Zrsr1

Summary

Gene Symbol: Zrsr1
Description: zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
Alias: D11Ncvs75, Irlgs2, SP2, U2af1-rs1, U2afbp-rs, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1, CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1, related sequence 1, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 35 kDa, related sequence 1, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), related sequence 1, U2(RNU2) small nuclear RNA auxiliary factor 1-like 1
Species: mouse

Top Publications

  1. ncbi Genome imprinting regulated by the mouse Polycomb group protein Eed
    Jesse Mager
    Department of Genetics and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 103 Mason Farm Road, Chapel Hill, North Carolina 27599 7264, USA
    Nat Genet 33:502-7. 2003
  2. ncbi Identification of an imprinted U2af binding protein related sequence on mouse chromosome 11 using the RLGS method
    Y Hayashizaki
    RIKEN Tsukuba Life Science Center, Institute of Physical and Chemical Research, Ibaraki, Japan
    Nat Genet 6:33-40. 1994
  3. pmc Mouse U2af1-rs1 is a neomorphic imprinted gene
    A Nabetani
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Mol Cell Biol 17:789-98. 1997
  4. pmc The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene
    Youdong Wang
    Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501, Japan
    Mol Cell Biol 24:270-9. 2004
  5. pmc Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice
    Bart van De Sluis
    Laboratory of Metabolic and Endocrine Diseases, Room KC 02 069 1, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Mol Cell Biol 27:4142-56. 2007
  6. ncbi Stochastic imprinting in the progeny of Dnmt3L-/- females
    Philippe Arnaud
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
    Hum Mol Genet 15:589-98. 2006
  7. ncbi Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene
    R S Weiss
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 59:32-9. 1999
  8. ncbi The oocyte-specific methylated region of the U2afbp-rs/U2af1-rs1 gene is dispensable for its imprinted methylation
    S Sunahara
    Division of DNA Biology and Embryo Engineering, CREST, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo, Minato ku, 108 8639, Japan
    Biochem Biophys Res Commun 268:590-5. 2000
  9. ncbi Identification, expression analysis, and mapping of B3galt6, a putative galactosyl transferase gene with similarity to Drosophila brainiac
    S E Cole
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mamm Genome 12:177-9. 2001
  10. pmc DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1
    R I Gregory
    Programme in Developmental Genetics, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 21:5426-36. 2001

Scientific Experts

  • B M Cattanach
  • Philippe Arnaud
  • Andrew J Wood
  • I Hatada
  • Rebecca J Oakey
  • H Shibata
  • Y Hayashizaki
  • Xu Wang
  • Q Wang
  • Alexandre Wagschal
  • Reiner Schulz
  • Bart van De Sluis
  • M Fukasawa
  • Youdong Wang
  • K E Latham
  • M Muramatsu
  • A Nabetani
  • Jesse Mager
  • S Sunahara
  • J D Choi
  • S E Cole
  • R I Gregory
  • T Mukai
  • M Katsuki
  • R Feil
  • T Ueda
  • Wendy A Bickmore
  • Heidi G Sutherland
  • Karim Chebli
  • Kathryn Woodfine
  • Andrew G Clark
  • Amandine Henckel
  • L Mishra
  • Elaine R Mardis
  • Qi Sun
  • Robert Feil
  • Paul D Soloway
  • R S Weiss
  • Sean D McGrath
  • Gudrun E Moore
  • David Monk
  • Amy Chen
  • Roland G Roberts
  • Cisca Wijmenga
  • Arjan J Groot
  • Paul P Liu
  • Patricia Muller
  • Leo W Klomp
  • Karen Duran
  • S Morita
  • V M Chapman
  • T Horii
  • W Dean
  • S Hirotsune
  • T Ochiya
  • Y Okazaki
  • Y Gondo
  • I Kalcheva
  • C Plass
  • M Kimura
  • Akira Nabetani
  • D E Watkins-Chow
  • Sadahiko Masuko
  • Hidenobu Soejima
  • Satoshi Okinami
  • Tsunehiro Mukai
  • Hitomi Yatsuki
  • Colin V Beechey
  • Keiichiro Joh
  • Terry Magnuson
  • N Takagi
  • Fernando Pardo Manuel de Villena
  • H Morisaki
  • Nathan D Montgomery
  • W N deVries
  • R J Oakey
  • T F Vogt
  • K Yoshino
  • L P O'Neill
  • S H Johnston
  • C A Johnson
  • M S Mao
  • T E Randall
  • B M Turner
  • L A Underkoffler
  • J N Collins
  • S Khosla
  • Y G Chung
  • M Struwe
  • S M Marchegiani

Detail Information

Publications32

  1. ncbi Genome imprinting regulated by the mouse Polycomb group protein Eed
    Jesse Mager
    Department of Genetics and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 103 Mason Farm Road, Chapel Hill, North Carolina 27599 7264, USA
    Nat Genet 33:502-7. 2003
    ..These data identify Eed as a member of a new class of trans-acting factors that regulate parent-of-origin expression at imprinted loci...
  2. ncbi Identification of an imprinted U2af binding protein related sequence on mouse chromosome 11 using the RLGS method
    Y Hayashizaki
    RIKEN Tsukuba Life Science Center, Institute of Physical and Chemical Research, Ibaraki, Japan
    Nat Genet 6:33-40. 1994
    ..The amino-acid sequence deduced from the cDNA showed significant homology to the U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit...
  3. pmc Mouse U2af1-rs1 is a neomorphic imprinted gene
    A Nabetani
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Mol Cell Biol 17:789-98. 1997
    ..We have proposed the neomorphic origin of the U2af1-rs1 gene by retrotransposition and the particular mechanism of genomic imprinting of ectopic genes...
  4. pmc The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene
    Youdong Wang
    Department of Biomolecular Sciences, Saga Medical School, Saga 849 8501, Japan
    Mol Cell Biol 24:270-9. 2004
    ....
  5. pmc Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice
    Bart van De Sluis
    Laboratory of Metabolic and Endocrine Diseases, Room KC 02 069 1, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Mol Cell Biol 27:4142-56. 2007
    ..Thus, this study identifies COMMD1 as a novel regulator of HIF-1 activity and shows that Commd1 deficiency in mice leads to embryonic lethality associated with dysregulated placenta vascularization...
  6. ncbi Stochastic imprinting in the progeny of Dnmt3L-/- females
    Philippe Arnaud
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
    Hum Mol Genet 15:589-98. 2006
    ..This observation can provide a basis to understand mechanisms involved in some sporadic cases of imprinting-related diseases and polymorphic imprinting in human...
  7. ncbi Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene
    R S Weiss
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 59:32-9. 1999
    ..Finally, mouse Hus1 was found to be expressed in a variety of adult tissues and at several stages of embryonic development...
  8. ncbi The oocyte-specific methylated region of the U2afbp-rs/U2af1-rs1 gene is dispensable for its imprinted methylation
    S Sunahara
    Division of DNA Biology and Embryo Engineering, CREST, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo, Minato ku, 108 8639, Japan
    Biochem Biophys Res Commun 268:590-5. 2000
    ..We herein show that parental methylation differences still exist in the CpG island on the region II-deleted allele. These findings suggest that region II is dispensable for the imprinted methylation of the U2afbp-rs gene...
  9. ncbi Identification, expression analysis, and mapping of B3galt6, a putative galactosyl transferase gene with similarity to Drosophila brainiac
    S E Cole
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mamm Genome 12:177-9. 2001
  10. pmc DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1
    R I Gregory
    Programme in Developmental Genetics, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 21:5426-36. 2001
    ..Collectively, these data are consistent with the hypothesis that CpG methylation leads to deacetylation of histone H3, but not H4, through a process that involves selective binding of MBD proteins...
  11. ncbi Role of protein synthesis in the development of a transcriptionally permissive state in one-cell stage mouse embryos
    Q Wang
    Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biol Reprod 65:748-54. 2001
    ....
  12. ncbi Elf3 encodes a novel 200-kD beta-spectrin: role in liver development
    L Mishra
    Laboratory of Developmental Molecular Biology, Department of Veterans Affairs, Washington, DC 20422, USA
    Oncogene 18:353-64. 1999
    ..The differential expression, tissue localization, and functional studies demonstrate the importance of elf3 in modulating interactions between various components of the cytoskeleton proteins controlling liver and bile duct development...
  13. ncbi Genomic imprinting in Dicer1-hypomorphic mice
    M Fukasawa
    Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, Maebashi, Japan
    Cytogenet Genome Res 113:138-43. 2006
    ..We did not observe any abnormality in the allelic expression of imprinted genes in these mice or their offspring, suggesting that reduced expression of Dicer1 did not significantly affect the maintenance and reprogramming of imprinting...
  14. pmc Genomic imprinting in mammals: emerging themes and established theories
    Andrew J Wood
    Massachusetts General Hospital, United States of America
    PLoS Genet 2:e147. 2006
    ..We focus on a group of small imprinted domains, which consist of paternally expressed genes embedded within introns of multiexonic transcripts, to discuss the evolution of imprinting at these loci...
  15. pmc A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation
    Andrew J Wood
    Department of Medical and Molecular Genetics, King s College London, London, United Kingdom
    PLoS Genet 3:e20. 2007
    ..The striking correlation between imprinting and X chromosome provenance suggests that retrotransposed elements with homology to the X chromosome can be selectively targeted for methylation during mammalian oogenesis...
  16. pmc G9a histone methyltransferase contributes to imprinting in the mouse placenta
    Alexandre Wagschal
    Institute of Molecular Genetics, CNRS UMR 5535, and University of Montpellier, 1919, route de Mende, 34293 Montpellier, France
    Mol Cell Biol 28:1104-13. 2008
    ..These findings provide the first evidence for the involvement of an HMT and suggest that histone methylation contributes to imprinted gene repression in the trophoblast...
  17. pmc Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain
    Xu Wang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    PLoS ONE 3:e3839. 2008
    ....
  18. ncbi Stage-specific induction and regulation by genomic imprinting of the mouse U2afbp-rs gene during preimplantation development
    K E Latham
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Dev Biol 168:670-6. 1995
    ..Our data indicate that abundant expression of the U2afbp-rs gene is not essential for early development since gynogenones form blastocysts at a high frequency...
  19. ncbi Association of a redefined proximal mouse chromosome 11 imprinting region and U2afbp-rs/U2af1-rs1 expression
    B M Cattanach
    MRC Mammalian Genetics Unit, Didcot, Oxfordshire, UK
    Cytogenet Cell Genet 80:41-7. 1998
    ....
  20. ncbi Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes
    W Dean
    Laboratory of Developmental Genetics Programme, The Babraham Institute, Babraham Hall, Cambridge CB2 4AT, UK
    Development 125:2273-82. 1998
    ..Our study establishes a model for how early embryonic epigenetic alterations in imprinted genes persist to later developmental stages, and are associated with aberrant phenotypes...
  21. ncbi Requirement for protein synthesis during embryonic genome activation in mice
    Q Wang
    Fels Institute for Cancer Research and Molecular Biology, Philadelphia, Pennsylvania, USA
    Mol Reprod Dev 47:265-70. 1997
    ....
  22. ncbi Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5
    D E Watkins-Chow
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109, USA
    Genomics 40:114-22. 1997
    ..Comparison of the mouse and human maps with data for other species provides an emerging picture of mammalian chromosome evolution...
  23. ncbi Inactive allele-specific methylation and chromatin structure of the imprinted gene U2af1-rs1 on mouse chromosome 11
    H Shibata
    Genome Science Laboratory, RIKEN Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, 3 1 1 Koyadai, Tsukuba Ibaraki, 305, Japan
    Genomics 35:248-52. 1996
    ....
  24. ncbi Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin containing TCP-1 (Cct4) gene to proximal chromosome 11
    A Nabetani
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, 565, Japan
    Genomics 34:246-9. 1996
    ....
  25. pmc A new imprinted gene cloned by a methylation-sensitive genome scanning method
    I Hatada
    National Cardiovascular Center Research Institute, Osaka, Japan
    Nucleic Acids Res 21:5577-82. 1993
    ....
  26. ncbi Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5
    I Kalcheva
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffallo, NY 14263
    Cytogenet Cell Genet 68:19-24. 1995
    ..The location of the human homologue has been determined using both somatic cell hybrid genetic analysis and fluorescence in situ hybridization. These analyses have mapped the human locus U2AFBPL to human chromosome 5q23-->q31...
  27. pmc A genetic linkage map of the mouse using restriction landmark genomic scanning (RLGS)
    Y Hayashizaki
    Gene Bank, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genetics 138:1207-38. 1994
    ..Different combinations of restriction enzymes yield different sets of RLGS loci providing expanded power for genetic mapping...
  28. ncbi Genetic mapping and systematic screening of mouse endogenously imprinted loci detected with restriction landmark genome scanning method (RLGS)
    H Shibata
    Gene Bank, RIKEN Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Mamm Genome 5:797-800. 1994
  29. pmc Allele-specific methylation and expression of an imprinted U2af1-rs1 (SP2) gene
    I Hatada
    National Cardiovascular Center Research Institute, Osaka, Japan
    Nucleic Acids Res 23:36-41. 1995
    The mouse U2af1-rs1(SP2) gene, which was cloned by a two-dimensional genome scanning method, is expressed exclusively from the paternally inherited chromosome...
  30. ncbi Localization of mouse imprinted gene U2af1-rs1 to A3.2-4 band of chromosome 11 by FISH
    M Tada
    Division of Biological Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    Mamm Genome 5:655. 1994
  31. ncbi The use of restriction landmark genomic scanning to scan the mouse genome for endogenous loci with imprinted patterns of methylation
    H Shibata
    RIKEN Tsukuba Life Science Center, Ibaraki, Japan
    Electrophoresis 16:210-7. 1995
    ..Irlgs 1 and 3 are B6- and D2-specific loci that had the same strain distribution pattern which mapped to the central region of chromosome 9.(ABSTRACT TRUNCATED AT 250 WORDS)..
  32. ncbi Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes
    J D Choi
    Division of Human Genetics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 12:758-64. 2001
    ..Interpretation of the microarray data requires careful preparation of age- and strain-matched samples and attention to detail in tissue dissection technique...