Genomes and Genes
Gene Symbol: Gabra1
Description: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
Alias: Gabra-1, gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, GABAA alpha 1, GABAAR alpha1
Publications111 found, 100 shown here
- GABA(A) receptor expression and inhibitory post-synaptic currents in cerebellar Purkinje cells in dystrophin-deficient mdx miceS L L Kueh
School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
Clin Exp Pharmacol Physiol 35:207-10. 2008..4. These results may explain some of the behavioural problems and cognitive impairment reported in DMD...
- Pre- and postsynaptic GABA receptors at reciprocal dendrodendritic synapses in the olfactory bulbPatrizia Panzanelli
Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Corso Massimo D Azeglio, 52, I 10126 Turin, Italy
Eur J Neurosci 20:2945-52. 2004..Such presynaptic receptors may be activated by spillover of GABA from adjacent inhibitory synapses and modulate glutamate release, thereby providing a novel mechanism regulating dendrodendritic inhibition in the olfactory bulb...
- Glycine receptors and GABA receptor alpha 1 and gamma 2 subunits during the development of mouse hypoglossal nucleusEmilie Muller
UMR 7102 Neurobiologie des Processus Adaptatifs, Universite Pierre et Marie Curie, 7 quai Saint Bernard, 75252 Paris Cedex 05, France
Eur J Neurosci 20:3286-300. 2004..A developmental sequence of the postsynaptic events is proposed in which diffuse extrasynaptic GABA(A)Rs accumulate at inhibitory synapses to form postsynaptic clusters, most of them being colocalized with GlyR clusters in the adult...
- Mice lacking the major adult GABAA receptor subtype have normal number of synapses, but retain juvenile IPSC kinetics until adulthoodLaurens W J Bosman
Department of Experimental Neurophysiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
J Neurophysiol 94:338-46. 2005..Hence, they form a good model to study the functional role of developmental GABA(A) receptor subunit switching...
- Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fearJames M Sonner
Department of Anesthesiology, University of California, San Francisco, San Francisco, California, USA
Mol Pharmacol 68:61-8. 2005..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane...
- Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypesU Rudolph
Institute of Pharmacology, University of Zurich, Switzerland
Nature 401:796-800. 1999..Thus, benzodiazepine-induced behavioural responses are mediated by specific GABA(A) receptor subtypes in distinct neuronal circuits, which is of interest for drug design...
- Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtypeR M McKernan
Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
Nat Neurosci 3:587-92. 2000..This finding suggests ways to improve anxiolytics and to develop drugs for other neurological disorders based on their specificity for GABA(A) receptor subtypes in distinct neuronal circuits...
- GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neuronsS Vicini
Department of Physiology and Biophysics, Georgetown University Medical School, Washington, DC 20007, USA
J Neurosci 21:3009-16. 2001..We propose that an increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents that are normally observed during postnatal development...
- Loss of the major GABA(A) receptor subtype in the brain is not lethal in miceC Sur
Neuroscience Research Center, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, CM20 2QR, United Kingdom
J Neurosci 21:3409-18. 2001..Our data confirm that alpha1beta2gamma2 is the major GABA(A) receptor subtype in the murine brain and demonstrate that, surprisingly, the loss of this receptor subtype is not lethal...
- GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidemJ E Kralic
Department of Pharmacology, University of North Carolina at Chapel Hill, 27599, USA
Neuropharmacology 43:685-94. 2002..Such adaptations reveal important relationships between subunit expression, receptor function and behavioral responses...
- Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunitsLaurens W J Bosman
Department of Experimental Neurophysiology, Research Institute Neurosciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
J Physiol 545:169-81. 2002..Thus, distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex...
- Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunitPeter A Goldstein
C V Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, New York 10021, USA
J Neurophysiol 88:3208-17. 2002....
- A shared vesicular carrier allows synaptic corelease of GABA and glycineSonja M Wojcik
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
Neuron 50:575-87. 2006..Since GABA and glycine compete for vesicular uptake, these data point to a close association of Viaat with GABA-synthesizing enzymes as a key factor in specifying GABAergic neuronal phenotypes...
- Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or deltaStephane F Maison
Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Neurosci 26:10315-26. 2006..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear...
- Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptorsAnnarita Patrizi
Department of Anatomy, Pharmacology, and Forensic Medicine, and National Institute of Neuroscience Italy, C so Massimo d Azeglio, 52, I 10126 Turin, Italy
Proc Natl Acad Sci U S A 105:13151-6. 2008..However, GABAergic signaling appears to be crucial for activity-dependent regulation of synapse density during neuronal maturation...
- Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortexFederica Briatore
Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, and National Institute of Neuroscience Italy, Torino, Italy
PLoS ONE 5:e12119. 2010..Based on the pure quantity of GABAergic synapses onto interneurons, we propose that mutual inhibition must play an important, yet largely neglected, computational role in the cerebellar cortex...
- The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor geneW J Keir
Department of Pharmacology, Alcohol Research Center, University of Colorado Health Sciences Center, Denver
Genomics 9:390-5. 1991..Excluding deletions, the murine GABAA alpha 1 receptor exhibits 96% nucleotide and 100% amino acid sequence homology to the rat alpha 1 receptor cDNA and ..
- Reorganization of GABAergic circuits maintains GABAA receptor-mediated transmission onto CA1 interneurons in alpha1-subunit-null miceEdith M Schneider Gasser
Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Eur J Neurosci 25:3287-304. 2007..No genotype difference was observed in the effects of kainic acid, indicating that the absence of a major GABA(A) receptor subtype is functionally compensated for in hippocampal interneurons by a reorganization of inhibitory circuits...
- Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout miceJ E Kralic
Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599 7178, USA
J Pharmacol Exp Ther 302:1037-45. 2002..These data emphasize the significance of alpha1 subunit expression and its involvement in the regulation of CNS excitability...
- Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient miceWaltraud Ogris
Division of Biochemistry and Molecular Biology, Center for Brain Research, and Section of Biochemical Psychiatry, University Clinic for Psychiatry, Medical University Vienna, Vienna, Austria
J Neurochem 96:136-47. 2006..Our results do not support a significant compensatory synthesis of other GABAA receptor subunits in the cerebellum of alpha1 -/- mice...
- Differential dependence of axo-dendritic and axo-somatic GABAergic synapses on GABAA receptors containing the alpha1 subunit in Purkinje cellsJean Marc Fritschy
Institute of Pharmacology and Toxicology, University of Zurich, CH 8057 Zurich, Switzerland
J Neurosci 26:3245-55. 2006..In contrast, maintenance of axo-somatic GABAergic synapses does not depend on functional GABAA receptors, suggesting differential regulation in distinct subcellular compartments...
- GABAA receptor subunit mRNA expression in the weaver cerebellum: modulation by cell-cell interactionsC E Beattie
Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106 4965, USA
Brain Res Dev Brain Res 88:171-7. 1995..In contrast, the absolute level of transcript expression attained appears to be modulated by cell-cell interactions or by other extrinsic cues present in the cerebellar environment...
- Genetic mapping of 21 genes on mouse chromosome 11 reveals disruptions in linkage conservation with human chromosome 5D E Watkins-Chow
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109, USA
Genomics 40:114-22. 1997..Comparison of the mouse and human maps with data for other species provides an emerging picture of mammalian chromosome evolution...
- The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agentH S Waagepetersen
PharmaBiotec Research Center, Department of Pharmacology, Royal Danish School of Pharmacy, Copenhagen
J Neurochem 73:1335-42. 1999..These aspects are discussed in relation to the different functional roles of GABA and its prominent involvement in epileptogenic activity...
- Impaired dendritic spine maturation in GABAA receptor alpha1 subunit knock out miceK Heinen
Department of Experimental Neurophysiology, Research Institute Neurosciences, Faculty of Earth and Life Sciences and Centre for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
Neuroscience 122:699-705. 2003..We propose that an increased efficacy of the inhibitory synaptic transmission in the alpha1 knock out mice may lead to an enhancement of the outgrowth of filopodia around eye opening, but to a failure in spine maturation at later stages...
- Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonistDavid N Stephens
Department of Psychology, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK
Eur J Pharmacol 526:240-50. 2005..Although inverse agonists acting at alpha5-containing receptors reduce ethanol self-administration, alpha5 subunits may not be essential to signaling ethanol reward...
- Attack behaviors in mice: from factorial structure to quantitative trait loci mappingPierre L Roubertoux
Genetique, Neurogénétique, Comportement, CNRS Université de Parìs V, then P3M CNRS Université de la Méditerranée, Marseille, France
Eur J Pharmacol 526:172-85. 2005....
- Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11H M Hood
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97006 8921, USA
Genes Brain Behav 5:1-10. 2006....
- Production of conditional point mutant knockin miceKristen Skvorak
Graduate Program in Biochemistry and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Genesis 44:345-53. 2006..This strategy will be useful for a wide variety of studies that require precise conditional replacement of an endogenous wild type gene with a point mutant...
- GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout miceAkiko Mizokami
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka, Japan
J Neurochem 114:302-10. 2010..PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells...
- RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networksNobuyuki Shiina
Structural Biology Center, National Institute of Genetics, Research Organization of Information and Systems, and Department of Genetics, SOKENDAI, Mishima, Shizuoka 411 8540, Japan
J Neurosci 30:12816-30. 2010..The present study first demonstrates the in vivo role of RNG105 in the dendritic localization of mRNAs and uncovers a novel link between dendritic mRNA localization and the development and maintenance of functional networks...
- GABAA receptor signaling induces osmotic swelling and cell cycle activation of neonatal prominin+ precursorsTiziana Cesetti
Department of Neurobiology, Interdisciplinary Center for Neurosciences IZN, University of Heidelberg, Heidelberg, Germany
Stem Cells 29:307-19. 2011..Our results also have potential implications for the therapeutic practices that involve exposure to GABA(A) Rs modulators during neurodevelopment...
- Functional modifications of acid-sensing ion channels by ligand-gated chloride channelsXuanmao Chen
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 6:e21970. 2011..We conclude that GABA(A) receptors and glycine receptors modify ASICs in neurons through mechanisms that require the opening of chloride channels...
- Effect of delta-opioid receptor over-expression on cortical expression of GABAA receptor alpha1-subunit in hypoxiaYuAn Feng
First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
Chin J Physiol 54:118-23. 2011..Since DOR over-expression increases cortical tolerance to hypoxia, an increase in GABA receptors expression (an energy-costing process) may not be necessary in the cortex with DOR over-expression...
- Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinctionGeorgette M Gafford
Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA 30329, USA
Proc Natl Acad Sci U S A 109:16330-5. 2012..These data indicate that disturbance of CRF containing GABA(A)α1 neurons causes increased anxiety and impaired fear extinction, both of which are symptoms diagnostic for anxiety disorders, such as posttraumatic stress disorder...
- Synaptic competition sculpts the development of GABAergic axo-dendritic but not perisomatic synapsesElena Frola
Department of Neurosciences, University of Turin, and National Institute of Neuroscience Italy, Torino, Italy
PLoS ONE 8:e56311. 2013....
- Involvement of the K+-Cl- co-transporter KCC2 in the sensitization to morphine-induced hyperlocomotion under chronic treatment with zolpidem in the mesolimbic systemMasahiro Shibasaki
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo 142 8501, Japan
J Neurochem 125:747-55. 2013..These results suggest that the mesolimbic dopaminergic system could be amenable to neuroplastic change through a pPKCγ-PP-1-KCC2 pathway by chronic treatment with zolpidem...
- Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndromeChengwen Zhou
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 288:21458-72. 2013....
- Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARsL Mou
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA Howard Hughes Medical Institute, Chevy Chase, MD, USA
Neuroscience 255:33-44. 2013..This work may inform future studies aimed at elucidating the pathways connecting BDNF, GABAA systems, gephyrin, and their role in underlying amygdala-dependent learning. ..
- Dystroglycan mediates homeostatic synaptic plasticity at GABAergic synapsesHoria Pribiag
Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, Research Institute of McGill University Health Center, Montreal, QC, Canada H3G 1A4
Proc Natl Acad Sci U S A 111:6810-5. 2014..These data demonstrate that DG is regulated in a physiologically relevant manner in neurons and that DG and its glycosylation are essential for homeostatic plasticity at inhibitory synapses...
- Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currentsZhi Peng Liu
Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China
Mol Brain 7:32. 2014..While both of them are critically engaged in limiting the activity of amygdala, their roles in the amygdala disinhibition subsequent to chronic stress exposure are largely unknown...
- Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleusNicole L Corteen
Institute for Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael s Building, White Swan Road, Portsmouth, PO1 2DT, UK
Brain Struct Funct 220:2739-63. 2015..Only a topographically located sub-population of serotonergic neurons exhibited GABAAR alpha1 subunit immunoreactivity...
- Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colonMohsen Seifi
Institute for Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, PO1 2DT, United Kingdom
J Neurosci 34:10361-78. 2014..The study demonstrates the molecular and functional diversity of the GABAAR system within the mouse colon providing a framework for developing GABAAR-based therapeutics in GI disorders. ..
- GABAAα1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selectionAndrew M Swanson
1 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA 2 Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA 3 Graduate Program in Neuroscience, Emory University, Atlanta, GA, USA
Neuropsychopharmacology 40:1027-36. 2015..Using in vivo viral-mediated gene silencing, we knocked down Gabra1 in the orbitofrontal prefrontal cortex (oPFC) in mice, decreasing oPFC GABAAα1 expression, as well as expression ..
- Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampusJiwon Mo
Department of Anatomy and Division of Brain Korea 21 Biomedical Science, College of Medicine, Korea University, Seoul, Korea
J Neurochem 133:489-500. 2015..Neuronal activity-dependent up-regulation of Egr-1 might lead to altered subtypes of GABAA receptors for the maintenance of homeostatic excitatory and inhibitory balance for the regulation of synaptic strength. ..
- Adolescent-onset GABAA α1 silencing regulates reward-related decision makingLaura M Butkovich
Graduate Program in Neuroscience, Emory University, Atlanta, GA, USA
Eur J Neurosci 42:2114-21. 2015..selectively in the medial prefrontal cortex (prelimbic subregion) of mice using viral-mediated gene silencing of Gabra1. Adolescent-onset Gabra1 knockdown delayed the acquisition of a cocaine-reinforced instrumental response but ..
- The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in miceCorinna Lappe-Siefke
Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, Hamburg, Germany
PLoS Genet 5:e1000631. 2009..Although other currently unknown changes might be involved, our data show that ubiquitin-dependent GABA(A)R turnover at cerebellar synapses contributes to ax(J)-mediated behavioural impairment...
- The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdalaBrian J Wiltgen
Department of Psychology, University of Virginia Charlottesville, VA 22904, USA
Front Behav Neurosci 3:37. 2009..Together, these results suggest that inhibitory transmission mediated by alpha1-containing GABA(A) receptors plays a critical role in amygdala plasticity and fear learning...
- Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in miceGyula Telegdy
Department of Pathophysiology, Neuroscience Group of the Hungarian Academy of Sciences, University of Szeged, Szeged, Hungary
Behav Brain Res 233:232-6. 2012....
- Lack of molecular-anatomical evidence for GABAergic influence on axon initial segment of cerebellar Purkinje cells by the pinceau formationAtsushi Iwakura
Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
J Neurosci 32:9438-48. 2012..Together, BCs do not appear to exert GABAergic synaptic inhibition on the AIS, although the mode of action of the pinceau formation remains to be explored...
- Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunitFazal M Arain
Department of Neurology, Vanderbilt University, Nashville, Tennessee 37232 8552, USA
Epilepsia 53:e161-5. 2012..These findings suggest that α1 subunit haploinsufficiency can produce epilepsy and may be a major mechanism by which the S326fs328X and A322D mutations cause these epilepsy syndromes...
- GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatmentChristiaan H Vinkers
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
PLoS ONE 7:e43054. 2012..Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABA(A)-receptor subtypes...
- The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during developmentJ B Wang
Department of Pharmacology, University of Maryland School of Medicine, Baltimore 21201
J Mol Neurosci 3:177-84. 1992....
- Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5, and Irf-1 on mouse chromosome 11M S Buckwalter
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618
Mamm Genome 3:604-7. 1992
- GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brainN R Zahniser
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262
Brain Res Mol Brain Res 14:196-206. 1992....
- Molecular cloning and characterization of the mouse UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I geneS Pownall
Biomedical Research Centre, University of British Columbia, Vancouver, Canada
Genomics 12:699-704. 1992..RNA analyses of Mgat-1 expression levels revealed significant variation among normal tissues and cells...
- Sequence comparison of the GABAA receptor alpha 1 subunit cDNA in long and short sleep mice by direct sequencing of polymerase chain reaction amplified cDNAW J Keir
University of Colorado Alcohol Research Center, Denver 80262
Ann N Y Acad Sci 625:551-4. 1991
- Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic diseaseV J Buckle
Nuffield Department of Clinical Medicine, University of Oxford, England
Neuron 3:647-54. 1989..The combined results locate the human alpha 3 gene within band Xq28, in a location that makes it a candidate gene for the X-linked form of manic depression...
- Differential expression of GABAA/benzodiazepine receptor subunit mRNAs and ligand binding sites in mouse cerebellar neurons following in vivo ethanol administration: an autoradiographic analysisC H Wu
Department of Pharmacology, Ohio State University, Columbus 43210, USA
J Neurochem 65:1229-39. 1995..The observed changes were not restricted to any one cerebellar cell type, because subunit expression in Purkinje, granule, and deep cerebellar cells was similarly affected...
- Localization of three genes expressed in retina on mouse chromosome 11C A Kozak
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
Mamm Genome 6:142-4. 1995
- Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: hypnotic and hypothermic effectsV G Erwin
Alcohol Research Center and School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
J Pharmacol Exp Ther 280:911-8. 1997..Common QTL indicate that genes regulating NT receptor and/or NT-ir expression may be the same as those regulating sensitivity to ethanol...
- The GABAA receptor alpha 6 subunit gene (Gabra6) is tightly linked to the alpha 1-gamma 2 subunit cluster on mouse chromosome 11K M Garrett
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
Brain Res Mol Brain Res 45:133-7. 1997We have established that the GABAA receptor alpha 6 (Gabra6) and alpha 1 (Gabra 1) subunit genes are tightly linked on mouse chromosome 11 by analysing the strain distribution patterns of RFLPs for the two genes and microsatellite ..
- Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axisD S Jessop
Division of Medicine, Department of Clinical Medicine, University of Bristol, Marlborough Street, Bristol BS2 8HW, UK
J Endocrinol 160:169-80. 1999
- Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25T Ben-Zur
The Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
Genomics 58:102-3. 1999
- Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signallingJane H Ives
School of Biological and Biomedical Sciences, University of Durham, Science Research Laboratories, Durham, UK
J Neurochem 80:317-27. 2002..The intracellular pool of alpha6 was not affected. Thus, GABAR subunits are subject to differentially regulated trafficking, affording yet greater scope for GABAR diversity and plasticity...
- Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugsYuri A Blednov
Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Austin, Texas 78712 0159, USA
J Pharmacol Exp Ther 304:30-6. 2003..Overall, these data confirm the crucial role of the GABAA receptor in mechanisms mediating sedative/hypnotic effects...
- Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapsesJian Wang
Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1
J Neurosci 23:826-36. 2003..Thus, an activity-dependent physical and functional interaction between CaN and GABA(A) receptors is both necessary and sufficient for inducing LTD at CA1 individual inhibitory synapses...
- BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2Fernando Aguado
Department of Cell Biology Faculty of Biology, and Barcelona Science Park, University of Barcelona, Barcelona 08028, Spain
Development 130:1267-80. 2003..Given that BDNF itself is regulated by neuronal activity, we suggest that BDNF acts as a homeostatic factor controlling the emergence, complexity and networking properties of spontaneous networks...
- Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anestheticsJ E Kralic
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Pharmacol Exp Ther 305:600-7. 2003..These receptors do not appear to be necessary for most ethanol responses, suggesting involvement of other GABA(A) receptor subtypes or other targets altogether...
- GABA(A) alpha 1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatmentD S Reynolds
Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
Neuropharmacology 44:190-8. 2003..These data demonstrate subtle changes in behaviours mediated by neurotransmitters other than GABA in alpha1 KO mice and suggest that compensation may have occurred beyond the GABAergic system...
- Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptorDina Herring
Department of Pharmacology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
J Biol Chem 278:24046-52. 2003..This is the first report to our knowledge that an AP2 adaptin dileucine recognition motif is critical for the endocytosis of ligand-gated ion channels belonging to this superfamily...
- Enhanced GABA(A) receptor-mediated activity following activation of NMDA receptors in Cajal-Retzius cells in the developing mouse neocortexChun Hung Chan
Center for Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Physiol 550:103-11. 2003..Overall, this study uncovered a synergistic interaction between these receptors, whereby activation of NMDA receptors leads to enhanced GABAA receptor-mediated activity through a Ca2+-dependent mechanism...
- Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neuronsSabine Levi
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 24:207-17. 2004..This clustered gephyrin may then recruit glycine receptors, additional GABA(A)Rs, and other signal-transducing components...
- Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 miceChristian Caldji
Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Centre, McGill University, Montreal, Canada
Neuropsychopharmacology 29:1344-52. 2004..Such findings may reflect a mammalian example of an indirect genetic effect mediated by maternal care...
- Morphological development and maturation of the GABAergic synapses in the mouse cerebellar granular layerChitoshi Takayama
Department of Molecular Neuroanatomy, Hokkaido University School of Medicine, Kita 15 Nishi 7, Kita, Sapporo 060 8638, Japan
Brain Res Dev Brain Res 150:177-90. 2004..Furthermore, it was suggested that GABAergic innervation could initiate expression and trafficking of the GABA(A) receptors containing the alpha1 and alpha6 subunits...
- Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptorsSarah J Bailey
Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 24:6343-51. 2004..These data indicate that BZ-resistant anxiety results from a developmental arrest of GABA(A)R expression in SW-R-/- mice, and a similar mechanism may be responsible for the BZ insensitivity of some anxiety patients...
- Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal systemJ L Temple
National Institute of Neurological Disorders and Stroke, Cellular and Developmental Neurobiology Section, Bethesda, MD 20892, USA
J Neuroendocrinol 17:591-9. 2005..5 to adulthood, as well as in nasal explants. We show that GABAAalpha2 and alpha6 are present in the GnRH-1 neuronal system both in vivo and in vitro and that the levels of expression are altered as a function of age...
- Genetic basis for the psychostimulant effects of nicotine: a quantitative trait locus analysis in AcB/BcA recombinant congenic miceK J Gill
Research Institute of the McGill University Health Centre and Psychiatry Department, McGill University, 1604 Pine Avenue West, Montreal, Quebec, Canada H3G 1B4
Genes Brain Behav 4:401-11. 2005..A number of putative candidate genes were in proximity to regions identified with nicotine sensitivity, including the alpha2 subunit of the nicotinic acetylcholine receptor and the dopamine D3 receptor...
- An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunitsTim G Hales
Department of Pharmacology and Physiology
J Biol Chem 281:17034-43. 2006..Moreover, the conserved TM2-3 loop lysine has an asymmetric function in different GABAA subunits...
- Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptorsIgor Ponomarev
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
J Neurosci 26:5673-83. 2006....
- An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin miceC M Borghese
Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, University of Texas at Austin, Austin, TX 78712 0159, USA
J Pharmacol Exp Ther 319:208-18. 2006..This knockin mouse line should be useful in determining which behavioral actions of volatile anesthetics and ethanol are mediated by the GABA(A)Rs containing the alpha(1) subunit...
- Tyrosine kinase phosphorylation of GABA(A) receptor alpha1, beta2 and gamma2 subunits following chronic intermittent ethanol (CIE) exposure of cultured cortical neurons of miceC R Marutha Ravindran
Department of Pharmacology, The University of Texas Health Science Center, 7703 Floyd Curl MC 7764 Dr, San Antonio, TX 78229 3900, USA
Neurochem Res 31:1111-8. 2006..In conclusion, the CIE exposure, unlike chronic/acute ethanol exposure, regulates the tyrosine kinase phosphorylation of the selective population of GABA(A )receptors in a long lasting manner...
- Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transportersPavel I Ortinski
Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
J Neurosci 26:9323-31. 2006....
- Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at pubertyHui Shen
Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA
Nat Neurosci 10:469-77. 2007..Therefore, inhibition of alpha4beta2delta GABAA receptors by THP provides a mechanism for the generation of anxiety at puberty...
- GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulbSamuel Lagier
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 104:7259-64. 2007..We conclude, therefore, that fast oscillations in the OB circuit are strongly constrained by the precise location, subunit composition and kinetics of GABA(A) receptors expressed in mitral cells...
- Cortical glutamatergic neurons mediate the motor sedative action of diazepamA Zeller
Laboratory of Genetic Neuropharmacology, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA
Mol Pharmacol 73:282-91. 2008....
- The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cellsMurray B Herd
Neurosciences Institute, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
J Physiol 586:989-1004. 2008..The unambiguous identification of these distinct pools of synaptic and extrasynaptic GABA(A) receptors should aid our understanding of how they act in harmony, to regulate hippocampal signalling in health and disease...
- gamma-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeabilityNeetu Tyagi
Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40292, USA
Endothelium 14:315-23. 2007..The data suggest that Hcy increases EC layer permeability through inhibition of GABA(A) receptor and F-actin formation, in part, by transducing ERK and MMP-9 activation...
- Consequences of prenatal exposure to diazepam on the respiratory parameters, respiratory network activity and gene expression of alpha1 and alpha2 subunits of GABA(A) receptor in newborn ratNathalie Picard
Universite de Picardie Jules Verne, Amiens, France
Adv Exp Med Biol 605:144-8. 2008..On the other hand, the effects of DZP exposure on reduced preparations suggested changes in the GABA(A) receptor efficiency and/or disruption of the normal development of the medullary respiratory network...
- Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferationMichael Andäng
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
Nature 451:460-4. 2008..These results indicate the presence of a fundamentally different mechanism of proliferation control in these stem cells, in comparison with most somatic cells, involving proteins in the DNA damage checkpoint pathway...
- Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasksRaymond B Berry
Department of Psychology, The University of Memphis, Memphis, TN 38152, USA
Neurobiol Learn Mem 90:580-3. 2008..These results suggested that normal performance of the spatial and nonspatial water maze tasks may be dependent upon a natural alpha1 subunit array...
- GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosisIrene Carunchio
Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier 1, 00173 Rome, Italy
Eur J Neurosci 28:1275-85. 2008..These data show that the functionality and expression of GABA(A) receptors are altered in G93A motor neurons inducing a higher Cl(-) influx into the cell with a possible consequent neuronal excitotoxicity acceleration...
- Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptorsMurray B Herd
Division of Medical Sciences, Centre for Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
Eur J Neurosci 29:1177-87. 2009..synaptic alpha(1)-subunit-containing GABA(A)Rs of thalamocortical neurones represent an important molecular target underpinning the sedative actions of THIP...
- Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapsesLucian Medrihan
Center for Physiology, Georg August University and DFG Research Center of Molecular Physiology of the Brain, D 37073 Gottingen, Germany
J Physiol 587:5095-106. 2009....
- GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in miceGrace Lee
University of Wisconsin, Zoology Department, 1117 West Johnson Street, Madison, WI 53706, USA
Behav Brain Res 213:230-7. 2010....
- Amygdala-specific reduction of alpha1-GABAA receptors disrupts the anticonvulsant, locomotor, and sedative, but not anxiolytic, effects of benzodiazepines in miceScott A Heldt
Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
J Neurosci 30:7139-51. 2010....
- The cellular expression of GABA(A) receptor alpha1 subunit during spermatogenesis in the mouse testisKiyoto Kanbara
Department of Anatomy and Cell Biology, Division of Life Sciences, Osaka Medical College, Daigaku machi, Takatsuki, Osaka, Japan
Histol Histopathol 25:1229-38. 2010....
- Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibitionArmen M Abramian
Department of Neuroscience, Tufts University, Boston, Massachusetts 02111, USA
J Biol Chem 285:41795-805. 2010..These results suggest that PKC-dependent phosphorylation of the α4 subunit plays a significant role in enhancing the cell surface stability and activity of GABA(A)R subtypes that mediate tonic inhibition...
- Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in miceR A Harris
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 1 University Station, A4800, Austin, TX 78712, United States
Neurosci Lett 488:31-5. 2011....
- Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabellingYu Kasugai
Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki, Japan
Eur J Neurosci 32:1868-88. 2010..Assuming similar antibody access to all receptors, about 60% of these subunits are in extrasynaptic receptors...
- Rapid brain-derived neurotrophic factor-dependent sequestration of amygdala and hippocampal GABA(A) receptors via different tyrosine receptor kinase B-mediated phosphorylation pathwaysL Mou
Howard Hughes Medical Institute, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
Neuroscience 176:72-85. 2011....
- ANESTHETIC MECHANISMS IN GABAA R GENE TARGETED MICEGregg Homanics; Fiscal Year: 2001....
- GABAa-R Alpha4 Subunit in Ethanol-Related BehaviorsGregg Homanics; Fiscal Year: 2006..A5. Analyze these genetically manipulated animals with a battery of tests to assess basic physiology, behavior, and phenotypic alterations in ethanol-induced behaviors...
- HETEROGENEITY OF SYNAPTIC NMDA RECEPTORSStefano Vicini; Fiscal Year: 2002..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS. ..
- HETEROGENEITY OF SYNAPTIC NMDA RECEPTORSStefano Vicini; Fiscal Year: 2003..Data obtained from these specific aims will permit the understanding of the molecular determinant responsible for synaptic plasticity in CNS possibly relevant o for the understanding of neuropsychiatric disorders. ..
- Anesthetic Effects on Thalamic Synaptic TransmissionPETER GOLDSTEIN; Fiscal Year: 2008..By better understanding how anesthetic agents interact with specific subunits of the GABA-A receptor in different regions of the brain, it may be possible to design more selective, and therefore safer, anesthetics. ..
- ETHANOL MECHANISMS IN GABAAR GENE TARGETED MICEGregg Homanics; Fiscal Year: 2008..Ultimately that knowledge could lead to novel therapeutic approaches for combating alcohol abuse and alcoholism. ..