Arcn1

Summary

Gene Symbol: Arcn1
Description: archain 1
Alias: coatomer subunit delta, delta-COP, delta-coat protein
Species: rat
Products:     Arcn1

Top Publications

  1. Lowe M, Kreis T. In vivo assembly of coatomer, the COP-I coat precursor. J Biol Chem. 1996;271:30725-30 pubmed
    ..These results describe for the first time in vivo assembly of a coat protein complex involved in membrane traffic and extend our knowledge of how coatomer is structured. ..
  2. Xu X, Kedlaya R, Higuchi H, Ikeda S, Justice M, Setaluri V, et al. Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration. PLoS Genet. 2010;6:e1000956 pubmed publisher
    ..By positional cloning, we identified that the nur17 mouse carries a T-to-C missense mutation in archain 1 (Arcn1) gene which encodes the delta subunit of the coat protein I (COPI) complex required for intracellular trafficking...
  3. Boutchueng Djidjou M, Collard Simard G, Fortier S, Hébert S, Kelly I, Landry C, et al. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Mol Cell Proteomics. 2015;14:1079-92 pubmed publisher
    ..These results suggest the presence of a signaling mechanism that senses adenylate synthesis, ATP levels, and IR activation states and that acts in regulating IR autophosphorylation and endocytosis. ..
  4. Orcl L, Palmer D, Amherdt M, Rothman J. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993;364:732-4 pubmed
    ..COP-coated buds may therefore form essentially by self-assembly from Golgi cisternae after an initial step in which GTP is used to allow ARF binding. ..
  5. Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama Sorimachi N, et al. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem. 2006;281:11214-24 pubmed
    ..These results strongly suggest novel functions for nCL-2 that involve the membrane trafficking of mucus cells via interactions with coat protein. ..

Detail Information

Publications5

  1. Lowe M, Kreis T. In vivo assembly of coatomer, the COP-I coat precursor. J Biol Chem. 1996;271:30725-30 pubmed
    ..These results describe for the first time in vivo assembly of a coat protein complex involved in membrane traffic and extend our knowledge of how coatomer is structured. ..
  2. Xu X, Kedlaya R, Higuchi H, Ikeda S, Justice M, Setaluri V, et al. Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration. PLoS Genet. 2010;6:e1000956 pubmed publisher
    ..By positional cloning, we identified that the nur17 mouse carries a T-to-C missense mutation in archain 1 (Arcn1) gene which encodes the delta subunit of the coat protein I (COPI) complex required for intracellular trafficking...
  3. Boutchueng Djidjou M, Collard Simard G, Fortier S, Hébert S, Kelly I, Landry C, et al. The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. Mol Cell Proteomics. 2015;14:1079-92 pubmed publisher
    ..These results suggest the presence of a signaling mechanism that senses adenylate synthesis, ATP levels, and IR activation states and that acts in regulating IR autophosphorylation and endocytosis. ..
  4. Orcl L, Palmer D, Amherdt M, Rothman J. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993;364:732-4 pubmed
    ..COP-coated buds may therefore form essentially by self-assembly from Golgi cisternae after an initial step in which GTP is used to allow ARF binding. ..
  5. Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama Sorimachi N, et al. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem. 2006;281:11214-24 pubmed
    ..These results strongly suggest novel functions for nCL-2 that involve the membrane trafficking of mucus cells via interactions with coat protein. ..