Nr1h3

Summary

Gene Symbol: Nr1h3
Description: nuclear receptor subfamily 1, group H, member 3
Alias: AU018371, LXR, RLD1, Unr1, oxysterols receptor LXR-alpha, LXR alpha, liver X receptor alpha, ubiquitously-expressed nuclear receptor 1
Species: mouse
Products:     Nr1h3

Top Publications

  1. Joseph S, Bradley M, Castrillo A, Bruhn K, Mak P, Pei L, et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004;119:299-309 pubmed
    ..We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses...
  2. Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116:607-14 pubmed
    ..Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis ..
  3. Wu S, Yin R, Ernest R, Li Y, Zhelyabovska O, Luo J, et al. Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling. Cardiovasc Res. 2009;84:119-26 pubmed publisher
    ..We investigated LXR expression patterns in pressure overload-induced hypertrophic hearts and the hypertrophic growth of the LXRalpha-..
  4. Repa J, Turley S, Lobaccaro J, Medina J, Li L, Lustig K, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289:1524-9 pubmed
    ..Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine...
  5. Repa J, Liang G, Ou J, Bashmakov Y, Lobaccaro J, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14:2819-30 pubmed
    ..In this report, we describe a novel LXR target, the sterol regulatory element-binding protein-1c gene (SREBP-1c), which encodes a membrane-bound ..
  6. Hashimoto K, Cohen R, Yamada M, Markan K, Monden T, Satoh T, et al. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem. 2006;281:295-302 pubmed
    ..reduced hepatic cholesterol content in MUT animals are likely because of cross-talk between TR-beta and liver X receptor alpha (LXR-alpha), which both bind to a direct repeat + 4 (DR+4) element in the CYP7A1 promoter...
  7. Plosch T, Bloks V, Terasawa Y, Berdy S, Siegler K, Van Der Sluijs F, et al. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology. 2004;126:290-300 pubmed
    ..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen...
  8. Cummins C, Volle D, Zhang Y, McDonald J, Sion B, Lefrançois Martinez A, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest. 2006;116:1902-12 pubmed
    ..in all aspects of cholesterol utilization, including the steroidogenic acute regulatory protein, StAR, a novel LXR target. Under chronic dietary stress, adrenal glands from Lxralphabeta-/- mice accumulated free cholesterol...
  9. Meng Z, Nie J, Ling J, Sun J, Zhu Y, Gao L, et al. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 2009;52:125-35 pubmed publisher
    ..We found that both Lxralpha (also known as Nr1h3) and Lxrbeta (also known as Nr1h2) were expressed and transactivated the LXR response element in HIT-T15 and MIN6 ..
  10. Efanov A, Sewing S, Bokvist K, Gromada J. Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes. 2004;53 Suppl 3:S75-8 pubmed
    ..Culture of pancreatic islets or insulin-secreting MIN6 cells with a LXR specific agonist T0901317 caused an increase in glucose-dependent insulin secretion and islet insulin content...

Detail Information

Publications72

  1. Joseph S, Bradley M, Castrillo A, Bruhn K, Mak P, Pei L, et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004;119:299-309 pubmed
    ..We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses...
  2. Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006;116:607-14 pubmed
    ..Synthetic LXR agonists promote cholesterol efflux and inhibit inflammation in vivo and inhibit the development of atherosclerosis ..
  3. Wu S, Yin R, Ernest R, Li Y, Zhelyabovska O, Luo J, et al. Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling. Cardiovasc Res. 2009;84:119-26 pubmed publisher
    ..We investigated LXR expression patterns in pressure overload-induced hypertrophic hearts and the hypertrophic growth of the LXRalpha-..
  4. Repa J, Turley S, Lobaccaro J, Medina J, Li L, Lustig K, et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science. 2000;289:1524-9 pubmed
    ..Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine...
  5. Repa J, Liang G, Ou J, Bashmakov Y, Lobaccaro J, Shimomura I, et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev. 2000;14:2819-30 pubmed
    ..In this report, we describe a novel LXR target, the sterol regulatory element-binding protein-1c gene (SREBP-1c), which encodes a membrane-bound ..
  6. Hashimoto K, Cohen R, Yamada M, Markan K, Monden T, Satoh T, et al. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem. 2006;281:295-302 pubmed
    ..reduced hepatic cholesterol content in MUT animals are likely because of cross-talk between TR-beta and liver X receptor alpha (LXR-alpha), which both bind to a direct repeat + 4 (DR+4) element in the CYP7A1 promoter...
  7. Plosch T, Bloks V, Terasawa Y, Berdy S, Siegler K, Van Der Sluijs F, et al. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology. 2004;126:290-300 pubmed
    ..It has been proposed that ABCG5/ABCG8 heterodimers mediate secretion of plant sterols and cholesterol by hepatocytes into bile and their efflux from enterocytes into the intestinal lumen...
  8. Cummins C, Volle D, Zhang Y, McDonald J, Sion B, Lefrançois Martinez A, et al. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest. 2006;116:1902-12 pubmed
    ..in all aspects of cholesterol utilization, including the steroidogenic acute regulatory protein, StAR, a novel LXR target. Under chronic dietary stress, adrenal glands from Lxralphabeta-/- mice accumulated free cholesterol...
  9. Meng Z, Nie J, Ling J, Sun J, Zhu Y, Gao L, et al. Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest. Diabetologia. 2009;52:125-35 pubmed publisher
    ..We found that both Lxralpha (also known as Nr1h3) and Lxrbeta (also known as Nr1h2) were expressed and transactivated the LXR response element in HIT-T15 and MIN6 ..
  10. Efanov A, Sewing S, Bokvist K, Gromada J. Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes. 2004;53 Suppl 3:S75-8 pubmed
    ..Culture of pancreatic islets or insulin-secreting MIN6 cells with a LXR specific agonist T0901317 caused an increase in glucose-dependent insulin secretion and islet insulin content...
  11. Tangirala R, Bischoff E, Joseph S, Wagner B, Walczak R, Laffitte B, et al. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002;99:11896-901 pubmed
    Recent studies have identified the liver X receptors (LXR alpha and LXR beta) as important regulators of cholesterol metabolism and transport...
  12. Lei P, Baysa A, Nebb H, Valen G, Skomedal T, Osnes J, et al. Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia-reperfusion injury. Basic Res Cardiol. 2013;108:323 pubmed publisher
    Liver X receptor (LXR)-? and -? play a major role in lipid and glucose homeostasis. Their expression and function in the heart is not well characterized...
  13. Patel R, Patel M, Tsai R, Lin V, Bookout A, Zhang Y, et al. LXR? is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J Clin Invest. 2011;121:431-41 pubmed publisher
    ..Here, we show LXR? is required to mediate many of the negative side effects of glucocorticoids...
  14. Cao G, Beyer T, Yang X, Schmidt R, Zhang Y, Bensch W, et al. Phospholipid transfer protein is regulated by liver X receptors in vivo. J Biol Chem. 2002;277:39561-5 pubmed
    Liver X receptors (LXR) belong to the nuclear receptor superfamily that can regulate important lipid metabolic pathways...
  15. Tachibana H, Ogawa D, Matsushita Y, Bruemmer D, Wada J, Teshigawara S, et al. Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy. J Am Soc Nephrol. 2012;23:1835-46 pubmed publisher
    ..for liver X receptors (LXRs) suppress the expression of proinflammatory genes, including osteopontin, but whether LXR activation modulates diabetic nephropathy is unknown...
  16. Archer A, Venteclef N, Mode A, Pedrelli M, Gabbi C, Clement K, et al. Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice. Mol Endocrinol. 2012;26:1980-90 pubmed publisher
    ..We hypothesized that the LXR transcription factors could influence Fgf21 expression, which is induced in response to fasting...
  17. Plosch T, van der Veen J, Havinga R, Huijkman N, Bloks V, Kuipers F. Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice. Am J Physiol Gastrointest Liver Physiol. 2006;291:G414-23 pubmed
    ..Treatment with the liver X receptor (LXR) agonist T0901317 increased the maximal sterol excretion capacity in wild-type mice (fourfold), concomitant with ..
  18. Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, et al. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest. 2001;107:565-73 pubmed
    ..We have generated mouse lines with targeted disruptions of each of these LXR receptors and have compared their responses to dietary cholesterol...
  19. Juvet L, Andresen S, Schuster G, Dalen K, Tobin K, Hollung K, et al. On the role of liver X receptors in lipid accumulation in adipocytes. Mol Endocrinol. 2003;17:172-82 pubmed
    ..We have studied the role of LXR in fat cells and demonstrate that LXR is regulated during adipogenesis and augments fat accumulation in mature ..
  20. Volle D, Mouzat K, Duggavathi R, Siddeek B, Dechelotte P, Sion B, et al. Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility. Mol Endocrinol. 2007;21:1014-27 pubmed
    Oxysterol nuclear receptors liver X receptor (LXR)alpha and LXRbeta are known to regulate lipid homeostasis in cells exposed to high amounts of cholesterol and/or fatty acids...
  21. Laffitte B, Repa J, Joseph S, Wilpitz D, Kast H, Mangelsdorf D, et al. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001;98:507-12 pubmed
    ..We show that LXR/RXR heterodimers regulate apoE transcription directly, through interaction with a conserved LXR response element ..
  22. Bensinger S, Bradley M, Joseph S, Zelcer N, Janssen E, Hausner M, et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008;134:97-111 pubmed publisher
    ..that cellular cholesterol levels in dividing T cells are maintained in part through reciprocal regulation of the LXR and SREBP transcriptional programs...
  23. Li X, Zhang S, Blander G, Tse J, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 2007;28:91-106 pubmed
    ..Here we show that SIRT1 is a positive regulator of liver X receptor (LXR) proteins, nuclear receptors that function as cholesterol sensors and regulate whole-body cholesterol and lipid ..
  24. Plosch T, Kok T, Bloks V, Smit M, Havinga R, Chimini G, et al. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem. 2002;277:33870-7 pubmed
    ..Expression of the Abca1 gene is under control of the liver X receptor (LXR)...
  25. Gerin I, Dolinsky V, Shackman J, Kennedy R, Chiang S, Burant C, et al. LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem. 2005;280:23024-31 pubmed
    Liver X receptors (LXR) alpha and beta are nuclear oxysterol receptors with established roles in cholesterol, lipid, and carbohydrate metabolism...
  26. Mouzat K, Prod homme M, Volle D, Sion B, Dechelotte P, Gauthier K, et al. Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus. J Biol Chem. 2007;282:4693-701 pubmed
    ..Upon treatment with an LXR agonist that mimics activation by oxysterols, expression of these target genes was increased in wild-type mice, ..
  27. A Gonzalez N, Bensinger S, Hong C, Beceiro S, Bradley M, Zelcer N, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009;31:245-58 pubmed publisher
    ..We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance...
  28. Viennois E, Esposito T, Dufour J, Pommier A, Fabre S, Kemeny J, et al. Lxr? regulates the androgen response in prostate epithelium. Endocrinology. 2012;153:3211-23 pubmed publisher
    ..We show that liver X receptor (Lxr)-? knockout mice (lxr?(-/-)) develop ventral prostate hypertrophy, correlating with an overaccumulation of secreted ..
  29. Grefhorst A, Elzinga B, Voshol P, Plosch T, Kok T, Bloks V, et al. Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles. J Biol Chem. 2002;277:34182-90 pubmed
    The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid metabolism; activation of LXR induces transcription of lipogenic genes...
  30. Qin Y, Dalen K, Gustafsson J, Nebb H. Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c. Biochim Biophys Acta. 2009;1791:140-7 pubmed publisher
    ..We demonstrate that Liver X Receptor alpha (LXRalpha) and sterol regulatory binding protein-1c (SREBP-1c) regulate hepatic Elovl5 expression...
  31. Erbay E, Babaev V, Mayers J, Makowski L, Charles K, Snitow M, et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med. 2009;15:1383-91 pubmed publisher
  32. Whitney K, Watson M, Goodwin B, Galardi C, Maglich J, Wilson J, et al. Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. J Biol Chem. 2001;276:43509-15 pubmed
    The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol...
  33. Lehmann J, Kliewer S, Moore L, Smith Oliver T, Oliver B, Su J, et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997;272:3137-40 pubmed
    ..In addition, we have identified an LXR response element in the promoter region of the rat cholesterol 7alpha-hydroxylase gene...
  34. Hu T, Foxworthy P, Siesky A, Ficorilli J, Gao H, Li S, et al. Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha. Endocrinology. 2005;146:5380-7 pubmed
    ..In this study we provide evidence that the liver X receptor (LXR) regulates the expression of the genetic program for peroxisomal beta-oxidation in liver...
  35. Robertson K, Schuster G, Steffensen K, Hovatta O, Meaney S, Hultenby K, et al. The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis. Endocrinology. 2005;146:2519-30 pubmed
    The liver X receptor (LXR)alpha and -beta has been found to play a central role in maintaining cellular cholesterol homeostasis...
  36. Whitney K, Watson M, Collins J, Benson W, Stone T, Numerick M, et al. Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol. 2002;16:1378-85 pubmed
    The nuclear oxysterol receptors liver X receptor-alpha [LXRalpha (NR1H3)] and LXRbeta (NR1H2) coordinately regulate genes involved in cholesterol homeostasis...
  37. Stulnig T, Steffensen K, Gao H, Reimers M, Dahlman Wright K, Schuster G, et al. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol Pharmacol. 2002;62:1299-305 pubmed
    Liver X receptor (LXR) alpha and LXRbeta are nuclear oxysterol receptors whose biological function has so far been elucidated only with respect to cholesterol and lipid metabolism...
  38. Frenoux J, Vernet P, Volle D, Britan A, Saez F, Kocer A, et al. Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions. J Mol Endocrinol. 2004;33:361-75 pubmed
    In this study we looked at the epididymides and spermatozoa of mice knocked-out for nuclear oxysterol receptors (LXR)...
  39. Ulven S, Dalen K, Gustafsson J, Nebb H. Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue. J Lipid Res. 2004;45:2052-62 pubmed
    ..LXRalpha gene is highly induced in vivo and in vitro in mouse and human adipocytes in the presence of the synthetic LXR agonist T0901317...
  40. Ross S, Erickson R, Gerin I, DeRose P, Bajnok L, Longo K, et al. Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol Cell Biol. 2002;22:5989-99 pubmed
    ..we used the microarray data to identify potentially important adipocyte genes and chose one of these, the liver X receptor alpha (LXR alpha), for further analyses...
  41. Hong C, Kidani Y, A Gonzalez N, Phung T, Ito A, Rong X, et al. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012;122:337-47 pubmed publisher
    ..Using gain- and loss-of-function models, we found that LXR signaling regulated the efficient clearance of senescent neutrophils by peripheral tissue APCs in a Mer-dependent ..
  42. Korach Andre M, Archer A, Gabbi C, Barros R, Pedrelli M, Steffensen K, et al. Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice. Am J Physiol Endocrinol Metab. 2011;301:E210-22 pubmed publisher
    ..Recently, LXRs have been proposed as a glucose sensor affecting LXR-dependent gene expression...
  43. Beaven S, Wroblewski K, Wang J, Hong C, BENSINGER S, Tsukamoto H, et al. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011;140:1052-62 pubmed publisher
    ..We investigated the role of LXR signaling stellate cell activation and susceptibility to fibrotic liver disease...
  44. Joseph S, Castrillo A, Laffitte B, Mangelsdorf D, Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003;9:213-9 pubmed
    ..Transcriptional profiling of lipopolysaccharide (LPS)-induced macrophages reveals reciprocal LXR-dependent regulation of genes involved in lipid metabolism and the innate immune response...
  45. Korf H, Vander Beken S, Romano M, Steffensen K, Stijlemans B, Gustafsson J, et al. Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice. J Clin Invest. 2009;119:1626-37 pubmed publisher
    ..Upon intratracheal infection with M. tuberculosis, LXRs and LXR target genes were induced in CD11c+ lung and alveolar cells...
  46. Tobin K, Ulven S, Schuster G, Steineger H, Andresen S, Gustafsson J, et al. Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem. 2002;277:10691-7 pubmed
    The nuclear receptor liver X receptor (LXR) alpha, an important regulator of cholesterol and bile acid metabolism, was analyzed after insulin stimulation in liver in vitro and in vivo...
  47. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100-4 pubmed publisher
    ..Here we show that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeostasis, not only through promotion of cholesterol efflux but also through ..
  48. Cui G, Qin X, Wu L, Zhang Y, Sheng X, Yu Q, et al. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest. 2011;121:658-70 pubmed publisher
    ..We report here that ectopic expression of liver X receptor (LXR) inhibits Th17 polarization of mouse CD4+ T cells, while LXR deficiency promotes Th17 differentiation in vitro...
  49. Hong C, Walczak R, Dhamko H, Bradley M, Marathe C, Boyadjian R, et al. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res. 2011;52:531-9 pubmed publisher
    ..One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects...
  50. Choe S, Choi A, Lee J, Kim K, Chung J, Park J, et al. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 2007;56:1534-43 pubmed
    Liver X receptor (LXR)alpha and LXRbeta play important roles in fatty acid metabolism and cholesterol homeostasis...
  51. Boergesen M, Pedersen T, Gross B, van Heeringen S, Hagenbeek D, Bindesbøll C, et al. Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor ? in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol. 2012;32:852-67 pubmed publisher
    ..RXR agonist-induced hypertriglyceridemia and hepatic steatosis in mice are dependent on LXRs and correlate with an LXR-dependent hepatic induction of lipogenic genes...
  52. Repa J, Berge K, Pomajzl C, Richardson J, Hobbs H, Mangelsdorf D. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem. 2002;277:18793-800 pubmed
    ..Here we demonstrate that the ABCG5 and ABCG8 genes are direct targets of the oxysterol receptors liver X receptor (LXR) alpha and LXRbeta...
  53. Bradley M, Hong C, Chen M, Joseph S, Wilpitz D, Wang X, et al. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007;117:2337-46 pubmed
    ..However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain unclear...
  54. Yu L, York J, von Bergmann K, Lutjohann D, Cohen J, Hobbs H. Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8. J Biol Chem. 2003;278:15565-70 pubmed
    Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the trafficking of sterols between tissues...
  55. Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, et al. A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPAR?. Biochimie. 2013;95:556-67 pubmed publisher
    ..As expected, T0901317 and fenofibrate induce expression of genes involved LXR-dependent and PPAR?-dependent lipogenic responses...
  56. Astapova I, Lee L, Morales C, Tauber S, Bilban M, Hollenberg A. The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008;105:19544-9 pubmed publisher
    ..Interestingly, NCoR recruitment to LXR is also impaired in this model, leading to activation of LXR-target genes, further demonstrating that NCoR ..
  57. Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya Kudo M, Matsuzaka T, et al. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. Mol Endocrinol. 2003;17:1255-67 pubmed
    ..fatty acid degradation, whereas sterol regulatory element-binding protein-1c activated by liver X receptor (LXR) regulates fatty acid synthesis...
  58. Valledor A, Hsu L, Ogawa S, Sawka Verhelle D, Karin M, Glass C. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A. 2004;101:17813-8 pubmed
    ..In addition, combined activation of LXR and RXR protected macrophages from apoptosis caused by infection with Bacillus anthracis, Escherichia coli, and ..
  59. Bischoff E, Daige C, Petrowski M, Dedman H, Pattison J, Juliano J, et al. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res. 2010;51:900-6 pubmed publisher
    ..activity of LXRalpha and LXRbeta and determine the ability of each subtype to mediate the biological response to LXR agonists...
  60. Sun D, Zhang J, Xie J, Wei W, Chen M, Zhao X. MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. FEBS Lett. 2012;586:1472-9 pubmed publisher
    ..regulations of cholesterol metabolism by liver X receptors (LXRs) have been well studied, the potential effects of LXR-responsive microRNAs (miRNAs) still need to be unveiled...
  61. Zhang Y, Breevoort S, Angdisen J, Fu M, Schmidt D, Holmstrom S, et al. Liver LXR? expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest. 2012;122:1688-99 pubmed publisher
    Liver X receptors (LXR? and LXR?) are important regulators of cholesterol and lipid metabolism, and their activation has been shown to inhibit cardiovascular disease and reduce atherosclerosis in animal models...
  62. Muscat G, Wagner B, Hou J, Tangirala R, Bischoff E, Rohde P, et al. Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors. J Biol Chem. 2002;277:40722-8 pubmed
    ..Furthermore we show that treatment of muscle cells in vitro with synthetic agonists of LXR increases the efflux of intracellular cholesterol to extracellular acceptors such as high density lipoprotein, thus ..
  63. Kalaany N, Gauthier K, Zavacki A, Mammen P, Kitazume T, Peterson J, et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 2005;1:231-44 pubmed
    ..Here we show that LXR null mice are defective in hepatic lipid metabolism and are resistant to obesity when challenged with a diet ..
  64. Chu K, Miyazaki M, Man W, Ntambi J. Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation. Mol Cell Biol. 2006;26:6786-98 pubmed
    ..In this study, we investigated the regulation of mouse SCD1 by liver X receptor (LXR) and its role in plasma lipoprotein metabolism upon LXR activation...
  65. Peet D, Turley S, Ma W, Janowski B, Lobaccaro J, Hammer R, et al. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998;93:693-704 pubmed
    We demonstrate that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in excess of that which they synthesize de novo...
  66. Villablanca E, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, et al. Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat Med. 2010;16:98-105 pubmed publisher
    ..was also observed in chimeric mice transplanted with bone marrow from mice lacking the gene encoding LXR-alpha (Nr1h3(-/-) mice) Thus, we show a new mechanism of tumor immunoescape involving products of cholesterol metabolism...
  67. Hashimoto K, Matsumoto S, Yamada M, Satoh T, Mori M. Liver X receptor-alpha gene expression is positively regulated by thyroid hormone. Endocrinology. 2007;148:4667-75 pubmed
    ..In the current study, we demonstrated that thyroid hormone (T(3)) up-regulated mouse LXR-alpha, but not LXR-beta, mRNA expression in the liver and that cholesterol administration did not affect the LXR-..
  68. Kim H, Andersson L, Bouton D, Warner M, Gustafsson J. Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice. Proc Natl Acad Sci U S A. 2009;106:558-63 pubmed publisher
    With specific liver X receptor alpha and beta (LXRalpha and LXRbeta) antibodies, we found that LXRalpha is strongly expressed in the luminal and basal cells of prostatic epithelium...
  69. Steffensen K, Nilsson M, Schuster G, Stulnig T, Dahlman Wright K, Gustafsson J. Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively. Biochem Biophys Res Commun. 2003;310:589-93 pubmed
    The nuclear receptors liver X receptors (LXR) alpha and beta are important regulators of genes involved in lipid, cholesterol, and carbohydrate metabolism and are highly expressed in mature adipocyte tissue...
  70. Colin S, Bourguignon E, Boullay A, Tousaint J, Huet S, Caira F, et al. Intestine-specific regulation of PPARalpha gene transcription by liver X receptors. Endocrinology. 2008;149:5128-35 pubmed publisher
    ..Here, using gene expression assays, we identified PPARalpha as an intestine-specific LXR target gene...
  71. Lee J, Gong H, Khadem S, Lu Y, Gao X, Li S, et al. Androgen deprivation by activating the liver X receptor. Endocrinology. 2008;149:3778-88 pubmed publisher
    ..Genetic or pharmacological activation of the liver X receptor (LXR) in vivo lowered androgenic activity by inducing the hydroxysteroid sulfotransferase 2A1, an enzyme essential for ..
  72. Castrillo A, Joseph S, Marathe C, Mangelsdorf D, Tontonoz P. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem. 2003;278:10443-9 pubmed
    ..Treatment of murine peritoneal macrophages with the synthetic LXR agonists GW3965 or T1317 reduces MMP-9 mRNA expression and blunts its induction by pro-inflammatory stimuli ..