interleukin 3

Summary

Gene Symbol: interleukin 3
Description: interleukin 3
Alias: interleukin-3, IL-3, MCGF, P-cell-stimulating factor, hematopoietic growth factor, mast cell growth factor, multipotential colony-stimulating factor
Species: rat
Products:     interleukin 3

Top Publications

  1. Ray S, Britschgi M, HERBERT C, Takeda Uchimura Y, Boxer A, Blennow K, et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 2007;13:1359-62 pubmed
    ..Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease. ..
  2. Dougan M, Li D, Neuberg D, Mihm M, Googe P, WONG K, et al. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest. 2011;121:2436-46 pubmed publisher
  3. del C Esandi M, van Someren G, Van Der Velde I, Van Bekkum D, Valerio D, Noteboom J, et al. Cloning, biological characterization and high-level expression of rat interleukin-3 using recombinant adenovirus: description of a new splicing variant. Gene. 1998;211:151-8 pubmed
    ..The biological properties in vitro and in vivo demonstrate that the cDNA sequences of IL-3beta presented here encode active rat IL-3 protein. ..
  4. Tsuji K, Lyman S, Sudo T, Clark S, Ogawa M. Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood. 1992;79:2855-60 pubmed
    ..In contrast, SF is unique among the synergistic factors in that it interacts either with growth factors such as IL-3 or GM-CSF or with synergistic factors such as IL-6, IL-11, or G-CSF. ..
  5. Miyake Y, Tanaka K, Arakawa M. IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health study. Scand J Immunol. 2014;79:410-4 pubmed publisher
  6. Miyake Y, Tanaka K, Arakawa M. IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. Cytokine. 2013;64:86-9 pubmed publisher
    ..We could not find evidence for interactions between SNP rs40401 and smoking or older siblings affecting rhinoconjunctivitis. ..
  7. Shao Y, Zhang W, Dong X, Liu W, Zhang C, Zhang J, et al. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Acta Virol. 2010;54:261-7 pubmed
    ..IFN-?, ?), tumor necrosis factor ? (TNF-?), colony stimulating factors (CSFs) as G-CSF, GM-CSF, interleukin 3 (IL-3), growth factors (EGF, KGF, and IGF-?1), defensins, selectins, leukocyte function-associated antigens (..
  8. Fortin M, Wagner J, Brault J, Harkema J, Renzi P, Paquet L, et al. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Cytokine. 2010;52:194-202 pubmed publisher
    ..c and CCR3 could play important roles in the modulation of the allergic response, and their inhibition may represent a promising therapeutic approach for AR. ..
  9. Lee J, Lim S, Song B, Cha M, Ham O, Lee S, et al. MicroRNA-29b inhibits migration and proliferation of vascular smooth muscle cells in neointimal formation. J Cell Biochem. 2015;116:598-608 pubmed publisher
  10. Mroczko B, Szmitkowski M, Wereszczynska Siemiatkowska U, Jurkowska G. Hematopoietic cytokines in the sera of patients with pancreatic cancer. Clin Chem Lab Med. 2005;43:146-50 pubmed
    ..investigated in pancreatic cancer patients the serum levels of selected HCs, such as stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-..

Scientific Experts

Detail Information

Publications49

  1. Ray S, Britschgi M, HERBERT C, Takeda Uchimura Y, Boxer A, Blennow K, et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med. 2007;13:1359-62 pubmed
    ..Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease. ..
  2. Dougan M, Li D, Neuberg D, Mihm M, Googe P, WONG K, et al. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest. 2011;121:2436-46 pubmed publisher
  3. del C Esandi M, van Someren G, Van Der Velde I, Van Bekkum D, Valerio D, Noteboom J, et al. Cloning, biological characterization and high-level expression of rat interleukin-3 using recombinant adenovirus: description of a new splicing variant. Gene. 1998;211:151-8 pubmed
    ..The biological properties in vitro and in vivo demonstrate that the cDNA sequences of IL-3beta presented here encode active rat IL-3 protein. ..
  4. Tsuji K, Lyman S, Sudo T, Clark S, Ogawa M. Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture. Blood. 1992;79:2855-60 pubmed
    ..In contrast, SF is unique among the synergistic factors in that it interacts either with growth factors such as IL-3 or GM-CSF or with synergistic factors such as IL-6, IL-11, or G-CSF. ..
  5. Miyake Y, Tanaka K, Arakawa M. IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health study. Scand J Immunol. 2014;79:410-4 pubmed publisher
  6. Miyake Y, Tanaka K, Arakawa M. IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. Cytokine. 2013;64:86-9 pubmed publisher
    ..We could not find evidence for interactions between SNP rs40401 and smoking or older siblings affecting rhinoconjunctivitis. ..
  7. Shao Y, Zhang W, Dong X, Liu W, Zhang C, Zhang J, et al. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Acta Virol. 2010;54:261-7 pubmed
    ..IFN-?, ?), tumor necrosis factor ? (TNF-?), colony stimulating factors (CSFs) as G-CSF, GM-CSF, interleukin 3 (IL-3), growth factors (EGF, KGF, and IGF-?1), defensins, selectins, leukocyte function-associated antigens (..
  8. Fortin M, Wagner J, Brault J, Harkema J, Renzi P, Paquet L, et al. Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis. Cytokine. 2010;52:194-202 pubmed publisher
    ..c and CCR3 could play important roles in the modulation of the allergic response, and their inhibition may represent a promising therapeutic approach for AR. ..
  9. Lee J, Lim S, Song B, Cha M, Ham O, Lee S, et al. MicroRNA-29b inhibits migration and proliferation of vascular smooth muscle cells in neointimal formation. J Cell Biochem. 2015;116:598-608 pubmed publisher
  10. Mroczko B, Szmitkowski M, Wereszczynska Siemiatkowska U, Jurkowska G. Hematopoietic cytokines in the sera of patients with pancreatic cancer. Clin Chem Lab Med. 2005;43:146-50 pubmed
    ..investigated in pancreatic cancer patients the serum levels of selected HCs, such as stem cell factor (SCF), interleukin 3 (IL-3), granulocyte-macrophage-colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-..
  11. Shelburne C, McCoy M, Piekorz R, Sexl V, Roh K, Jacobs Helber S, et al. Stat5 expression is critical for mast cell development and survival. Blood. 2003;102:1290-7 pubmed
    ..These results indicate that Stat5A and Stat5B are critical regulators of in vitro and in vivo mast cell development and survival. ..
  12. Xu J, Liu D, Songyang Z. The role of Asp-462 in regulating Akt activity. J Biol Chem. 2002;277:35561-6 pubmed
    ..In particular, caspases are able to render Akt inactive and dominantly inhibit the Akt pathway by cleaving off the C-terminal hydrophobic motif. Consequently, the survival signal is quickly down-regulated to allow apoptosis to occur. ..
  13. Okajima Y, Matsumura I, Nishiura T, Hashimoto K, Yoshida H, Ishikawa J, et al. Insulin-like growth factor-I augments erythropoietin-induced proliferation through enhanced tyrosine phosphorylation of STAT5. J Biol Chem. 1998;273:22877-83 pubmed
    ..These results suggest that IGF-I may augment EPO-induced proliferation by enhancing tyrosine phosphorylation of STAT5 and raise the possibility that Ras may be involved in the augmentation of STAT5 tyrosyl phosphorylation. ..
  14. Barge R, Willemze R, Vandenabeele P, Fiers W, Beyaert R. Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett. 1997;409:207-10 pubmed
    ..In contrast, DEVD-fmk as well as ZVAD-fmk protect 32D cells from ActD-induced apoptosis. These results indicate that different caspases are involved in apoptosis induced by growth factor withdrawal and by chemotherapy. ..
  15. Silvennoinen O, Witthuhn B, Quelle F, Cleveland J, Yi T, Ihle J. Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci U S A. 1993;90:8429-33 pubmed
    b>Interleukin 3 (IL-3) regulates the proliferation and differentiation of hematopoietic cells. Although the IL-3 receptor chains lack kinase catalytic domains, IL-3 induces tyrosine phosphorylation of cellular proteins...
  16. Helmy A, Carpenter K, Menon D, Pickard J, Hutchinson P. The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production. J Cereb Blood Flow Metab. 2011;31:658-70 pubmed publisher
    ..No clear arterio-jugular venous gradients were apparent. These data provide evidence for the cerebral production of these cytokines and show a stereotyped temporal pattern after TBI. ..
  17. Ichino M, Mori T, Kusaka M, Kuroyanagi Y, Ishikawa K, Shiroki R, et al. Global gene expression profiling of renal scarring in a rat model of pyelonephritis. Pediatr Nephrol. 2008;23:1059-71 pubmed publisher
    ..The products of these genes may thus potentially be novel non-invasive diagnostic or prognostic biomarkers of renal scarring. ..
  18. Okada S, Nakauchi H, Nagayoshi K, Nakamura M, Miura Y, Suda T. Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors. Exp Hematol. 1992;20:546-51 pubmed
    It has been reported that interleukin 6 (IL-6) acts on hemopoietic stem cells in synergism with interleukin 3 (IL-3), but it has not yet been clarified whether IL-6 acts directly on the stem cells or not...
  19. Seo S, Chen Y, Ivanovska I, Ranger A, Hong S, Dawson V, et al. BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J Biol Chem. 2004;279:42240-9 pubmed
    ..These findings suggest that BAD is more than an inert death factor in healthy cells; it is also a pro-survival factor, prior to its role in promoting cell death. ..
  20. Klimchenko O, Di Stefano A, Geoerger B, Hamidi S, Opolon P, Robert T, et al. Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood. 2011;117:3065-75 pubmed publisher
    ..Trophic and immunosuppressive functions of M2-polarized macrophages link fetus and tumor development, and hESCs offer a valuable experimental model for in vitro studies of mechanisms sustaining these processes. ..
  21. Cohen D, Hapel A, Young I. Cloning and expression of the rat interleukin-3 gene. Nucleic Acids Res. 1986;14:3641-58 pubmed
    ..There was little cross-reactivity of the respective IL-3 species on mouse and rat bone marrow cells suggesting that rat IL-3, in concert with its receptor, has evolved significantly away from the mouse IL-3/receptor system. ..
  22. Ito T, Jagus R, May W. Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A. 1994;91:7455-9 pubmed
    In a murine interleukin 3 (IL-3)-dependent cell line, IL-3 deprivation resulted in increased autophosphorylation of double-stranded RNA-dependent protein kinase (PKR) that has been reported to inhibit protein synthesis by phosphorylating ..
  23. Park B, Kim L, Choi Y, Lee J, Rhim T, Lee Y, et al. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. J Hum Genet. 2004;49:517-27 pubmed
    ..007). This information about the genetic association of important genes with asthma might provide valuable insights into strategies for the pathogenesis of asthma and atopy. ..
  24. Chen J, Olsen J, Ford S, Mirza S, Walker A, Murphy J, et al. A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. J Biol Chem. 2009;284:5763-73 pubmed publisher
    ..Both the SP1 and SP2 isoforms activated the Jak2/STAT5, Akt, and Erk1/2 signaling pathways in M1 cells, although the activation was more prolonged for the SP2 isoform. ..
  25. Zhang K, Liu R, Yin G, Li X, Li J, Zhang J. Differential cytokine secretion of cultured bone marrow stromal cells from patients with psoriasis and healthy volunteers. Eur J Dermatol. 2010;20:49-53 pubmed publisher
    ..Our data demonstrate for the first time that the hematopoietic microenvironment is altered in patients with psoriasis, suggesting that an aberrant hematopoietic microenvironment may be one mechanism for the pathogenesis of the disease. ..
  26. Traver D, Akashi K, Weissman I, Lagasse E. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Immunity. 1998;9:47-57 pubmed
    ..Taken together, these data suggest that Fas has a novel role in the regulation of myelopoiesis and that Fas may act as a tumor suppressor to control leukemogenic transformation in myeloid progenitor cells. ..
  27. Miyazaki T, Liu Z, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, et al. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell. 1995;81:223-31 pubmed
    ..These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation. ..
  28. Chiang C, Kanies C, Kim K, Fang W, Parkhurst C, Xie M, et al. Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol Cell Biol. 2003;23:6350-62 pubmed
    ..Thus, PP2A dephosphorylation of pSer112 is the key initiating event regulating the activation of BAD during interleukin-3 withdrawal-induced apoptosis. ..
  29. Esandi M, van Someren G, Bout A, Mulder A, Van Bekkum D, Valerio D, et al. IL-1/IL-3 gene therapy of non-small cell lung cancer (NSCLC) in rats using 'cracked' adenoproducer cells. Gene Ther. 1998;5:778-88 pubmed
    ..These findings seem to justify further exploration of IL-1 and IL-3 gene transfer for the treatment of cancers. ..
  30. Kieslinger M, Woldman I, Moriggl R, Hofmann J, Marine J, Ihle J, et al. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 2000;14:232-44 pubmed
    ..Taken together, our findings suggest that Stat5 may promote cytokine-dependent survival and proliferation of differentiating myeloid progenitor cells in stress or pathological situations, such as inflammation. ..
  31. Lum J, Bui T, Gruber M, Gordan J, DeBerardinis R, Covello K, et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 2007;21:1037-49 pubmed
    ..Together, these data suggest that HIF-1alpha contributes to the regulation of growth factor-stimulated glucose metabolism even in the absence of hypoxia...
  32. Ikeda K, Nakajima H, Suzuki K, Watanabe N, Kagami S, Iwamoto I. Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol. 2005;137 Suppl 1:45-50 pubmed
    ..These results indicate that Stat5a plays an important role in mast cell development, proliferation, and survival. ..
  33. Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui T, et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell. 2004;13:329-40 pubmed
    ..Thus, our results provide a molecular mechanism by which JNK contributes to cell survival. ..
  34. Deng A, Rapp J. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. J Clin Invest. 1995;95:2170-7 pubmed
    ..In F2(S x MNS) functionally variant alleles at both QTL influence blood pressure, but in F2(S x WKY) only the QTL marked by Nos2 is segregating alleles influencing blood pressure. ..
  35. Rick F, Schally A, Block N, Halmos G, Perez R, Fernandez J, et al. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Prostate. 2011;71:736-47 pubmed publisher
    ..Our findings shed light on the mechanism of action of LHRH antagonists in BPH. ..
  36. Zhu W, Liu N, Zhao Y, Jia H, Cui B, Ning G. Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. J Endocrinol Invest. 2010;33:751-5 pubmed publisher
    ..The interaction of 6-locus from the 5 genes might confer higher risk for GD and GO than single risk allele. ..
  37. Shelton R, Claiborne J, Sidoryk Wegrzynowicz M, Reddy R, Aschner M, Lewis D, et al. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry. 2011;16:751-62 pubmed publisher
    ..The results of this study indicate that post-mortem brain tissue samples from BA10, a region that is involved in reward-related behavior, show evidence of local inflammatory, apoptotic, and oxidative stress in MDD. ..
  38. Eschbach M, Klemm U, Kolbaum J, Blankenhaus B, Brattig N, Breloer M. Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-gamma production in mice. Parasite Immunol. 2010;32:370-83 pubmed publisher
    ..Finally, comparing artificial infections induced by subcutaneous injection of larvae to natural infections, we observed similar antigen-specific T cell responses although the natural infection led to a significantly lower worm burden...
  39. Ploemacher R, van Soest P, Boudewijn A, Neben S. Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia. 1993;7:1374-80 pubmed
    ..The observed activity of IL-12, however, required the presence of a least two factors, i.e. either IL-3 + IL-11, or IL-3 + SF. ..
  40. Wauquier N, Becquart P, Padilla C, Baize S, Leroy E. Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. PLoS Negl Trop Dis. 2010;4: pubmed publisher
    ..Immunosuppression was characterized by very low levels of circulating cytokines produced by T lymphocytes and by massive loss of peripheral CD4 and CD8 lymphocytes, probably through Fas/FasL-mediated apoptosis. ..
  41. Antoku K, Maser R, Scully W, Delach S, Johnson D. Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. Biochem Biophys Res Commun. 2001;286:1003-10 pubmed
  42. Nishihara T, Ochi M, Sugimoto K, Takahashi H, Yano H, Kumon Y, et al. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Exp Neurol. 2011;229:507-16 pubmed publisher
    ..The cytokine mixture injection significantly reduced mortality of the 5FU-treated rats. These results suggest that the combination of IL-3 and GM-CSF serves as a promising agent to ameliorate TBI via action on BINCs. ..
  43. de Wilt J, Bout A, Eggermont A, van Tiel S, de Vries M, ten Hagen T, et al. Adenovirus-mediated interleukin 3 beta gene transfer by isolated limb perfusion inhibits growth of limb sarcoma in rats. Hum Gene Ther. 2001;12:489-502 pubmed
  44. Gómez Ravetti M, Moscato P. Identification of a 5-protein biomarker molecular signature for predicting Alzheimer's disease. PLoS ONE. 2008;3:e3111 pubmed publisher
  45. Huang C, Cong L, Xie J, Qiao B, Lo S, Zheng T. Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes. BMC Proc. 2009;3 Suppl 7:S75 pubmed
    ..As we will discuss in this paper, the reported possible interactions between genes may suggest potential biological activities of RA. ..
  46. van Dijk S, Feskens E, Heidema A, Bos M, van de Rest O, Geleijnse J, et al. Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects. PLoS ONE. 2010;5:e14422 pubmed publisher
  47. Haig D, McMenamin C, Redmond J, Brown D, Young I, Cohen S, et al. Rat IL-3 stimulates the growth of rat mucosal mast cells in culture. Immunology. 1988;65:205-11 pubmed
    ..The demonstration that IL-3 is responsible for the development and proliferation of MMC should lead to a better understanding of the functional roles of these cells. ..
  48. Hilton D, Hilton A, Raicevic A, Rakar S, Harrison Smith M, Gough N, et al. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 1994;13:4765-75 pubmed
    ..The expression of both NR1 and gp130 was also necessary for Ba/F3 cells to proliferate and M1 cells to undergo macrophage differentiation in response to IL-11. ..
  49. Lum J, Bauer D, Kong M, Harris M, Li C, Lindsten T, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005;120:237-48 pubmed
    ..Thus, growth factor signal transduction is required to direct the utilization of sufficient exogenous nutrients to maintain cell viability. ..