Cebpa

Summary

Gene Symbol: Cebpa
Description: CCAAT/enhancer binding protein alpha
Alias: DBPCEP, CCAAT/enhancer-binding protein alpha, C/EBP alpha, CAAT/enhancer-binding protein, DNA-binding protein, CCAAT/enhancer binding protein (C/EBP), alpha
Species: rat

Top Publications

  1. ncbi Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells
    S Hong
    Hormone Research Center, Chonnam National University, Kwangju 500 757, Korea
    J Biol Chem 276:28098-105. 2001
  2. ncbi C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
    Brice Courselaud
    INSERM U522, CHRU Pontchaillou, 35033 Rennes Cedex, France
    J Biol Chem 277:41163-70. 2002
  3. doi C/EBPalpha identifies differentiating preadipocytes around hair follicles in foetal and neonatal rat and mouse skin
    Kamila Wojciechowicz
    School of Biological and Biomedical Sciences, University of Durham, Durham, UK
    Exp Dermatol 17:675-80. 2008
  4. ncbi The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest
    Christine Muller
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    J Biol Chem 279:7353-8. 2004
  5. pmc Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, Spinal Cord and Brain Injury Research Center, and Sanders Brown Research Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 101:2173-8. 2004
  6. ncbi Isolation of a recombinant copy of the gene encoding C/EBP
    W H Landschulz
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genes Dev 2:786-800. 1988
  7. pmc CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
    V Ossipow
    Department of Molecular Biology, University of Geneva, Switzerland
    Proc Natl Acad Sci U S A 90:8219-23. 1993
  8. pmc A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription
    John F Enwright
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0578, USA
    Mol Endocrinol 17:209-22. 2003
  9. pmc CCAAT/enhancer-binding proteins: structure, function and regulation
    Dipak P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
    Biochem J 365:561-75. 2002
  10. pmc Translational control of C/EBPalpha and C/EBPbeta isoform expression
    C F Calkhoven
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 14:1920-32. 2000

Research Grants

Scientific Experts

  • D P Ramji
  • Inci Kazkayası
  • Wei Chen
  • Steven A Bloomer
  • ROBERT JAMES MASON
  • Maria Miller
  • Hui Kang Liu
  • Hong Yin
  • Kewei Wang
  • Ming Chang Chiang
  • Christine Muller
  • María G Zubiría
  • Diego Gómez-Nicola
  • Amanda P Siegel
  • Juan Ren
  • Hung Chuan Pan
  • Joanna Karbowska
  • Jin Yu Liu
  • Jun Zhong
  • Jessica Tong
  • Qian yun Zhou
  • Veronica Ramberg
  • Y Fong
  • Xiaopeng Qi
  • Nayoung Kim
  • Rajat Sandhir
  • Katrin Zaragoza
  • Yijuang Chern
  • Xueqing Wang
  • Jonathan Brouillette
  • D H Cai
  • Richard N Day
  • Kamila Wojciechowicz
  • Achim Leutz
  • Cornelis F Calkhoven
  • Sheng Feng Chen
  • Hiromi Ikeda
  • Amandine Gautier-Stein
  • Yoshitaka Sato
  • T Nobuoka
  • Karen Keeshan
  • Svetlana Dinić
  • Qiang Tong
  • Feijie Zhang
  • Guang Cun Huang
  • Eric M Blalock
  • Sun Mi Shin
  • John F Enwright
  • Marina Tinel
  • Eduardo Spinedi
  • Elizabeth Rosenberg
  • Juana Vidal-Bravo
  • Brice Courselaud
  • A J Lincoln
  • Andres Giovambattista
  • Meei Ling Sheu
  • Hsing Ru Tien
  • Stefano Suzzi
  • Wen Jane Lee
  • Nina L Fransen
  • Xuan Wang
  • Chiang Ting Chou
  • Dongmin Li
  • Cheng Ning Yang
  • Nicole M Hays
  • Jason Sheehan
  • Chin Chang Shen
  • V Hugh Perry
  • Yi Wen Hung
  • Jie Ma
  • Shemin Lu
  • Jianhuai Zheng
  • Xi Lan
  • Yue Li
  • S Hong
  • Fang Zeng
  • Dan Guo
  • Ru Xu You
  • B T Porse
  • Zdzislaw Kochan
  • Yu Zhang
  • T A Pedersen
  • C Nerlov
  • Yu Xiang
  • Michael Tamm
  • Li Sze Yeo
  • Chiun Gung Juo
  • Didier Lardinois
  • L J Chen
  • Malin Samuelsson

Detail Information

Publications64

  1. ncbi Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells
    S Hong
    Hormone Research Center, Chonnam National University, Kwangju 500 757, Korea
    J Biol Chem 276:28098-105. 2001
    ..This observation highlights a unique mechanism by which the levels of the general replication factor can strongly modulate the functional activity of the specific transcription factor as a coactivator...
  2. ncbi C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
    Brice Courselaud
    INSERM U522, CHRU Pontchaillou, 35033 Rennes Cedex, France
    J Biol Chem 277:41163-70. 2002
    ..Taken together, these data demonstrate that C/EBPalpha is likely to be a key regulator of HEPC gene transcription and provide a novel mechanism for cross-talk between the C/EBP pathway and iron metabolism...
  3. doi C/EBPalpha identifies differentiating preadipocytes around hair follicles in foetal and neonatal rat and mouse skin
    Kamila Wojciechowicz
    School of Biological and Biomedical Sciences, University of Durham, Durham, UK
    Exp Dermatol 17:675-80. 2008
    ....
  4. ncbi The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest
    Christine Muller
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    J Biol Chem 279:7353-8. 2004
    ....
  5. pmc Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, Spinal Cord and Brain Injury Research Center, and Sanders Brown Research Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 101:2173-8. 2004
    ..These findings suggest a new model of AD pathogenesis in which a genomically orchestrated up-regulation of tumor suppressor-mediated differentiation and involution processes induces the spread of pathology along myelinated axons...
  6. ncbi Isolation of a recombinant copy of the gene encoding C/EBP
    W H Landschulz
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genes Dev 2:786-800. 1988
    ..A 60-amino-acid segment located within the DNA-binding domain of C/EBP bears sequence similarity to the products of the myc and fos oncogenes...
  7. pmc CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials
    V Ossipow
    Department of Molecular Biology, University of Geneva, Switzerland
    Proc Natl Acad Sci U S A 90:8219-23. 1993
    ..The production of multiple proteins from a single mRNA is not only shared between different C/EBP family members but also appears to be conserved in vertebrate evolution...
  8. pmc A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription
    John F Enwright
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 0578, USA
    Mol Endocrinol 17:209-22. 2003
    ..Together our results suggest that the intranuclear positioning of these factors determines whether they activate or silence PRL promoter activity...
  9. pmc CCAAT/enhancer-binding proteins: structure, function and regulation
    Dipak P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
    Biochem J 365:561-75. 2002
    ..This review deals with the structure, biological function and the regulation of the C/EBP family...
  10. pmc Translational control of C/EBPalpha and C/EBPbeta isoform expression
    C F Calkhoven
    Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    Genes Dev 14:1920-32. 2000
    ..Our results demonstrate that the translational controlled ratio of C/EBPalpha and C/EBPbeta isoform expression determines cell fate...
  11. ncbi E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo
    B T Porse
    Laboratory of Gene Therapy Research, 2100 Copenhagen Ø, Denmark
    Cell 107:247-58. 2001
    ....
  12. pmc Relationship between impaired adipogenesis of retroperitoneal adipose tissue and hypertrophic obesity: role of endogenous glucocorticoid excess
    María G Zubiría
    Neuroendocrine Unit, IMBICE CONICET La Plata CICPBA, La Plata, Argentina
    J Cell Mol Med 18:1549-61. 2014
    ....
  13. ncbi Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA
    Marina Tinel
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 481, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
    J Hepatol 39:171-8. 2003
    ..Several cytochromes P450 (CYPs) are expressed in differentiated hepatocytes, but downregulated in growth-stimulated cells. We determined the signals involved in CYP downregulation by epidermal growth factor (EGF)...
  14. ncbi Transthyretin: a key gene involved in the maintenance of memory capacities during aging
    Jonathan Brouillette
    Department of Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada H4H 1R3
    Neurobiol Aging 29:1721-32. 2008
    ..Our study provides genetic, behavioural and molecular evidence that TTR is involved in the maintenance of normal cognitive processes during aging by acting on the retinoid signalling pathway...
  15. pmc Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size
    Christine Muller
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    EMBO J 29:897-909. 2010
    The messenger RNA of the intronless CEBPA gene is translated into distinct protein isoforms through the usage of consecutive translation initiation sites...
  16. pmc Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes
    Katrin Zaragoza
    Max Delbrueck Center for Molecular Medicine, Tumorigenesis and Cell Differentiation, Robert Roessle Str 10, 13125 Berlin, Germany
    Mol Cell Biol 30:2293-304. 2010
    ..Our data suggest a tripartite balance between C/EBPalpha, E2F/DP, and pocket proteins in the control of proliferation, differentiation, and tumorigenesis...
  17. doi Lamin A/C deficiency is associated with fat infiltration of muscle and bone
    Jessica Tong
    Ageing Bone Research Program, Sydney Medical School Nepean, The University of Sydney, Penrith, NSW 2750, Australia
    Mech Ageing Dev 132:552-9. 2011
    ..In conclusion, lamin A/C could constitute the determinant factor in the pathogenesis and potential treatment of both sarcopenia and osteopenia, which are commonly observed in the frailty syndrome...
  18. ncbi Inhibition of CCAAT/enhancer-binding protein alpha and beta translation by upstream open reading frames
    A J Lincoln
    Advanced BioScience Laboratories Basic Research Program, NCI Frederick Cancer Research and Development Center, National Institutes of Health, Frederick, Maryland 21702 1201, USA
    J Biol Chem 273:9552-60. 1998
    ..Our data indicate that the uORFs regulate translation of full-length C/EBPalpha and C/EBPbeta and do not play a role in generating truncated forms of these proteins, as has been suggested by start site multiplicity models...
  19. pmc C/EBPα regulates osteoclast lineage commitment
    Wei Chen
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Proc Natl Acad Sci U S A 110:7294-9. 2013
    ..These discoveries establish C/EBPα as the key transcriptional regulator of OC lineage commitment, providing a unique therapeutic target for diseases of excessive bone resorption, such as osteoporosis and arthritis...
  20. doi The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease
    Ming Chang Chiang
    Graduate Institute of Biotechnology, Chinese Culture University, Taipei 111, Taiwan
    Biochim Biophys Acta 1812:1111-20. 2011
    ..These findings show that the impairment of PPARγ contributes to the liver dysfunction observed in HD. Treatment with PPARγ agents (TZD and rosiglitazone) enhanced the function of PPARγ, and might lead to therapeutic benefits...
  21. pmc The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide
    Veronica Ramberg
    Department of Neurochemistry, Stockholm University, SE 10691 Stockholm, Sweden
    J Neuroinflammation 8:34. 2011
    ..It is therefore important to delineate the inflammatory mediators and signaling pathways affected by Aβ deposits with the aim of defining new therapeutic targets...
  22. doi Regulation of microglial proliferation during chronic neurodegeneration
    Diego Gómez-Nicola
    Centre for Biological Sciences, University of Southampton, SO16 6YD, Southampton, United Kingdom
    J Neurosci 33:2481-93. 2013
    ....
  23. doi Effects of experimental diabetes on C/EBP proteins in rat hippocampus, sciatic nerve and ganglia
    Inci Kazkayası
    Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, 06100 Sihhiye, Ankara, Turkey
    Cell Mol Neurobiol 33:559-67. 2013
    ..This study indicated, for the first time, that DM altered the immunoreactivity of C/EBPs in the nervous system. C/EBPs might be one of the important molecular targets which are responsible for neurodegeneration seen in diabetes...
  24. pmc Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice
    Rajat Sandhir
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurochem Int 56:188-93. 2010
    ..In addition elevated C/EBPdelta levels following TBI in the aged brain may play a role in the link between TBI and Alzheimer's disease...
  25. ncbi Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease
    Ming Chang Chiang
    Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan
    Hum Mol Genet 16:483-98. 2007
    ..Treatments aimed at repairing the urea cycle deficiency may provide a new strategy for dealing with HD...
  26. doi HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes
    Juan Ren
    Department of Genetics and Molecular Biology, Xi an Jiaotong University College of Medicine, Xi an, Shaanxi 710061, PR China
    Mol Cell Endocrinol 374:35-45. 2013
    ..The results suggested that HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression...
  27. doi Reciprocal modulation of C/EBP-α and C/EBP-β by IL-13 in activated microglia prevents neuronal death
    Hung Chuan Pan
    Faculty of Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan
    Eur J Immunol 43:2854-65. 2013
    ..In parallel, ER stress-related calpain downregulates the PPAR-γ/HO-1 pathway via C/EBP-β and leads to aggravated death of activated microglia via IL-13, thereby preventing cerebral inflammation and neuronal injury. ..
  28. ncbi [Analysis of focal macular ERG in idiopathic central serous chorioretinopathy]
    N Shiroyama
    Department of Ophthalmology, Nagoya University School of Medicine, Japan
    Nippon Ganka Gakkai Zasshi 94:1048-56. 1990
    ..The present study showed that the abnormal pattern of MERG in CSC cannot be explained simply by the assumption of receptor disorientation or a disturbance of photopigment regeneration by analyzing similar conditions in normal eyes...
  29. ncbi Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene
    A Y Kolyada
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Physiol 269:C1408-16. 1995
    ..These results indicate that members of the C/EBP family of transcription factors are involved in the regulation of hepatic and vascular smooth muscle transcription of the human NHE1 gene...
  30. ncbi CCAAT-enhancer binding protein alpha is expressed in activated microglial cells after brain injury
    M Walton
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine and Health Science, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res Mol Brain Res 61:11-22. 1998
    ..These results suggest that C/EBP alpha might regulate gene expression and consequentially have a role in the activation and/or proliferation of microglia following brain injury...
  31. pmc CCAAT/enhancer binding protein alpha regulates p21 protein and hepatocyte proliferation in newborn mice
    N A Timchenko
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 17:7353-61. 1997
    ....
  32. pmc Unraveling transcription factor interactions with heterochromatin protein 1 using fluorescence lifetime imaging microscopy and fluorescence correlation spectroscopy
    Amanda P Siegel
    Indiana University School of Medicine, Department of Cellular and Integrative Physiology, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Biomed Opt 18:25002. 2013
    ..The functional significance of these interactions is discussed...
  33. pmc Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia
    Jin Yu Liu
    Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Med Food 15:923-9. 2012
    ..The results indicate that ASP can suppress the expression of hepcidin in rats with IDA, and may be useful for the treatment of IDA...
  34. doi Intermittent fasting up-regulates Fsp27/Cidec gene expression in white adipose tissue
    Joanna Karbowska
    Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland
    Nutrition 28:294-9. 2012
    ..The regulation of the Fsp27 gene expression in WAT is largely unknown. We investigated the nutritional regulation of FSP27 in WAT...
  35. doi Albumin mediates PPAR-gamma or C/EBP-alpha-induced phenotypic changes in pancreatic stellate cells
    Nayoung Kim
    Laboratory of Cellular Oncology, Korea University Graduate School of Medicine, Ansan, Gyeonggi do 425 707, Republic of Korea
    Biochem Biophys Res Commun 391:640-4. 2010
    ..Therefore, our findings suggest that albumin may be a downstream effector of PPAR-gamma and C/EBP-alpha in PSCs and that it can be an attractive molecular target for anti-fibrotic therapies...
  36. ncbi Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes
    Elizabeth Rosenberg
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Room 1, John Morgan Building, Philadelphia, PA 19104 6068, USA
    Biochim Biophys Acta 1575:82-90. 2002
    ..The data indicate that C/EBPs facilitate SP-A gene expression, possibly by overcoming transcriptional silencing...
  37. doi C/EBPα down-regulation is associated with reduced hepatic cellular viability during hypoxia in vitro and in vivo
    Qian yun Zhou
    Department of Clinical Laboratory, The First Affiliated Hospital, Chongqing Medical University, No 1 Youyi Road, Yuzhong District, Chongqing, 400016, PR China
    Exp Toxicol Pathol 63:307-10. 2011
    ..These results suggested that C/EBPα down-regulation may be one mechanism of reduced hepatocyte viability in these settings...
  38. doi Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α
    Jun Zhong
    Pulmonary Cell Research, Department Biomedicine, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Lung Cancer 73:166-70. 2011
    ..From this rat model, we conclude that in pleural mesothelioma, p38δ in C/EBP-α mediate proliferation and thus may represent new targets in mesothelioma therapy...
  39. doi Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats
    Y Fong
    Department of Surgery, Chi Mei Medical Center, Yong Kang City, Tainan County, Taiwan, ROC
    Horm Metab Res 43:261-7. 2011
    ..The changes of expression of C/EBPβ and C/EBPδ are not caused by changes of osmolarity but by D-glucose itself...
  40. pmc CCAAT/enhancer-binding protein alpha (C/EBPalpha) is critical for interleukin-4 expression in response to FcepsilonRI receptor cross-linking
    Xiaopeng Qi
    Division of Allergy and Immunology, Department of Medicine, National Jewish Health, University of Colorado Denver School of Medicine, Denver, Colorado 80206, USA
    J Biol Chem 286:16063-73. 2011
    ..Our study demonstrates that C/EBPα, in cooperation with NFAT, directly regulates Il4 gene transcription...
  41. pmc Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation
    T A Pedersen
    Laboratory of Gene Therapy Research, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Genes Dev 15:3208-16. 2001
    ....
  42. doi C/EBPα and C/EBPβ binding proteins modulate hepatocyte apoptosis through iNOS signaling pathway
    Kewei Wang
    Departments of Pediatrics and Surgery Section of Pediatric Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Biochim Biophys Acta 1813:1395-403. 2011
    ..These findings indicate that C/EBPα and C/EBPβ regulate the iNOS expression, which may further modify cell responses such as apoptosis and cell survival...
  43. pmc Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element
    M Ubeda
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 16:1479-89. 1996
    ..We conclude that CHOP may serve a dual role both as an inhibitor of the ability of C/EBP proteins to activate some target genes and as a direct activator of others...
  44. ncbi A revised sequence of the rat c/ebp gene
    A J Lincoln
    ABL Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genes Dev 8:1131-2. 1994
  45. ncbi IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP
    V Poli
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 63:643-53. 1990
    ....
  46. pmc Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma
    H Thomassin
    Le Centre de recherche en cancérologie, l Université Laval, L Hôtel Dieu de Québec, Canada
    Nucleic Acids Res 20:3091-8. 1992
    ..The high levels of C/EBP beta and gamma mRNAs in rat yolk sac and fetal liver, where C/EBP alpha is poorly expressed, suggest that C/EBP beta and/or gamma could be preponderant or early regulators of the AFP gene in these tissues...
  47. ncbi Portal blood flow regulates volume recovery of the rat liver after partial hepatectomy: molecular evaluation
    T Nobuoka
    Department of Surgery I, Sapporo Medical University Hospital, Sapporo, Japan
    Eur Surg Res 38:522-32. 2006
    ..The aim of this study was to investigate the molecular effect of portal blood flow on hepatocyte proliferation and gene regulation during liver regeneration...
  48. ncbi Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells
    Guang Cun Huang
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
    Biochem Biophys Res Commun 324:1309-18. 2004
    ..In conclusions, C/EBP-alpha gene is involved in in vitro activation of rat HSCs...
  49. pmc Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation
    Qiang Tong
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Ave, Bldg 1, Rm 207, Boston, MA 02115, USA
    Mol Cell Biol 25:706-15. 2005
    ..Thus, these results show that in addition to its previously recognized function in suppressing PPARgamma transcriptional activity, interaction of GATA factors with C/EBP is necessary for their ability to negatively regulate adipogenesis...
  50. ncbi C/EBP alpha and C/EBP beta regulate haptoglobin gene expression during rat liver development and the acute-phase response
    Svetlana Dinić
    Department of Molecular Biology, Institute for Biological Research, Despot Stefan Blvd 142, Belgrade 11060, Serbia and Montenegro
    Mol Biol Rep 32:141-7. 2005
    ..These results indicate that Hp gene transcription is regulated by C/EBP alpha during normal liver development, whereas C/EBP beta is involved in the AP regulation during the later phase of differentiation and in the adult...
  51. ncbi CCAAT enhancer-binding protein alpha suppresses the rat placental glutathione S-transferase gene in normal liver
    Hiromi Ikeda
    Departments of Biochemistry and Ophthalmology, Hokkaido University Graduate School of Medicine, N15, W7, Kita ku, Sapporo 060 8638, Japan
    J Biol Chem 281:6734-41. 2006
    ..These results indicate that C/EBPalpha is a negative regulator of GST-P gene expression in normal liver...
  52. pmc Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226
    H K Liu
    Division of Pathology and Neurosciences, Ninewells Medical School, University of Dundee, Dundee, DD1 9SY, UK
    BMC Mol Biol 7:14. 2006
    ..We aimed to establish whether CEBPalpha is a link between GSK3 and these gene promoters...
  53. ncbi Sumoylation of CCAAT/enhancer-binding protein alpha and its functional roles in hepatocyte differentiation
    Yoshitaka Sato
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Nagoya 464 8603, Japan
    J Biol Chem 281:21629-39. 2006
    ..This result suggests that BRG1 down-regulates the expression of the dihydrofolate reductase gene. These findings provide the insight that SUMO acts as a space regulator, which affects protein-protein interactions...
  54. pmc Down regulation of PSA by C/EBPalpha is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell line
    Hong Yin
    Feist Weiller Cancer Center and Department of Medicine, LSU Health Sciences Center, Shreveport, LA, USA
    BMC Cancer 6:158. 2006
    ..C/EBPalpha is a transcription factor essential for terminal differentiation of several cell types. It has not known if C/EBPalpha protein is expressed and functions in the prostate gland...
  55. ncbi Hepatic CCAAT/enhancer binding protein (C/EBP-alpha and C/EBP-beta) expression changes with riboflavin deficiency, diet restriction and starvation in rats
    R B Chapin
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA
    J Nutr 124:2365-75. 1994
    ....
  56. ncbi Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha
    Amandine Gautier-Stein
    INSERM, U 449, F 69372 Lyon, France
    J Biol Chem 281:31268-78. 2006
    ..These results allow us to identify intestine-specific regulators of the Glc6Pase gene and to improve the understanding of the differences in the regulation of gluconeogenesis in the intestine compared with the liver...
  57. ncbi Lipogenesis in fetal rat lung: importance of C/EBPalpha, SREBP-1c, and stearoyl-CoA desaturase
    Feijie Zhang
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:174-83. 2004
    ..SCD-1 and phosphatidate cytidylyltransferase are important components of the lipogenic response in the fetal lung that have not been recognized previously...
  58. pmc Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia
    Karen Keeshan
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Cell 10:401-11. 2006
    ..Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha...
  59. pmc Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells
    Robert J Mason
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Clin Invest 112:244-55. 2003
    ..In summary, KGF stimulates lipogenesis in type II cells by a coordinated expression of lipogenic enzymes and transport proteins regulated by C/EBP isoforms and SREBP-1c...
  60. ncbi Dexamethasone reverses TGF-beta-mediated inhibition of primary rat preadipocyte differentiation
    Sun Mi Shin
    Laboratory of Immunology, Korea Research Institute of Bioscience and Biotechnology, 305 333, Daejon, South Korea
    FEBS Lett 543:25-30. 2003
    ..These results indicate that dexamethasone reverses the TGF-beta-mediated suppression of adipocyte differentiation by regulating the expression of C/EBPalpha and PPARgamma, which is dependent on the cellular context...
  61. ncbi [PPARgamma and C/EBPalpha mRNA expression in the primary culture of rat preadipocytes during differentiation]
    Sheng Feng Chen
    College of Animal Science, South China Agricultural University, Guangzhou 510642
    Fen Zi Xi Bao Sheng Wu Xue Bao 40:272-5. 2007
    ..In a conclusion, this study suggested that both the initiating and maintaining of differentiation process were regulated by PPARgamma, while C/EBPalpha was likely to participate in the maintaining of differentiation process only...
  62. pmc C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1
    D H Cai
    Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 27:2772-9. 2008
    ..C/EBPalpha:cJun binds and activates the endogenous PU.1 promoter, providing one mechanism for induction of monopoiesis by this complex...
  63. doi Over-expression of C/EBP-alpha induces apoptosis in cultured rat hepatic stellate cells depending on p53 and peroxisome proliferator-activated receptor-gamma
    Xueqing Wang
    Department of Pathology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, PR China
    Biochem Biophys Res Commun 380:286-91. 2009
    ..In addition, Fas, FasL, DR4, DR5, and TRAIL were studied. The results indicated that the death receptor pathway was mainly involved and regulated by PPAR-gamma and p53 in the process of apoptosis triggered by C/EBP-alpha in HSCs...
  64. ncbi Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha
    Maria Miller
    Protein Structure Section, Macromolecular Crystallography Laboratory, and the Regulation of Cell Growth Laboratory, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    J Biol Chem 278:15178-84. 2003
    ..Our studies also help to explain the phenotypes of mice carrying targeted mutations in the C/EBPalpha bZIP region...

Research Grants1

  1. Conference:Lung Surfactant:Cellular & Molecular Biology
    Robert Mason; Fiscal Year: 2002
    ..abstract_text> ..