Met

Summary

Gene Symbol: Met
Description: met proto-oncogene
Alias: AI838057, HGF, HGFR, Par4, c-Met, hepatocyte growth factor receptor, HGF receptor, HGF/SF receptor, SF receptor, met proto-oncogene tyrosine kinase, proto-oncogene c-Met, scatter factor receptor, tyrosine-protein kinase Met
Species: mouse
Products:     Met

Top Publications

  1. Daston G, Lamar E, Olivier M, Goulding M. Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 1996;122:1017-27 pubmed
    ..The failure of limb muscle precursors to invade the limb in splotch mice is associated with the absence of c-met expression in premigratory cells, together with a change in the morphology of the ventral dermomyotome...
  2. Rong S, Bodescot M, Blair D, Dunn J, Nakamura T, Mizuno K, et al. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol. 1992;12:5152-8 pubmed
    The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells...
  3. Mellado Gil J, Rosa T, Demirci C, Gonzalez Pertusa J, Velazquez Garcia S, Ernst S, et al. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2011;60:525-36 pubmed publisher
    To determine the role of hepatocyte growth factor (HGF)/c-Met on ?-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro...
  4. Gomez Quiroz L, Factor V, Kaposi Novak P, Coulouarn C, Conner E, Thorgeirsson S. Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. J Biol Chem. 2008;283:14581-9 pubmed publisher
    The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction pathway that controls cell survival...
  5. Park M, Dean M, Cooper C, Schmidt M, O Brien S, Blair D, et al. Mechanism of met oncogene activation. Cell. 1986;45:895-904 pubmed
    The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell line with N-methyl-N'-nitronitrosoguanidine (MNNG) is related to the tyrosine kinase gene family...
  6. Araújo T, Oliveira A, Carvalho B, Guadagnini D, Protzek A, Carvalheira J, et al. Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology. 2012;153:5760-9 pubmed publisher
    ..Additionally, blockages of HGF receptor (Met) worsen the impaired insulin-induced insulin signaling in liver of diet-induced obesity rats...
  7. Woolf A, Kolatsi Joannou M, Hardman P, Andermarcher E, Moorby C, Fine L, et al. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol. 1995;128:171-84 pubmed
    Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several fibroblast lines, may elicit morphogenesis in adjacent epithelial cells...
  8. Roccisana J, Reddy V, Vasavada R, Gonzalez Pertusa J, Magnuson M, Garcia Ocana A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes. 2005;54:2090-102 pubmed
    ..In the current studies, we have used conditional ablation of the c-met gene to uncover the physiological role of HGF in beta-cell growth and function...
  9. Cramer A, Kleiner S, Westermann M, Meissner A, Lange A, Friedrich K. Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3. J Cell Biochem. 2005;95:805-16 pubmed
    c-Met is the receptor for hepatocyte growth factor/scatter factor (HGF/SF)...
  10. Sonnenberg E, Meyer D, Weidner K, Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol. 1993;123:223-35 pubmed
    ..The cell surface receptor for this factor was recently identified: it is the product of the c-met protooncogene, a receptor-type tyrosine kinase...

Detail Information

Publications74

  1. Daston G, Lamar E, Olivier M, Goulding M. Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 1996;122:1017-27 pubmed
    ..The failure of limb muscle precursors to invade the limb in splotch mice is associated with the absence of c-met expression in premigratory cells, together with a change in the morphology of the ventral dermomyotome...
  2. Rong S, Bodescot M, Blair D, Dunn J, Nakamura T, Mizuno K, et al. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol. 1992;12:5152-8 pubmed
    The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). It was previously shown that, like the oncogenic tpr-met, the mouse met proto-oncogene transforms NIH 3T3 cells...
  3. Mellado Gil J, Rosa T, Demirci C, Gonzalez Pertusa J, Velazquez Garcia S, Ernst S, et al. Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes. Diabetes. 2011;60:525-36 pubmed publisher
    To determine the role of hepatocyte growth factor (HGF)/c-Met on ?-cell survival in diabetogenic conditions in vivo and in response to cytokines in vitro...
  4. Gomez Quiroz L, Factor V, Kaposi Novak P, Coulouarn C, Conner E, Thorgeirsson S. Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. J Biol Chem. 2008;283:14581-9 pubmed publisher
    The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction pathway that controls cell survival...
  5. Park M, Dean M, Cooper C, Schmidt M, O Brien S, Blair D, et al. Mechanism of met oncogene activation. Cell. 1986;45:895-904 pubmed
    The met oncogene activated in vitro by treatment of a human osteogenic sarcoma (HOS) cell line with N-methyl-N'-nitronitrosoguanidine (MNNG) is related to the tyrosine kinase gene family...
  6. Araújo T, Oliveira A, Carvalho B, Guadagnini D, Protzek A, Carvalheira J, et al. Hepatocyte growth factor plays a key role in insulin resistance-associated compensatory mechanisms. Endocrinology. 2012;153:5760-9 pubmed publisher
    ..Additionally, blockages of HGF receptor (Met) worsen the impaired insulin-induced insulin signaling in liver of diet-induced obesity rats...
  7. Woolf A, Kolatsi Joannou M, Hardman P, Andermarcher E, Moorby C, Fine L, et al. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol. 1995;128:171-84 pubmed
    Several lines of evidence suggest that hepatocyte growth factor/scatter factor (HGF/SF), a soluble protein secreted by embryo fibroblasts and several fibroblast lines, may elicit morphogenesis in adjacent epithelial cells...
  8. Roccisana J, Reddy V, Vasavada R, Gonzalez Pertusa J, Magnuson M, Garcia Ocana A. Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass. Diabetes. 2005;54:2090-102 pubmed
    ..In the current studies, we have used conditional ablation of the c-met gene to uncover the physiological role of HGF in beta-cell growth and function...
  9. Cramer A, Kleiner S, Westermann M, Meissner A, Lange A, Friedrich K. Activation of the c-Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT3. J Cell Biochem. 2005;95:805-16 pubmed
    c-Met is the receptor for hepatocyte growth factor/scatter factor (HGF/SF)...
  10. Sonnenberg E, Meyer D, Weidner K, Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol. 1993;123:223-35 pubmed
    ..The cell surface receptor for this factor was recently identified: it is the product of the c-met protooncogene, a receptor-type tyrosine kinase...
  11. Demirci C, Ernst S, Alvarez Perez J, Rosa T, Valle S, Shridhar V, et al. Loss of HGF/c-Met signaling in pancreatic ?-cells leads to incomplete maternal ?-cell adaptation and gestational diabetes mellitus. Diabetes. 2012;61:1143-52 pubmed publisher
    Hepatocyte growth factor (HGF) is a mitogen and insulinotropic agent for the ?-cell. However, whether HGF/c-Met has a role in maternal ?-cell adaptation during pregnancy is unknown...
  12. Graveel C, DeGroot J, Su Y, Koeman J, Dykema K, Leung S, et al. Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer. Proc Natl Acad Sci U S A. 2009;106:12909-14 pubmed publisher
    ..The oncogene MET is associated with decreased survival in breast cancer, yet the role that MET plays in the various breast cancer ..
  13. Moumen A, Ieraci A, Patanè S, Sole C, Comella J, Dono R, et al. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner. Hepatology. 2007;45:1210-7 pubmed
    ..Although hepatocyte growth factor (HGF) and its receptor Met are known to mediate cell survival in developing livers, the molecular mechanisms involved in ..
  14. Weidner K, Sachs M, Birchmeier W. The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J Cell Biol. 1993;121:145-54 pubmed
    Depending on the target cells and culture conditions, scatter factor/hepatocyte growth factor (SF/HGF) mediates several distinct activities, i.e...
  15. Chan A, King H, Deakin E, Tempest P, Hilkens J, Kroezen V, et al. Characterization of the mouse met proto-oncogene. Oncogene. 1988;2:593-9 pubmed
    The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor...
  16. Coudriet G, He J, Trucco M, Mars W, Piganelli J. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE. 2010;5:e15384 pubmed publisher
    ..These changes were a direct result of signaling through the HGF receptor, MET, as effects were reversed in the presence of a selective inhibitor of MET (SU11274) or when using BMM from ..
  17. del Castillo G, Factor V, Fernandez M, Alvarez Barrientos A, Fabregat I, Thorgeirsson S, et al. Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro. Am J Pathol. 2008;172:1238-47 pubmed publisher
    The hepatocyte growth factor (HGF)/Met signaling system is essential for liver development, homeostasis, and function...
  18. Dietrich S, Abou Rebyeh F, Brohmann H, Bladt F, Sonnenberg Riethmacher E, Yamaai T, et al. The role of SF/HGF and c-Met in the development of skeletal muscle. Development. 1999;126:1621-9 pubmed
    ..Previous work shows that the formation of migratory precursors requires the c-Met and SF/HGF genes...
  19. Kaposi Novak P, Lee J, Gòmez Quiroz L, Coulouarn C, Factor V, Thorgeirsson S. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest. 2006;116:1582-95 pubmed
    ..Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis...
  20. Huh C, Factor V, Sánchez A, Uchida K, Conner E, Thorgeirsson S. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004;101:4477-82 pubmed
    ..Because homozygous null mice for either hgf/sf or c-met die in utero, we used Cre/loxP-mediated gene targeting to investigate the function of c-met ..
  21. Epstein J, Shapiro D, Cheng J, Lam P, Maas R. Pax3 modulates expression of the c-Met receptor during limb muscle development. Proc Natl Acad Sci U S A. 1996;93:4213-8 pubmed
    ..The tyrosine kinase receptor for hepatocyte growth factor/scatter factor encoded by the c-met protooncogene is also expressed in limb muscle progenitors and, like Pax-3, is required in the mouse for limb ..
  22. Iyer A, Kmiecik T, Park M, Daar I, Blair D, Dunn K, et al. Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ. 1990;1:87-95 pubmed
    A 6.7-kilobase met complementary DNA (cDNA) was isolated from a pcD cDNA library prepared from C3H mouse fibroblast cell line polyadenylated RNA. Sequence analysis of 6...
  23. Ma H, Saenko M, Opuko A, Togawa A, Soda K, Marlier A, et al. Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. Kidney Int. 2009;76:868-76 pubmed publisher
    Hepatocyte growth factor and its receptor, Met, activate biological pathways necessary for repair and regeneration following kidney injury...
  24. Giacobini P, Messina A, Wray S, Giampietro C, Crepaldi T, Carmeliet P, et al. Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. J Neurosci. 2007;27:431-45 pubmed
    ..In this study, the role of HGF and its receptor Met during development of the GnRH-1 system was examined...
  25. Graveel C, Su Y, Koeman J, Wang L, Tessarollo L, Fiscella M, et al. Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A. 2004;101:17198-203 pubmed
    Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers...
  26. Mennerich D, Schafer K, Braun T. Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb. Mech Dev. 1998;73:147-58 pubmed
    ..Analysis of splotch mutant mice showed that lbx1 and c-met are differently affected by the lack of Pax-3...
  27. Yang X, Vogan K, Gros P, Park M. Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice. Development. 1996;122:2163-71 pubmed
    Hepatocyte growth factor/scatter factor (HGF/SF) stimulates proliferation, dissociation, migration and morphogenesis of cells in culture...
  28. Ebens A, Brose K, Leonardo E, Hanson M, Bladt F, Birchmeier C, et al. Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron. 1996;17:1157-72 pubmed
    ..Here we identify the limb mesenchyme-derived chemoattractant as hepatocyte growth factor/scatter factor (HGF/SF), a diffusible ligand for the c-Met receptor tyrosine kinase, and we also implicate HGF/SF at later stages as a ..
  29. Brohmann H, Jagla K, Birchmeier C. The role of Lbx1 in migration of muscle precursor cells. Development. 2000;127:437-45 pubmed
    ..We suggest that Lbx1 controls the expression of genes that are essential for the recognition or interpretation of cues that guide migrating muscle precursors and maintain their migratory potential. ..
  30. Anastasi S, Giordano S, Sthandier O, Gambarotta G, Maione R, Comoglio P, et al. A natural hepatocyte growth factor/scatter factor autocrine loop in myoblast cells and the effect of the constitutive Met kinase activation on myogenic differentiation. J Cell Biol. 1997;137:1057-68 pubmed
    ..To analyze the biological effects of HGF/SF receptor activation, we stably expressed the constitutively activated receptor catalytic domain (p65(tpr-met)) in C2 ..
  31. Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 1995;376:768-71 pubmed
    ..Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and ..
  32. Dai C, Huh C, Thorgeirsson S, Liu Y. Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am J Pathol. 2005;167:429-36 pubmed
    Hepatocyte growth factor (HGF) and its c-met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic beta-cell survival, proliferation, and function...
  33. Rappolee D, Iyer A, Patel Y. Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis. Circ Res. 1996;78:1028-36 pubmed
    ..b>HGF receptor mRNA is detected in the mesoderm of the headfold stage and persists in myocardial precursors of the ventricles ..
  34. Crepaldi T, Bersani F, Scuoppo C, Accornero P, Prunotto C, Taulli R, et al. Conditional activation of MET in differentiated skeletal muscle induces atrophy. J Biol Chem. 2007;282:6812-22 pubmed
    ..Here we examined the effects of inducing expression of an oncogenic version of the Met receptor (Tpr-Met) in terminally differentiated skeletal muscle...
  35. Tönges L, Ostendorf T, Lamballe F, Genestine M, Dono R, Koch J, et al. Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J Neurochem. 2011;117:892-903 pubmed publisher
    ..Together with its corresponding receptor c-mesenchymal-epithelial transition factor (Met), it is expressed in the developing and the adult murine, rat and human CNS...
  36. Borowiak M, Garratt A, Wüstefeld T, Strehle M, Trautwein C, Birchmeier C. Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A. 2004;101:10608-13 pubmed
    ..a crucial role of the Met tyrosine kinase receptor and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver, muscle, and placenta...
  37. Wang X, DeFrances M, Dai Y, Pediaditakis P, Johnson C, Bell A, et al. A mechanism of cell survival: sequestration of Fas by the HGF receptor Met. Mol Cell. 2002;9:411-21 pubmed
    ..Here, we report the discovery of a cell survival mechanism by which Met, a growth factor receptor tyrosine kinase, directly binds to and sequesters the death receptor Fas in hepatocytes...
  38. Judson M, BERGMAN M, Campbell D, Eagleson K, Levitt P. Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain. J Comp Neurol. 2009;513:511-31 pubmed publisher
    ..proliferation, migration, differentiation, and survival-all of which can be mediated by hepatocyte growth factor (HGF) signaling through the Met receptor tyrosine kinase...
  39. Maina F, Casagranda F, Audero E, Simeone A, Comoglio P, Klein R, et al. Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell. 1996;87:531-42 pubmed
    Hepatocyte growth factor (HGF) and its receptor, the Met tyrosine kinase, are determinants of placenta, liver, and muscle development. Here, we show that Met function in vivo requires signaling via two carboxy-terminal tyrosines...
  40. Dai C, Saleem M, Holzman L, Mathieson P, Liu Y. Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria. Kidney Int. 2010;77:962-73 pubmed publisher
    ..role in podocyte homeostasis, injury, and repair in vivo, we generated conditional knockout mice in which the HGF receptor, c-met, was specifically deleted in podocytes using the Cre-LoxP system...
  41. Chmielowiec J, Borowiak M, Morkel M, Stradal T, Munz B, Werner S, et al. c-Met is essential for wound healing in the skin. J Cell Biol. 2007;177:151-62 pubmed
    ..We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre ..
  42. Morozov V, Massoll N, Vladimirova O, Maul G, Ishov A. Regulation of c-met expression by transcription repressor Daxx. Oncogene. 2008;27:2177-86 pubmed
    The protooncogene c-met encodes the tyrosine kinase receptor for the hepatocyte growth factor/scatter factor (HGF/SF). While overexpression of c-met is documented in many types of tumors, the mechanism of c-met regulation remains elusive...
  43. Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, et al. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development. 2009;136:337-45 pubmed publisher
    ..Although hepatocyte growth factor and its receptor Met have been shown to stimulate branching morphogenesis in explanted embryonic kidneys, loss of Met expression is ..
  44. Jung W, Castren E, Odenthal M, Vande Woude G, Ishii T, Dienes H, et al. Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain. J Cell Biol. 1994;126:485-94 pubmed
    ..HGF-SF activity is mediated by the c-met protooncogene, a membrane-bound tyrosine kinase...
  45. Tulasne D, Deheuninck J, Lourenco F, Lamballe F, Ji Z, Leroy C, et al. Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Mol Cell Biol. 2004;24:10328-39 pubmed
    The MET tyrosine kinase, the receptor of hepatocyte growth factor-scatter factor (HGF/SF), is known to be essential for normal development and cell survival...
  46. Judson M, Eagleson K, Wang L, Levitt P. Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain. J Comp Neurol. 2010;518:4463-78 pubmed publisher
    Human genetic findings and murine neuroanatomical expression mapping have intersected to implicate Met receptor tyrosine kinase signaling in the development of forebrain circuits controlling social and emotional behaviors that are ..
  47. Martins G, Plachez C, Powell E. Loss of embryonic MET signaling alters profiles of hippocampal interneurons. Dev Neurosci. 2007;29:143-58 pubmed
    ..dorsally in response to cues, including hepatocyte growth factor/scatter factor which signals via its receptor MET. Examination of the hippocampus in adult mice in which MET had been inactivated in the embryonic proliferative ..
  48. Yamamoto H, Yun E, Gerber H, Ferrara N, Whitsett J, Vu T. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007;308:44-53 pubmed
    ..Lung endothelial cells express Hgf, and selective deletion of the Hgf receptor gene in respiratory epithelium phenocopies the malformation of septae, confirming the requirement for ..
  49. deAngelis T, Morrione A, Baserga R. Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1. J Cell Physiol. 2010;224:658-63 pubmed publisher
    The insulin receptor substrate-1 (IRS-1) and c-met, the receptor for the hepatocyte growth factor (HGF) co-immuno-precipitate from lysates treated with the respective antibodies...
  50. Ponzo M, Lesurf R, Petkiewicz S, O Malley F, Pinnaduwage D, Andrulis I, et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc Natl Acad Sci U S A. 2009;106:12903-8 pubmed publisher
    Elevated MET receptor tyrosine kinase correlates with poor outcome in breast cancer, yet the reasons for this are poorly understood...
  51. Szabo R, Rasmussen A, Moyer A, Kosa P, Schafer J, Molinolo A, et al. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011;30:2003-16 pubmed publisher
    ..and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene...
  52. Lin H, Lai P, Lin Y, Huang J, Yang B. Fas ligand enhances malignant behavior of tumor cells through interaction with Met, hepatocyte growth factor receptor, in lipid rafts. J Biol Chem. 2012;287:20664-73 pubmed publisher
    ..We report here a novel signaling mechanism for FasL that hijacks the Met signal pathway to promote tumor metastasis...
  53. Modali S, Parekh V, Kebebew E, Agarwal S. Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors. Mol Endocrinol. 2015;29:224-37 pubmed publisher
    ..in MIN6 mouse insulinoma cells down-regulated the expression of the protooncogene c-Met (hepatocyte growth factor receptor), and these cells showed significantly reduced cell migration/invasion...
  54. Hwang C, Matoso A, Corney D, Flesken Nikitin A, Körner S, Wang W, et al. Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A. 2011;108:14240-5 pubmed publisher
    ..we show that conditional inactivation of p53 or expression of its mutant forms results in overexpression of MET receptor tyrosine kinase, a crucial regulator of invasive growth...
  55. Yamin M, Gorn A, Flannery M, Jenkins N, Gilbert D, Copeland N, et al. Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology. 1994;135:2635-43 pubmed
    ..The differential cellular and tissue distribution of these functionally distinct CTR isoforms provides the molecular basis for the previously reported widespread distribution and functional heterogeneity of the CTR. ..
  56. Gavalas A, Ruhrberg C, Livet J, Henderson C, Krumlauf R. Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Development. 2003;130:5663-79 pubmed
    ..Therefore, we have delineated the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2. ..
  57. Zhang X, Liu Y. Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1. Am J Physiol Renal Physiol. 2003;284:F1216-25 pubmed
    Hepatocyte growth factor (HGF) receptor, the product of the c-met protooncogene, is transcriptionally regulated by a wide variety of cytokines as well as extracellular environmental cues...
  58. Lock L, Maroun C, Naujokas M, Park M. Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. Mol Biol Cell. 2002;13:2132-46 pubmed
    ..Gab1 acts to diversify the signal downstream from the Met receptor tyrosine kinase through the recruitment of multiple signaling proteins, and is essential for epithelial ..
  59. Speicher T, Siegenthaler B, Bogorad R, Ruppert R, Petzold T, Padrissa Altés S, et al. Knockdown and knockout of ?1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling. Nat Commun. 2014;5:3862 pubmed publisher
  60. Martins G, Shahrokh M, Powell E. Genetic disruption of Met signaling impairs GABAergic striatal development and cognition. Neuroscience. 2011;176:199-209 pubmed publisher
    ..of the striatal neurons and their assembly into functional circuits, we used a mouse with a targeted conditional Met mutation in post-mitotic cells of the ventral telencephalon...
  61. Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, et al. The semaphorin 4D receptor controls invasive growth by coupling with Met. Nat Cell Biol. 2002;4:720-4 pubmed
    ..expressing the endogenous proteins, Plexin B1 (the Sema 4D Receptor) and Met (the Scatter Factor 1/ Hepatocyte Growth Factor Receptor) associate in a complex...
  62. Wilks A, Kurban R, Hovens C, Ralph S. The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989;85:67-74 pubmed
    ..In addition to a number of previously described PTK sequences, a novel mammalian PTK-related sequence was uncovered. ..
  63. Gastaldi S, Sassi F, Accornero P, Torti D, Galimi F, Migliardi G, et al. Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer. Oncogene. 2013;32:1428-40 pubmed publisher
    ..models, we found that luminal progenitors express high levels of the Met receptor for hepatocyte growth factor (HGF), as compared with the other mammary epithelial sub-populations...
  64. Li Y, Hoffman R, Le Beau M, Espinosa R, Jenkins N, Gilbert D, et al. Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization. J Biol Chem. 1992;267:26011-6 pubmed
  65. Rosu Myles M, Stewart E, Trowbridge J, Ito C, Zandstra P, Bhatia M. A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. J Cell Sci. 2005;118:4343-52 pubmed
    ..antibody, but could be reduced by addition of c-met-blocking antibody and augmented by hepatocyte growth factor (HGF), the putative ligand for c-met...
  66. Swoboda A, Schanab O, Tauber S, Bilban M, Berger W, Petzelbauer P, et al. MET expression in melanoma correlates with a lymphangiogenic phenotype. Hum Mol Genet. 2012;21:3387-96 pubmed publisher
    ..of vascular endothelial growth factor C (VEGF-C) and platelet derived growth factor C (PDGF-C) as well as of the met proto-oncogene (MET) and its targets to be associated with this lymphangiogenic phenotype...
  67. Wu H, Levitt P. Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem. Dev Neurosci. 2013;35:1-16 pubmed publisher
    Signaling via MET receptor tyrosine kinase (MET) has been implicated in a number of neurodevelopmental events, including cell migration, dendritic and axonal development and synaptogenesis...
  68. Ogunwobi O, Puszyk W, Dong H, Liu C. Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma. PLoS ONE. 2013;8:e63765 pubmed publisher
    Hepatocyte growth factor (HGF) and its receptor, c-Met, are important regulators of growth and differentiation of healthy hepatocytes...
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    ..Embryonic Foxf1(+/-) lungs exhibited diminished expression of hepatocyte growth factor receptor c-Met, myosin VI, the transcription factors SP-3, BMI-1, ATF-2, and glucocorticoid receptor, and ..
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    We inserted the sequence coding for the cytoplasmic portion of the human MET receptor into an 18-kb genomic fragment containing the entire human A1AT gene (encoding alpha-1-antitrypsin)...
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    ..The mechanisms promoting postoperative peritoneal tumor dissemination are unclear. This study aimed to investigate postoperative tumor dissemination over time on both tissue and molecular levels...
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    ..blood vascular endothelial cells (BVEC) revealed that LEC express significantly higher levels of hepatocyte growth factor receptor (HGF-R)...
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    ..In addition, loss of expression of ZAC has been described for a number of breast and ovarian carcinomas, suggesting that ZAC is a potential tumor suppressor gene. ..