Retn

Summary

Gene Symbol: Retn
Description: resistin
Alias: resistin
Species: rat
Products:     Retn

Top Publications

  1. Gu N, Han S, Fei L, Pan X, Guo M, Chen R, et al. Resistin-binding peptide antagonizes role of resistin on white adipose tissue. Acta Pharmacol Sin. 2007;28:221-6 pubmed
    To investigate the direct effects of resistin and resistin-binding peptide (RBP) on lipid metabolism and endocrine function in adipose tissue...
  2. Wang B, Hung H, Chang H, Kuan P, Shyu K. Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol. 2007;293:H2305-12 pubmed
    The heart is a resistin target tissue and can function as an autocrine organ...
  3. Pravdova E, Macho L, Hlavacova N, Fickova M. Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Gen Physiol Biophys. 2007;26:221-9 pubmed
    Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker...
  4. Liu F, Fan H, Qiu J, Wang B, Zhang M, Gu N, et al. A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance. World J Gastroenterol. 2008;14:95-100 pubmed
    To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro...
  5. Luvizotto R, Síbio M, Olímpio R, Nascimento A, Lima Leopoldo A, Leopoldo A, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43:452-7 pubmed publisher
    ..present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...
  6. Steppan C, Bailey S, Bhat S, Brown E, Banerjee R, Wright C, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12 pubmed
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  7. Lee S, Ha J, Kim J, Choi E, Park S, Kang S, et al. Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. Coron Artery Dis. 2009;20:33-9 pubmed publisher
    Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear...
  8. Adeghate E. An update on the biology and physiology of resistin. Cell Mol Life Sci. 2004;61:2485-96 pubmed
    b>Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules alpha, beta and gamma in structure and function...
  9. Smalley D, Sheman N, Nelson K, Theodorescu D. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J Proteome Res. 2008;7:2088-96 pubmed publisher
    ..five proteins associated with the epidermal growth factor receptor pathway, the alpha subunit of GsGTP binding protein, resistin, and retinoic acid-induced protein 3. Further studies will be needed to validate these potential biomarkers.
  10. Vazquez M, González C, Varela L, Lage R, Tovar S, Sangiao Alvarellos S, et al. Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. Endocrinology. 2008;149:4534-43 pubmed publisher
    Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated mechanisms...

Detail Information

Publications62

  1. Gu N, Han S, Fei L, Pan X, Guo M, Chen R, et al. Resistin-binding peptide antagonizes role of resistin on white adipose tissue. Acta Pharmacol Sin. 2007;28:221-6 pubmed
    To investigate the direct effects of resistin and resistin-binding peptide (RBP) on lipid metabolism and endocrine function in adipose tissue...
  2. Wang B, Hung H, Chang H, Kuan P, Shyu K. Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol. 2007;293:H2305-12 pubmed
    The heart is a resistin target tissue and can function as an autocrine organ...
  3. Pravdova E, Macho L, Hlavacova N, Fickova M. Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Gen Physiol Biophys. 2007;26:221-9 pubmed
    Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker...
  4. Liu F, Fan H, Qiu J, Wang B, Zhang M, Gu N, et al. A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance. World J Gastroenterol. 2008;14:95-100 pubmed
    To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro...
  5. Luvizotto R, Síbio M, Olímpio R, Nascimento A, Lima Leopoldo A, Leopoldo A, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43:452-7 pubmed publisher
    ..present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...
  6. Steppan C, Bailey S, Bhat S, Brown E, Banerjee R, Wright C, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12 pubmed
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  7. Lee S, Ha J, Kim J, Choi E, Park S, Kang S, et al. Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. Coron Artery Dis. 2009;20:33-9 pubmed publisher
    Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear...
  8. Adeghate E. An update on the biology and physiology of resistin. Cell Mol Life Sci. 2004;61:2485-96 pubmed
    b>Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules alpha, beta and gamma in structure and function...
  9. Smalley D, Sheman N, Nelson K, Theodorescu D. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J Proteome Res. 2008;7:2088-96 pubmed publisher
    ..five proteins associated with the epidermal growth factor receptor pathway, the alpha subunit of GsGTP binding protein, resistin, and retinoic acid-induced protein 3. Further studies will be needed to validate these potential biomarkers.
  10. Vazquez M, González C, Varela L, Lage R, Tovar S, Sangiao Alvarellos S, et al. Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. Endocrinology. 2008;149:4534-43 pubmed publisher
    Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated mechanisms...
  11. Lee T, Lin C, Tsai J, Wu Y, Su K, Lu K, et al. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 2009;84:97-104 pubmed publisher
    b>Resistin promotes macrophage-foam cell formation, but the mechanisms are unclear...
  12. Borst S, Conover C, Bagby G. Association of resistin with visceral fat and muscle insulin resistance. Cytokine. 2005;32:39-44 pubmed
    ..058). Glucose tolerance was not significantly affected by surgical fat removal. In VF- animals, serum resistin was reduced 26% (p<0.05) and serum adiponectin was reduced 30% (p<0...
  13. Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, et al. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res. 2002;10:1095-103 pubmed
    ..have been implicated in the development of type 2 diabetes, among them, the recently discovered adiponectin and resistin proteins...
  14. Delhanty P, Mesotten D, McDougall F, Baxter R. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology. 2002;143:2445-8 pubmed
    ..A possible mediator of these effects is the recently identified white adipose tissue (WAT)-derived factor resistin that has been shown to impair glucose tolerance and inhibit adipocyte differentiation...
  15. Schaffler A, Büchler C, Müller Ladner U, Herfarth H, Ehling A, Paul G, et al. Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus. Horm Metab Res. 2004;36:702-7 pubmed
    b>Resistin, a peptide hormone, has been discussed controversially as a missing link between obesity and insulin resistance...
  16. Szulińska M, Musialik K, Suliburska J, Lis I, Bogdanski P. The effect of L-arginine supplementation on serum resistin concentration in insulin resistance in animal models. Eur Rev Med Pharmacol Sci. 2014;18:575-80 pubmed
    ..The aim of this study was to examine the effects of L-arginine on the secretion of resistin in the context of insulin resistance in animal models...
  17. Kim S, Nian C, McIntosh C. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J Biol Chem. 2007;282:34139-47 pubmed
    ..of an intermediary molecule, and the current studies focused on the possible contribution of the adipokine resistin. In differentiated 3T3-L1 adipocytes, GIP, in the presence of insulin, increased resistin secretion through a ..
  18. Park S, Hong S, Sung S, Jung H. Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling. Endocrinology. 2008;149:445-54 pubmed
    To determine the long-term effect of central leptin and resistin on energy homeostasis, peripheral insulin resistance, and beta-cell function and mass, intracerebroventricular (ICV) infusion of leptin (3 ng/h), resistin (80 ng/h), leptin ..
  19. Roth C, Elfers C, Figlewicz D, Melhorn S, Morton G, Hoofnagle A, et al. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Hepatology. 2012;55:1103-11 pubmed publisher
    ..48, P < 0.05). Hepatic messenger RNA (mRNA) levels of Toll-like receptors (TLR)2, TLR4, and TLR9, as well as resistin, interleukins (IL)-1β, IL-4, and IL-6 and oxidative stress marker heme oxygenase (HO)-1, were higher in WD+VDD ..
  20. Tsioufis C, Dimitriadis K, Selima M, Miliou A, Toutouzas K, Roussos D, et al. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Am J Hypertens. 2010;23:681-6 pubmed publisher
    Evidence suggests that resistin, a recently described protein, is associated with subclinical atherosclerosis in different clinical settings...
  21. Li Y, Wang Y, Li Q, Chen Y, Sun S, Zhang W, et al. Effect of resistin on vascular endothelium secretion dysfunction in rats. Endothelium. 2007;14:207-14 pubmed
    b>Resistin, a novel adipokine, was recently suggested to be involved in the development of endothelial dysfunction. However, the mechanisms of how resistin works are still unknown...
  22. Lu S, Shieh W, Chen C, Hsu S, Chen H. Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Lett. 2002;530:158-62 pubmed
    Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis...
  23. Shyu K, Lien L, Wang B, Kuan P, Chang H. Resistin contributes to neointimal formation via oxidative stress after vascular injury. Clin Sci (Lond). 2011;120:121-9 pubmed publisher
    b>Resistin may play a major potential role in vascular remodelling and may contribute to atherogenesis. However, the role of VSMC (vascular smooth muscle cell)-derived resistin in neointimal formation is not well understood...
  24. Suriyaprom K, Phonrat B, Namjuntra P, Chanchay S, Tungtrongchitr R. The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais. J Clin Biochem Nutr. 2009;44:104-10 pubmed publisher
    The prevalence of type 2 diabetes has been increased in Thais. Resistin is an adipokine that involve in glucose homeostasis and is a candidate gene for type 2 diabetes...
  25. Kreier F, Fliers E, Voshol P, Van Eden C, Havekes L, Kalsbeek A, et al. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications. J Clin Invest. 2002;110:1243-50 pubmed
    ..Moreover, expression of resistin and leptin mRNA decreased, whereas adiponectin mRNA did not change...
  26. Kang S, Chemaly E, Hajjar R, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73 pubmed publisher
    b>Resistin has been suggested to be involved in the development of diabetes and insulin resistance...
  27. Rathner J, Chen F, Kosari S, Badoer E. Centrally administered resistin enhances sympathetic nerve activity to the hindlimb but attenuates the activity to brown adipose tissue. Endocrinology. 2011;152:2626-33 pubmed publisher
    b>Resistin, an adipokine, is believed to act in the brain to influence energy homeostasis. Plasma resistin levels are elevated in obesity and are associated with metabolic and cardiovascular disease...
  28. Yang G, Li L, Tang Y, Boden G. Short-term pioglitazone treatment prevents free fatty acid-induced hepatic insulin resistance in normal rats: possible role of the resistin and adiponectin. Biochem Biophys Res Commun. 2006;339:1190-6 pubmed
    ..with pioglitazone (Pio, 4mg/kg x d) on hepatic and peripheral insulin sensitivity, plasma adiponectin, and resistin concentrations in lipid-infused rats...
  29. Norata G, Ongari M, Garlaschelli K, Tibolla G, Grigore L, Raselli S, et al. Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. J Intern Med. 2007;262:104-12 pubmed
    b>Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and to be predictive of coronary atherosclerosis and type II diabetes in humans...
  30. Steppan C, Brown E, Wright C, Bhat S, Banerjee R, Dai C, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci U S A. 2001;98:502-6 pubmed
    We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells...
  31. Fernández C, del Arco A, Gallardo N, Aguado L, Rodriguez M, Ros M, et al. S-resistin inhibits adipocyte differentiation and increases TNFalpha expression and secretion in 3T3-L1 cells. Biochim Biophys Acta. 2010;1803:1131-41 pubmed publisher
    S-resistin is a non-secretable resistin spliced variant described in white adipose tissue from Wistar rats...
  32. Nogueiras R, Gallego R, Gualillo O, Caminos J, Garcia Caballero T, Casanueva F, et al. Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner. FEBS Lett. 2003;548:21-7 pubmed
    b>Resistin is a polypeptide hormone first reported from human and rodent adipocytes. In order to better define the potential biological role of resistin we undertook a detailed analysis of its expression in different rat tissues...
  33. Choi K, Lee S, Yoo H, Ryu O, Lee K, Kim S, et al. Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007;357:62-7 pubmed
    ..We examined the expression of visfatin, adiponectin, and resistin mRNA in visceral adipose tissue of Wistar rats fed a high-fat diet and 3T3-L1 adipocytes treated with PPAR-delta ..
  34. Ribot J, Rodriguez A, Rodriguez E, Palou A. Adiponectin and resistin response in the onset of obesity in male and female rats. Obesity (Silver Spring). 2008;16:723-30 pubmed publisher
    Studying the sex-dependent response of adiponectin and resistin adipose tissue expression and circulating levels in the onset of dietary obesity...
  35. Kim M, Oh J, Sakata S, Liang I, Park W, Hajjar R, et al. Role of resistin in cardiac contractility and hypertrophy. J Mol Cell Cardiol. 2008;45:270-80 pubmed publisher
    ..Recently, a novel paradigm for the role of the adipocytokine resistin in diabetes has emerged. Resistin has been proposed to be a link between obesity, insulin resistance and diabetes...
  36. Gong H, Ni Y, Guo X, Fei L, Pan X, Guo M, et al. Resistin promotes 3T3-L1 preadipocyte differentiation. Eur J Endocrinol. 2004;150:885-92 pubmed
    To investigate the relationship between resistin (a potential link between obesity and type 2 diabetes) and preadipocyte differentiation...
  37. Kuzmicki M, Telejko B, Szamatowicz J, Zonenberg A, Nikolajuk A, Kretowski A, et al. High resistin and interleukin-6 levels are associated with gestational diabetes mellitus. Gynecol Endocrinol. 2009;25:258-63 pubmed publisher
    b>Resistin is a cysteine-rich adipokine originally described as a molecular link between obesity and insulin resistance in rodents...
  38. Koch A, Gressner O, Sanson E, Tacke F, Trautwein C. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Crit Care. 2009;13:R95 pubmed publisher
    ..The pathogenesis of insulin resistance (IR) in critically ill patients is complex and not fully understood. Resistin is a hormone mainly derived from macrophages in humans and from adipose tissue in rodents, which regulates ..
  39. Hussain S, Asghar M, Javed Q. Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients. Transl Res. 2010;155:142-7 pubmed publisher
    b>Resistin, a novel cytokine, is associated with an inflammatory process and is suggested to induce hypertrophy in rat cardiomyocytes. Resistin gene expression has not been investigated in patients with hypertrophic cardiomyopathy (HCM)...
  40. Nogueiras R, Barreiro M, Caminos J, Gaytan F, Suominen J, Navarro V, et al. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. J Cell Sci. 2004;117:3247-57 pubmed
    b>Resistin, a recently cloned adipose-secreted factor, is primarily involved in the modulation of insulin sensitivity and adipocyte differentiation...
  41. Rodriguez Pacheco F, Vazquez Martinez R, Martinez Fuentes A, Pulido M, Gahete M, Vaudry H, et al. Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways. Endocrinology. 2009;150:4643-52 pubmed publisher
    The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function...