Pten

Summary

Gene Symbol: Pten
Description: phosphatase and tensin homolog
Alias: 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, mitochondrial PTENalpha, mutated in multiple advanced cancers 1
Species: mouse
Products:     Pten

Top Publications

  1. Snaidero N, Mobius W, Czopka T, Hekking L, Mathisen C, Verkleij D, et al. Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell. 2014;156:277-90 pubmed publisher
    ..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life. ..
  2. Perets R, Wyant G, Muto K, Bijron J, Poole B, Chin K, et al. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell. 2013;24:751-65 pubmed publisher
    ..lesion to high-grade serous ovarian and peritoneal carcinomas in animal models targeting the Brca, Tp53, and Pten genes...
  3. Melchor L, Molyneux G, Mackay A, Magnay F, Atienza M, Kendrick H, et al. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol. 2014;233:124-37 pubmed publisher
    ..Here, we generated mice in which Brca2, Pten and p53 were depleted in either basal mammary epithelial cells or luminal oestrogen receptor (ER)-negative cells...
  4. Aytes A, Mitrofanova A, Lefebvre C, Alvarez M, Castillo Martin M, Zheng T, et al. Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 2014;25:638-651 pubmed publisher
    ..Thus, genome-wide cross-species interrogation of regulatory networks represents a valuable strategy to identify causal mechanisms of human cancer. ..
  5. Liu J, Voisin V, Wang S, Wang D, Jones R, Datti A, et al. Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014;6:1542-60 pubmed publisher
    The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood...
  6. Moorehead R, Hojilla C, De Belle I, Wood G, Fata J, Adamson E, et al. Insulin-like growth factor-II regulates PTEN expression in the mammary gland. J Biol Chem. 2003;278:50422-7 pubmed
    The tumor suppressor PTEN is altered in many cancers, including breast cancer, but only a handful of factors are known to control its expression...
  7. King J, Xu J, Wongvipat J, Hieronymus H, Carver B, Leung D, et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 2009;41:524-6 pubmed publisher
    ..TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
  8. Gregorian C, Nakashima J, Dry S, Nghiemphu P, Smith K, Ao Y, et al. PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A. 2009;106:19479-84 pubmed publisher
    ..In a series of genetically engineered murine models, we perturbed RAS/RAF/MAPK or/and PTEN/PI3K/AKT pathway, individually or simultaneously, via conditional activation of K-ras oncogene or deletion of Nf1 ..
  9. Gu T, Zhang Z, Wang J, Guo J, Shen W, Yin Y. CREB is a novel nuclear target of PTEN phosphatase. Cancer Res. 2011;71:2821-5 pubmed publisher
    b>PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions...
  10. Xiao A, Wu H, Pandolfi P, Louis D, van Dyke T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002;1:157-68 pubmed
    ..Indeed, astrocytoma development was accelerated in a PTEN(+/-), but not p53(+/-), background...

Detail Information

Publications112 found, 100 shown here

  1. Snaidero N, Mobius W, Czopka T, Hekking L, Mathisen C, Verkleij D, et al. Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell. 2014;156:277-90 pubmed publisher
    ..Our model can explain assembly of myelin as a multilayered structure, abnormal myelin outfoldings in neurological disease, and plasticity of myelin biogenesis observed in adult life. ..
  2. Perets R, Wyant G, Muto K, Bijron J, Poole B, Chin K, et al. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell. 2013;24:751-65 pubmed publisher
    ..lesion to high-grade serous ovarian and peritoneal carcinomas in animal models targeting the Brca, Tp53, and Pten genes...
  3. Melchor L, Molyneux G, Mackay A, Magnay F, Atienza M, Kendrick H, et al. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol. 2014;233:124-37 pubmed publisher
    ..Here, we generated mice in which Brca2, Pten and p53 were depleted in either basal mammary epithelial cells or luminal oestrogen receptor (ER)-negative cells...
  4. Aytes A, Mitrofanova A, Lefebvre C, Alvarez M, Castillo Martin M, Zheng T, et al. Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. Cancer Cell. 2014;25:638-651 pubmed publisher
    ..Thus, genome-wide cross-species interrogation of regulatory networks represents a valuable strategy to identify causal mechanisms of human cancer. ..
  5. Liu J, Voisin V, Wang S, Wang D, Jones R, Datti A, et al. Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K. EMBO Mol Med. 2014;6:1542-60 pubmed publisher
    The tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood...
  6. Moorehead R, Hojilla C, De Belle I, Wood G, Fata J, Adamson E, et al. Insulin-like growth factor-II regulates PTEN expression in the mammary gland. J Biol Chem. 2003;278:50422-7 pubmed
    The tumor suppressor PTEN is altered in many cancers, including breast cancer, but only a handful of factors are known to control its expression...
  7. King J, Xu J, Wongvipat J, Hieronymus H, Carver B, Leung D, et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet. 2009;41:524-6 pubmed publisher
    ..TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
  8. Gregorian C, Nakashima J, Dry S, Nghiemphu P, Smith K, Ao Y, et al. PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A. 2009;106:19479-84 pubmed publisher
    ..In a series of genetically engineered murine models, we perturbed RAS/RAF/MAPK or/and PTEN/PI3K/AKT pathway, individually or simultaneously, via conditional activation of K-ras oncogene or deletion of Nf1 ..
  9. Gu T, Zhang Z, Wang J, Guo J, Shen W, Yin Y. CREB is a novel nuclear target of PTEN phosphatase. Cancer Res. 2011;71:2821-5 pubmed publisher
    b>PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions...
  10. Xiao A, Wu H, Pandolfi P, Louis D, van Dyke T. Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002;1:157-68 pubmed
    ..Indeed, astrocytoma development was accelerated in a PTEN(+/-), but not p53(+/-), background...
  11. Ruan H, Li J, Ren S, Gao J, Li G, Kim R, et al. Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury. J Mol Cell Cardiol. 2009;46:193-200 pubmed publisher
    b>PTEN is a dual lipid and protein phosphatase that antagonizes PI3K as well as other signaling pathways and regulates cellular survival and growth. However, its potential role in cardiac ischemia/reperfusion injury remains unknown...
  12. Alimonti A, Carracedo A, Clohessy J, Trotman L, Nardella C, Egia A, et al. Subtle variations in Pten dose determine cancer susceptibility. Nat Genet. 2010;42:454-8 pubmed publisher
    ..However, this hypothesis has not yet been definitively supported in vivo. Pten is a TSG frequently lost in human cancer and mutated in inherited cancer-predisposition syndromes...
  13. Dong Y, Sui L, Yamaguchi F, Kamitori K, Hirata Y, Suzuki A, et al. Role of phosphatase and tensin homolog in the development of the mammalian auditory system. Neuroreport. 2010;21:731-5 pubmed publisher
    Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene that controls neural stem cell renewal and differentiation and is a potential target for regeneration in the optic nerve...
  14. Darido C, Georgy S, Wilanowski T, Dworkin S, Auden A, Zhao Q, et al. Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis. Cancer Cell. 2011;20:635-48 pubmed publisher
    ..Deletion of Grhl3 in adult epidermis evokes loss of expression of PTEN, a direct GRHL3 target, resulting in aggressive SCC induced by activation of PI3K/AKT/mTOR signaling...
  15. Mulholland D, Kobayashi N, Ruscetti M, Zhi A, Tran L, Huang J, et al. Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer Res. 2012;72:1878-89 pubmed publisher
    b>PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis...
  16. Zhong C, Saribekyan G, Liao C, Cohen M, Roy Burman P. Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis. Cancer Res. 2006;66:2188-94 pubmed
    ..overexpression of a mitogenic polypeptide (fibroblast growth factor 8, isoform b or FGF8b) and loss of function of PTEN tumor suppressor] were recapitulated into a new combinatorial mouse model...
  17. Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, Shen Y, et al. Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science. 2008;319:611-3 pubmed publisher
    ..We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of ..
  18. Huang X, Wullschleger S, Shpiro N, McGuire V, Sakamoto K, Woods Y, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J. 2008;412:211-21 pubmed publisher
    ..the importance of the LKB1-AMPK pathway in regulating tumorigenesis in mice resulting from deficiency of the PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor, which drives cell growth through ..
  19. Memarzadeh S, Zong Y, Janzen D, Goldstein A, Cheng D, Kurita T, et al. Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. Proc Natl Acad Sci U S A. 2010;107:17298-303 pubmed publisher
    ..In the majority of these tumors, PTEN expression is lost in the epithelium but maintained in tumor stroma...
  20. Bronisz A, Godlewski J, Wallace J, Merchant A, Nowicki M, Mathsyaraja H, et al. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011;14:159-67 pubmed publisher
    b>PTEN (Phosphatase and tensin homolog deleted on chromosome 10) expression in stromal fibroblasts suppresses epithelial mammary tumours, but the underlying molecular mechanisms remain unknown...
  21. Daikoku T, Hirota Y, Tranguch S, Joshi A, DeMayo F, Lydon J, et al. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 2008;68:5619-27 pubmed publisher
    ..b>Pten(+/-) mice are currently being used as a model to study EMC...
  22. Ahmad I, Morton J, Singh L, Radulescu S, Ridgway R, Patel S, et al. ?-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene. 2011;30:178-89 pubmed publisher
    ..These lesions were characterized by a marked increase of the phosphatase and tensin homologue (PTEN) tumour suppressor protein...
  23. Lee J, Nakada D, Yilmaz O, Tothova Z, Joseph N, Lim M, et al. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell. 2010;7:593-605 pubmed publisher
    b>Pten deficiency depletes hematopoietic stem cells (HSCs) but expands leukemia-initiating cells, and the mTOR inhibitor, rapamycin, blocks these effects...
  24. Ding Z, Wu C, Jaskelioff M, Ivanova E, Kost Alimova M, Protopopov A, et al. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012;148:896-907 pubmed publisher
    ..telomerase reverse transcriptase (mTert) allele was crossed onto a prostate cancer-prone mouse model null for Pten and p53 tumor suppressors...
  25. Muir K, Hazim A, He Y, Peyressatre M, Kim D, Song X, et al. Proteomic and lipidomic signatures of lipid metabolism in NASH-associated hepatocellular carcinoma. Cancer Res. 2013;73:4722-31 pubmed publisher
    ..Mice with hepatocytic deletion of Pten develop NASH and HCC later in life...
  26. Omori S, Cato M, Anzelon Mills A, Puri K, Shapiro Shelef M, Calame K, et al. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity. 2006;25:545-57 pubmed
    ..Consistently, mice lacking the lipid phosphatase, PTEN, in B cells exhibited a hyper-IgM condition due to impaired CSR, which could be restored in vitro by specific ..
  27. Schade B, Rao T, Dourdin N, Lesurf R, Hallett M, Cardiff R, et al. PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis. J Biol Chem. 2009;284:19018-26 pubmed publisher
    Overexpression and/or amplification of the ErbB-2 oncogene as well as inactivation of the PTEN tumor suppressor are two important genetic events in human breast carcinogenesis...
  28. Ellwood Yen K, Keilhack H, Kunii K, Dolinski B, Connor Y, Hu K, et al. PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models. Cancer Res. 2011;71:3052-65 pubmed publisher
    ..Unexpectedly, long-term PDK1 knockdown revealed a lack of potent antitumor efficacy in 3 different mouse models of PTEN-deficient cancer...
  29. Glass C, Singla D. MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart. Am J Physiol Heart Circ Physiol. 2011;301:H2038-49 pubmed publisher
    ..05). Our data suggest miR-1 drives cardiac myocyte differentiation from transplanted ES cells and inhibits apoptosis post-MI, ultimately giving rise to enhanced cardiac repair, regeneration, and function. ..
  30. Kalaitzidis D, Sykes S, Wang Z, Punt N, Tang Y, Ragu C, et al. mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell. 2012;11:429-39 pubmed publisher
    ..Ablation of Raptor also significantly extends survival of mice in models of leukemogenesis evoked by Pten deficiency...
  31. Cully M, Elia A, Ong S, Stambolic V, Pawson T, Tsao M, et al. grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice. Proc Natl Acad Sci U S A. 2004;101:15358-63 pubmed
    b>PTEN is a tumor suppressor gene implicated in both sporadic cancers and inherited tumor-prone syndromes. Here we show that pten+/- mice display a partially penetrant embryonic lethality...
  32. Zhou J, Blundell J, Ogawa S, Kwon C, Zhang W, Sinton C, et al. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci. 2009;29:1773-83 pubmed publisher
    b>PTEN (phosphatase and tensin homolog deleted on chromosome ten) is a lipid phosphatase that counteracts the function of phosphatidylinositol-3 kinase (PI3K)...
  33. Anzelon A, Wu H, Rickert R. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003;4:287-94 pubmed
    Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-..
  34. Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, et al. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol. 2007;9:36-44 pubmed
    ..In contrast, loss of the PtdIns(3,4,5)P(3) phosphatase PTEN had no impact on neutrophil chemotaxis...
  35. Gupta A, Dey C. PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase. Mol Cell Endocrinol. 2009;309:55-62 pubmed publisher
    ..Here we report that PTEN and SHIP2, the phosphatases widely implicated as negative regulators of insulin signaling, to be responsible for ..
  36. Vilgelm A, Lian Z, Wang H, Beauparlant S, Klein Szanto A, Ellenson L, et al. Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer Res. 2006;66:3375-80 pubmed
    b>PTEN is a tumor suppressor gene frequently mutated in human cancers...
  37. Hettinger K, Vikhanskaya F, Poh M, Lee M, de Belle I, Zhang J, et al. c-Jun promotes cellular survival by suppression of PTEN. Cell Death Differ. 2007;14:218-29 pubmed
    ..expression of c-Jun promotes cellular survival by negatively regulating the expression of the tumor-suppressor PTEN, resulting in the concomitant activation of the Akt survival pathway...
  38. Puig I, Champeval D, de Santa Barbara P, Jaubert F, Lyonnet S, Larue L. Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. J Clin Invest. 2009;119:3586-96 pubmed publisher
    ..As phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a phosphatase that is critical for controlling cell growth, proliferation, and death, we investigated the role ..
  39. Diegel C, Cho K, El Naggar A, Williams B, Lindvall C. Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma. Cancer Res. 2010;70:9143-52 pubmed publisher
    ..a mouse model in which both pathways are constitutively activated by the conditional inactivation of the Apc and Pten tumor suppressor genes. Loss of either Apc or Pten alone did not cause tumor development...
  40. Chow L, Endersby R, Zhu X, Rankin S, Qu C, Zhang J, et al. Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell. 2011;19:305-16 pubmed publisher
    Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of human glioblastomas...
  41. Chen Z, Trotman L, Shaffer D, Lin H, Dotan Z, Niki M, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005;436:725-30 pubmed
    ..The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in human cancer including ..
  42. Wu R, Hendrix Lucas N, Kuick R, Zhai Y, Schwartz D, Akyol A, et al. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell. 2007;11:321-33 pubmed
    ..We now show that defects in the PI3K/Pten and Wnt/beta-catenin signaling pathways often occur together in a subset of human OEAs, suggesting their ..
  43. Saal L, Gruvberger Saal S, Persson C, Lövgren K, Jumppanen M, Staaf J, et al. Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat Genet. 2008;40:102-7 pubmed
    ..Here we show that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly ..
  44. Klezovitch O, Risk M, Coleman I, Lucas J, Null M, True L, et al. A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci U S A. 2008;105:2105-10 pubmed publisher
    ..Our data demonstrate that ERG plays an important causal role in the transformation of prostate epithelium and should be considered as a target for prevention or early therapeutic intervention. ..
  45. Chen Z, Carracedo A, Lin H, Koutcher J, Behrendt N, Egia A, et al. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal. 2009;2:ra44 pubmed publisher
    ..Acute loss of Pten leads to an increase in the abundance of p19(Arf), p53, and p21 proteins as part of a fail-safe senescence response...
  46. Monet M, Francoeur N, Boulay G. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012;287:17672-81 pubmed publisher
    ..In this study we showed phosphoinositide 3-kinase and its antagonistic phosphatase, PTEN, are involved in the activation of TRPC6...
  47. Crackower M, Oudit G, Kozieradzki I, Sarao R, Sun H, Sasaki T, et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002;110:737-49 pubmed
    The PTEN/PI3K signaling pathway regulates a vast array of fundamental cellular responses...
  48. Abate Shen C, Banach Petrosky W, Sun X, Economides K, Desai N, Gregg J, et al. Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res. 2003;63:3886-90 pubmed
    ..Here, we have investigated the malignant potential of the high-grade PIN lesions that form in Nkx3.1(+/-); Pten(+/-) compound mutant mice and demonstrate their neoplastic progression in a serial transplantation/tissue ..
  49. Meuillet E, Mahadevan D, Berggren M, Coon A, Powis G. Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity. Arch Biochem Biophys. 2004;429:123-33 pubmed
    ..The molecular mechanisms for the promotion of tumorigenesis by Trx-1 are not known. PTEN is a major tumor suppressor of human cancer that acts by hydrolyzing membrane phosphatidylinositol (PtdIns)-3-..
  50. Lian Z, De Luca P, Di Cristofano A. Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer. J Cell Physiol. 2006;208:255-66 pubmed
    Loss of PTEN is the earliest detectable genetic lesion in the endometrioid subtype of endometrial cancer (EEC), a tumor thought to be associated with an increase in unopposed estrogen activity...
  51. Heit B, Robbins S, Downey C, Guan Z, Colarusso P, Miller B, et al. PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nat Immunol. 2008;9:743-52 pubmed publisher
    ..Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants...
  52. Puzio Kuter A, Castillo Martin M, Kinkade C, Wang X, Shen T, Matos T, et al. Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 2009;23:675-80 pubmed publisher
    ..We show that combined deletion of p53 and Pten in bladder epithelium leads to invasive cancer in a novel mouse model...
  53. Liu K, Lu Y, Lee J, Samara R, Willenberg R, Sears Kraxberger I, et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010;13:1075-81 pubmed publisher
    ..We found that PTEN/mTOR are critical for controlling the regenerative capacity of mouse corticospinal neurons...
  54. Kim J, Coffey D, Creighton C, Yu Z, Hawkins S, Matzuk M. High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012;109:3921-6 pubmed publisher
    ..By conditionally deleting Dicer, an essential gene for microRNA synthesis, and Pten, a key negative regulator of the PI3K pathway, we show that high-grade serous carcinomas arise from the fallopian ..
  55. Wang Z, Mitrofanova A, Bergren S, Abate Shen C, Cardiff R, Califano A, et al. Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity. Nat Cell Biol. 2013;15:274-83 pubmed publisher
    ..Our results reveal the inherent plasticity of basal cells, and support a model in which different cells of origin generate distinct molecular subtypes of prostate cancer. ..
  56. Steck P, Pershouse M, Jasser S, Yung W, Lin H, Ligon A, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997;15:356-62 pubmed
    ..We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA...
  57. Sun H, Lesche R, Li D, Liliental J, Zhang H, Gao J, et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999;96:6199-204 pubmed
    To investigate the molecular basis of PTEN-mediated tumor suppression, we introduced a null mutation into the mouse Pten gene by homologous recombination in embryonic stem (ES) cells...
  58. Li L, Liu F, Ross A. PTEN regulation of neural development and CNS stem cells. J Cell Biochem. 2003;88:24-8 pubmed
    ..Such a phosphatase, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), was cloned as a tumor suppressor for gliomas...
  59. Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006;442:457-60 pubmed
    ..Deletion of the tumour suppressor phosphatase and tensin homolog (PTEN) enhances signalling and electrotactic responses...
  60. Wei Q, Clarke L, Scheidenhelm D, Qian B, Tong A, Sabha N, et al. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 2006;66:7429-37 pubmed
    ..in these tumors are overexpression/mutation of the epidermal growth factor receptor (EGFR) vIII and loss of PTEN/MMAC1 expression...
  61. Buckler J, Walsh P, Porrett P, Choi Y, Turka L. Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol. 2006;177:4262-6 pubmed
    Recent studies suggest that the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) plays a critical role in the maintenance of self-tolerance...
  62. Wong J, Kim P, Peacock J, Yau T, Mui A, Chung S, et al. Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity. Diabetologia. 2007;50:395-403 pubmed
    ..The protein/lipid phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) attenuates PI3K signalling by dephosphorylating the ..
  63. Wang X, Trotman L, Koppie T, Alimonti A, Chen Z, Gao Z, et al. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007;128:129-39 pubmed
    The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis...
  64. Vasudevan K, Burikhanov R, Goswami A, Rangnekar V. Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras. Cancer Res. 2007;67:10343-50 pubmed
    ..Ras suppresses the expression of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 (PTEN), and this action of oncogenic Ras is mediated by the Raf-mitogen-activated protein kinase/extracellular signal-..
  65. Xue L, Nolla H, Suzuki A, Mak T, Winoto A. Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice. Proc Natl Acad Sci U S A. 2008;105:2022-7 pubmed publisher
    b>PTEN is a tumor suppressor gene but whether cancer can develop in all PTEN-deficient cells is not known...
  66. Kwon C, Zhao D, Chen J, Alcantara S, Li Y, Burns D, et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 2008;68:3286-94 pubmed publisher
    ..achieve high grade, they are frequently accompanied by Akt activation, reminiscent of the frequent association of PTEN mutations in human high-grade glioma...
  67. Korpershoek E, Loonen A, Corvers S, van Nederveen F, Jonkers J, Ma X, et al. Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma. J Pathol. 2009;217:597-604 pubmed publisher
    ..Here we describe adrenal tumours generated in a Pten conditional knock-out (KO) mouse model...
  68. Mulholland D, Xin L, Morim A, Lawson D, Witte O, Wu H. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res. 2009;69:8555-62 pubmed publisher
    We have shown previously that Pten deletion leads to the expansion of subset of prostate cancer cells positive for CK5 and p63...
  69. Wang S, Garcia A, Wu M, Lawson D, Witte O, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006;103:1480-5 pubmed
    b>PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers...
  70. Xiao C, Srinivasan L, Calado D, Patterson H, Zhang B, Wang J, et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol. 2008;9:405-14 pubmed publisher
    ..The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim...
  71. Siddall H, Warrell C, Yellon D, Mocanu M. Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency. Basic Res Cardiol. 2008;103:560-8 pubmed publisher
    Activation of the PI3K/Akt pathway protects the heart from ischemia-reperfusion injury (IRI). The phosphatase PTEN is the main negative regulator of this pathway. We hypothesized that reduced PTEN levels could protect against IRI...
  72. Wang X, Kruithof de Julio M, Economides K, Walker D, Yu H, Halili M, et al. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature. 2009;461:495-500 pubmed publisher
    ..Furthermore, targeted deletion of the Pten tumour suppressor gene in CARNs results in rapid carcinoma formation after androgen-mediated regeneration...
  73. Diaz Ruiz O, Zapata A, Shan L, Zhang Y, Tomac A, Malik N, et al. Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons. PLoS ONE. 2009;4:e7027 pubmed publisher
    The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions...
  74. Schabbauer G, Matt U, Günzl P, Warszawska J, Furtner T, Hainzl E, et al. Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. J Immunol. 2010;185:468-76 pubmed publisher
    ..role of the PI3K pathway and its endogenous antagonist phosphatase and tensin homolog deleted on chromosome 10 (PTEN) during clinically relevant bacterial infections is still poorly understood...
  75. Di Cristofano A, Pesce B, Cordon Cardo C, Pandolfi P. Pten is essential for embryonic development and tumour suppression. Nat Genet. 1998;19:348-55 pubmed
    The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers...
  76. Yilmaz O, Valdez R, Theisen B, Guo W, Ferguson D, Wu H, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441:475-82 pubmed
    ..Here we address this issue by conditionally deleting the Pten tumour suppressor gene in adult haematopoietic cells...
  77. Taniguchi C, Tran T, Kondo T, Luo J, Ueki K, Cantley L, et al. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proc Natl Acad Sci U S A. 2006;103:12093-7 pubmed
    ..levels which are due, at least in part, to diminished activity of the (3,4,5)-trisphosphate phosphatase PTEN. Thus, the regulatory subunit p85alpha is a critical modulator of insulin sensitivity in vivo not only because of ..
  78. Gao H, Ouyang X, Banach Petrosky W, Shen M, Abate Shen C. Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice. Cancer Res. 2006;66:7929-33 pubmed
    ..In particular, we have been studying the evolution of androgen independence in Nkx3.1; Pten mutant mice, which develop prostatic intraepithelial neoplasia and adenocarcinoma as a consequence of aging, as ..
  79. Lindsay Y, McCoull D, Davidson L, Leslie N, Fairservice A, Gray A, et al. Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression. J Cell Sci. 2006;119:5160-8 pubmed
    ..A similar distribution of PtdIns(3,4,5)P3 was observed in U87MG cells, which lack the PtdIns(3,4,5)P3 phosphatase, PTEN. Re-expression of PTEN into U87MG cells ablated plasma membrane PtdIns(3,4,5)P3, but not the nuclear pool of this ..
  80. Fraser M, Bayazitov I, Zakharenko S, Baker S. Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience. 2008;151:476-88 pubmed
    ..The tumor-suppressor phosphatase with tensin homology (PTEN) is the central negative regulator of the PI3K pathway...
  81. Bleau A, Hambardzumyan D, Ozawa T, Fomchenko E, Huse J, Brennan C, et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell. 2009;4:226-35 pubmed publisher
    ..In this cell population, Akt, but not its downstream target mTOR, regulates ABCG2 activity, and loss of PTEN increases the SP. This Akt-induced ABCG2 activation results from its transport to the plasma membrane...
  82. Goebbels S, Oltrogge J, Kemper R, Heilmann I, Bormuth I, Wolfer S, et al. Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination. J Neurosci. 2010;30:8953-64 pubmed publisher
    ..By generating conditional mouse mutants, we found that Pten-deficient Schwann cells are enhanced in number and can sort and myelinate axons with calibers well below 1 microm...
  83. Harrington E, Zhao C, Fancy S, Kaing S, Franklin R, Rowitch D. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann Neurol. 2010;68:703-16 pubmed publisher
    ..As cellular pathways regulated by phosphatase and tensin homologue deleted on chromosome 10 (PTEN; eg, phosphatidylinositol-3-kinase [PI-3K]) have been reported to enhance axon regeneration and oligodendrocyte ..
  84. Hübner A, Mulholland D, Standen C, Karasarides M, Cavanagh Kyros J, Barrett T, et al. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A. 2012;109:12046-51 pubmed publisher
    ..the JNK signaling pathway reduces the development of invasive adenocarcinoma in the phosphatase and tensin homolog (Pten) conditional deletion model of prostate cancer...
  85. Manning B, Logsdon M, Lipovsky A, Abbott D, Kwiatkowski D, Cantley L. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 2005;19:1773-8 pubmed
    The PTEN and TSC2 tumor suppressors inhibit mammalian target of rapamycin (mTOR) signaling and are defective in distinct hamartoma syndromes...
  86. Hagenbeek T, Spits H. T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus. Leukemia. 2008;22:608-19 pubmed
    Phosphatase and tensin homolog deleted on chromosome 10 (Pten) is a tumor suppressor protein whose loss of lipid phosphatase activity is associated with lymphomagenesis...
  87. Sinclair L, Finlay D, Feijoo C, Cornish G, Gray A, Ager A, et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol. 2008;9:513-21 pubmed publisher
    ..PI(3)K-mTOR nutrient-sensing pathways also determined expression of the chemokine receptor CCR7 and regulated lymphocyte trafficking in vivo. Hence, lymphocytes use PI(3)K and mTOR to match metabolism and trafficking. ..
  88. Choi D, Nguyen K, Wang L, Schroer S, Suzuki A, Mak T, et al. Partial deletion of Pten in the hypothalamus leads to growth defects that cannot be rescued by exogenous growth hormone. Endocrinology. 2008;149:4382-6 pubmed publisher
    ..is largely mediated by the phosphoinositide 3-kinase signaling pathway, and phosphatase with tensin homology (PTEN) is a potent negative regulator of this pathway...
  89. Fan H, Liu Z, Cahill N, Richards J. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Mol Endocrinol. 2008;22:2128-40 pubmed publisher
    ..To identify the physiological role of the PI3K pathway in vivo we disrupted the PI3K suppressor, Pten, in developing ovarian follicles...
  90. Ozcelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U, et al. Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci. 2010;30:4120-31 pubmed publisher
    ..We conclude that regulation of epithelial-like polarization is a critical determinant of myelin sheath structure and function. ..
  91. Ning K, Drepper C, Valori C, Ahsan M, Wyles M, Higginbottom A, et al. PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons. Hum Mol Genet. 2010;19:3159-68 pubmed publisher
    Phosphatase and tensin homolog (PTEN), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, is widely involved in the regulation of protein synthesis...
  92. Kamo N, Ke B, Busuttil R, Kupiec Weglinski J. PTEN-mediated Akt/?-catenin/Foxo1 signaling regulates innate immune responses in mouse liver ischemia/reperfusion injury. Hepatology. 2013;57:289-98 pubmed publisher
    The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) regulates innate immune responses inversely with phosphoinositide 3-kinase (PI3K) and its direct downstream target gene, Akt...