MSTN

Summary

Gene Symbol: MSTN
Description: myostatin
Alias: GDF8, GDF8:MSTN, growth/differentiation factor 8, GDF-8, growth differentiation factor 8
Species: pig

Top Publications

  1. Stinckens A, Bijttebier J, Luyten T, Van den Maagdenberg K, Harmegnies N, De Smet S, et al. Detection of polymorphisms in the myostatin gene in Belgian Pietrain pigs. Commun Agric Appl Biol Sci. 2005;70:37-41 pubmed
  2. Liu D, Xu Q, Zang L, Liang S, Wu Y, Wei S, et al. Identification and genetic effect of haplotypes in the promoter region of porcine myostatin gene. Anim Genet. 2011;42:6-14 pubmed publisher
    ..01). Moreover, the mRNA levels of MyHCI, MyHCIIa, MyHCIIb and MyHCIIx and the muscle fibre diameter and density were also compared between BC and CC animals. ..
  3. Stinckens A, Luyten T, Bijttebier J, Van den Maagdenberg K, Dieltiens D, Janssens S, et al. Characterization of the complete porcine MSTN gene and expression levels in pig breeds differing in muscularity. Anim Genet. 2008;39:586-96 pubmed publisher
    Myostatin (MSTN), a transforming growth factor beta superfamily member, is an essential factor for the growth and development of muscle mass...
  4. Tu P, Shiau J, Ding S, Lin E, Wu M, Wang P. The association of genetic variations in the promoter region of myostatin gene with growth traits in Duroc pigs. Anim Biotechnol. 2012;23:291-8 pubmed publisher
    ..Myostatin (MSTN), previously called GDF8, is a member of transforming growth factor β (TGFβ) superfamily...
  5. Jiao J, Yuan T, Zhou Y, Xie W, Zhao Y, Zhao J, et al. Analysis of myostatin and its related factors in various porcine tissues. J Anim Sci. 2011;89:3099-106 pubmed publisher
    ..We conclude that myostatin is a factor broadly expressed in the internal organs and muscle tissues of pigs. ..
  6. Yang T, Chen X, Huang Z, Wen W, Xu M, Chen D, et al. MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression. Animal. 2014;8:1867-72 pubmed publisher
    ..Besides, overexpression of miR-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin. Our data suggest that miR-27a positive regulates porcine myoblast proliferation via targeting myostatin. ..
  7. Yu Z, Li Y, Meng Q, Yuan J, Zhao Z, Li W, et al. Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene. Sci China C Life Sci. 2005;48:168-80 pubmed
    Myostatin (GDF8, MSTN) is a member of the transforming growth factor beta superfamily that is essential for proper regulation of skeletal muscle mass...
  8. Deng B, Wen J, Ding Y, Gao Q, Huang H, Ran Z, et al. Functional analysis of pig myostatin gene promoter with some adipogenesis- and myogenesis-related factors. Mol Cell Biochem. 2012;363:291-9 pubmed publisher
    Myostatin (MSTN) is primarily expressed in muscle and plays an important role in muscle and fat development in pigs. However, there is little information about the regulation of pig MSTN...
  9. Ma X, Cao Y, Shu D, Bi Y. Cloning and expression of swine myostatin gene and its application in animal immunization trial. Sci China C Life Sci. 2005;48:368-74 pubmed
    We have amplified swine myostatin (MSTN) gene by reverse transcription polymerase chain reaction (RT-PCR) and cloned it into pGEM-T Easy vector...
  10. Wang K, Ouyang H, Xie Z, Yao C, Guo N, Li M, et al. Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System. Sci Rep. 2015;5:16623 pubmed publisher
    ..In this study, we aimed to disrupt the porcine myostatin (MSTN) gene, which functions as a negative regulator of muscle growth...

Detail Information

Publications20

  1. Stinckens A, Bijttebier J, Luyten T, Van den Maagdenberg K, Harmegnies N, De Smet S, et al. Detection of polymorphisms in the myostatin gene in Belgian Pietrain pigs. Commun Agric Appl Biol Sci. 2005;70:37-41 pubmed
  2. Liu D, Xu Q, Zang L, Liang S, Wu Y, Wei S, et al. Identification and genetic effect of haplotypes in the promoter region of porcine myostatin gene. Anim Genet. 2011;42:6-14 pubmed publisher
    ..01). Moreover, the mRNA levels of MyHCI, MyHCIIa, MyHCIIb and MyHCIIx and the muscle fibre diameter and density were also compared between BC and CC animals. ..
  3. Stinckens A, Luyten T, Bijttebier J, Van den Maagdenberg K, Dieltiens D, Janssens S, et al. Characterization of the complete porcine MSTN gene and expression levels in pig breeds differing in muscularity. Anim Genet. 2008;39:586-96 pubmed publisher
    Myostatin (MSTN), a transforming growth factor beta superfamily member, is an essential factor for the growth and development of muscle mass...
  4. Tu P, Shiau J, Ding S, Lin E, Wu M, Wang P. The association of genetic variations in the promoter region of myostatin gene with growth traits in Duroc pigs. Anim Biotechnol. 2012;23:291-8 pubmed publisher
    ..Myostatin (MSTN), previously called GDF8, is a member of transforming growth factor β (TGFβ) superfamily...
  5. Jiao J, Yuan T, Zhou Y, Xie W, Zhao Y, Zhao J, et al. Analysis of myostatin and its related factors in various porcine tissues. J Anim Sci. 2011;89:3099-106 pubmed publisher
    ..We conclude that myostatin is a factor broadly expressed in the internal organs and muscle tissues of pigs. ..
  6. Yang T, Chen X, Huang Z, Wen W, Xu M, Chen D, et al. MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression. Animal. 2014;8:1867-72 pubmed publisher
    ..Besides, overexpression of miR-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin. Our data suggest that miR-27a positive regulates porcine myoblast proliferation via targeting myostatin. ..
  7. Yu Z, Li Y, Meng Q, Yuan J, Zhao Z, Li W, et al. Comparative analysis of the pig BAC sequence involved in the regulation of myostatin gene. Sci China C Life Sci. 2005;48:168-80 pubmed
    Myostatin (GDF8, MSTN) is a member of the transforming growth factor beta superfamily that is essential for proper regulation of skeletal muscle mass...
  8. Deng B, Wen J, Ding Y, Gao Q, Huang H, Ran Z, et al. Functional analysis of pig myostatin gene promoter with some adipogenesis- and myogenesis-related factors. Mol Cell Biochem. 2012;363:291-9 pubmed publisher
    Myostatin (MSTN) is primarily expressed in muscle and plays an important role in muscle and fat development in pigs. However, there is little information about the regulation of pig MSTN...
  9. Ma X, Cao Y, Shu D, Bi Y. Cloning and expression of swine myostatin gene and its application in animal immunization trial. Sci China C Life Sci. 2005;48:368-74 pubmed
    We have amplified swine myostatin (MSTN) gene by reverse transcription polymerase chain reaction (RT-PCR) and cloned it into pGEM-T Easy vector...
  10. Wang K, Ouyang H, Xie Z, Yao C, Guo N, Li M, et al. Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System. Sci Rep. 2015;5:16623 pubmed publisher
    ..In this study, we aimed to disrupt the porcine myostatin (MSTN) gene, which functions as a negative regulator of muscle growth...
  11. Stinckens A, Luyten T, Van den Maagdenberg K, Janssens S, De Smet S, Georges M, et al. Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor. Domest Anim Endocrinol. 2009;37:227-35 pubmed publisher
    ..Recently, a fourth possible QTN was found in porcine myostatin (MSTN)...
  12. Stratil A, Kopecny M. Genomic organization, sequence and polymorphism of the porcine myostatin (GDF8; MSTN) gene. Anim Genet. 1999;30:468-70 pubmed
  13. Patruno M, Caliaro F, Maccatrozzo L, Sacchetto R, Martinello T, Toniolo L, et al. Myostatin shows a specific expression pattern in pig skeletal and extraocular muscles during pre- and post-natal growth. Differentiation. 2008;76:168-81 pubmed
    ..Myostatin (mstn) is a secreted growth factor that plays a pivotal role in skeletal muscle mass regulation...
  14. Sonstegard T, Rohrer G, Smith T. Myostatin maps to porcine chromosome 15 by linkage and physical analyses. Anim Genet. 1998;29:19-22 pubmed
    ..The development of highly polymorphic markers associated with myostatin will support population studies to identify alleles of this gene that affects muscle mass and/or fat deposition in swine. ..
  15. McPherron A, Lee S. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci U S A. 1997;94:12457-61 pubmed
    ....
  16. Bongiorni S, Tilesi F, Bicorgna S, Iacoponi F, Willems D, Gargani M, et al. Promoter polymorphisms in genes involved in porcine myogenesis influence their transcriptional activity. BMC Genet. 2014;15:119 pubmed publisher
    ..Differentiation gene, MYOD1) and to Growth and Differentiation Factors (GDF) gene family (Myostatin gene, MSTN, GDF8), in Casertana and Large White breeds...
  17. Jia Y, Gao G, Song H, Cai D, Yang X, Zhao R. Low-protein diet fed to crossbred sows during pregnancy and lactation enhances myostatin gene expression through epigenetic regulation in skeletal muscle of weaning piglets. Eur J Nutr. 2016;55:1307-14 pubmed publisher
    ..was aimed to investigate the effects of a maternal low-protein diet on transcriptional regulation of the myostatin (MSTN) gene in skeletal muscle of weaning piglets...
  18. Li J, Deng J, Yu S, Zhang J, Cheng D, Wang H. The virtual element in proximal promoter of porcine myostatin is regulated by myocyte enhancer factor 2C. Biochem Biophys Res Commun. 2012;419:175-81 pubmed publisher
    ..Thus, we propose that MEF2C could modulate and restrain myogenesis by myostatin activation and myostatin-dependent gene processing in porcine...
  19. Tu P, Lo L, Chen Y, Hsu C, Shiau J, Lin E, et al. Polymorphisms in the promoter region of myostatin gene are associated with carcass traits in pigs. J Anim Breed Genet. 2014;131:116-22 pubmed publisher
    ..Myostatin (MSTN), previously called GDF8, is a member of transforming growth factor-β (TGF-β) superfamily...
  20. Rao S, Fujimura T, Matsunari H, Sakuma T, Nakano K, Watanabe M, et al. Efficient modification of the myostatin gene in porcine somatic cells and generation of knockout piglets. Mol Reprod Dev. 2016;83:61-70 pubmed publisher
    Myostatin (MSTN) is a negative regulator of myogenesis, and disruption of its function causes increased muscle mass in various species...