Tfam

Summary

Gene Symbol: Tfam
Description: transcription factor A, mitochondrial
Alias: Mttfa, transcription factor A, mitochondrial
Species: rat

Top Publications

  1. ncbi Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
    N G Larsson
    Department of Molecular Medicine, Center for Molecular Medicine L8 02, Stockholm, Sweden
    Nat Genet 18:231-6. 1998
  2. ncbi Acetylation and level of mitochondrial transcription factor A in several organs of young and old rats
    Maria M Dinardo
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Bari, Via Orabona 4, Bari 70125, Italy
    Biochem Biophys Res Commun 301:187-91. 2003
  3. pmc Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle
    Liam D Tryon
    Muscle Health Research Centre, York University, Toronto, Ontario, Canada and School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Am J Physiol Cell Physiol 309:C228-38. 2015
  4. pmc AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle
    Brennan K Smith
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
    J Physiol 591:1551-61. 2013
  5. pmc Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver
    Anna Picca
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, United States of America
    PLoS ONE 8:e74644. 2013
  6. pmc A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat
    Anna Picca
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, 2004 Mowry Rd, Gainesville, FL 32611, USA
    Biochim Biophys Acta 1840:2184-91. 2014
  7. pmc Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy
    Julia M Santos
    Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Diabetes Metab Res Rev 29:204-13. 2013
  8. pmc Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock
    Wayne W Chaung
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Int J Mol Med 30:199-203. 2012
  9. pmc PARK2 variability in Polish Parkinson's disease patients--interaction with mitochondrial haplogroups
    Katarzyna Gaweda-Walerych
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    Parkinsonism Relat Disord 18:520-4. 2012
  10. doi Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    J Neurosci Res 90:1200-8. 2012

Research Grants

  1. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
  2. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010

Scientific Experts

  • Larissa Arning
  • Andrea Carmine Belin
  • Kartik Shankar
  • Yoshihiko Nishio
  • H Inagaki
  • CLAUDE PIANTADOSI
  • A H V Remels
  • Monika Pietrowska
  • Benoit R Gauthier
  • Ashu Johri
  • N G Larsson
  • Anna Picca
  • Julia M Santos
  • Katarzyna Gaweda-Walerych
  • Flavio Fracasso
  • Liam D Tryon
  • Anna Maria Joseph
  • Vito Pesce
  • Christiaan Leeuwenburgh
  • Brennan K Smith
  • Wayne W Chaung
  • Q Zhang
  • Renu A Kowluru
  • Nobutoshi Morimoto
  • Maria Barcikowska
  • Krzysztof Safranow
  • Cezary Zekanowski
  • Yi Zhong
  • Gaurav Patki
  • Atai Watanabe
  • Aleksandra Maruszak
  • Y Han
  • Elahe Taherzadeh-Fard
  • Rajnish K Chaturvedi
  • Jorge Suarez
  • Wei Yin
  • Katarina Fredriksson
  • Victoria Alvarez
  • Dongchon Kang
  • Maria Pilar Alcolea
  • Tomonori Yoshida
  • Martina Gaspari
  • Yoichiro Yoshida
  • Maria M Dinardo
  • Matthew J Crilly
  • Gemma Gadaleta
  • David A Hood
  • Angela Maria Serena Lezza
  • Xiaocheng Dong
  • Maria Mezzina
  • Yon Sik Choi
  • Akio Kanazawa
  • Graham P Holloway
  • Angela M S Lezza
  • George J F Heigenhauser
  • Lawrence L Spriet
  • James S Lally
  • Brendon J Gurd
  • Kazutaka Mukai
  • Amy C Maher
  • Tohru Matsuura
  • Monika Bialecka
  • Krzysztof Czyzewski
  • Tomoko Kurata
  • Y Hu
  • Marek Drozdzik
  • Jaroslaw Slawek
  • Ping Wang
  • Monika Rudzinska
  • Owen A Ross
  • Y Wu
  • Tomomi Ide
  • Stephanie A Cobb
  • Youxin Ji
  • P Zhang
  • Kazunori Miyazaki
  • A Rantanen
  • J Zhu
  • Weifeng Dong
  • Rongqian Wu
  • Kenya Nishioka
  • Barbara Jasinska-Myga
  • Yoshio Ikeda
  • J Jia
  • Grzegorz Opala
  • Maria Styczynska
  • H Sha
  • Zbigniew K Wszolek
  • Gabriela Klodowska-Duda
  • Koji Abe

Detail Information

Publications41

  1. ncbi Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
    N G Larsson
    Department of Molecular Medicine, Center for Molecular Medicine L8 02, Stockholm, Sweden
    Nat Genet 18:231-6. 1998
    ..We have disrupted the mouse gene for mitochondrial transcription factor A (Tfam; formerly known as m-mtTFA) by gene targetting of loxP-sites followed by cre-mediated excision in vivo...
  2. ncbi Acetylation and level of mitochondrial transcription factor A in several organs of young and old rats
    Maria M Dinardo
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Bari, Via Orabona 4, Bari 70125, Italy
    Biochem Biophys Res Commun 301:187-91. 2003
    To gain further information on the role of mitochondrial transcription factor A (TFAM) in mitochondrial biogenesis, we studied the post-translational modifications of the protein in 6- and 28-month-old rat liver...
  3. pmc Effect of denervation on the regulation of mitochondrial transcription factor A expression in skeletal muscle
    Liam D Tryon
    Muscle Health Research Centre, York University, Toronto, Ontario, Canada and School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Am J Physiol Cell Physiol 309:C228-38. 2015
    The purpose of this study was to determine how the expression of mitochondrial transcription factor A (Tfam), a protein that governs mitochondrial DNA (mtDNA) transcription and replication, is regulated during a state of reduced organelle ..
  4. pmc AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle
    Brennan K Smith
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
    J Physiol 591:1551-61. 2013
    ..peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and mitochondrial transcription factor A (Tfam) have been implicated in the direct regulation of the mitochondrial genome in mice, although SS and IMF differences ..
  5. pmc Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver
    Anna Picca
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, United States of America
    PLoS ONE 8:e74644. 2013
    ..we found an age-related decrease in mitochondrial DNA (mtDNA) content and mitochondrial transcription factor A (TFAM) amount, fully prevented by CR...
  6. pmc A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat
    Anna Picca
    Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, 2004 Mowry Rd, Gainesville, FL 32611, USA
    Biochim Biophys Acta 1840:2184-91. 2014
    Mitochondrial Transcription Factor A (TFAM) is regarded as a histone-like protein of mitochondrial DNA (mtDNA), performing multiple functions for this genome...
  7. pmc Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy
    Julia M Santos
    Kresge Eye Institute, Wayne State University, Detroit, MI 48201, USA
    Diabetes Metab Res Rev 29:204-13. 2013
    ..In the transcription and replication of mtDNA, nuclear-encoded mitochondrial transcription factor A (TFAM) is considered a key activator...
  8. pmc Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock
    Wayne W Chaung
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Int J Mol Med 30:199-203. 2012
    ..Mitochondrial transcription factor A (TFAM) is a transcription factor for mitochondrial DNA...
  9. pmc PARK2 variability in Polish Parkinson's disease patients--interaction with mitochondrial haplogroups
    Katarzyna Gaweda-Walerych
    Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    Parkinsonism Relat Disord 18:520-4. 2012
    ..Parkin complexed with mitochondrial transcription factor A (TFAM) binds mtDNA and promotes mitochondrial biogenesis, which is abolished by PARK2 gene mutations...
  10. doi Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    J Neurosci Res 90:1200-8. 2012
    ..susceptible to oxidative damage and has little potential for repair, although mitochondrial transcription factor A (TFAM) plays essential roles in maintaining mitochondrial DNA by reducing oxidative stress, promoting mtDNA transcription,..
  11. doi Exercise induces mitochondrial biogenesis after brain ischemia in rats
    Q Zhang
    Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China
    Neuroscience 205:10-7. 2012
    ..7 days of training, the levels of mtDNA, nuclear respiratory factor 1, NRF-1, mitochondrial transcription factor A, TFAM, and the mitochondrial protein cytochrome C oxidase subunit IV (COXIV) and heat shock protein-60 (HSP60) also ..
  12. pmc Impact of exercise on mitochondrial transcription factor expression and damage in the striatum of a chronic mouse model of Parkinson's disease
    Gaurav Patki
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204, USA
    Neurosci Lett 505:268-72. 2011
    ....
  13. pmc Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid
    Julia M Santos
    Kresge Eye Institute, Wayne State University, Detroit, Michigan 48201, USA
    Invest Ophthalmol Vis Sci 52:8791-8. 2011
    ..This study is to investigate the role of mitochondria biogenesis (regulated by nuclear mitochondrial signaling) in the metabolic memory phenomenon...
  14. pmc Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst
    Kartik Shankar
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 152:4158-70. 2011
    ..proinflammatory genes (CCL4 and CCL5) increased and expression of antioxidant (GPx3) and mitochondrial (TFAM and NRF1) genes decreased in the obese embryos...
  15. doi Impaired mitochondrial biogenesis in hippocampi of rats with chronic seizures
    Y Han
    Department of Neurology, Qilu Hospital, Shandong University, Jinan 250012, China
    Neuroscience 194:234-40. 2011
    ..receptor gamma coactivator-1α, nuclear respiratory factor-1, and mitochondrial transcription factor A (Tfam), but depended on reduced Tfam-DNA binding activity...
  16. doi The impact of mitochondrial and nuclear DNA variants on late-onset Alzheimer's disease risk
    Aleksandra Maruszak
    Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland
    J Alzheimers Dis 27:197-210. 2011
    ..haplogroups, and polymorphisms in nuclear genes essential for mitochondrial biogenesis and function (PGC-1α TFAM) to late-onset Alzheimer's disease (LOAD) risk...
  17. pmc PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease
    Elahe Taherzadeh-Fard
    Department of Human Genetics, Ruhr University Bochum, Germany
    Mol Neurodegener 6:32. 2011
    ..In this study, we hypothesised that polymorphisms in PGC-1alpha downstream targets might also contribute to the variation in the AO...
  18. pmc Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:3190-205. 2010
    ..In the striatum of the HD mice, the baseline levels of PGC-1alpha, NRF1, NRF2, Tfam, COX-II, PPARdelta, CREB and ERRalpha mRNA and mitochondrial DNA (mtDNA), were significantly reduced...
  19. pmc Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure
    Katarina Fredriksson
    Department of Anesthesiology and Intensive Care, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 3:e3686. 2008
    ..Here we use detailed phenotyping and genomics to elucidate mechanisms leading to these impairments and the molecular consequences...
  20. doi Mitochondrial transcription factor A (TFAM) gene variation in Parkinson's disease
    Victoria Alvarez
    Genetica Molecular, Hospital Central de Asturias Maternidad, 33006 Oviedo, Spain
    Neurosci Lett 432:79-82. 2008
    ..The mitochondrial transcription factor A (TFAM) controls the transcription of mtDNA and regulates the mtDNA-copy number, thus being important for maintaining ATP ..
  21. pmc Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury
    Wei Yin
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Stroke 39:3057-63. 2008
    ..In this study, we report for the first time rapidly increased mitochondrial biogenesis in a rat model of neonatal hypoxic/ischemic brain injury (H-I)...
  22. ncbi Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease
    Andrea Carmine Belin
    Department of Neuroscience, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden
    Neurosci Lett 420:257-62. 2007
    ..Mitochondrial transcription factor A (TFAM) is needed for mtDNA maintenance, regulating mtDNA copy number and is absolutely required for transcriptional ..
  23. pmc Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy
    H Li
    Department of Molecular Medicine, CMM L8 02, Karolinska Hospital, S 17176 Stockholm, Sweden
    Proc Natl Acad Sci U S A 97:3467-72. 2000
    ..The gene for mouse mitochondrial transcription factor A, Tfam (also called mtTFA), a nucleus-encoded key regulator of mtDNA expression, was targeted with loxP sites (Tfam(loxP)) and disrupted in ..
  24. ncbi Isolation of rat mitochondrial transcription factor A (r-Tfam) cDNA
    H Inagaki
    Department of Chemistry, National Industrial Research Institute of Nagoya, Japan
    DNA Seq 11:131-5. 2000
    We have isolated rat mitochondrial transcription factor A (Tfam; formerly known as mtTFA) cDNA clones from a rat cerebellum cDNA library using human Tfam cDNA as a probe...
  25. ncbi Downregulation of Tfam and mtDNA copy number during mammalian spermatogenesis
    A Rantanen
    Department of Medical Nutrition, Karolinska Institutet, Novum, Huddinge Hospital, S 14186 Huddinge, 76 Stockholm, Sweden
    Mamm Genome 12:787-92. 2001
    Mitochondrial transcription factor A (Tfam) is required for mtDNA maintenance, and mitochondrial Tfam protein levels directly affect mtDNA copy number...
  26. ncbi Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart
    Akio Kanazawa
    Department of Biochemistry, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Am J Physiol Endocrinol Metab 282:E778-85. 2002
    To evaluate abnormalities in the mitochondrial transcription factor A (mtTFA) function as a cause of mitochondrial dysfunction in diabetes, we measured the mRNA contents of the proteins consisting of the mitochondrial respiratory chain ..
  27. ncbi Characterization of the mtTFA gene and identification of a processed pseudogene in rat
    Maria Mezzina
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Bari, Via Orabona 4, 70125 Bari, Italy
    Gene 286:105-12. 2002
    ..Among these there is the mitochondrial transcription factor A (mtTFA or Tfam)...
  28. ncbi Characterization of the 5'-flanking region of the rat gene for mitochondrial transcription factor A (Tfam)
    Yon Sik Choi
    Division of Metabolic Disease Research, Department of Biomedical Sciences, National Institute of Health, 122 701, Seoul, South Korea
    Biochim Biophys Acta 1574:200-4. 2002
    Mitochondrial transcription factor A (Tfam) is essential for the initiation of transcription and the replication of mitochondrial DNA (mtDNA)...
  29. pmc Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma
    Xiaocheng Dong
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 277:43309-18. 2002
    ..The mRNA levels for the hepatoma cytochrome c oxidase I, II, and NADH dehydrogenase 5, 6, the downstream targets of Tfam, were augmented 10-, 8-, 5-, and 3-fold, respectively. Interestingly, Tfam was also found in the hepatoma nucleus...
  30. ncbi P53 physically interacts with mitochondrial transcription factor A and differentially regulates binding to damaged DNA
    Yoichiro Yoshida
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu Fukuoka 807 8555, Japan
    Cancer Res 63:3729-34. 2003
    Mitochondrial transcription factor A (mtTFA; also designated Tfam) is necessary for both transcription and maintenance of mitochondrial DNA. mtTFA preferentially recognizes cisplatin-damaged DNA, as well as oxidized DNA...
  31. ncbi Regulation and role of the mitochondrial transcription factor in the diabetic rat heart
    Yoshihiko Nishio
    Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    Ann N Y Acad Sci 1011:78-85. 2004
    ..of mitochondrial DNA could not be explained by mRNA or protein contents of mitochondrial transcription factor (mtTFA), but mtTFA binding to the promoter sequence of mitochondrial DNA, assessed by gel-shift assay, was attenuated in ..
  32. pmc The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells
    Martina Gaspari
    Department of Medical Nutrition, Karolinska Institute, Novum, Karolinska University Hospital, Stockholm, Sweden
    EMBO J 23:4606-14. 2004
    ..depends on three proteins: mitochondrial RNA polymerase (POLRMT), mitochondrial transcription factor A (TFAM) and mitochondrial transcription factor B2 (TFB2M)...
  33. ncbi Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery
    Tomonori Yoshida
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Atherosclerosis 178:39-47. 2005
    ..We hypothesized that mitochondrial transcription factor A (mtTFA), a prerequisite factor for the transcription and replication of mtDNA, may be upregulated in VSMC of injured rat ..
  34. ncbi Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1
    Claude A Piantadosi
    Department of Medicine, Duke University, Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 281:324-33. 2006
    The nuclear expression of mitochondrial transcription factor A (Tfam), which is required for mitochondrial DNA (mtDNA) transcription and replication, must be linked to cellular energy needs...
  35. ncbi Mitochondrial transcription factor A (TFAM) is increased in rat embryo during placentation and associated with mitochondrial differentiation
    Maria Pilar Alcolea
    Grup de Metabolisme Energètic i Nutrició Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Cell Physiol Biochem 17:79-88. 2006
    ..single strand DNA binding protein (mtSSB)), mtDNA transcription (mitochondrial transcription factor A (TFAM)), as well as in mitochondrial function (cytochrome c oxidase subunit I (COXI))...
  36. ncbi Mitochondrial transcription factor A is the major protein in rodent hepatocytes that recognizes DNA lesions induced by N-acetoxy-acetylaminofluorene
    Monika Pietrowska
    Department of Experimental and Clinical Radiobiology, Maria Skłodowska Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland
    Acta Biochim Pol 53:777-82. 2006
    ..from rat tissue and analyzed it by mass spectrometry and identified it as mitochondrial transcription factor A (TFAM). Experiments with bacterially expressed recombinant TFAM confirmed its high affinity for DNA damaged by AAAF...
  37. ncbi Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
    ..PGC)-1alpha in regulation of skeletal muscle morphology and metabolism, and mitochondrial transcription factor A (TFAM) has been implicated in the process of mitochondrial biogenesis...
  38. doi Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging
    Yi Zhong
    Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    FEBS J 278:2500-10. 2011
    ..This study also provides new insights into the development of presbycusis...
  39. doi Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription
    Atai Watanabe
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Cardiovasc Res 90:57-67. 2011
    ..Messenger RNA (mRNA) for these enzymes is transcribed by mitochondrial transcription factors A (TFAM) and B2 (TFB2M)...
  40. pmc PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression
    Benoit R Gauthier
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Cell Metab 10:110-8. 2009
    ..Transcript profiling revealed suppression of nuclear-encoded mitochondrial factor A (TFAM). Herein, we show that Pdx1 suppression in adult mice reduces islet TFAM expression coinciding with hyperglycemia...
  41. pmc Alterations in mitochondrial function and cytosolic calcium induced by hyperglycemia are restored by mitochondrial transcription factor A in cardiomyocytes
    Jorge Suarez
    Dept of Medicine, Univ of California, San Diego, La Jolla, CA 92093 0618, USA
    Am J Physiol Cell Physiol 295:C1561-8. 2008
    Mitochondrial transcription factor A (TFAM) is essential for mitochondrial DNA transcription and replication. TFAM transcriptional activity is decreased in diabetic cardiomyopathy; however, the functional implications are unknown...

Research Grants2

  1. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  2. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..compensation involvingmitochondrialbiogenesis, which requires activation ofmitochondrial transcription factor A (mtTFA) and two nuclear transcription factors, nuclear respiratory factor-1 and -2 (NRF-1 and -2),and a co-activator, PGC-..