Slc9a3

Summary

Gene Symbol: Slc9a3
Description: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Alias: 9030624O13Rik, AI930210, NHE-3, NHE3, sodium/hydrogen exchanger 3
Species: mouse
Products:     Slc9a3

Top Publications

  1. du Cheyron D, Chalumeau C, Defontaine N, Klein C, Kellermann O, Paillard M, et al. Angiotensin II stimulates NHE3 activity by exocytic insertion of the transporter: role of PI 3-kinase. Kidney Int. 2003;64:939-49 pubmed
    Low-concentration angiotensin II (Ang II) stimulates Na+/H+ exchanger 3 (NHE3) activity in renal proximal tubule mainly via angiotensin II type 1 (AT1) receptors...
  2. Schultheis P, Clarke L, Meneton P, Miller M, Soleimani M, Gawenis L, et al. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet. 1998;19:282-5 pubmed
    NHE3 is one of five plasma membrane Na+/H+ exchangers and is encoded by the mouse gene Slc9a3. It is expressed on apical membranes of renal proximal tubule and intestinal epithelial cells and is thought to play a major role in NaCl and ..
  3. Brooks H, Sorensen A, Terris J, Schultheis P, Lorenz J, Shull G, et al. Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics. J Physiol. 2001;530:359-66 pubmed
    The Na+-H+ exchanger NHE3 and the thiazide-sensitive Na+-Cl- cotransporter NCC are the major apical sodium transporters in the proximal convoluted tubule and the distal convoluted tubule of the kidney, respectively...
  4. Saifur Rohman M, Emoto N, Nonaka H, Okura R, Nishimura M, Yagita K, et al. Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney. Kidney Int. 2005;67:1410-9 pubmed
    ..The mRNA expression profiles of NHE3 and clock genes were examined in mice and rat kidneys...
  5. Amlal H, Ledoussal C, Sheriff S, Shull G, Soleimani M. Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3. J Physiol. 2003;553:511-22 pubmed
    The apical Na+-H+ exchanger NHE3 plays an important role in fluid reabsorption in the proximal tubule. However, whether its deletion alters the salt and water transport in the distal nephron remains unknown...
  6. Noonan W, Woo A, Nieman M, Prasad V, Schultheis P, Shull G, et al. Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine. Am J Physiol Regul Integr Comp Physiol. 2005;288:R685-91 pubmed
    b>NHE3 Na(+)/H(+) exchanger knockout (Nhe3(-/-)) mice have severe absorptive deficits in the kidney proximal tubule and intestinal tract...
  7. Fenton R, Poulsen S, de la Mora Chavez S, Soleimani M, Dominguez Rieg J, Rieg T. Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis. Kidney Int. 2017;92:397-414 pubmed publisher
    The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it facilitates sodium (re)absorption and proton secretion...
  8. Quigley R, Chakravarty S, Zhao X, Imig J, Capdevila J. Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice. Nephron Physiol. 2009;113:p23-8 pubmed publisher
    ..Expression of the sodium-hydrogen exchanger 3 (NHE3), the predominant transporter responsible for sodium transport in this segment, was measured by immunoblot...
  9. Duan Y, Weinstein A, Weinbaum S, Wang T. Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells. Proc Natl Acad Sci U S A. 2010;107:21860-5 pubmed publisher
    ..single proximal tubule showed that flow-dependent Na(+) and HCO(3)(-) reabsorption is due to a modulation of both NHE3 and vacuolar H(+)-ATPase (V-ATPase) activity...
  10. Singh V, Raheja G, Borthakur A, Kumar A, Gill R, Alakkam A, et al. Lactobacillus acidophilus upregulates intestinal NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1393-401 pubmed publisher
    ..However, the effects of LA on NHE3, the Na(+)/H(+) exchanger involved in the coupled electroneutral NaCl absorption, are not known...

Detail Information

Publications62

  1. du Cheyron D, Chalumeau C, Defontaine N, Klein C, Kellermann O, Paillard M, et al. Angiotensin II stimulates NHE3 activity by exocytic insertion of the transporter: role of PI 3-kinase. Kidney Int. 2003;64:939-49 pubmed
    Low-concentration angiotensin II (Ang II) stimulates Na+/H+ exchanger 3 (NHE3) activity in renal proximal tubule mainly via angiotensin II type 1 (AT1) receptors...
  2. Schultheis P, Clarke L, Meneton P, Miller M, Soleimani M, Gawenis L, et al. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet. 1998;19:282-5 pubmed
    NHE3 is one of five plasma membrane Na+/H+ exchangers and is encoded by the mouse gene Slc9a3. It is expressed on apical membranes of renal proximal tubule and intestinal epithelial cells and is thought to play a major role in NaCl and ..
  3. Brooks H, Sorensen A, Terris J, Schultheis P, Lorenz J, Shull G, et al. Profiling of renal tubule Na+ transporter abundances in NHE3 and NCC null mice using targeted proteomics. J Physiol. 2001;530:359-66 pubmed
    The Na+-H+ exchanger NHE3 and the thiazide-sensitive Na+-Cl- cotransporter NCC are the major apical sodium transporters in the proximal convoluted tubule and the distal convoluted tubule of the kidney, respectively...
  4. Saifur Rohman M, Emoto N, Nonaka H, Okura R, Nishimura M, Yagita K, et al. Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney. Kidney Int. 2005;67:1410-9 pubmed
    ..The mRNA expression profiles of NHE3 and clock genes were examined in mice and rat kidneys...
  5. Amlal H, Ledoussal C, Sheriff S, Shull G, Soleimani M. Downregulation of renal AQP2 water channel and NKCC2 in mice lacking the apical Na+-H+ exchanger NHE3. J Physiol. 2003;553:511-22 pubmed
    The apical Na+-H+ exchanger NHE3 plays an important role in fluid reabsorption in the proximal tubule. However, whether its deletion alters the salt and water transport in the distal nephron remains unknown...
  6. Noonan W, Woo A, Nieman M, Prasad V, Schultheis P, Shull G, et al. Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine. Am J Physiol Regul Integr Comp Physiol. 2005;288:R685-91 pubmed
    b>NHE3 Na(+)/H(+) exchanger knockout (Nhe3(-/-)) mice have severe absorptive deficits in the kidney proximal tubule and intestinal tract...
  7. Fenton R, Poulsen S, de la Mora Chavez S, Soleimani M, Dominguez Rieg J, Rieg T. Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis. Kidney Int. 2017;92:397-414 pubmed publisher
    The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it facilitates sodium (re)absorption and proton secretion...
  8. Quigley R, Chakravarty S, Zhao X, Imig J, Capdevila J. Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice. Nephron Physiol. 2009;113:p23-8 pubmed publisher
    ..Expression of the sodium-hydrogen exchanger 3 (NHE3), the predominant transporter responsible for sodium transport in this segment, was measured by immunoblot...
  9. Duan Y, Weinstein A, Weinbaum S, Wang T. Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells. Proc Natl Acad Sci U S A. 2010;107:21860-5 pubmed publisher
    ..single proximal tubule showed that flow-dependent Na(+) and HCO(3)(-) reabsorption is due to a modulation of both NHE3 and vacuolar H(+)-ATPase (V-ATPase) activity...
  10. Singh V, Raheja G, Borthakur A, Kumar A, Gill R, Alakkam A, et al. Lactobacillus acidophilus upregulates intestinal NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol. 2012;303:G1393-401 pubmed publisher
    ..However, the effects of LA on NHE3, the Na(+)/H(+) exchanger involved in the coupled electroneutral NaCl absorption, are not known...
  11. Murtazina R, Kovbasnjuk O, Zachos N, Li X, Chen Y, Hubbard A, et al. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum ve. J Biol Chem. 2007;282:25141-51 pubmed
    ..domain containing protein Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) binds to Na(+)/H(+) exchanger 3 (NHE3) and is associated with the brush border (BB) membrane of murine kidney and small intestine...
  12. Evans R, Bell S, Schultheis P, Shull G, Melvin J. Targeted disruption of the Nhe1 gene prevents muscarinic agonist-induced up-regulation of Na(+)/H(+) exchange in mouse parotid acinar cells. J Biol Chem. 1999;274:29025-30 pubmed
    ..Although multiple NHE isoforms (NHE1, NHE2, and NHE3) have been identified in salivary glands, little is known about their specific function(s) in resting and secreting ..
  13. Sandu C, Artunc F, Palmada M, Rexhepaj R, Grahammer F, Hussain A, et al. Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse. Am J Physiol Gastrointest Liver Physiol. 2006;291:G868-76 pubmed
    ..stimulating effect of serum- and glucocorticoid-inducible kinase (SGK)1 on the activity of the Na+/H+ exchanger (NHE3)...
  14. Thomson R, Wang T, Thomson B, Tarrats L, Girardi A, Mentone S, et al. Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A. 2005;102:13331-6 pubmed
    Na-H exchanger NHE3 and Cl-anion exchanger CFEX (SLC26A6, PAT1) play principal roles in the reabsorption of Na and Cl in the proximal tubule of the mammalian kidney...
  15. Grahammer F, Henke G, Sandu C, Rexhepaj R, Hussain A, Friedrich B, et al. Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1114-23 pubmed
    ..SGK1) to stimulate intestinal Na(+)-coupled glucose cotransporter 1 (SGLT1) and intestinal Na(+)/H(+) exchanger 3 (NHE3). The present study explored the contribution of SGK1 to the regulation of intestinal transport in vivo...
  16. Choi J, Shah M, Lee M, Schultheis P, Shull G, Muallem S, et al. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. J Clin Invest. 2000;105:1141-6 pubmed
    ..Several NHE isoforms have been cloned, but only NHE3 and NHE2 are known to be present on the apical membrane of the PCT...
  17. Teng C, Li Y, Stockton P, Foley J. Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney. PLoS ONE. 2011;6:e26961 pubmed publisher
    ..Taken together, our data suggest that fasting activates the energy balance program in the OSOM of the kidney. ..
  18. Woo A, Noonan W, Schultheis P, Neumann J, Manning P, Lorenz J, et al. Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect. Am J Physiol Renal Physiol. 2003;284:F1190-8 pubmed
    The degree to which loss of the NHE3 Na(+)/H(+) exchanger in the kidney contributes to impaired Na(+)-fluid volume homeostasis in NHE3-deficient (Nhe3(-/-)) mice is unclear because of the coexisting intestinal absorptive defect...
  19. Clayburgh D, Musch M, Leitges M, Fu Y, Turner J. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J Clin Invest. 2006;116:2682-94 pubmed
    ..but not LIGHT, inhibited Na+ absorption due to TNF-induced internalization of the brush border Na+/H+ exchanger NHE3. LIGHT did not cause NHE3 internalization...
  20. Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, et al. Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice. Pflugers Arch. 2007;454:575-86 pubmed
    ..transmembrane conductance regulator (CFTR), the anion exchangers SLC26A3 and SLC26A6 and the Na(+)/H(+) exchanger NHE3, all of which are major transport proteins for intestinal anion secretion and salt absorption...
  21. Zhou Q, Clarke L, Nie R, Carnes K, Lai L, Lien Y, et al. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A. 2001;98:14132-7 pubmed
    ..It is shown that estrogen regulates expression of the Na(+)/H(+) exchanger-3 (NHE3) and the rate of (22)Na(+) transport, sensitive to an NHE3 inhibitor...
  22. Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, et al. Evidence for a causal link between adaptor protein PDZK1 downregulation and Na⁺/H⁺ exchanger NHE3 dysfunction in human and murine colitis. Pflugers Arch. 2015;467:1795-807 pubmed publisher
    A dysfunction of the Na(+)/H(+) exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine...
  23. Li X, Shull G, Miguel Qin E, Zhuo J. Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension. Physiol Genomics. 2015;47:479-87 pubmed publisher
    ..The present study tested the hypothesis that the Na(+)/H(+) exchanger 3 (NHE3) is required for ANG II-induced hypertension in mice...
  24. Bacic D, Kaissling B, McLeroy P, Zou L, Baum M, Moe O. Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule. Kidney Int. 2003;64:2133-41 pubmed
    ..Proximal tubule natriuresis is effected through inhibition of the apical membrane Na/H exchanger NHE3. We examined whether dopamine directly and acutely decreases apical membrane NHE3 protein using renal tissue in two ..
  25. Laubitz D, Larmonier C, Bai A, Midura Kiela M, Lipko M, Thurston R, et al. Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis. Am J Physiol Gastrointest Liver Physiol. 2008;295:G63-G77 pubmed publisher
    Na+/H+ exchanger 3 (NHE3) provides a major route for intestinal Na+ absorption...
  26. Singh A, Liu Y, Riederer B, Engelhardt R, Thakur B, Soleimani M, et al. Molecular transport machinery involved in orchestrating luminal acid-induced duodenal bicarbonate secretion in vivo. J Physiol. 2013;591:5377-91 pubmed publisher
    ..Using genetically engineered mouse models lacking Scl26a3, Slc26a6, Slc26a9 or Slc9a3 (NHE3), the study was carried out to assess the role of these transporters in mediating the protective duodenal ..
  27. Xia W, Yu Q, Riederer B, Singh A, Engelhardt R, Yeruva S, et al. The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine. Pflugers Arch. 2014;466:1541-56 pubmed
    ..was performed in anaesthetised wild type (WT) as well as in mice deficient in DRA, PAT-1, Na+/H+ exchanger 3 (NHE3) or NHE2, and in carbonic anhydrase II (CAII). Unbuffered saline (pH 7...
  28. Magalhães D, Cabral J, Soares da Silva P, Magro F. Role of epithelial ion transports in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2016;310:G460-76 pubmed publisher
    ..In addition, the downregulation of apical NHE and ENaC and the upregulation of apical large-conductance KC all contribute to the IBD-associated diarrhea by lowering sodium absorption and/or increasing potassium secretion. ..
  29. Larmonier C, Laubitz D, Thurston R, Bucknam A, Hill F, Midura Kiela M, et al. NHE3 modulates the severity of colitis in IL-10-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2011;300:G998-G1009 pubmed publisher
    b>NHE3, the major intestinal Na(+)/H(+) exchanger, was shown to be downregulated and/or inhibited in patients with inflammatory bowel disease (IBD), a phenomenon believed to contribute to inflammation-associated diarrhea...
  30. Pasham V, Rotte A, Gu S, Yang W, Bhandaru M, Rexhepaj R, et al. Upregulation of intestinal NHE3 following saline ingestion. Kidney Blood Press Res. 2013;37:48-57 pubmed publisher
    ..SGK1 is in turn a powerful stimulator of the intestinal Na(+)/H(+) exchanger NHE3. The present study was thus performed to elucidate, whether the NaCl content of beverages influences NHE3 activity...
  31. Tamimi R, Steingrimsson E, Montgomery Dyer K, Copeland N, Jenkins N, Tapscott S. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively. Genomics. 1997;40:355-7 pubmed
    ..NEUROD2 maps to human chromosome 17q12 and mouse chromosome 11. NEUROD3 maps to human chromosome 5q23-q31 and mouse chromosome 13. ..
  32. Pathak B, Shull G, Jenkins N, Copeland N. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996;31:261-3 pubmed
    The Na/H exchanger genes Slc9a1, Slc9a2, Slc9a3, and Slc9a4 have been mapped in the mouse using an interspecific backcross panel...
  33. Mennone A, Biemesderfer D, Negoianu D, Yang C, Abbiati T, Schultheis P, et al. Role of sodium/hydrogen exchanger isoform NHE3 in fluid secretion and absorption in mouse and rat cholangiocytes. Am J Physiol Gastrointest Liver Physiol. 2001;280:G247-54 pubmed
    ..The isoform NHE3 has been localized to apical surfaces of epithelia and in some tissues may facilitate the absorption of NaCl...
  34. Petrovic S, Barone S, Wang Z, McDonough A, Amlal H, Soleimani M. Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule. Am J Nephrol. 2008;28:330-8 pubmed
    ..The purpose of the present study was to examine the effect of Slc26a6 deletion on the apical Na+/H+ exchanger 3 (NHE3) in the straight segment (S3) of the proximal tubule, which is the major site for the reabsorption of filtered ..
  35. Wang Y, Lin Y, Wu Y, Chen Y, Lin Y, Cheng C, et al. Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice. PLoS Genet. 2017;13:e1006715 pubmed publisher
    ..Some patients have a single copy deletion of the solute carrier family 9 isoform 3 (SLC9A3) gene...
  36. Nishinaga H, Komatsu R, Doi M, Fustin J, Yamada H, Okura R, et al. Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla. Biomed Res. 2009;30:87-93 pubmed
    Renal tubular NHE3, the Na+/H+ exchanger, is a critical enzyme for electrolyte and acid-base homeostasis in the kidney...
  37. Schultheis P, Clarke L, Meneton P, Harline M, Boivin G, Stemmermann G, et al. Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J Clin Invest. 1998;101:1243-53 pubmed
    ....
  38. Bosse A, Stoykova A, Nieselt Struwe K, Chowdhury K, Copeland N, Jenkins N, et al. Identification of a novel mouse Iroquois homeobox gene, Irx5, and chromosomal localisation of all members of the mouse Iroquois gene family. Dev Dyn. 2000;218:160-74 pubmed
    ..Together, with the data obtained from the chromosomal mapping analysis, the results indicate that these genes have appeared in vertebrates during evolution as a result of gene duplication. ..
  39. Lee M, Ahn W, Choi J, Luo X, Seo J, Schultheis P, et al. Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct. J Clin Invest. 2000;105:1651-8 pubmed
    ..H(+) transporters, we characterized H(+) efflux mechanisms in the pancreatic duct in wild-type, NHE2(-/-), and NHE3(-/-) mice...
  40. Park J, Ryu J, Yun S, Kim M, Han H. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: involvement of RhoA, Ca(2+)/CaM, and ERK. Biochim Biophys Acta. 2012;1820:1618-27 pubmed publisher
    ..Thus, this study analyzed the relationship between FN and NHE in regulating the migration of mouse ESCs and their related signaling pathways. ..
  41. Shawki A, Engevik M, Kim R, Knight P, Baik R, Anthony S, et al. Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse. Am J Physiol Gastrointest Liver Physiol. 2016;311:G423-30 pubmed publisher
    ..exchanger (NHE) isoforms by examining iron homeostasis and intestinal iron handling in mice lacking NHE2 or NHE3. We observed modestly depleted liver iron stores in NHE2-null (NHE2(-/-)) mice stressed on a low-iron diet but no ..
  42. Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, et al. Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3. Cell Physiol Biochem. 2013;32:1386-402 pubmed
    Trafficking, brush border membrane (BBM) retention, and signal-specific regulation of the Na+/H+ exchanger NHE3 is regulated by the Na+/H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adaptor proteins, which enable the formation of ..
  43. Wang T, Yang C, Abbiati T, Shull G, Giebisch G, Aronson P. Essential role of NHE3 in facilitating formate-dependent NaCl absorption in the proximal tubule. Am J Physiol Renal Physiol. 2001;281:F288-92 pubmed
    ..The formate recycling process requires H(+) secretion. Although Na(+)-H(+) exchanger isoform NHE3 accounts for the largest component of H(+) secretion in the proximal tubule, 40-50% of the rates of HCO absorption ..
  44. Gawenis L, Hut H, Bot A, Shull G, de Jonge H, Stien X, et al. Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel. Am J Physiol Gastrointest Liver Physiol. 2004;287:G1140-9 pubmed
    ..Under basal conditions, electroneutral Na(+) absorption mediated by Na(+)/H(+) exchanger 3 (NHE3) predominates; under stimulated conditions, increased anion secretion mediated by CFTR occurs concurrently with ..
  45. Boedtkjer E, Praetorius J, Matchkov V, Stankevicius E, Mogensen S, Füchtbauer A, et al. Disruption of Na+,HCO₃⁻ cotransporter NBCn1 (slc4a7) inhibits NO-mediated vasorelaxation, smooth muscle Ca²⁺ sensitivity, and hypertension development in mice. Circulation. 2011;124:1819-29 pubmed publisher
    ..Intracellular acidification of smooth muscle and endothelial cells after knockout of NBCn1 inhibits NO-mediated and rho-kinase-dependent signaling in isolated arteries and perturbs blood pressure regulation. ..
  46. Baum M, Twombley K, Gattineni J, Joseph C, Wang L, Zhang Q, et al. Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice. Am J Physiol Renal Physiol. 2012;303:F1495-502 pubmed publisher
    b>NHE3 is the predominant Na(+)/H(+) exchanger on the brush-border membrane (BBM) of the proximal tubule in adults. However, NHE3 null mice still have significant renal BBM Na(+)/H(+) activity...
  47. Shull G, Miller M, Schultheis P. Lessons from genetically engineered animal models VIII. Absorption and secretion of ions in the gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2000;278:G185-90 pubmed
    ..This approach is leading to a clearer understanding of the functions of these transporters in the living animal...
  48. Siyanov V, Baltz J. NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos. Biol Reprod. 2013;88:157 pubmed publisher
    ..membrane NHE isoforms, mouse oocytes and preimplantation embryos express mRNAs encoding NHE1 (SLC9A1), NHE3 (SLC9A3), and NHE4 (SLC9A4), with higher mRNA levels for each in oocytes through one-cell stage embryos and lower levels ..
  49. Praetorius J, Andreasen D, Jensen B, Ainsworth M, Friis U, Johansen T. NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000;278:G197-206 pubmed
    ..NHE1, NHE2, and NHE3 were expressed at the mRNA level (RT-PCR) as well as at the protein level (Western blot analysis)...
  50. Lorenz J, Schultheis P, Traynor T, Shull G, Schnermann J. Micropuncture analysis of single-nephron function in NHE3-deficient mice. Am J Physiol. 1999;277:F447-53 pubmed
    The Na/H exchanger isoform 3 (NHE3) is expressed in the proximal tubule and thick ascending limb and contributes to the reabsorption of fluid and electrolytes in these segments...
  51. Catalán M, Nakamoto T, Gonzalez Begne M, Camden J, Wall S, Clarke L, et al. Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland. J Physiol. 2010;588:713-24 pubmed publisher
    ..In summary, our results demonstrate that NaCl absorption requires and is likely to be mediated by functionally dependent Cftr and ENaC channels localized to the apical membranes of mouse salivary gland duct cells. ..
  52. Good D, George T, Watts B. Nongenomic regulation by aldosterone of the epithelial NHE3 Na(+)/H(+) exchanger. Am J Physiol Cell Physiol. 2006;290:C757-63 pubmed
    ..In the MTAL, apical NHE3 mediates H(+) secretion necessary for HCO(3)(-) absorption; basolateral NHE1 influences HCO(3)(-) absorption by ..
  53. Jeong H, Jeon U, Koo B, Kim W, Im S, Shin J, et al. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest. 2009;119:3290-300 pubmed publisher
    ....
  54. Lin Z, Jin S, Duan X, Wang T, Martini S, Hulamm P, et al. Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3). J Biol Chem. 2011;286:22833-45 pubmed publisher
    ..Absence of ClC-5 in mice is associated with reduced surface expression of NHE3 in proximal tubules. The molecular basis for this change is not fully understood...
  55. Cinar A, Chen M, Riederer B, Bachmann O, Wiemann M, Manns M, et al. NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes. J Physiol. 2007;581:1235-46 pubmed
    The PDZ-binding protein PDZK1 (NHERF3/CAP70/PDZ-dc-1) in vitro binds to NHE3, but its role in the regulation of NHE3 activity in native enterocytes is unknown...
  56. Nakamura K, Stokes J, McCray P. Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung. Am J Physiol Cell Physiol. 2002;283:C762-72 pubmed
    ....
  57. He P, Zhao L, Zhu L, Weinman E, De Giorgio R, Koval M, et al. Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss. J Clin Invest. 2015;125:3519-31 pubmed publisher
    ..We found that the expression of Na+/H+ exchanger NHE3 and several scaffold proteins, including NHE3 regulatory factors (NHERFs), inositol trisphosphate (IP₃) receptor-..
  58. Shenolikar S, Voltz J, Minkoff C, Wade J, Weinman E. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A. 2002;99:11470-5 pubmed
    ..were identified as essential factors for protein kinase A-mediated inhibition of the sodium-hydrogen exchanger, NHE3. NHERF-1 and NHERF-2 also bound other cellular targets including the sodium-phosphate cotransporter type IIa ..
  59. Larmonier C, Laubitz D, Hill F, Shehab K, Lipinski L, Midura Kiela M, et al. Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2013;305:G667-77 pubmed publisher
    ..b>NHE3 expression is essential for the maintenance of the epithelial barrier function...
  60. Singh A, Riederer B, Chen M, Xiao F, Krabbenhöft A, Engelhardt R, et al. The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function. Am J Physiol Cell Physiol. 2010;298:C1057-65 pubmed publisher
    ..The duodena of anesthetized CFTR-, NHE3-, Slc26a6-, and Scl26a3-deficient mice and wild-type (WT) littermates were perfused, and duodenal bicarbonate (HCO(..
  61. Lin S, Yeruva S, He P, Singh A, Zhang H, Chen M, et al. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology. 2010;138:649-58 pubmed publisher
    ..The bulk of sodium and water absorption in the intestine is mediated by Na(+)/H(+) exchanger 3 (NHE3), located in the luminal membrane of enterocytes...
  62. Beck F, Neuhofer W, Dörge A, Giebisch G, Wang T. Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice. Pflugers Arch. 2003;446:100-5 pubmed
    ..absorption is greatly reduced in mice in which the gene encoding the Na/H exchanger isoform 3 has been ablated (NHE3-/-)...