Fasl

Summary

Gene Symbol: Fasl
Description: Fas ligand (TNF superfamily, member 6)
Alias: APT1LG1, CD178, CD95-L, CD95L, Fas-L, Faslg, Tnfsf6, Tnlg1a, gld, tumor necrosis factor ligand superfamily member 6, CD95 ligand, Fas antigen ligand, generalized lymphoproliferative disease, tumor necrosis factor ligand 1a
Species: mouse
Products:     Fasl

Top Publications

  1. Nagata S, Golstein P. The Fas death factor. Science. 1995;267:1449-56 pubmed
    Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells...
  2. Stranges P, Watson J, Cooper C, Choisy Rossi C, Stonebraker A, Beighton R, et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007;26:629-41 pubmed
    ..Thus, Fas-dependent elimination of APCs is a major regulatory mechanism curbing autoimmune responses and acts in concert with Fas-mediated regulation of chronically activated autoimmune T cells. ..
  3. Yao P, Lin Y, Sawhney P, Richburg J. Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury. J Biol Chem. 2007;282:5420-31 pubmed
    The Fas/FasL signaling pathway has previously been demonstrated to be critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury...
  4. Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan D, et al. Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS Lett. 2001;509:255-62 pubmed
    ..In murine T cells, membrane-bound CD95L (Fas ligand) also acts as a costimulatory receptor to coordinate activation and function in vivo...
  5. O Reilly L, Tai L, Lee L, Kruse E, Grabow S, Fairlie W, et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009;461:659-63 pubmed publisher
    Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity...
  6. Chakour R, Allenbach C, Desgranges F, Charmoy M, Mauel J, Garcia I, et al. A new function of the Fas-FasL pathway in macrophage activation. J Leukoc Biol. 2009;86:81-90 pubmed publisher
    ..The Fas-FasL pathway, although not involved in Th cell differentiation, was reported to be necessary for complete resolution of ..
  7. Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet J, Sato K, et al. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004;199:1121-31 pubmed
    To clarify the link between autoimmune disease and hypercholesterolemia, we created the gld.apoE(-/-) mouse as a model of accelerated atherosclerosis. Atherosclerotic lesion area was significantly increased in gld...
  8. Hao Z, Hampel B, Yagita H, Rajewsky K. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med. 2004;199:1355-65 pubmed
    To study the role of Fas-Fas ligand (FasL) interaction-mediated apoptosis in lymphocyte homeostasis, we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre-mediated recombination...
  9. Zhang J, Okumura C, McCarty T, Shin M, Mukhopadhyay P, Hori M, et al. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med. 2004;200:1467-78 pubmed
    Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms...
  10. Karray S, Kress C, Cuvellier S, Hue Beauvais C, Damotte D, Babinet C, et al. Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele. J Immunol. 2004;172:2118-25 pubmed
    ..It stands in sharp contrast with the milder disease observed in gld (generalized lymphoproliferative disease) mice, indicating that the FasL allele of these mice encodes a protein still able to bind, albeit ..

Detail Information

Publications65

  1. Nagata S, Golstein P. The Fas death factor. Science. 1995;267:1449-56 pubmed
    Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells...
  2. Stranges P, Watson J, Cooper C, Choisy Rossi C, Stonebraker A, Beighton R, et al. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007;26:629-41 pubmed
    ..Thus, Fas-dependent elimination of APCs is a major regulatory mechanism curbing autoimmune responses and acts in concert with Fas-mediated regulation of chronically activated autoimmune T cells. ..
  3. Yao P, Lin Y, Sawhney P, Richburg J. Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury. J Biol Chem. 2007;282:5420-31 pubmed
    The Fas/FasL signaling pathway has previously been demonstrated to be critical for triggering germ cell apoptosis in response to mono-(2-ethylhexyl)phthalate (MEHP)-induced Sertoli cell injury...
  4. Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan D, et al. Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS Lett. 2001;509:255-62 pubmed
    ..In murine T cells, membrane-bound CD95L (Fas ligand) also acts as a costimulatory receptor to coordinate activation and function in vivo...
  5. O Reilly L, Tai L, Lee L, Kruse E, Grabow S, Fairlie W, et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009;461:659-63 pubmed publisher
    Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses and prevention of autoimmunity...
  6. Chakour R, Allenbach C, Desgranges F, Charmoy M, Mauel J, Garcia I, et al. A new function of the Fas-FasL pathway in macrophage activation. J Leukoc Biol. 2009;86:81-90 pubmed publisher
    ..The Fas-FasL pathway, although not involved in Th cell differentiation, was reported to be necessary for complete resolution of ..
  7. Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet J, Sato K, et al. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004;199:1121-31 pubmed
    To clarify the link between autoimmune disease and hypercholesterolemia, we created the gld.apoE(-/-) mouse as a model of accelerated atherosclerosis. Atherosclerotic lesion area was significantly increased in gld...
  8. Hao Z, Hampel B, Yagita H, Rajewsky K. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med. 2004;199:1355-65 pubmed
    To study the role of Fas-Fas ligand (FasL) interaction-mediated apoptosis in lymphocyte homeostasis, we generated a mutant fas allele allowing conditional inactivation of the fas gene through Cre-mediated recombination...
  9. Zhang J, Okumura C, McCarty T, Shin M, Mukhopadhyay P, Hori M, et al. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med. 2004;200:1467-78 pubmed
    Germline mutations in Fas and Fasl induce nonmalignant T cell hyperplasia and systemic autoimmunity and also greatly increase the risk of B cell neoplasms...
  10. Karray S, Kress C, Cuvellier S, Hue Beauvais C, Damotte D, Babinet C, et al. Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele. J Immunol. 2004;172:2118-25 pubmed
    ..It stands in sharp contrast with the milder disease observed in gld (generalized lymphoproliferative disease) mice, indicating that the FasL allele of these mice encodes a protein still able to bind, albeit ..
  11. Gallagher S, Yang J, Baksh K, Haines K, Carpenter H, Epling Burnette P, et al. Acute pancreatitis induces FasL gene expression and apoptosis in the liver. J Surg Res. 2004;122:201-9 pubmed
    ..In this work, we sought to characterize the role of Fas Ligand (FasL) in liver injury during acute pancreatitis...
  12. Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, et al. ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death Differ. 2007;14:1040-9 pubmed
    The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity...
  13. Liu Y, Pop R, Sadegh C, Brugnara C, Haase V, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006;108:123-33 pubmed
    ..A high proportion of splenic early erythroblasts coexpressed the death receptor Fas, and its ligand, FasL. Fas-positive early erythroblasts were significantly more likely to coexpress annexin V than equivalent, Fas-..
  14. Akiyama K, Chen C, Wang D, Xu X, Qu C, Yamaza T, et al. Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell. 2012;10:544-55 pubmed publisher
    ..Here we show that in mice systemic infusion of BMMSCs induced transient T cell apoptosis via the FAS ligand (FASL)-dependent FAS pathway and could ameliorate disease phenotypes in fibrillin-1 mutated systemic sclerosis (SS) and ..
  15. Gregory M, Repp A, Holhbaum A, Saff R, Marshak Rothstein A, Ksander B. Membrane Fas ligand activates innate immunity and terminates ocular immune privilege. J Immunol. 2002;169:2727-35 pubmed
    It has been proposed that the constitutive expression of Fas ligand (FasL) in the eye maintains immune privilege, in part through inducing apoptosis of infiltrating Fas(+) T cells...
  16. Vargo Gogola T, Crawford H, Fingleton B, Matrisian L. Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand. Arch Biochem Biophys. 2002;408:155-61 pubmed
    ..However, there are contradictory reports that the soluble form of FasL is inactive or anti-apoptotic, resulting in significant controversy in the literature...
  17. Legge K, Braciale T. Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression. Immunity. 2005;23:649-59 pubmed
    ..with inoculum dose and is controlled by lymph-node-resident dendritic cells (LNDC) through IL-12p40-regulated FasL-dependent T cell apoptosis...
  18. He J, Ostergaard H. CTLs contain and use intracellular stores of FasL distinct from cytolytic granules. J Immunol. 2007;179:2339-48 pubmed
    CTL lyse target cells through the release of cytolytic granule contents and cell surface expression of Fas ligand (FasL)...
  19. Ishikawa T, Yamada H, Oyamada A, Goshima F, Nishiyama Y, Yoshikai Y. Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice. J Virol. 2009;83:11777-83 pubmed publisher
    ..In this study, we examined the roles of Fas-Fas ligand (FasL) signaling in lethal infection with HSV-2 by using mice with mutated Fas (lpr) or FasL (gld) in C57BL/6 background...
  20. Dace D, Khan A, Stark J, Kelly J, Cross A, Apte R. Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy. PLoS ONE. 2009;4:e7121 pubmed publisher
    ..Macrophage-mediate demyelination is dependent on Fas-ligand (FasL)-mediated Schwann cell death...
  21. Letellier E, Kumar S, Sancho Martinez I, Krauth S, Funke Kaiser A, Laudenklos S, et al. CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site. Immunity. 2010;32:240-52 pubmed publisher
    ..Here, we showed that, in rodents and humans, injury to the spinal cord triggered surface expression of CD95 ligand (CD95L, FasL) on peripheral blood myeloid cells...
  22. Apte R, Richter J, Herndon J, Ferguson T. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med. 2006;3:e310 pubmed
    ..IL-10 regulates macrophage activity in the eye and is an attractive therapeutic target in order to suppress or inhibit CNV in AMD that can otherwise lead to blindness. ..
  23. Zhang Y, Xu G, Zhang L, Roberts A, Shi Y. Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma. J Immunol. 2008;181:190-6 pubmed
    ..activation-induced cell death (AICD), a common mechanism for elimination of activated T cells, required the Fas and FasL interaction: Fas was stably expressed, while FasL was up-regulated upon TCR reactivation of Th17 cells; Ab ligation ..
  24. Tsutsui H, Kayagaki N, Kuida K, Nakano H, Hayashi N, Takeda K, et al. Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity. 1999;11:359-67 pubmed
    ..Here, we investigated caspase-1-independent processing of IL-18 in Fas ligand (FasL)-stimulated macrophages and its involvement in liver injury. Administration of Propionibacterium acnes (P...
  25. Bonfoco E, Stuart P, Brunner T, Lin T, Griffith T, Gao Y, et al. Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells. Immunity. 1998;9:711-20 pubmed
    Fas (CD95) and Fas ligand (FasL) play major roles in staphylococcal enterotoxin B (SEB)-induced peripheral deletion of Vbeta8+ T cells...
  26. Smyth M, Thia K, Cretney E, Kelly J, Snook M, Forbes C, et al. Perforin is a major contributor to NK cell control of tumor metastasis. J Immunol. 1999;162:6658-62 pubmed
    ..Fas ligand mutant gld mice displayed uncompromised protection against tumor metastasis...
  27. Nakagawa R, Nagafune I, Tazunoki Y, Ehara H, Tomura H, Iijima R, et al. Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. J Immunol. 2001;166:6578-84 pubmed
    ..Whereas alpha-GalCer did not increase serum alanine aminotransferase activity in B6-lpr/lpr mice and B6-gld/gld mice, it increased the antitumor cytotoxicity of liver MNCS: The alpha-GalCer-induced increase in survival rate ..
  28. Reap E, Roof K, Maynor K, Borrero M, Booker J, Cohen P. Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions. Proc Natl Acad Sci U S A. 1997;94:5750-5 pubmed
    ..assess whether some of the apoptosis known to occur after ionizing radiation might be mediated by Fas/Fas ligand (FasL) interactions, we quantitated in vitro apoptosis by flow cytometry measurement of DNA content in splenic T and B ..
  29. Booker J, Reap E, Cohen P. Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice. J Immunol. 1998;161:4536-41 pubmed
    ..This study demonstrates that lpr mice can produce functional Fas protein. This system is also appropriate for identifying the in vivo role of Fas/FasL in apoptosis following other cell manipulations.
  30. Arai H, Gordon D, Nabel E, Nabel G. Gene transfer of Fas ligand induces tumor regression in vivo. Proc Natl Acad Sci U S A. 1997;94:13862-7 pubmed
    The Fas-Fas ligand (FasL) system plays an important role in the induction of lymphoid apoptosis and has been implicated in the suppression of immune responses...
  31. Borges V, Falcao H, Leite JĂșnior J, Alvim L, Teixeira G, Russo M, et al. Fas ligand triggers pulmonary silicosis. J Exp Med. 2001;194:155-64 pubmed
    ..Strikingly, Fas ligand-deficient generalized lymphoproliferative disease mutant (gld) mice did not develop silicosis...
  32. Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, et al. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J Clin Invest. 1999;104:13-9 pubmed
    ..a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy...
  33. Takahashi T, Tanaka M, Brannan C, Jenkins N, Copeland N, Suda T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 1994;76:969-76 pubmed
    Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and suffer from autoimmune disease...
  34. Schneider E, Moreau G, Arnould A, Vasseur F, Khodabaccus N, Dy M, et al. Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice. Blood. 1999;94:2613-21 pubmed
    ..Similar changes occurred in C57BL/6-gld/gld mice, indicating that they resulted from Fas/FasL interactions. Medullary hematopoiesis was not significantly modified in adult mice of either strain...
  35. Zhu B, Beaudette B, Rifkin I, Marshak Rothstein A. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur J Immunol. 2000;30:1778-84 pubmed
    ..However, reconstitution with double Fas-/Fas ligand (FasL)-deficient stem cells does not result in wasting disease, demonstrating that FasL expression is an important ..
  36. Sata M, Walsh K. Fas ligand-deficient mice display enhanced leukocyte infiltration and intima hyperplasia in flow-restricted vessels. J Mol Cell Cardiol. 2000;32:1395-400 pubmed
    Fas ligand (FasL) is a death factor that induces apoptosis in Fas-bearing cells...
  37. Giese T, Davidson W. Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr. J Immunol. 1992;149:3097-106 pubmed
    Mice homozygous for lpr and gld develop profound lymphadenopathy characterized by the accumulation of two functionally anergic T cell subsets, a predominant B220+CD4-CD8- double negative (DN) population and a minor, closely related CD4 ..
  38. Malipiero U, Frei K, Spanaus K, Agresti C, Lassmann H, Hahne M, et al. Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice. Eur J Immunol. 1997;27:3151-60 pubmed
    The expression and action of Fas/Fas ligand (FasL) in multiple sclerosis has been postulated as a major pathway leading to inflammatory demyelination...
  39. Su X, Hu Q, Kristan J, Costa C, Shen Y, Gero D, et al. Significant role for Fas in the pathogenesis of autoimmune diabetes. J Immunol. 2000;164:2523-32 pubmed
    ..NOD mice bearing the lpr mutation (NOD-lpr/lpr) fail to develop IDDM; 2) transgenic expression of Fas ligand (FasL) on beta cells in NOD mice may result in accelerated IDDM; and 3) irradiated NOD-lpr/lpr mice are resistant to ..
  40. Roths J, Murphy E, Eicher E. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J Exp Med. 1984;159:1-20 pubmed
    A newly discovered autosomal recessive mutation, generalized lymphoproliferative disease (gld), in the C3H/HeJ strain of mice, determines the development of early onset massive lymphoid hyperplasia with autoimmunity...
  41. Hoek R, Kortekaas M, Sedgwick J. Allele-specific PCR analysis for detection of the gld Fas-ligand point mutation. J Immunol Methods. 1997;210:109-12 pubmed
    ..of a naturally occurring missense point mutation in the gene encoding Fas-ligand (FasL/CD95L) in generalized lymphoproliferative disease (gld) mice has lead to the characterization of FasL as an important mediator of apoptosis...
  42. Pakala S, Chivetta M, Kelly C, Katz J. In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha. J Exp Med. 1999;189:1053-62 pubmed
    ..These results argue that islet cells play a TNF-alpha-dependent role in their own demise. ..
  43. Suda T, Nagata S. Why do defects in the Fas-Fas ligand system cause autoimmunity?. J Allergy Clin Immunol. 1997;100:S97-101 pubmed
    ..We also have demonstrated that lpr and gld mice, well-known animal models of autoimmune disease are loss-of-function mutants of the Fas and Fas ligand genes, ..
  44. Owen Schaub L, van Golen K, Hill L, Price J. Fas and Fas ligand interactions suppress melanoma lung metastasis. J Exp Med. 1998;188:1717-23 pubmed
    ..These findings provide the first evidence that Fas-Fas ligand interactions can suppress metastasis and that tumor Fas loss-of-function may be causally linked to metastatic progression. ..
  45. Hahne M, Peitsch M, Irmler M, Schroter M, Lowin B, Rousseau M, et al. Characterization of the non-functional Fas ligand of gld mice. Int Immunol. 1995;7:1381-6 pubmed
    ..The lpr mutation is characterized by the absence of functional Fas, whereas gld mice exhibit an inactive FasL due to a point mutation proximal to the extracellular C-terminus...
  46. Wenkel H, Streilein J. Evidence that retinal pigment epithelium functions as an immune-privileged tissue. Invest Ophthalmol Vis Sci. 2000;41:3467-73 pubmed
    ..RPE grafts were prepared from eyes of neonatal C57BL/6 or C57BL/6 gld/gld (deficient in CD95 ligand expression) mice...
  47. Cohen P, Eisenberg R. Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol. 1991;9:243-69 pubmed
    The autosomal recessive lpr and gld genes induce in mice multiple autoantibodies and the progressive accumulation of large numbers of non-malignant CD4- CD8- T lymphocytes...
  48. Lowin B, Hahne M, Mattmann C, Tschopp J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature. 1994;370:650-2 pubmed
    ..Thus, two complementary, specific cytotoxic mechanisms are functional in CTLs, one based on the secretion of lytic proteins and one which depends on cell-surface ligand-receptor interaction. ..
  49. Chu J, Ramos P, Rosendorff A, Nikolic Zugic J, Lacy E, Matsuzawa A, et al. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. J Exp Med. 1995;181:393-8 pubmed
    ..Since the Fas ligand (FasL) has recently been shown to be partly responsible for T cell-mediated cytotoxicity, lymph node cells from lpr and ..
  50. French L, Hahne M, Viard I, Radlgruber G, Zanone R, Becker K, et al. Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Biol. 1996;133:335-43 pubmed
    The cell surface receptor Fas (FasR, Apo-1, CD95) and its ligand (FasL) are mediators of apoptosis that have been shown to be implicated in the peripheral deletion of autoimmune cells, activation-induced T cell death, and one of the two ..
  51. Hunt J, Vassmer D, Ferguson T, Miller L. Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus. J Immunol. 1997;158:4122-8 pubmed
    ..To evaluate the postulate that cell traffic is restricted by expression of Fas ligand (FasL) in the uterus and placenta, FasL mRNA was identified by using reverse transcription-PCR, and FasL protein was ..
  52. Reap E, Piecyk M, Oliver A, Sobel E, Waldschmidt T, Cohen P, et al. Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld mice. Clin Immunol Immunopathol. 1996;78:21-9 pubmed
    ..B cells from gld mice showed the same phenotypic abnormalities as those from lpr...
  53. Lynch D, Watson M, Alderson M, Baum P, Miller R, Tough T, et al. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity. 1994;1:131-6 pubmed
    The gene for the mouse Fas ligand was cloned and its chromosomal position determined. Fasl was tightly linked to gld (no crossovers in 567 meiotic events) on mouse chromosome 1 and closely linked with a novel member of the same TNF family ..
  54. Nagata S, Suda T. Fas and Fas ligand: lpr and gld mutations. Immunol Today. 1995;16:39-43 pubmed
    Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis...
  55. Watanabe D, Suda T, Hashimoto H, Nagata S. Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders. EMBO J. 1995;14:12-8 pubmed
    Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and splenomegaly and suffer from autoimmune disease...
  56. Kayagaki N, Yamaguchi N, Nagao F, Matsuo S, Maeda H, Okumura K, et al. Polymorphism of murine Fas ligand that affects the biological activity. Proc Natl Acad Sci U S A. 1997;94:3914-9 pubmed
    Fas ligand (FasL) is a member of the tumor necrosis factor family and induces apoptosis in Fas (CD95)-bearing target cells...
  57. Ramsdell F, Seaman M, Miller R, Tough T, Alderson M, Lynch D. gld/gld mice are unable to express a functional ligand for Fas. Eur J Immunol. 1994;24:928-33 pubmed
    Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders...
  58. Waldner H, Sobel R, Howard E, Kuchroo V. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J Immunol. 1997;159:3100-3 pubmed
    ..To determine the roles of Fas and FasL in the involvement of CNS autoimmune injury, we determined susceptibility to EAE of Fas-or FasL-deficient mice...
  59. Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S. Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol. 1994;6:1567-74 pubmed
    Fas ligand (FasL) is a 40 kDa type II membrane protein belonging to the tumor necrosis factor family, which induces apoptosis by binding to its receptor, Fas. In this report, we isolated the chromosomal gene for human FasL...
  60. Allison J, Georgiou H, Strasser A, Vaux D. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci U S A. 1997;94:3943-7 pubmed
    Binding of CD95 (Fas/APO-1) by its ligand (CD95L) commonly induces apoptosis. Apoptosis of activated T cells, induced by CD95L expressed in the rodent testis, has been proposed to be the mechanism of immune privilege [Bellgrau, D...
  61. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 1993;75:1169-78 pubmed
    ..Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis. ..
  62. Davidson W, Giese T, Fredrickson T. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions. J Exp Med. 1998;187:1825-38 pubmed
    ..In this report we investigated the possibility that mutations at the Fas (lpr) and Fasl (gld) loci, which prevent Fas-mediated apoptosis and cause an early onset benign lymphoid hyperplasia and ..
  63. Kaplan H, Leibole M, Tezel T, Ferguson T. Fas ligand (CD95 ligand) controls angiogenesis beneath the retina. Nat Med. 1999;5:292-7 pubmed
    ..degeneration demonstrated a pattern of Fas+ new vessels in the center of the vascular complex, surrounded by FasL+ retinal pigment epithelial cells...