Itoh
  • T Maeda
  • M Asami
  • T Takenawa
  • T Kuno

Detail Information

Publications27

  1. ncbi A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning
    T Yoshida
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    J Cell Sci 107:1725-35. 1994
    A calcineurin (type 2B)-like protein phosphatase gene designated ppb1+ was isolated from the fission yeast Schizosaccharomyces pombe. The predicted amino acid sequence was 57% identical to rat PP2B alpha...
  2. pmc pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast
    R Sugiura
    Department of Pharmacology, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650, Japan
    EMBO J 17:140-8. 1998
    ..Here, we show that disruption of the calcineurin gene (ppb1(+)) in fission yeast results in a drastic chloride ion (Cl-)-sensitive growth defect and that a high copy number of ..
  3. ncbi The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch
    R Sugiura
    Department of Pharmacology, Kobe University School of Medicine, Japan
    Nature 399:479-83. 1999
    ..This switch-like mechanism could contribute to the all-or-none physiological response mediated by the MAPK signalling pathway...
  4. pmc Transient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeast
    Yan Ma
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 6:e22421. 2011
    ..These results suggest that Pmk1 MAPK and calcineurin positively and negatively regulate the Cch1-Yam8 complex, respectively, via modulating the balance between phosphorylation and dyphosphorylation state...
  5. pmc Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast
    Hirofumi Takada
    Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, 577 8502, Japan
    Mol Biol Cell 18:4794-802. 2007
    ..Together, our results suggest that PP2C is involved in a negative feedback loop of the Pmk1 signaling, and results also demonstrate that Atf1 is a key component of the cell integrity signaling downstream of Pmk1 MAPK...
  6. pmc Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast
    Yan Ma
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 17:5028-37. 2006
    ..Together, our results demonstrate that Cpp1 is a key component of the Pck2-Pmk1 signaling through the spatial control of the small GTPase Rho2...
  7. pmc Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast
    Lu Deng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 17:4790-800. 2006
    ....
  8. ncbi Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast
    Sonoko Hirayama
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 278:18078-84. 2003
    ..Our results suggest that calcineurin activates at least two distinct signaling branches, i.e. the Prz1-dependent transcriptional regulation and an unknown mechanism, which functions antagonistically with the Pmk1 MAPK pathway...
  9. ncbi Feedback regulation of MAPK signalling by an RNA-binding protein
    Reiko Sugiura
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nature 424:961-5. 2003
    ..Our findings--the post-transcriptional mRNA stabilization of a MAPK phosphatase mediated by an RNA-binding protein--provide an additional regulatory mechanism for fine-tuning of MAPK signalling pathways...
  10. pmc Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast
    Ayako Kita
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Mol Biol Cell 15:2920-31. 2004
    ....
  11. ncbi The role of the regulatory subunit of fission yeast calcineurin for in vivo activity and its relevance to FK506 sensitivity
    Susie O Sio
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Graduate School of Medicine, Kobe University, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 280:12231-8. 2005
    ..The fission yeast genome encodes a single set of catalytic (Ppb1) and regulatory (Cnb1) subunits, providing an ideal model system to study the functions of these subunits in vivo...
  12. doi Spatial control of calcineurin in response to heat shock in fission yeast
    Mari Higa
    Laboratory of Molecular Pharmacogenomics, School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashi Osaka, Osaka, 577 8502, Japan
    Genes Cells 20:95-107. 2015
    In fission yeast, Ppb1, the Ca2+/calmodulin-dependent protein phosphatase calcineurin regulates multiple biological processes, such as cytokinesis, Ca2+-homeostasis, membrane trafficking and cell wall integrity...
  13. pmc Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast
    Eugenia Cisneros-Barroso
    Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Institute of Biomedical Research August Pi i Sunyer IDIBAPS, Barcelona 08036, Catalunya, Spain
    Nucleic Acids Res 42:9573-87. 2014
    ..These results are the first insights into Cmk1 and Ckk2 function in Schizosaccharomyces pombe. ..
  14. ncbi [Cnb1 involved in cytokinesis in Schizosaccharomyces pombe]
    Jie Qiong Fan
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China E mail
    Yi Chuan 35:1030-9. 2013
    ..In Schizosaccharomyces pombe, CN exists as a heterodimer composed by catalytic subunit Ppb1 and regulatory subunit Cnb1...
  15. doi Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress
    Junpei Ishiguro
    Department of Biology, Faculty of Science and Engineering, Konan University, Okamoto 8 9 1, Kobe 658 8501, Japan
    Mol Genet Genomics 288:63-75. 2013
    ..This finding may shed light on our understanding of a new stress-responsive mechanism in TOR signaling in higher organisms...
  16. doi The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast
    Angela Cadou
    CNRS UMR6290 Institut de Génétique et Développement de Rennes, France
    Biol Cell 105:129-48. 2013
    ..The Kin1 protein kinase of fission yeast, which regulates cell surface cohesiveness during interphase cell growth, is also present at the cell division site during mitosis; however, its function in cell division has remained elusive...
  17. pmc A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe
    Xin Zhou
    Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, China
    PLoS ONE 8:e65904. 2013
    ..Altogether, our findings provide useful information for new potential drug combinations in the treatment of fungal infections...
  18. ncbi Calcineurin is implicated in the regulation of the septation initiation network in fission yeast
    Yabin Lu
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Genes Cells 7:1009-19. 2002
    ..In fission yeast, calcineurin has been implicated in cytokinesis because calcineurin-deleted cells form multiple septa and cell separation is impeded. However, this mechanism remains unclear...
  19. pmc Genetic evidence for phospholipid-mediated regulation of the Rab GDP-dissociation inhibitor in fission yeast
    Yan Ma
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Hyogo, Japan
    Genetics 174:1259-71. 2006
    ..Together, our findings suggest that Spo20 modulates Gdi1 function via regulation of phospholipid metabolism of the membranes...
  20. pmc Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway and its connection to calcineurin function
    Hong Cheng
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, Japan
    Mol Biol Cell 13:2963-76. 2002
    ..These results suggest that Ypt3 is required at multiple steps of the exocytic pathway and its mutation affects diverse cellular processes and that calcineurin is functionally connected to these cellular processes...
  21. pmc Genetic interaction between calcineurin and type 2 myosin and their involvement in the regulation of cytokinesis and chloride ion homeostasis in fission yeast
    Masaaki Fujita
    Division of Molecular Pharmacology and Pharmacogenomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Genetics 161:971-81. 2002
    ..These results indicate that calcineurin is involved in the regulation of cytokinesis and that chloride ion homeostasis is mediated by type 2 myosin...
  22. pmc The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast
    Hirofumi Takada
    Laboratory of Molecular Pharmacogenomics, Laboratory of Molecular and Cellular Biology, and Laboratory of Bioinformatics, School of Pharmaceutical Sciences, Kinki University, Higashi Osaka, 577 8502, Japan
    Mol Biol Cell 21:674-85. 2010
    ..Our results suggest that Ecm33 is involved in the negative feedback regulation of Pmk1 cell integrity signaling and is linked to cellular Ca(2+) signaling...
  23. doi Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth
    Kazunori Kume
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8530, Japan
    Nat Cell Biol 13:234-42. 2011
    ..Importantly, NETO delay requires activation of calcineurin, which is carried out by Cds1, resulting in Tip1 dephosphorylation. Thus, our study establishes a critical link between calcineurin and checkpoint-dependent cell morphogenesis...
  24. ncbi Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast
    Y Zhang
    Department of Pharmacology, Kobe University School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 275:35600-6. 2000
    The ppb1(+) gene encodes a fission yeast homologue of the mammalian calcineurin. We have recently shown that Ppb1 is essential for chloride ion homeostasis, and acts antagonistically with Pmk1 mitogen-activated protein kinase pathway...
  25. ncbi The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway
    T Toda
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, London, UK
    J Cell Sci 109:2331-42. 1996
    ....
  26. ncbi Protein phosphatases in cell division: how vital are they?
    M Yanagida
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Princess Takamatsu Symp 22:137-44. 1991
    ..The ppx1+ product is an intermediate of type 1 and 2A, while the ppb1+ product is similar to Ca(2+)-dependent type 2B...
  27. pmc Selected list of books and journals for the small medical library
    A N Brandon
    Bull Med Libr Assoc 63:149-72. 1975
    ..The cost of only the asterisked items recommended for first purchase totals approximately $4,100...