Genomes and Genes
Gene Symbol: Map2
Description: microtubule-associated protein 2
Alias: G1-397-34, MAP-2, Mtap-2, Mtap2, repro4, microtubule-associated protein 2
Publications150 found, 100 shown here
- Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteinsDaisuke Tanaka
Graduate School of Frontier Biosciences, Osaka University, Machikaneyama 1 3, Toyonaka, Osaka 560 8531, Japan
Development 130:5803-13. 2003..At least a part of these neurons may descend toward the CP. Our results also suggest that intracortical migration of GABAergic neurons occurs independent of GPI-anchored proteins...
- The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in miceFiona Pickford
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 118:2190-9. 2008..We conclude that beclin 1 deficiency disrupts neuronal autophagy, modulates APP metabolism, and promotes neurodegeneration in mice and that increasing beclin 1 levels may have therapeutic potential in AD...
- Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brainD S Rice
Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Development 125:3719-29. 1998..This suggests that Dab1 accumulates in the absence of a Reln-evoked signal. Taken together, these results indicate that Dab1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain...
- Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanismsBalazs Hegedus
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Cell Stem Cell 1:443-57. 2007..Together, these findings demonstrate that neurofibromin is required for normal glial and neuronal development involving separable Ras-dependent and cAMP-dependent mechanisms...
- Preferential binding of a kinesin-1 motor to GTP-tubulin-rich microtubules underlies polarized vesicle transportTakao Nakata
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
J Cell Biol 194:245-55. 2011..Collectively, these data suggest that the abundance of GTP-tubulin in axonal microtubules may underlie selective KIF5 localization and polarized axonal vesicular transport...
- Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndromeEva K Wirth
Neuroscience Research Center, Charite Universitatsmedizin Berlin, Berlin, Germany
J Neurosci 29:9439-49. 2009....
- Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain developmentRusty L Montgomery
Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
Proc Natl Acad Sci U S A 106:7876-81. 2009..These results reveal redundant and essential roles for HDAC1 and HDAC2 in the progression of neuronal precursors to mature neurons in vivo...
- Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migrationNaoya Yamashita
Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
J Neurosci 26:13357-62. 2006..Loss of crmp1 in a dab1 heterozygous background led to the disruption of hippocampal lamination, a Reeler-like phenotype. In addition to axon guidance, CRMP1 regulates neuronal migration by mediating Reln signaling...
- Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopmentI L Schurov
Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
Mol Psychiatry 9:1100-10. 2004..Together, these results suggest that DISC1 may play a critical role in brain development, consistent with the neurodevelopmental hypothesis of the etiology of schizophrenia...
- Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheresS Xuan
Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Neuron 14:1141-52. 1995..These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation...
- DLX-2, MASH-1, and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrainM H Porteus
Nina Ireland Laboratory of Developmental Biology, Department of Psychiatry, University of California, San Francisco 94143 0984
J Neurosci 14:6370-83. 1994....
- Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheresC L Dou
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cereb Cortex 9:543-50. 1999..These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium...
- Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cellsShizue Ohsawa
Department of Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
J Neurosci Res 79:451-8. 2005..These results raise the possibility that NPAS1 plays a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level...
- The protein dendrite arborization and synapse maturation 1 (Dasm-1) is dispensable for dendrite arborizationArchana Mishra
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
Mol Cell Biol 28:2782-91. 2008..These findings indicate that the dendrite arborization phenotype was caused by off-target effects and that Dasm-1 is dispensable for hippocampal dendrite arborization...
- Expression of Disabled 1 suppresses astroglial differentiation in neural stem cellsIl Sun Kwon
Department of Anatomy, School of Medicine, Ajou University, Suwon, 443 749, South Korea
Mol Cell Neurosci 40:50-61. 2009..Our results suggest that Dab1 participates in the differentiation of NSCs into a specific cell lineage, thereby maintaining a balance between neurogenesis and gliogenesis...
- Frizzled-3 is required for the development of major fiber tracts in the rostral CNSYanshu Wang
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 22:8563-73. 2002..In contrast, there is little cell death, as assayed by terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling, in the cortex. These data provide the first link between Frizzled signaling and axonal development...
- Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cordS Ozaki
Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 380:215-29. 1997..The pathways taken by developing sensory afferents are compatible with the idea that cells in inappropriate laminae exert inhibitory influences on sensory axons which regulate their laminar specificity...
- Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neuronsS A Anderson
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
Neuron 19:27-37. 1997..Several lines of evidence suggest that mutations in Dlx-1 and Dlx-2 produce abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons...
- Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tractY Sato
Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
J Neurosci 18:7800-10. 1998..Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are "guidepost cells" for mitral cell axons...
- Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2M Trommsdorff
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
Cell 97:689-701. 1999..These findings suggest that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1...
- Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levelsC Gonzalez-Billault
Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
Mol Cell Neurosci 16:408-21. 2000..Analyses of these mice indicate the presence of several neural defects and suggest the participation of MAP1B in neuronal migration...
- Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneuronsS J Pleasure
Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
Neuron 28:727-40. 2000..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
- Tbr1 regulates differentiation of the preplate and layer 6R F Hevner
Nina Ireland Laboratory of, Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 29:353-66. 2001..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development...
- Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organizationJ Teng
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Cell Biol 155:65-76. 2001MAP1B and MAP2 are major members of neuronal microtubule-associated proteins (MAPs). To gain insights into the function of MAP2 in vivo, we generated MAP2-deficient (map2(-/-)) mice...
- Transcriptional regulation of cortical neuron migration by POU domain factorsRobert J McEvilly
Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037 0648, USA
Science 295:1528-32. 2002....
- MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transductionAkihiro Harada
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
J Cell Biol 158:541-9. 2002Microtubule-associated protein 2 (MAP2) is a major component of cross-bridges between microtubules in dendrites, and is known to stabilize microtubules...
- Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effectorBenny Björkblom
Turku Centre for Biotechnology, Abo Akademi and Turku University, BioCity, FIN 20521 Turku, Finland
J Neurosci 25:6350-61. 2005..for candidate mediators, we identify the dendrite-specific high-molecular-weight microtubule-associated protein 2 (MAP2) as a JNK substrate in the brain...
- Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortexFumiyasu Imai
Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
Development 133:1735-44. 2006..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions...
- From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain developmentToshiko R Matsugami
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
Proc Natl Acad Sci U S A 103:12161-6. 2006....
- Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosisYinghua Ma
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
J Cell Biol 175:209-15. 2006..These findings reveal novel functions for TLR8 in the mammalian nervous system that are distinct from the classical role of TLRs in immunity...
- Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethalityYuehai Ke
Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Mol Cell Biol 27:6706-17. 2007..Together, these results identify Shp2 as a critical signaling molecule in coordinated regulation of progenitor cell proliferation and neuronal/astroglial cell differentiation...
- Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical developmentKonstantinos Zarbalis
Department of Neurology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:14002-7. 2007..Furthermore, we provide evidence that defects in meningeal differentiation can lead to severe cortical dysplasia...
- Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortexMaria Pia Postiglione
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Neuron 72:269-84. 2011..Our results indicate that the orientation of progenitor cell divisions is important for correct lineage specification in the developing mammalian brain...
- Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brainJ B Pellet
Institut de Biologie Cellulaire et de Morphologie, IBCM, Rue du Bugnon 9, 1005 Lausanne, Switzerland
Eur J Neurosci 12:621-32. 2000....
- Cajal-Retzius cells and subplate neurons differentially express vesicular glutamate transporters 1 and 2 during development of mouse cortexAyuka Ina
Laboratory of Neuroendocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 3574, Japan
Eur J Neurosci 26:615-23. 2007..By dual labeling combined with immunostaining for microtubule-associated protein 2 (MAP2) or reelin, we showed that MAP2-positive preplate and marginal zone neurons and subplate neurons express VGLUT1, ..
- Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerveElli Chatzopoulou
Institut National de la Sante et de la Recherche Medicale, Unité 711, Universite Pierre et Marie Curie, Faculte de Medecine, Hopital de la Salpetriere, Institut Fédératif de Recherche 70, F 75013 Paris, France
J Neurosci 28:7624-36. 2008..Therefore, TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve...
- Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neuronsMary Wines-Samuelson
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Dev Biol 277:332-46. 2005..These findings show a cell-autonomous role for PS1 in cortical lamination and radial glial development, and a non-cell-autonomous role for PS1 in CR neuron survival...
- Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell deathK A Roth
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 97:466-71. 2000....
- Dispersion of chromogranin/secretogranin secretory protein family loci in mammalian genomesS K Mahata
Department of Medicine, University of California, San Diego, California, 92161, USA
Genomics 33:135-9. 1996..Our results indicate that each locus lies in a region of locally syntenic chromosomal homology across the three species...
- Vinculin knockout results in heart and brain defects during embryonic developmentW Xu
The Burnham Institute, La Jolla, CA 92037, USA
Development 125:327-37. 1998....
- Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatumL Sussel
Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
Development 126:3359-70. 1999..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
- Presenilin-1 regulates neuronal differentiation during neurogenesisM Handler
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Development 127:2593-606. 2000..1997, Nature 387, 288-292). These results provide direct evidence that PS1 controls neuronal differentiation in association with the downregulation of Notch signalling during neurogenesis...
- Developmental history of the subplate and developing white matter in the murine neocortex. Neuronal organization and relationship with the main afferent systems at embryonic and perinatal stagesJ A Del Rio
Department of Cell Biology, Faculty of Biology and Neuroscience Research Center, C E R N, University of Barcelona, E 08028 Barcelona, Spain
Cereb Cortex 10:784-801. 2000....
- Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNSS Sakakibara
Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
J Neurosci 21:8091-107. 2001..These two RNA-binding proteins may exert common functions in neural precursor cells by regulating gene expression at the post-transcriptional level...
- Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepitheliumDonna M Martin
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, 48109, USA
Dev Biol 252:84-99. 2002..Our results suggest that PITX2 expression in postmitotic neurons may contribute to development of GABAergic and other differentiated neuronal phenotypes...
- Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiationAnnalisa Bolis
Cell Adhesion Unit, Department of Molecular Biology and Functional Genomics, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Eur J Neurosci 18:2417-24. 2003..Our data implicate Rac3 in neuronal differentiation, and support a specific role of this GTPase in actin-mediated remodelling of Purkinje cell neuritic terminals at time of synaptogenesis...
- P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds miceHeike Franke
Rudolf Boehm lnstitute of Pharmacology and Toxicology, University of Leipzig, D 04107 Leipzig, Germany
Neurochem Int 47:235-42. 2005..Hence, we suggest that, in BALBCrds mice, an early up-regulation of neuronal P2X(7) receptors may cause injury of retinal neurons and thereby functionally contribute to the retinal damage...
- Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNSYasushi Enokido
Department of Molecular Geneticsy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
FASEB J 19:1854-6. 2005....
- A shared vesicular carrier allows synaptic corelease of GABA and glycineSonja M Wojcik
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Neuron 50:575-87. 2006..Since GABA and glycine compete for vesicular uptake, these data point to a close association of Viaat with GABA-synthesizing enzymes as a key factor in specifying GABAergic neuronal phenotypes...
- Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cellsTakehisa Sakaguchi
Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
Mol Cell Biol 26:6557-70. 2006..These results demonstrate that Jam-B is dispensable for normal mouse development and stem cell identity in embryonic, neural, and hematopoietic stem cells...
- NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formationSeho Kim
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
Nat Neurosci 9:1294-301. 2006..NGL-2 knockdown reduced excitatory, but not inhibitory, synapse numbers and currents. These results suggest that NGL regulates the formation of excitatory synapses...
- Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic functionKoji Ikegami
Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
Proc Natl Acad Sci U S A 104:3213-8. 2007..These data provide evidence for a role of polyglutamylation of alpha-tubulin in vivo, as a molecular traffic sign for targeting of KIF1 kinesin required for continuous synaptic transmission...
- Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of gliaFabien D'Autréaux
Department of Pathology and Cell Biology, Columbia University, P and S, New York, NY 10032, USA
Development 134:2237-49. 2007..We suggest that enteric neuronal development occurs in stages and that Hand2 expression is required for terminal differentiation but not for precursors to enter the neuronal lineage...
- Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1Ge Bai
Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Dev Cell 13:283-97. 2007..These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos...
- Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alphaHaihong Ye
Institute of Molecular and Cell Biology, Singapore, Singapore
EMBO J 27:188-200. 2008..We propose a signaling complex in which PTPalpha mediates CHL1 and NB-3-regulated apical dendrite projection in the developing caudal cortex...
- C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachmentAnne K Voss
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Development 135:2139-49. 2008..In C3G-deficient cells, Rap1 GTP loading in response to reelin stimulation is reduced. In conclusion, the Ras family regulator C3G is essential for two aspects of cortex development, namely radial glial attachment and neuronal migration...
- Aspects of the neuroendocrine cerebellum: expression of secretogranin II, chromogranin A and chromogranin B in mouse cerebellar unipolar brush cellsM G Nunzi
Department of Cell and Molecular Biology, The Feinberg School of Medicine of Northwestern University, Searle 5 474, 320 East Superior Street, Chicago, IL 60611, USA
Neuroscience 162:673-87. 2009....
- Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during developmentAlina Smorodchenko
Institute of Cell Biology and Neurobiology, Charite Universitatsmedizin, Berlin, Germany
Biochim Biophys Acta 1788:2309-19. 2009..UCP4 preferential expression in neurons and its developmental expression pattern under physiological conditions may indicate a specific protein function, e.g. in neuronal cell differentiation...
- Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stagesTakayuki Uchida
Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi 467 8603, Japan
J Neurosci 29:10653-62. 2009..It is thus strongly suggested that Reelin exerts critical actions on migrating projection neurons at their early/premigratory stages en route to their final destinations, in the developing cerebral cortex and cerebellum...
- Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous systemYoko Kawase-Koga
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
Dev Dyn 238:2800-12. 2009..Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development...
- Increased expression of MAP2 inhibits melanoma cell proliferation, invasion and tumor growth in vitro and in vivoZhiqi Song
Department of Dermatology, No 1 Hospital of China Medical University, Key Laboratory of Immunodermatology, Ministry of Health China Medical University, Shenyang, China
Exp Dermatol 19:958-64. 2010..Microtubule-associated proteins 2 (MAP2) is expressed abundantly in majority of melanocytic nevi and primary melanomas, but absent in metastatic melanomas...
- PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndromeFrançois Mouton-Liger
Functional Adaptive Biology BFA, Centre National de la Recherche Scientifique CNRS EAC4413, Université Paris Diderot Paris7, 75205 Paris Cedex 13, France
J Comp Neurol 519:2779-802. 2011..TgPCP4 and Ts1Cje mice developed similar modifications, demonstrating that these mechanisms may account for abnormal neuronal development in DS...
- Retinoic acid functions as a key GABAergic differentiation signal in the basal gangliaChristina Chatzi
Sanford Burnham Medical Research Institute, Development and Aging Program, La Jolla, California, United States of America
PLoS Biol 9:e1000609. 2011..Our observation that endogenous RA is required for generation of LGE-derived GABAergic neurons in the basal ganglia establishes a key role for RA signaling in development of the forebrain...
- Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5Kyoji Ohyama
Department of Anatomy and Neurobiology, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
Gene Expr Patterns 12:36-45. 2012..Given that Nat5 is only a known member of Nat family protein that interacts with Mdm20, our data imply that Mdm20 may function either with an unidentified Nat protein partner(s) or possibly in a Nat-independent manner...
- Overstimulation of NMDA receptors impairs early brain development in vivoTomomi Aida
Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, Tokyo Japan
PLoS ONE 7:e36853. 2012..However, how prenatal disturbance of NMDARs leads to schizophrenia-associated developmental defects is largely unknown...
- The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortexDaijiro Konno
Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
PLoS ONE 7:e46577. 2012....
- Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactionsIngo Bormuth
Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Gottingen, Germany
J Neurosci 33:641-51. 2013..Our findings define a new stage in corpus callosum development and demonstrate that neocortical projection neurons require transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote connectivity...
- Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferationTessa Walcher
Institute of Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg Munich, Germany
Development 140:1123-36. 2013..Thus, Pax6 achieves its key roles in the developing forebrain by utilizing particular subdomains to coordinate patterning, neurogenesis and proliferation simultaneously...
- EGF transactivation of Trk receptors regulates the migration of newborn cortical neuronsDirk Puehringer
Institute for Clinical Neurobiology, University of Wuerzburg, Wuerzburg, Germany
Nat Neurosci 16:407-15. 2013..Our results provide genetic evidence that TrkB and TrkC activation in early cortical neurons do not depend on BDNF and NT-3, but instead on transactivation by EGFR signaling...
- Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical developmentChoo Peng Goh
Brain Development and Regeneration Laboratory, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3010, Australia
Neurosci Lett 555:225-30. 2013..This consistent but dynamic pattern of Ndfip1 expression in temporal and spatial domains of the cortical landscape is indicative of complex programs of protein ubiquitination during corticogenesis. ..
- Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortexRajiv Dixit
Departments of Biochemistry and Molecular Biology and Medical Genetics, Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Pathology and Laboratory Medicine, Southern Alberta Cancer Research Institute, University of Calgary, Alberta T2N 4N1, Canada, Programs in Cell Biology, and Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto M5G 1L7, Canada, Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, Institute of Medical Science and Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada, and Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
J Neurosci 34:539-53. 2014..Neurog1 and Neurog2 thus have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of early-born CR/lot cells and specifying the identities of later-born layer II/III neurons. ..
- A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientationChun Ting Chen
Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
Curr Biol 24:2327-34. 2014..Not only do these data reveal a spindle-pole-localized complex for spindle orientation, but they identify key spindle symmetry proteins involved in the pathogenesis of MOPDII...
- Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell SubtypesMatthew L Kraushar
Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School and
J Neurosci 35:10911-26. 2015..This mechanism may enable targeted and rapid spatiotemporal control of ribosome composition and selective mRNA translation in complex developing systems like the neocortex...
- 3-Phosphoglycerate dehydrogenase, a key enzyme for l-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brainM Yamasaki
Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
J Neurosci 21:7691-704. 2001....
- Stage-specific modulation of cortical neuronal development by Mmu-miR-134Philip Gaughwin
Department of Stem Cell and Developmental Biology, A STAR Genome Institute of Singapore 138672, Singapore
Cereb Cortex 21:1857-69. 2011....
- Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivoToshinao Oyama
Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Development 138:5235-46. 2011..These results indicate that engagement of Mam is essential for Notch signaling, and that the three Mam isoforms have distinct roles in vivo...
- α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2Jacque P K Ip
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Nat Neurosci 15:39-47. 2011..These findings establish a new α2-chimaerin-dependent mechanism underlying neuronal migration and proper functioning of the cerebral cortex and provide insights into the pathogenesis of seizure-related neurodevelopmental disorders...
- The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene clusterNoel Ghanem
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
J Neurosci 32:8219-30. 2012....
- Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neuronsMarek Pacal
Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Canada
Dev Dyn 241:1525-44. 2012..Here, we timed cell cycle and neuronal protein silencing/induction during cell birth in the developing murine retina...
- Complete sequence of a cDNA encoding mouse MAP2D Wang
Department of Biochemistry, NYU Medical Center 10016
Nucleic Acids Res 16:11369-70. 1988
- The murine dilute suppressor gene encodes a cell autonomous suppressorK J Moore
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
Genetics 138:491-7. 1994..In addition, we have further refined the map location of dsu in order to examine a number of possible dsu candidate genes mapping in the region and to provide a genetic basis for the positional cloning of dsu...
- Organization of the embryonic and early postnatal murine hippocampus. I. Immunocytochemical characterization of neuronal populations in the subplate and marginal zoneE Soriano
Unit of Cell Biology, Faculty of Biology, University of Barcelona, Spain
J Comp Neurol 342:571-95. 1994..Sections were processed for the visualization of microtubule-associated protein 2 (MAP2) and other antigens such as neurotransmitters, neuropeptides, calcium-binding proteins and a synaptic antigen (Mab ..
- Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler miceT Miyata
Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
J Comp Neurol 372:215-28. 1996..The spatiotemporal expressions of the CR-50 antigen in the cerebellum are consistent with the possibility that this antigen is involved in cell-cell interactions related to the histogenetic assembly of Purkinje cells...
- BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortexT Ringstedt
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
Neuron 21:305-15. 1998..These results demonstrate a role for BDNF on cortical CR cells and identify Reelin as a direct effector of this neurotrophin during brain development...
- Essential roles for the Abl and Arg tyrosine kinases in neurulationA J Koleske
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Neuron 21:1259-72. 1998..Thus, Abl and Arg play essential roles in neurulation and can regulate the structure of the actin cytoskeleton...
- Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in miceT Kobayashi
Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
Cancer Res 59:1206-11. 1999..The mouse strain described here should provide a valuable experimental model to analyze the function of tuberin and its association with tumorigenesis...
- Hes1 and Hes5 as notch effectors in mammalian neuronal differentiationT Ohtsuka
Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, USA
EMBO J 18:2196-207. 1999..These results demonstrate that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation...
- The cytoskeleton of the myenteric neurons during murine embryonic lifeM S Faussone-Pellegrini
Department of Human Anatomy and Histology, University of Florence, Italy
Anat Embryol (Berl) 199:459-69. 1999....
- Ebf1 controls early cell differentiation in the embryonic striatumS Garel
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
Development 126:5285-94. 1999....
- Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transportM Setou
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Science 288:1796-802. 2000..This interaction, specific for a neurotransmitter receptor critically important for plasticity in the postsynaptic terminal, may be a regulatory point for synaptic plasticity and neuronal morphogenesis...
- Combinatorial roles of the nuclear receptor corepressor in transcription and developmentK Jepsen
Howard Hughes Medical Institute, Department of Biology, University of California, San Diego, La Jolla 92093, USA
Cell 102:753-63. 2000..Together, these findings suggest that specific combinations of corepressors and histone deacetylases mediate the gene-specific actions of DNA-bound repressors in development of multiple organ systems...
- Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localizationYu Kuramochi
Department of Clinical Biochemistry, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, 192 0392, Tokyo, Japan
Brain Res Mol Brain Res 98:81-92. 2002..These findings will contribute to the functional analysis of the BACH gene using mice including genetic studies...
- Functional peculiarities of MAP2 in DBA/2J inbred mice as a component of genetic predisposition to seizuresT A Chulanova
Group of the Mechanisms of Synaptic Transmission, Institute of Theoretical and Experimental Biophysics, Pushchino
Bull Exp Biol Med 132:1058-61. 2001..The revealed differences in protein content and phosphorylation can be attributed to the mechanisms mediating audiogenic seizures in DBA/2J mice and to differential sensitivity of these inbred lines to seizure-inducing factors...
- Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarityC Gonzalez-Billault
Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Campus Cantoblanco, Madrid, Spain
J Neurosci Res 67:713-9. 2002..In this report we have characterized the effect of the combined suppression of MAP1B and tau, and MAP1B and MAP2 on neuronal polarization in cultured hippocampal cells grown on a laminin-containing substrate...
- Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathologyShinjiro Fukami
Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
Neurosci Res 43:39-56. 2002....
- Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3aK Yamasaki
Department of Human Genetics, School of Medicine, Nagasaki University, 1 12 4 Sakamoto machi, Nagasaki, Japan
Hum Mol Genet 12:837-47. 2003..Reciprocal imprinting of sense and antisense transcripts present only in neurons suggests that the neuron-specific imprinting mechanism is related to the lineage determination of neural stem cells...
- Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memoryZ Khuchua
Vanderbilt University Medical Center, Department of Pediatrics, B3307 MCN, 1161 21 Avenue South, Nashville, TN 37232, USA
Neuroscience 119:101-11. 2003Microtubule-associated protein-2 (MAP2) is a brain specific A-kinase anchoring protein that targets the cyclic AMP-dependent protein kinase holoenzyme (PKA) to microtubules...
- An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesisFederico Calegari
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307, Dresden, Germany
J Cell Sci 116:4947-55. 2003..We propose a model that links the effects of cell fate determinants and asymmetric cell division to the length of the cell cycle...
- The Tlx gene regulates the timing of neurogenesis in the cortexKristine Roy
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 24:8333-45. 2004..These studies indicate that tlx is an essential intrinsic regulator in the decision to proliferate or differentiate in the developing forebrain...
- Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family membersJochen Herms
Zentrum für Neuropathologie und Prionforschung, Universitat Munchen, Munchen, Germany
EMBO J 23:4106-15. 2004..Collectively, our data reveal an essential role for APP family members in normal brain development and early postnatal survival...
- The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1Hye Yeong Ha
Department of Neuroscience, Neuroscience Research Center and Medical Research Institute, Ewha Womans University School of Medicine, Seoul 110 783, Korea
Dev Biol 277:184-99. 2005....
- Role of Pitx2 in the Mammalian Central Nervous SystemDonna Martin; Fiscal Year: 2005..5-14.5) mouse diencephalon, 2) Develop and analyze mice with Pitx2 loss of function, and 3) Develop and analyze transgenic mice with CNS-specific Pitx2 gain of function. ..
- A biochemical screen for novel regulators of neuronal morphogenesisANTHONY KOLESKE; Fiscal Year: 2007..Identifying these substrate will expand the "toolkit" available to dissect the molecular mechanisms of axon and dendrite morphogenesis. [unreadable] [unreadable]..
- Pitx2 Function in Developing Mouse Brain NeuronsDonna M Martin; Fiscal Year: 2010..These results will help guide future experiments aimed at directing neural stem cell differentiation toward specific neuronal cell subtypes. ..