Retn

Summary

Gene Symbol: Retn
Description: resistin
Alias: resistin
Species: rat
Products:     Retn

Top Publications

  1. Gu N, Han S, Fei L, Pan X, Guo M, Chen R, et al. Resistin-binding peptide antagonizes role of resistin on white adipose tissue. Acta Pharmacol Sin. 2007;28:221-6 pubmed
    To investigate the direct effects of resistin and resistin-binding peptide (RBP) on lipid metabolism and endocrine function in adipose tissue...
  2. Wang B, Hung H, Chang H, Kuan P, Shyu K. Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol. 2007;293:H2305-12 pubmed
    The heart is a resistin target tissue and can function as an autocrine organ...
  3. Pravdova E, Macho L, Hlavacova N, Fickova M. Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Gen Physiol Biophys. 2007;26:221-9 pubmed
    Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker...
  4. Liu F, Fan H, Qiu J, Wang B, Zhang M, Gu N, et al. A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance. World J Gastroenterol. 2008;14:95-100 pubmed
    To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro...
  5. Hung H, Wang B, Chang H, Shyu K. The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia. J Hypertens. 2008;26:2349-60 pubmed publisher
    b>Resistin has a potential role in atherosclerosis because resistin produces proinflammatory effects in the vascular wall. However, the molecular mechanism of resistin increase in atherosclerosis remains unclear...
  6. Luvizotto R, Síbio M, Olímpio R, Nascimento A, Lima Leopoldo A, Leopoldo A, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43:452-7 pubmed publisher
    ..present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...
  7. Nogueiras R, Gualillo O, Caminos J, Casanueva F, Dieguez C. Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Obes Res. 2003;11:408-14 pubmed
    b>Resistin was recently identified as a hormone secreted by adipocytes that is under hormonal and nutritional control. This hormone has been suggested to be the link between obesity and type 2 diabetes...
  8. Steppan C, Bailey S, Bhat S, Brown E, Banerjee R, Wright C, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12 pubmed
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  9. Diez J, Iglesias P, Fernández Reyes M, Aguilera A, Bajo M, Alvarez Fidalgo P, et al. Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. Clin Endocrinol (Oxf). 2005;62:242-9 pubmed
    ..Our aims were (1) to quantify the serum concentrations of leptin, adiponectin and resistin in uraemic patients on peritoneal dialysis (PD) and haemodialysis (HD), in comparison with patients on ..
  10. Lee T, Chen W, Chang N. Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats. Biosci Rep. 2016;36: pubmed publisher
    Myocardial infarction (MI) was associated with insulin resistance, in which resistin acts as a critical mediator...

Detail Information

Publications83

  1. Gu N, Han S, Fei L, Pan X, Guo M, Chen R, et al. Resistin-binding peptide antagonizes role of resistin on white adipose tissue. Acta Pharmacol Sin. 2007;28:221-6 pubmed
    To investigate the direct effects of resistin and resistin-binding peptide (RBP) on lipid metabolism and endocrine function in adipose tissue...
  2. Wang B, Hung H, Chang H, Kuan P, Shyu K. Mechanical stretch enhances the expression of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am J Physiol Heart Circ Physiol. 2007;293:H2305-12 pubmed
    The heart is a resistin target tissue and can function as an autocrine organ...
  3. Pravdova E, Macho L, Hlavacova N, Fickova M. Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Gen Physiol Biophys. 2007;26:221-9 pubmed
    Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker...
  4. Liu F, Fan H, Qiu J, Wang B, Zhang M, Gu N, et al. A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance. World J Gastroenterol. 2008;14:95-100 pubmed
    To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro...
  5. Hung H, Wang B, Chang H, Shyu K. The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia. J Hypertens. 2008;26:2349-60 pubmed publisher
    b>Resistin has a potential role in atherosclerosis because resistin produces proinflammatory effects in the vascular wall. However, the molecular mechanism of resistin increase in atherosclerosis remains unclear...
  6. Luvizotto R, Síbio M, Olímpio R, Nascimento A, Lima Leopoldo A, Leopoldo A, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43:452-7 pubmed publisher
    ..present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats...
  7. Nogueiras R, Gualillo O, Caminos J, Casanueva F, Dieguez C. Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Obes Res. 2003;11:408-14 pubmed
    b>Resistin was recently identified as a hormone secreted by adipocytes that is under hormonal and nutritional control. This hormone has been suggested to be the link between obesity and type 2 diabetes...
  8. Steppan C, Bailey S, Bhat S, Brown E, Banerjee R, Wright C, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12 pubmed
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  9. Diez J, Iglesias P, Fernández Reyes M, Aguilera A, Bajo M, Alvarez Fidalgo P, et al. Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. Clin Endocrinol (Oxf). 2005;62:242-9 pubmed
    ..Our aims were (1) to quantify the serum concentrations of leptin, adiponectin and resistin in uraemic patients on peritoneal dialysis (PD) and haemodialysis (HD), in comparison with patients on ..
  10. Lee T, Chen W, Chang N. Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats. Biosci Rep. 2016;36: pubmed publisher
    Myocardial infarction (MI) was associated with insulin resistance, in which resistin acts as a critical mediator...
  11. Cifani C, Durocher Y, Pathak A, Penicaud L, Smih F, Massi M, et al. Possible common central pathway for resistin and insulin in regulating food intake. Acta Physiol (Oxf). 2009;196:395-400 pubmed publisher
    ..Examination of adipocyte-secreted peptides led to the identification of a unique polypeptide, resistin (RSTN), which has been suggested as a link between obesity and diabetes...
  12. Jiang C, Wang W. Resistin aggravates the expression of proinflammatory cytokines in cerulein?stimulated AR42J pancreatic acinar cells. Mol Med Rep. 2017;15:502-506 pubmed publisher
    b>Resistin, an adipocytokine secreted by fat tissues, has been shown to be associated with increased local and systemic complications in acute pancreatitis (AP)...
  13. Rothwell S, Richards A, Pemberton C. Resistin worsens cardiac ischaemia-reperfusion injury. Biochem Biophys Res Commun. 2006;349:400-7 pubmed
    We provide the first report of direct effects of resistin upon haemodynamic and neurohumoral parameters in isolated perfused rat heart preparations...
  14. Tan M, Chang S, Chang D, Tsai J, Lee Y. Association of resistin gene 3'-untranslated region +62G-->A polymorphism with type 2 diabetes and hypertension in a Chinese population. J Clin Endocrinol Metab. 2003;88:1258-63 pubmed
    b>Resistin, a recently discovered polypeptide, antagonizes insulin action and may play a part in the pathogenesis of insulin resistance. This study investigates whether resistin gene polymorphism can be associated with type 2 diabetes...
  15. Zhao C, Yan L, Wang Y, Wang W, Zhou J, Zhen Z. [Role of resistin in inflammation of hepatocytes in nonalcoholic steatohepatitis]. Zhonghua Gan Zang Bing Za Zhi. 2009;17:683-7 pubmed
    To investigate the role and molecular mechanism of resistin in inflammation of hepatocytes in nonalcoholic steatohepatitis. Rat models of NASH were established successfully...
  16. Chung W, Jung E, Shin D, Choi S, Jung J, Chang J, et al. Low resistin level is associated with poor hospitalization-free survival in hemodialysis patients. J Korean Med Sci. 2012;27:377-81 pubmed publisher
    Malnutrition and inflammation are related to high rates of morbidity and mortality in hemodialysis patients. Resistin is associated with nutrition and inflammation...
  17. Zhang R, Wang Z, Zhu L, Wu F, Chen D, Sun L, et al. Resistin expression in adipose tissues and its effect on glucose metabolism in rats with brain injury. Genet Mol Res. 2016;15: pubmed publisher
    b>Resistin (RSTN) expression in subcutaneous adipose tissue, and its effect on glucose metabolism in rats with traumatic brain injury, was investigated using real-time PCR, western blots, and enzyme linked immunoassays...
  18. Pravenec M, Kazdova L, Landa V, Zidek V, Mlejnek P, Jansa P, et al. Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat. J Biol Chem. 2003;278:45209-15 pubmed
    Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance...
  19. Chi S, Lan C, Zhang S, Liu H, Wang X, Chen Y, et al. Association of -394C>G and -420C>G polymorphisms in the RETN gene with T2DM and CHD and a new potential SNP might be exist in exon 3 of RETN gene in Chinese. Mol Cell Biochem. 2009;330:31-8 pubmed publisher
    Genetic variations of the human RETN gene are associated with metabolic phenotypes, including obesity, insulin sensitivity, diabetes, and coronary heart disease (CHD)...
  20. Brown R, Thompson H, Imran S, Ur E, Wilkinson M. Traumatic brain injury induces adipokine gene expression in rat brain. Neurosci Lett. 2008;432:73-8 pubmed publisher
    ..Adipokine genes such as leptin (ob), resistin (rstn) and fasting-induced adipose factor (fiaf) are implicated in energy metabolism and body weight control and ..
  21. Osawa H, Ochi M, Kato K, Yamauchi J, Nishida W, Takata Y, et al. Serum resistin is associated with the severity of microangiopathies in type 2 diabetes. Biochem Biophys Res Commun. 2007;355:342-6 pubmed
    b>Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects...
  22. Huang S, Seow K, Ho L, Chien Y, Chung D, Chang C, et al. Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. FEBS Lett. 2005;579:449-54 pubmed
    b>Resistin, a hormone secreted by adipocytes, is suggested to be an important link between obesity and diabetes...
  23. Oliver P, Pico C, Serra F, Palou A. Resistin expression in different adipose tissue depots during rat development. Mol Cell Biochem. 2003;252:397-400 pubmed
    b>Resistin is a hormonal factor synthesised by adipocytes that was first thought to be related with the resistance to insulin in obesity, but whose function is not yet completely established...
  24. Adeghate E. An update on the biology and physiology of resistin. Cell Mol Life Sci. 2004;61:2485-96 pubmed
    b>Resistin is a newly discovered adipocyte hormone. It is related to resistin-like molecules alpha, beta and gamma in structure and function...
  25. Lee S, Ha J, Kim J, Choi E, Park S, Kang S, et al. Plasma adiponectin and resistin levels as predictors of mortality in patients with acute myocardial infarction: data from infarction prognosis study registry. Coron Artery Dis. 2009;20:33-9 pubmed publisher
    Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear...
  26. Vazquez M, González C, Varela L, Lage R, Tovar S, Sangiao Alvarellos S, et al. Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion. Endocrinology. 2008;149:4534-43 pubmed publisher
    Evidence suggests that the adipocyte-derived hormone resistin (RSTN) directly regulates both feeding and peripheral metabolism through, so far, undefined hypothalamic-mediated mechanisms...
  27. Smalley D, Sheman N, Nelson K, Theodorescu D. Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J Proteome Res. 2008;7:2088-96 pubmed publisher
    ..five proteins associated with the epidermal growth factor receptor pathway, the alpha subunit of GsGTP binding protein, resistin, and retinoic acid-induced protein 3. Further studies will be needed to validate these potential biomarkers.
  28. Fernández C, Moltó E, Gallardo N, del Arco A, Martinez C, Andrés A, et al. The expression of rat resistin isoforms is differentially regulated in visceral adipose tissues: effects of aging and food restriction. Metabolism. 2009;58:204-11 pubmed publisher
    Two variants of the adipose hormone resistin are generated by alternative splicing in Wistar rats...
  29. Lee T, Lin C, Tsai J, Wu Y, Su K, Lu K, et al. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 2009;84:97-104 pubmed publisher
    b>Resistin promotes macrophage-foam cell formation, but the mechanisms are unclear...
  30. Borst S, Conover C, Bagby G. Association of resistin with visceral fat and muscle insulin resistance. Cytokine. 2005;32:39-44 pubmed
    ..058). Glucose tolerance was not significantly affected by surgical fat removal. In VF- animals, serum resistin was reduced 26% (p<0.05) and serum adiponectin was reduced 30% (p<0...
  31. Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, et al. Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res. 2002;10:1095-103 pubmed
    ..have been implicated in the development of type 2 diabetes, among them, the recently discovered adiponectin and resistin proteins...
  32. Delhanty P, Mesotten D, McDougall F, Baxter R. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology. 2002;143:2445-8 pubmed
    ..A possible mediator of these effects is the recently identified white adipose tissue (WAT)-derived factor resistin that has been shown to impair glucose tolerance and inhibit adipocyte differentiation...
  33. Caja S, Puerta M. Control by reproduction-related hormones of resistin expression and plasma concentration. Horm Metab Res. 2007;39:501-6 pubmed
    Although not simultaneously, resistin expression in white adipose tissue (WAT) and resistin plasma concentration have been shown to increase in pregnant rats...
  34. Rasić D, Stolic R, Jovanovic A, Trajkovic G, Rasic J, Sovtic S. [The significance of resistin concentration in metabolical diseases]. Vojnosanit Pregl. 2010;67:965-8 pubmed
    ..The aim of this study was to determine the resistin significance in patients with various forms of metabolic diseases...
  35. Lingohr P, Dohmen J, Matthaei H, Konieczny N, Hoffmann J, Bölke E, et al. Cytokine expression in the visceral adipose tissue after laparoscopic and conventional surgery in a rodent model. Eur J Med Res. 2016;21:4 pubmed publisher
    ..Cytokine expression of leptin, resistin, and IL-6 was analyzed in VAT before and after resection by quantitative RT-PCR...
  36. Schaffler A, Büchler C, Müller Ladner U, Herfarth H, Ehling A, Paul G, et al. Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus. Horm Metab Res. 2004;36:702-7 pubmed
    b>Resistin, a peptide hormone, has been discussed controversially as a missing link between obesity and insulin resistance...
  37. Szulińska M, Musialik K, Suliburska J, Lis I, Bogdanski P. The effect of L-arginine supplementation on serum resistin concentration in insulin resistance in animal models. Eur Rev Med Pharmacol Sci. 2014;18:575-80 pubmed
    ..The aim of this study was to examine the effects of L-arginine on the secretion of resistin in the context of insulin resistance in animal models...
  38. Park S, Hong S, Sung S, Jung H. Long-term effects of central leptin and resistin on body weight, insulin resistance, and beta-cell function and mass by the modulation of hypothalamic leptin and insulin signaling. Endocrinology. 2008;149:445-54 pubmed
    To determine the long-term effect of central leptin and resistin on energy homeostasis, peripheral insulin resistance, and beta-cell function and mass, intracerebroventricular (ICV) infusion of leptin (3 ng/h), resistin (80 ng/h), leptin ..
  39. Jiménez Castro M, Casillas Ramirez A, Mendes Braz M, Massip Salcedo M, Gracia Sancho J, Elias Miró M, et al. Adiponectin and resistin protect steatotic livers undergoing transplantation. J Hepatol. 2013;59:1208-14 pubmed publisher
    ..Controversial roles for adiponectin and related adipocytokines visfatin and resistin have been described in different liver pathologies, nevertheless it is unknown their possible implication in ..
  40. Kim S, Nian C, McIntosh C. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J Biol Chem. 2007;282:34139-47 pubmed
    ..of an intermediary molecule, and the current studies focused on the possible contribution of the adipokine resistin. In differentiated 3T3-L1 adipocytes, GIP, in the presence of insulin, increased resistin secretion through a ..
  41. Sassek M, Pruszynska Oszmalek E, Kołodziejski P, Szczepankiewicz D, Kaczmarek P, Wieloch M, et al. Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion. Islets. 2016;8:177-185 pubmed
    b>Resistin participates in the regulation of energy homeostasis, insulin resistance, and inflammation...
  42. Roth C, Elfers C, Figlewicz D, Melhorn S, Morton G, Hoofnagle A, et al. Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Hepatology. 2012;55:1103-11 pubmed publisher
    ..48, P < 0.05). Hepatic messenger RNA (mRNA) levels of Toll-like receptors (TLR)2, TLR4, and TLR9, as well as resistin, interleukins (IL)-1?, IL-4, and IL-6 and oxidative stress marker heme oxygenase (HO)-1, were higher in WD+VDD ..
  43. Guzmán S, Marin S, Miranda A, Selivanov V, Centelles J, Harmancey R, et al. (13)C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes. BMC Syst Biol. 2014;8:109 pubmed publisher
    It has been suggested that the adipokine resistin links obesity and insulin resistance, although how resistin acts on muscle metabolism is controversial...
  44. Tsioufis C, Dimitriadis K, Selima M, Miliou A, Toutouzas K, Roussos D, et al. Association of resistin with urinary albumin excretion in nondiabetic patients with essential hypertension. Am J Hypertens. 2010;23:681-6 pubmed publisher
    Evidence suggests that resistin, a recently described protein, is associated with subclinical atherosclerosis in different clinical settings...
  45. Li Y, Wang Y, Li Q, Chen Y, Sun S, Zhang W, et al. Effect of resistin on vascular endothelium secretion dysfunction in rats. Endothelium. 2007;14:207-14 pubmed
    b>Resistin, a novel adipokine, was recently suggested to be involved in the development of endothelial dysfunction. However, the mechanisms of how resistin works are still unknown...
  46. Suriyaprom K, Phonrat B, Namjuntra P, Chanchay S, Tungtrongchitr R. The +299(G>A) resistin gene polymorphism and susceptibility to type 2 diabetes in Thais. J Clin Biochem Nutr. 2009;44:104-10 pubmed publisher
    The prevalence of type 2 diabetes has been increased in Thais. Resistin is an adipokine that involve in glucose homeostasis and is a candidate gene for type 2 diabetes...
  47. Gu N, Guo X, Ni Y, Liu F, Fei L, Chen R. [Overexpression of resistin affect 3T3-L1 adipocyte lipid metabolism]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24:251-5 pubmed
    To investigate the effect of resistin overexpression on 3T3-L1 adipocyte lipid and glucose metabolism. Expression vector for rat resistin gene was constructed and transfected into 3T3-L1 adipocytes...
  48. Lu S, Shieh W, Chen C, Hsu S, Chen H. Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Lett. 2002;530:158-62 pubmed
    Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis...
  49. Mazaki Tovi S, Vaisbuch E, Romero R, Kusanovic J, Chaiworapongsa T, Kim S, et al. Hyperresistinemia - a novel feature in systemic infection during human pregnancy. Am J Reprod Immunol. 2010;63:358-69 pubmed publisher
    b>Resistin, originally described as an adipokine, has emerged as a potent pro-inflammatory protein associated with both acute and chronic inflammation...
  50. Kreier F, Fliers E, Voshol P, Van Eden C, Havekes L, Kalsbeek A, et al. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications. J Clin Invest. 2002;110:1243-50 pubmed
    ..Moreover, expression of resistin and leptin mRNA decreased, whereas adiponectin mRNA did not change...
  51. Kang S, Chemaly E, Hajjar R, Lebeche D. Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. J Biol Chem. 2011;286:18465-73 pubmed publisher
    b>Resistin has been suggested to be involved in the development of diabetes and insulin resistance...
  52. Dong Z, Su L, Brymora J, Bird C, Xie Q, George J, et al. Resistin mediates the hepatic stellate cell phenotype. World J Gastroenterol. 2013;19:4475-85 pubmed publisher
    To describe the role of resistin in liver fibrosis. For the in vivo animal study, Sprague Dawley rats were subjected to bile duct ligation (BDL) for 4 wk...
  53. Rathner J, Chen F, Kosari S, Badoer E. Centrally administered resistin enhances sympathetic nerve activity to the hindlimb but attenuates the activity to brown adipose tissue. Endocrinology. 2011;152:2626-33 pubmed publisher
    b>Resistin, an adipokine, is believed to act in the brain to influence energy homeostasis. Plasma resistin levels are elevated in obesity and are associated with metabolic and cardiovascular disease...
  54. Sun S, Huang J, Meng M, Lu J, Hocher B, Liu K, et al. Improvement of lipid profile and reduction of body weight by shan he jian fei granules in high fat diet-induced obese rats. Clin Lab. 2012;58:81-7 pubmed
    The goal was to study lipid profiles (TG, TC, LDL, HDL), effects on serum leptin, and fat tissue adiponectin, and resistin as well as body weight effects of Shan He Jian Fei Granules (SHJFG) in rats on a high fat diet...
  55. Yang G, Li L, Tang Y, Boden G. Short-term pioglitazone treatment prevents free fatty acid-induced hepatic insulin resistance in normal rats: possible role of the resistin and adiponectin. Biochem Biophys Res Commun. 2006;339:1190-6 pubmed
    ..with pioglitazone (Pio, 4mg/kg x d) on hepatic and peripheral insulin sensitivity, plasma adiponectin, and resistin concentrations in lipid-infused rats...
  56. Ding W, Wang Y, Fan J. Regulation of adipokines by polyunsaturated fatty acids in a rat model of non-alcoholic steatohepatitis. Arch Iran Med. 2014;17:563-8 pubmed publisher
    ..Supplementing high-fat diet with omega-3 PUFA decreased serum levels of leptin and resistin, while adiponectin levels were slightly elevated...
  57. Kosari S, Rathner J, Badoer E. Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2. J Neuroendocrinol. 2012;24:1432-9 pubmed publisher
    b>Resistin is an adipokine, originally identified in adipose tissue, and its plasma levels are elevated in obesity...
  58. Norata G, Ongari M, Garlaschelli K, Tibolla G, Grigore L, Raselli S, et al. Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. J Intern Med. 2007;262:104-12 pubmed
    b>Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and to be predictive of coronary atherosclerosis and type II diabetes in humans...
  59. Steppan C, Brown E, Wright C, Bhat S, Banerjee R, Dai C, et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci U S A. 2001;98:502-6 pubmed
    We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells...
  60. Fernández C, del Arco A, Gallardo N, Aguado L, Rodriguez M, Ros M, et al. S-resistin inhibits adipocyte differentiation and increases TNFalpha expression and secretion in 3T3-L1 cells. Biochim Biophys Acta. 2010;1803:1131-41 pubmed publisher
    S-resistin is a non-secretable resistin spliced variant described in white adipose tissue from Wistar rats...
  61. Nogueiras R, Gallego R, Gualillo O, Caminos J, Garcia Caballero T, Casanueva F, et al. Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner. FEBS Lett. 2003;548:21-7 pubmed
    b>Resistin is a polypeptide hormone first reported from human and rodent adipocytes. In order to better define the potential biological role of resistin we undertook a detailed analysis of its expression in different rat tissues...
  62. Yang G, Li L, Fang C, Zhang L, Li Q, Tang Y, et al. Effects of free fatty acids on plasma resistin and insulin resistance in awake rats. Metabolism. 2005;54:1142-6 pubmed
    b>Resistin has been postulated to play a role in obesity-related insulin resistance. To explore this possibility, we have investigated effects of acute euglycemic (5.2+/-0...
  63. Nowacka Woszuk J, Pruszynska Oszmalek E, Szydlowski M, Sadkowski S, Szczerbal I. Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats. BMC Genet. 2015;16:113 pubmed publisher
    ..One of the important factors produced in fat tissue is resistin (Retn). It has been postulated that this hormone is involved in glucose homeostasis and insulin resistance...
  64. Dominguez Coello S, Cabrera de León A, Almeida González D, Gonzalez Hernandez A, Rodríguez Pérez M, Fernández Ramos N, et al. Inverse association between serum resistin and insulin resistance in humans. Diabetes Res Clin Pract. 2008;82:256-61 pubmed publisher
    To determine how serum concentrations of resistin are distributed in humans in relation to insulin resistance, type 2 diabetes, and obesity...
  65. Wang X, Wang D, Chen S, Zhang L, Ni Y. [The relationship between resistin and the peripheral neuropathy in type 2 diabetes]. Zhonghua Yi Xue Za Zhi. 2007;87:1755-7 pubmed
    To investigate the relationship between the serum resistin concentration and type 2 DM with peripheral neuropathy...
  66. Choi K, Lee S, Yoo H, Ryu O, Lee K, Kim S, et al. Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007;357:62-7 pubmed
    ..We examined the expression of visfatin, adiponectin, and resistin mRNA in visceral adipose tissue of Wistar rats fed a high-fat diet and 3T3-L1 adipocytes treated with PPAR-delta ..
  67. Ribot J, Rodriguez A, Rodriguez E, Palou A. Adiponectin and resistin response in the onset of obesity in male and female rats. Obesity (Silver Spring). 2008;16:723-30 pubmed publisher
    Studying the sex-dependent response of adiponectin and resistin adipose tissue expression and circulating levels in the onset of dietary obesity...
  68. Kim M, Oh J, Sakata S, Liang I, Park W, Hajjar R, et al. Role of resistin in cardiac contractility and hypertrophy. J Mol Cell Cardiol. 2008;45:270-80 pubmed publisher
    ..Recently, a novel paradigm for the role of the adipocytokine resistin in diabetes has emerged. Resistin has been proposed to be a link between obesity, insulin resistance and diabetes...
  69. Juan C, Chang C, Chuang T, Huang S, Kwok C, Ho L. Insulin sensitivity and resistin expression in nitric oxide-deficient rats. Diabetologia. 2006;49:3017-26 pubmed
    The aim of this study was to investigate changes in insulin sensitivity and expression of the gene encoding resistin (Retn) in adipocytes from long-term nitric oxide (NO)-deficient rats...
  70. Oliver P, Ribot J, Rodriguez A, Sanchez J, Pico C, Palou A. Resistin as a putative modulator of insulin action in the daily feeding/fasting rhythm. Pflugers Arch. 2006;452:260-7 pubmed
    b>Resistin and adiponectin are adipokines with postulated opposite functions. Resistin has been related with insulin resistance in obesity, while adiponectin could be associated to higher insulin sensitivity...
  71. Kuzmicki M, Telejko B, Szamatowicz J, Zonenberg A, Nikolajuk A, Kretowski A, et al. High resistin and interleukin-6 levels are associated with gestational diabetes mellitus. Gynecol Endocrinol. 2009;25:258-63 pubmed publisher
    b>Resistin is a cysteine-rich adipokine originally described as a molecular link between obesity and insulin resistance in rodents...
  72. Koch A, Gressner O, Sanson E, Tacke F, Trautwein C. Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients. Crit Care. 2009;13:R95 pubmed publisher
    ..The pathogenesis of insulin resistance (IR) in critically ill patients is complex and not fully understood. Resistin is a hormone mainly derived from macrophages in humans and from adipose tissue in rodents, which regulates ..
  73. Gong H, Ni Y, Guo X, Fei L, Pan X, Guo M, et al. Resistin promotes 3T3-L1 preadipocyte differentiation. Eur J Endocrinol. 2004;150:885-92 pubmed
    To investigate the relationship between resistin (a potential link between obesity and type 2 diabetes) and preadipocyte differentiation...
  74. Hussain S, Asghar M, Javed Q. Resistin gene promoter region polymorphism and the risk of hypertrophic cardiomyopathy in patients. Transl Res. 2010;155:142-7 pubmed publisher
    b>Resistin, a novel cytokine, is associated with an inflammatory process and is suggested to induce hypertrophy in rat cardiomyocytes. Resistin gene expression has not been investigated in patients with hypertrophic cardiomyopathy (HCM)...
  75. Rodriguez Pacheco F, Vazquez Martinez R, Martinez Fuentes A, Pulido M, Gahete M, Vaudry H, et al. Resistin regulates pituitary somatotrope cell function through the activation of multiple signaling pathways. Endocrinology. 2009;150:4643-52 pubmed publisher
    The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function...
  76. Nogueiras R, Barreiro M, Caminos J, Gaytan F, Suominen J, Navarro V, et al. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. J Cell Sci. 2004;117:3247-57 pubmed
    b>Resistin, a recently cloned adipose-secreted factor, is primarily involved in the modulation of insulin sensitivity and adipocyte differentiation...