Abcb1a

Summary

Gene Symbol: Abcb1a
Description: ATP binding cassette subfamily B member 1A
Alias: Abcb1, Mdr1a, ATP binding cassette subfamily B member 1A, ATP binding cassette subfamily B member 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, ATP-binding cassette, sub-family B (MDR/TAP), member 1A, ATP-binding cassette, subfamily B (MDR/TAP), member 1A, multiple drug resistant 1a
Species: rat
Products:     Abcb1a

Top Publications

  1. Goralski K, Hartmann G, Piquette Miller M, Renton K. Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br J Pharmacol. 2003;139:35-48 pubmed
    ..was to investigate if localized CNS inflammation induced by Escherichia coli lipopolysaccharide (LPS) would modify mdr1a/P-gp expression and function in the brain and liver. 2...
  2. Thiebaud N, Menetrier F, Belloir C, Minn A, Neiers F, Artur Y, et al. Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium. Neurosci Lett. 2011;505:180-5 pubmed publisher
    ..The pattern of expression and the distinct localization of the olfactory transporters showed in this work may highlight on their specific function in the whole olfactory epithelium...
  3. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond F, Mitchell A, et al. Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther. 2007;320:978-85 pubmed
    ..This reduction could explain the increased bioavailability of drugs in CRF. ..
  4. Liu H, Xu X, Yang Z, Deng Y, Liu X, Xie L. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Brain Res. 2006;1123:245-52 pubmed
    ..These results suggested that the function and expression of P-GP might be impaired in the BBB of STZ-induced diabetic rats. ..
  5. Chu X, Zhang Z, Yabut J, Horwitz S, Levorse J, Li X, et al. Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases. Mol Pharmacol. 2012;81:220-7 pubmed publisher
    ..A Wistar Hannover rat model lacking the multidrug resistance protein Mdr1a P-glycoprotein (P-gp) was generated using a rat Mdr1a-specific ZFN...
  6. Chaves C, Gómez Zepeda D, Auvity S, Menet M, Crété D, Labat L, et al. Effect of Subchronic Intravenous Morphine Infusion and Naloxone-Precipitated Morphine Withdrawal on P-gp and Bcrp at the Rat Blood-Brain Barrier. J Pharm Sci. 2016;105:350-8 pubmed
    ..microvessels, whereas naloxone-precipitated withdrawal after escalating or chronic morphine dose regimen increased Mdr1a and Bcrp mRNA levels by 1.4-fold and 2.4-fold, respectively...
  7. Ortiz D, Moseley J, Calderon G, Swift A, Li S, Arias I. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J Biol Chem. 2004;279:32761-70 pubmed
    ..These findings suggest that HAX-1 and cortactin participate in BSEP internalization from the apical membrane...
  8. Cizmarikova M, Wagnerova M, Schonova L, Habalova V, Kohut A, Linkova A, et al. MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. Pharmacogenomics J. 2010;10:62-9 pubmed publisher
    ..049, log-rank test) were observed in CC homozygotes. However, no significant association between hematologic toxicities and C3435T polymorphism was detectable. ..
  9. Yamada T, Mori Y, Hayashi R, Takada M, Ino Y, Naishiro Y, et al. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res. 2003;63:895-901 pubmed
    ..of MDR1 in intestinal tumorigenesis based on the following evidence: (a) aberrant induction of the Mdr1a (Abcb1a) gene product, P-glycoprotein, associated with nuclear accumulation of the beta-catenin protein, was observed even ..
  10. Wang Y, Qin H, Zhang C, Huan F, Yan T, Zhang L. The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Molecules. 2015;21:E46 pubmed publisher
    ..Then, Abcb1/P-GP expression was evaluated by qRT-PCR and Western blot. qRT-PCR analysis revealed that Abcb1a mRNA levels were increased in hippocampus and liver. In kidney, it only showed an upward trend...

Detail Information

Publications85

  1. Goralski K, Hartmann G, Piquette Miller M, Renton K. Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br J Pharmacol. 2003;139:35-48 pubmed
    ..was to investigate if localized CNS inflammation induced by Escherichia coli lipopolysaccharide (LPS) would modify mdr1a/P-gp expression and function in the brain and liver. 2...
  2. Thiebaud N, Menetrier F, Belloir C, Minn A, Neiers F, Artur Y, et al. Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium. Neurosci Lett. 2011;505:180-5 pubmed publisher
    ..The pattern of expression and the distinct localization of the olfactory transporters showed in this work may highlight on their specific function in the whole olfactory epithelium...
  3. Naud J, Michaud J, Boisvert C, Desbiens K, Leblond F, Mitchell A, et al. Down-regulation of intestinal drug transporters in chronic renal failure in rats. J Pharmacol Exp Ther. 2007;320:978-85 pubmed
    ..This reduction could explain the increased bioavailability of drugs in CRF. ..
  4. Liu H, Xu X, Yang Z, Deng Y, Liu X, Xie L. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Brain Res. 2006;1123:245-52 pubmed
    ..These results suggested that the function and expression of P-GP might be impaired in the BBB of STZ-induced diabetic rats. ..
  5. Chu X, Zhang Z, Yabut J, Horwitz S, Levorse J, Li X, et al. Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases. Mol Pharmacol. 2012;81:220-7 pubmed publisher
    ..A Wistar Hannover rat model lacking the multidrug resistance protein Mdr1a P-glycoprotein (P-gp) was generated using a rat Mdr1a-specific ZFN...
  6. Chaves C, Gómez Zepeda D, Auvity S, Menet M, Crété D, Labat L, et al. Effect of Subchronic Intravenous Morphine Infusion and Naloxone-Precipitated Morphine Withdrawal on P-gp and Bcrp at the Rat Blood-Brain Barrier. J Pharm Sci. 2016;105:350-8 pubmed
    ..microvessels, whereas naloxone-precipitated withdrawal after escalating or chronic morphine dose regimen increased Mdr1a and Bcrp mRNA levels by 1.4-fold and 2.4-fold, respectively...
  7. Ortiz D, Moseley J, Calderon G, Swift A, Li S, Arias I. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J Biol Chem. 2004;279:32761-70 pubmed
    ..These findings suggest that HAX-1 and cortactin participate in BSEP internalization from the apical membrane...
  8. Cizmarikova M, Wagnerova M, Schonova L, Habalova V, Kohut A, Linkova A, et al. MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. Pharmacogenomics J. 2010;10:62-9 pubmed publisher
    ..049, log-rank test) were observed in CC homozygotes. However, no significant association between hematologic toxicities and C3435T polymorphism was detectable. ..
  9. Yamada T, Mori Y, Hayashi R, Takada M, Ino Y, Naishiro Y, et al. Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice. Cancer Res. 2003;63:895-901 pubmed
    ..of MDR1 in intestinal tumorigenesis based on the following evidence: (a) aberrant induction of the Mdr1a (Abcb1a) gene product, P-glycoprotein, associated with nuclear accumulation of the beta-catenin protein, was observed even ..
  10. Wang Y, Qin H, Zhang C, Huan F, Yan T, Zhang L. The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Molecules. 2015;21:E46 pubmed publisher
    ..Then, Abcb1/P-GP expression was evaluated by qRT-PCR and Western blot. qRT-PCR analysis revealed that Abcb1a mRNA levels were increased in hippocampus and liver. In kidney, it only showed an upward trend...
  11. Huang L, Li X, Roberts J, Janosky B, Lin M. Differential role of P-glycoprotein and breast cancer resistance protein in drug distribution into brain, CSF and peripheral nerve tissues in rats. Xenobiotica. 2015;45:547-55 pubmed publisher
    1. This study was designed to evaluate how the absence of P-glycoprotein (Pgp, Mdr1a), breast cancer-resistance protein (Bcrp, Abcg2) or both affects drug distribution into sciatic nerves, brain and cerebrospinal fluid (CSF) in rats. 2...
  12. Jones S, Cyr D. Regulation and characterization of the ATP-binding cassette transporter-B1 in the epididymis and epididymal spermatozoa of the rat. Toxicol Sci. 2011;119:369-79 pubmed publisher
    ..The objective of this study was to characterize the expression profile and functional role of ABCB1a and ABCB1b along the different regions (initial segment, caput, corpus [CS], and cauda [CA]) of the adult rat ..
  13. Salimizand H, Amini S, Abdi M, Ghaderi B, Azadi N. Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia. Tumour Biol. 2016;37:791-8 pubmed publisher
    ..In the present study, the concurrent effects of three polymorphisms affecting the integrity of DNA consist of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp on development of chronic myeloid leukemia were studied...
  14. Zhu H, Liu G. Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism. Life Sci. 2004;75:1313-22 pubmed
    ..At this concentration, glutamate also enhanced rat mdr1a and mdr1b mRNA levels determined by RT-PCR analysis...
  15. Yokogawa K, Shimada T, Higashi Y, Itoh Y, Masue T, Ishizaki J, et al. Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone. Biochem Pharmacol. 2002;63:777-83 pubmed
    ..At this time, the expression of mdr1a mRNA and P-gp in the liver and intestine was increased, whereas CYP3A2 was unaffected at both the mRNA and protein ..
  16. Bankstahl J, Loscher W. Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res. 2008;82:70-85 pubmed publisher
    ..The data suggest that, at least under the conditions of the present study, alterations in Pgp are not critically involved in refractory SE. ..
  17. Hardy S, Goodfellow H, Valverde M, Gill D, Sepulveda V, Higgins C. Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 1995;14:68-75 pubmed
    ..These data demonstrate that PKC-mediated phosphorylation of P-gp regulates the activity of an endogenous chloride channel and thus indicate that P-gp is a channel regulator. ..
  18. Molinas A, Sicard G, Jakob I. Functional evidence of multidrug resistance transporters (MDR) in rodent olfactory epithelium. PLoS ONE. 2012;7:e36167 pubmed publisher
    ..Pgp and MRPs may be cellular constituents of olfactory receptor neurons and represent potential mechanisms for modulation of the olfactory response. ..
  19. Potocnik U, Ferkolj I, Glavac D, Dean M. Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Genes Immun. 2004;5:530-9 pubmed
    We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1 gene to perform association analysis in Slovenian patients with inflammatory bowel diseases and to obtain haplotype structure and patterns of linkage ..
  20. Hayashi Y, Ushijima K, Ando H, Yanagihara H, Ishikawa E, Tsuruoka S, et al. Influence of a time-restricted feeding schedule on the daily rhythm of abcb1a gene expression and its function in rat intestine. J Pharmacol Exp Ther. 2010;335:418-23 pubmed publisher
    ..It is reported that the daily rhythm of abcb1a mRNA is regulated by a circadian clock-controlled output pathway...
  21. Nakamura Y, Sato H, Motokura T. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Int J Cancer. 2006;118:2448-54 pubmed
    ..Although ploidy status and Tp53 mutations did not correlate with MDR, we found that Abcb1/Mdr1, encoding P-glycoprotein (Pgp), was significantly upregulated after K-selection...
  22. Kuo T, Yang J, Lin M, Hsu S, Lin J, Lin H, et al. Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. J Pharmacol Exp Ther. 2009;330:736-44 pubmed publisher
    ..we show that emodin has both toxic and survival effects in glioma cells and that the survival effects involve Mdr1a. Emodin inhibited the proliferation and induced apoptosis of C6 cells in a 12-h treatment, but C6 cells survived a ..
  23. Cattaneo D, Ruggenenti P, Baldelli S, Motterlini N, Gotti E, Sandrini S, et al. ABCB1 genotypes predict cyclosporine-related adverse events and kidney allograft outcome. J Am Soc Nephrol. 2009;20:1404-15 pubmed publisher
    Cyclosporine A (CsA) is a substrate of P-glycoprotein, an efflux transporter encoded by the ABCB1 gene...
  24. Han J, Lim H, Yoo Y, Shin E, Park Y, Lee S, et al. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Cancer. 2007;110:138-47 pubmed
    The authors investigated whether ABCB1, ABCC2, and ABCG2 genetic polymorphisms affect pharmacokinetics (PK) of irinotecan and treatment outcome of patients with advanced nonsmall cell lung cancer (NSCLC).
  25. Patel V, Dunn M, Sorokin A. Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. J Biol Chem. 2002;277:38915-20 pubmed
    ..These results prove the existence of a causal link between Cox-2 and P-gp activity, which would have implications for kidney function and multidrug resistance in tumors where Cox-2 is overexpressed. ..
  26. Shaik N, Giri N, Pan G, Elmquist W. P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution. Drug Metab Dispos. 2007;35:2076-85 pubmed
    ..In vivo brain distribution studies showed that the AUC(plasma) in mdr1a(-/-) CF-1 mutant mice was approximately 2-fold greater than the AUC(plasma) in the wild type, whereas the AUC(..
  27. Suzuki M, Komura H, Yoshikawa T, Enya S, Nagao A, Takubo H, et al. Characterization of gastrointestinal absorption of digoxin involving influx and efflux transporter in rats: application of mdr1a knockout (-/-) rats into absorption study of multiple transporter substrate. Xenobiotica. 2014;44:1039-45 pubmed publisher
    ..to characterize gastrointestinal absorption of digoxin using wild-type (WT) and multidrug resistance protein 1a [mdr1a; P-glycoprotein (P-gp)] knockout (-/-) rats. 2...
  28. Fujii S, Setoguchi C, Kawazu K, Hosoya K. Impact of P-glycoprotein on blood-retinal barrier permeability: comparison of blood-aqueous humor and blood-brain barrier using mdr1a knockout rats. Invest Ophthalmol Vis Sci. 2014;55:4650-8 pubmed publisher
    ..six compounds, including P-gp substrates (quinidine, digoxin, and verapamil), were investigated in wild-type and mdr1a knockout rats using retinal, aqueous humor, and brain uptake index (RUI, AHUI, and BUI, respectively) methods and ..
  29. Zhang L, Lu L, Jin S, Jing X, Yao D, Hu N, et al. Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats. Acta Pharmacol Sin. 2011;32:956-66 pubmed publisher
    ..In 5- and 8-week diabetic rats, Abcb1a mRNA levels were significantly decreased in cerebral cortices and intestinal mucosa, but dramatically increased in ..
  30. Schafer C, Gehrmann T, Richter L, Keitel V, Köhrer K, Haussinger D, et al. Modulation of gene expression profiles by hyperosmolarity and insulin. Cell Physiol Biochem. 2007;20:369-86 pubmed
    ..the insulin response of betaine homocysteine-S-methyl transferase, the multidrug resistance proteins Mdr1a (Abcb1a) and 2 (Abcb4), the Igfbp 2 and 5, cyclin G1, dual specificity phosphatase Dusp1, signal transducers and ..
  31. Saksena S, Goyal S, Raheja G, Singh V, Akhtar M, Nazir T, et al. Upregulation of P-glycoprotein by probiotics in intestinal epithelial cells and in the dextran sulfate sodium model of colitis in mice. Am J Physiol Gastrointest Liver Physiol. 2011;300:G1115-23 pubmed publisher
    ..In mice, L. acidophilus or L. rhamnosus treatment (3 × 10(9) colony-forming units) increased mdr1a/P-gp mRNA and protein expression in the ileum and colon (2- to 3-fold)...
  32. Narang V, Fraga C, Kumar N, Shen J, Throm S, Stewart C, et al. Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol. 2008;295:C440-50 pubmed publisher
    ..higher levels of drug efflux transporters such as breast cancer resistance protein (abcg2), P-glycoprotein (P-gp; abcb1a/abcb1b), and MDR protein 2 (Mrp2; abcc2) as indicted by protein and mRNA levels as well as by functional activity...
  33. Balayssac D, Cayre A, Authier N, Bourdu S, Penault Llorca F, Gillet J, et al. Patterns of P-glycoprotein activity in the nervous system during vincristine-induced neuropathy in rats. J Peripher Nerv Syst. 2005;10:301-10 pubmed
    ..With a validated rat model of VCT-induced neuropathy, (1) the expressions of mdr1a (P-gp), mdr1b (P-gp), mrp1 (MRP1), and mrp2 (MRP2) genes were assessed by quantitative real-time polymerase chain ..
  34. Donald S, Verschoyle R, Edwards R, Judah D, Davies R, Riley J, et al. Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat. Cancer Res. 2002;62:4256-62 pubmed
    ..from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human ..
  35. Iida A, Ouchi S, Oda T, Aketagawa J, Ito Y, Takizawa Y, et al. Changes of Absorptive and Secretory Transporting System of (1 ? 3) ?-D-glucan Based on Efflux Transporter in Indomethacin-induced Rat. Eur J Drug Metab Pharmacokinet. 2015;40:29-38 pubmed publisher
    ..Compared with controls, levels of Mdr1a mRNA were significantly decreased in the jejunum and ileum of 7.5 mg/kg indomethacin-treated rats...
  36. Sharma G, Mirza S, Parshad R, Srivastava A, Datta Gupta S, Pandya P, et al. CpG hypomethylation of MDR1 gene in tumor and serum of invasive ductal breast carcinoma patients. Clin Biochem. 2010;43:373-9 pubmed publisher
  37. Au A, Aziz Baba A, Goh A, Wahid Fadilah S, Teh A, Rosline H, et al. Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients. Biomed Pharmacother. 2014;68:343-9 pubmed publisher
    ..In the current study, the contribution of three common single nucleotide polymorphisms (SNPs) of ABCB1 (T1236C, G2677T/A and C3435T) and two SNPs of ABCG2 (G34A and C421A) genes in mediating resistance and/or good ..
  38. Deuchars K, Duthie M, Ling V. Identification of distinct P-glycoprotein gene sequences in rat. Biochim Biophys Acta. 1992;1130:157-65 pubmed
    ..We have also isolated a fourth clone which contains only a short, but highly conserved P-glycoprotein domain. This clone appears not be a member of the P-glycoprotein gene family, and its relationship to P-glycoprotein is unknown. ..
  39. Kwan P, Sills G, Butler E, Gant T, Meldrum B, Brodie M. Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure. Epilepsia. 2002;43:1318-23 pubmed
    ..We investigated the regional expression of mdr genes in genetically epilepsy-prone rat (GEPR) brain after a single audiogenic seizure...
  40. Rüstemoğlu A, Gul U, Gümüş Akay G, Gonul M, Yigit S, Bozkurt N, et al. MDR1 gene polymorphisms may be associated with Behçet's disease and its colchicum treatment response. Gene. 2012;505:333-9 pubmed publisher
    ..The human MDR1 (ABCB1) gene encoder P-glycoprotein (P-gp) plays a key role in drug disposition, serves as a protective mechanism against ..
  41. Fan X, Chai L, Zhang H, Wang Y, Zhang B, Gao X. Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model. Int J Mol Sci. 2015;16:27576-88 pubmed publisher
    ..accumulation of Rhodamine 123, enhanced verapamil and digoxin across the BBB in vitro model, and depressed mdr1a mRNA and P-gp expression...
  42. Chow E, Sun H, Khan A, Groothuis G, Pang K. Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo. Biopharm Drug Dispos. 2010;31:91-108 pubmed publisher
    ..In the kidney, VDR, Cyp24, Asbt and Mdr1a mRNA and protein expression increased significantly (2- to 20-fold) in 1,25(OH)2D3-treated rats, and a 28-fold ..
  43. Wojnowski L, Kulle B, Schirmer M, Schlüter G, Schmidt A, Rosenberger A, et al. NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation. 2005;112:3754-62 pubmed
    ..Genetic variants in doxorubicin transport and free radical metabolism may modulate the individual risk to develop ACT. ..
  44. Wang B, Li X, Ma X, Hong X, Lu H, Guo Y. Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type. Am J Hematol. 2008;83:795-9 pubmed publisher
    ..54%, P = 0.1057; OS: 90% vs. 61%, P = 0.2028). Our results suggest that P-gp expression is related with poor treatment outcomes of extranodal NK/T-cell lymphoma, nasal type. ..
  45. Arana M, Tocchetti G, Zecchinati F, Londero A, Dominguez C, Perdomo V, et al. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Toxicology. 2017;390:22-31 pubmed publisher
    Multidrug resistance-associated protein 2 (Mrp2, ABCC2) and P-glycoprotein (P-gp, ABCB1) constitute essential components of the intestinal biochemical barrier that prevent incorporation of food contaminants, drugs or toxic metabolites ..
  46. Robillard K, Hoque M, Bendayan R. Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model. Biochem Biophys Res Commun. 2014;444:531-6 pubmed publisher
    P-glycoprotein (P-gp, product of Mdr1a and Mdr1b genes), multidrug resistance associated proteins (Mrps), and breast cancer resistance protein (Bcrp), all members of the ATP-binding cassette (ABC) membrane-associated drug transporters ..
  47. Kikuchi S, Hata M, Fukumoto K, Yamane Y, Matsui T, Tamura A, et al. Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet. 2002;31:320-5 pubmed
    ..These findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs...
  48. Zamek Gliszczynski M, Goldstein K, Paulman A, Baker T, Ryan T. Minor compensatory changes in SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats do not detract from their utility in the study of transporter-mediated pharmacokinetics. Drug Metab Dispos. 2013;41:1174-8 pubmed publisher
    b>Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for absorption, distribution, metabolism, and excretion (ADME) studies than murine models and previously demonstrated expected alterations in the pharmacokinetics of ..
  49. Cerveny L, Neumanova Z, Karbanova S, Havlova I, Staud F. Long-term administration of tenofovir or emtricitabine to pregnant rats; effect on Abcb1a, Abcb1b and Abcg2 expression in the placenta and in maternal and fetal organs. J Pharm Pharmacol. 2016;68:84-92 pubmed publisher
    ..On the 22nd day, the placenta and maternal/fetal intestine, brain, kidneys and liver were sampled and analysed for Abcb1a, Abcb1b and Abcg2 expression; placental and newborns' weights were also monitored...
  50. Alzoubi K, Khabour O, Al Azzam S, Mayyas F. The role of multidrug resistance-1 (MDR1) variants in response to fexofenadine among Jordanians. Int J Clin Pharmacol Ther. 2013;51:880-7 pubmed publisher
    ..The MDR1 gene polymorphism C1236T was associated with the anti-allergic effect of fexofenadine among male Jordanians. ..
  51. Soares R, Do T, Mabondzo A, Pons G, Chhun S. Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain. Fundam Clin Pharmacol. 2016;30:107-16 pubmed publisher
    ..We detected statistically significant higher expression of Abcb1b and Slc16a1 genes, and lower expression of Abcb1a and Abcg2 genes between the post-natal day 14 (P14) and the adult rat microvessels...
  52. Koraichi F, Inoubli L, Lakhdari N, Meunier L, Vega A, Mauduit C, et al. Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Toxicology. 2013;310:29-38 pubmed publisher
    ..Dose-dependent and long term modulations of mRNA and protein levels of Abcb1, Abcc1, Abcg2, Abcc4 and Abcc5 were observed, along with Abcc4 protein cellular delocalization...
  53. Tang X, Wu X, Xu L, Fang Y, Wang P, Zhu G, et al. eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells. PLoS ONE. 2015;10:e0125389 pubmed publisher
    ..P-glycoprotein, phospho-eEF-2, and eEF-2 expression were determined by western blot analysis. Mdr1a gene expression was analyzed by RT-PCR...
  54. Thevenod F, Wolff N, Bork U, Lee W, Abouhamed M. Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells. Biometals. 2007;20:807-20 pubmed
    ..RT-PCR shows Cd(2+)-induced increase of expression of c-myc and of the isoform Abcb1a at 3 h. The data prove for the first time that Cd2+ induces nuclear translocation of beta-catenin in PT cells...
  55. Vigano C, Julien M, Carrier I, Gros P, Ruysschaert J. Structural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopy. J Biol Chem. 2002;277:5008-16 pubmed
    ..It is proposed that this restructuring step would allow the binding and transport of another molecule of substrate. ..
  56. Mignogna C, Staibano S, Altieri V, De Rosa G, Pannone G, Santoro A, et al. Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis. BMC Cancer. 2006;6:293 pubmed
    ..These results could be useful to predict cancer evolution and to choose the appropriate treatment: this is another step that can stimulate further promising and interesting investigations on broader study population. ..
  57. Demeuse P, Fragner P, Leroy Noury C, Mercier C, Payen L, Fardel O, et al. Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines. J Neurochem. 2004;88:23-31 pubmed
    ..The mdr1a P-gp-encoding gene is exclusively expressed in the rodent BBB...
  58. Maeng H, Kim M, Jin H, Shin S, Tsuruo T, Kim S, et al. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Drug Metab Dispos. 2007;35:1996-2005 pubmed
    ..Taken together, these observations suggest that nitrosative stress leads to the up-regulation of the message for the efflux transporter and, ultimately, to the enhanced function, probably via a NF-kappaB-dependent mechanism...
  59. Nagaya Y, Nozaki Y, Takenaka O, Watari R, Kusano K, Yoshimura T, et al. Investigation of utility of cerebrospinal fluid drug concentration as a surrogate for interstitial fluid concentration using microdialysis coupled with cisternal cerebrospinal fluid sampling in wild-type and Mdr1a(-/-) rats. Drug Metab Pharmacokinet. 2016;31:57-66 pubmed publisher
    ..the CCSF with the CISF of 12 compounds, including P-gp substrates, under steady-state conditions in wild-type and Mdr1a(-/-) rats using microdialysis coupled with cisternal CSF sampling...
  60. Brocks D, Chaudhary H, Ben Eltriki M, Elsherbiny M, El Kadi A. Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro. Can J Physiol Pharmacol. 2014;92:140-8 pubmed publisher
    ..As expected, atorvastatin caused an increase in low density lipoprotein receptor and a decrease in MDR1A mRNA in the hepatocytes...
  61. Nishioka C, Sakaeda T, Nakamura T, Moriya Y, Okamura N, Tamura T, et al. MDR1, MRP1 and MRP2 genotypes and in vitro chemosensitivity in Japanese patients with colorectal adenocarcinomas. Kobe J Med Sci. 2004;50:181-8 pubmed
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    ..Radiographic quantification of osteitis may therefore be used to identify patients with P-gp overexpression thereby providing a novel potential therapeutic target. ..
  64. Jalali A, Ghasemian S, Najafzadeh H, Galehdari H, Seifi M, Zangene F, et al. Verapamil and rifampin effect on p-glycoprotein expression in hepatocellular carcinoma. Jundishapur J Nat Pharm Prod. 2014;9:e17741 pubmed
    ..A significant difference was found between verapamil treated group and the control regarding the mRNA level. The mdr1a mRNA was significantly decreased in the verapamil group (P ≤ 0.001)...
  65. Uno S, Uraki M, Ito A, Shinozaki Y, Yamada A, Kawase A, et al. Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. Biopharm Drug Dispos. 2009;30:49-54 pubmed publisher
    ..in mRNA levels of ABC and SLC transporters between the livers of AA and control rats on D7, except in the case of Mdr1a. However, levels of Mdr1a, Mrp2 and Oatp SLC transporters were significantly lower in AA than in the control ..
  66. Chen H, Hao J, Wang L, Li Y. Coexpression of invasive markers (uPA, CD44) and multiple drug-resistance proteins (MDR1, MRP2) is correlated with epithelial ovarian cancer progression. Br J Cancer. 2009;101:432-40 pubmed publisher
    ..05). Our results suggest that the overexpression of uPA, CD44 and MRD1 is correlated with EOC progression; both uPA and CD44 are related with drug resistance during EOC metastasis and could be useful therapeutically. ..
  67. Kong L, Zhuang X, Yang H, Yuan M, Xu L, Li H. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015;5:11747 pubmed publisher
    ..The results showed that when the function of P-gp was inhibited by mdr1a-1 siRNA or tariquidar, the systemic and hepatic exposures of TP were significantly increased...
  68. van Vliet E, Aronica E, Redeker S, Marchi N, Rizzi M, Vezzani A, et al. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res. 2004;60:203-13 pubmed
    ..We investigated the temporal and region-specific expression of two isoforms of the multidrug resistance gene (mdr1a and mdr1b, both encoding for P-gp) in two regions within the temporal lobe (the dentate gyrus (DG) and the ..
  69. Yamamoto A, Shofuda T, Islam M, Nakamura Y, Yamasaki M, Okano H, et al. ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage. J Neurosci Res. 2009;87:2615-23 pubmed publisher
    b>ABCB1 is a human ABC transporter originally characterized by its ability to cause resistance to chemotherapy drugs in cancer cells, and later found to be functionally expressed in human neural stem/progenitor cells (NSPCs) in vitro...
  70. Camassei F, Arancia G, Cianfriglia M, Bosman C, Francalanci P, Rava L, et al. Nephroblastoma: multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells. Am J Clin Pathol. 2002;117:484-90 pubmed
    ..Previous chemotherapy induced P-gp overexpression in tumor cells. ..
  71. Dopp J, Moran J, Abel N, Wiegert N, Cowgill J, Olson E, et al. Influence of intermittent hypoxia on myocardial and hepatic P-glycoprotein expression in a rodent model. Pharmacotherapy. 2009;29:365-72 pubmed publisher
    ..hypoxia, which mimics obstructive sleep apnea, would upregulate myocardial and hepatic P-gp expression and Abcb1a and Abcb1b messenger RNA (mRNA) expression (genes that encode for P-gp) in an animal model...
  72. Siegsmund M, Brinkmann U, Schäffeler E, Weirich G, Schwab M, Eichelbaum M, et al. Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors. J Am Soc Nephrol. 2002;13:1847-54 pubmed
    ..Especially T and TT carriers are at risk for developing non-CCRCC, i.e., papillary and chromophobe RCC as well as oncocytic adenomas. ..
  73. Ghoneim R, Piquette Miller M. Endotoxin-Mediated Downregulation of Hepatic Drug Transporters in HIV-1 Transgenic Rats. Drug Metab Dispos. 2016;44:709-19 pubmed publisher
    ..Although an augmented inflammatory response was seen in HIV-Tg rats, similar endotoxin- mediated downregulation of Abcb1a, Abcc2, Abcg2, Abcb11, Slco1a1, Slco1a2, Slco1b2, Slc10a1, Slc22a1, Cyp3a2, and Cyp3a9 gene expression was seen in ..
  74. Booth Genthe C, Louie S, Carlini E, Li B, Leake B, Eisenhandler R, et al. Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. J Pharmacol Toxicol Methods. 2006;54:78-89 pubmed
    ..The rat Abcb1a form of P-glycoprotein (formerly known as Mdr1a), the predominate isoform in the brain, has not been described in ..
  75. Gazzin S, Strazielle N, Schmitt C, Fevre Montange M, Ostrow J, Tiribelli C, et al. Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol. 2008;510:497-507 pubmed publisher
    ..b>ABCb1 (Pgp) and ABCc1 (Mrp1) transporters are two major proteins of neuroprotection whose localization and functional ..
  76. Hardwick R, Fisher C, Street S, Canet M, Cherrington N. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Drug Metab Dispos. 2012;40:450-60 pubmed publisher
    ..Hepatic expression of the biliary transporters Abcc2 and Abcb1 was also increased in MCD animals, but the biliary efflux of EZE-GLUC was slightly diminished, whereas biliary ..
  77. Guner Y, Franklin A, Chokshi N, Castle S, Pontarelli E, Wang J, et al. P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab Invest. 2011;91:1668-79 pubmed publisher
    P-glycoprotein (Pgp), a product of the multi-drug resistance gene MDR1a, is a broad specificity efflux ATP cassette transmembrane transporter that is predominantly expressed in epithelial tissues...
  78. Bleier B. Regional expression of epithelial MDR1/P-glycoprotein in chronic rhinosinusitis with and without nasal polyposis. Int Forum Allergy Rhinol. 2012;2:122-5 pubmed publisher
    P-glycoprotein (P-gp) is a 170-kDa transmembrane glycoprotein encoded by the MDR1 (ABCB1) gene and is constitutively expressed on lower airway epithelium...
  79. Jin R, Sun R, Xu X. [Expression of multidrug resistance gene and topiramate affect expression of multidrug resistance gene in the hippocampus of spontaneous epileptic rats]. Zhonghua Er Ke Za Zhi. 2005;43:733-7 pubmed
    ..Some studies show that expression of the multidrug resistance gene (mdr1a and mdr1b) and p-glycoprotein encoded by mdr1a and mdr1b are high in the brain, especially in the hippocampus, and ..
  80. Kopriva F, Dzubak P, Potesil J, Hajduch M. The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein (PGP) expression in asthmatic children. J Asthma. 2009;46:366-70 pubmed publisher
    ..The anti-inflammatory activity of ICS is more effective in decreasing the production of pro-inflammatory mediators and results in reduced multidrug resistence (MDR-1) gene activity and expression of lymphocyte PGP in asthmatic children. ..
  81. Uno S, Kawase A, Tsuji A, Tanino T, Iwaki M. Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis. Drug Metab Pharmacokinet. 2007;22:313-21 pubmed
    ..This decrease was supported by the finding that levels of mdr1a mRNA and P-gp protein were decreased in AA rats...
  82. He Y, Bi Y, Hua Y, Liu D, Wen S, Wang Q, et al. Ultrasound microbubble-mediated delivery of the siRNAs targeting MDR1 reduces drug resistance of yolk sac carcinoma L2 cells. J Exp Clin Cancer Res. 2011;30:104 pubmed publisher
    ..MDR1 silencing led to decreased P-glycoprotein activity and drug resistance of L2-RYC cells, which may be explored as a novel approach of combined gene and chemotherapy for yolk sac carcinoma. ..
  83. Siddiqui A, Kerb R, Weale M, Brinkmann U, Smith A, Goldstein D, et al. Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med. 2003;348:1442-8 pubmed
    ..must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1 and P-glycoprotein 170)...