Camk2a

Summary

Gene Symbol: Camk2a
Description: calcium/calmodulin-dependent protein kinase II alpha
Alias: CaMKII, R74975, mKIAA0968, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaMK II, alpha-CaMKII, caM kinase II subunit alpha, caMK-II subunit alpha
Species: mouse
Products:     Camk2a

Top Publications

  1. Kourrich S, Klug J, Mayford M, Thomas M. AMPAR-independent effect of striatal ?CaMKII promotes the sensitization of cocaine reward. J Neurosci. 2012;32:6578-86 pubmed publisher
    Changes in CaMKII-regulated synaptic excitability are a means through which experience may modify neuronal function and shape behavior...
  2. Hasegawa S, Furuichi T, Yoshida T, Endoh K, Kato K, Sado M, et al. Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression. Mol Brain. 2009;2:6 pubmed publisher
    Previous studies have demonstrated essential roles for alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and long-term potentiation (LTP)...
  3. Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci. 2011;31:346-58 pubmed publisher
    ..Interestingly, aberrant increased calcium/calmodulin-dependent protein kinase II (CaMKII) activity was observed in the mPFC of ATRX(?E2) mice...
  4. Cao X, Wang H, Mei B, An S, Yin L, Wang L, et al. Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation. Neuron. 2008;60:353-66 pubmed publisher
    ..Therefore, our study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain. ..
  5. Bayer K, Lohler J, Schulman H, Harbers K. Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system. Brain Res Mol Brain Res. 1999;70:147-54 pubmed
    ..Additionally, we describe the murine betaM-CaM kinase II, a variant of the 'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal muscle. ..
  6. Feng B, Raghavachari S, Lisman J. Quantitative estimates of the cytoplasmic, PSD, and NMDAR-bound pools of CaMKII in dendritic spines. Brain Res. 2011;1419:46-52 pubmed publisher
    b>CaMKII plays a critical role in long-term potentiation (LTP). The kinase is a major component of the postsynaptic density (PSD); however, it is also contained in the spine cytoplasm...
  7. Giese K, Fedorov N, Filipkowski R, Silva A. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science. 1998;279:870-3 pubmed
    The calcium-calmodulin-dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning...
  8. Cho Y, Giese K, Tanila H, Silva A, Eichenbaum H. Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice. Science. 1998;279:867-9 pubmed
    ..Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning. ..
  9. Kee N, Teixeira C, Wang A, Frankland P. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci. 2007;10:355-62 pubmed
    ..This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus. ..
  10. Glazewski S, Chen C, Silva A, Fox K. Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science. 1996;272:421-3 pubmed
    ..The synaptic plasticity mechanism of long-term potentiation requiring calcium-calmodulin-dependent kinase type II (CaMKII) could underlie experience-dependent plasticity...

Detail Information

Publications72

  1. Kourrich S, Klug J, Mayford M, Thomas M. AMPAR-independent effect of striatal ?CaMKII promotes the sensitization of cocaine reward. J Neurosci. 2012;32:6578-86 pubmed publisher
    Changes in CaMKII-regulated synaptic excitability are a means through which experience may modify neuronal function and shape behavior...
  2. Hasegawa S, Furuichi T, Yoshida T, Endoh K, Kato K, Sado M, et al. Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression. Mol Brain. 2009;2:6 pubmed publisher
    Previous studies have demonstrated essential roles for alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and long-term potentiation (LTP)...
  3. Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci. 2011;31:346-58 pubmed publisher
    ..Interestingly, aberrant increased calcium/calmodulin-dependent protein kinase II (CaMKII) activity was observed in the mPFC of ATRX(?E2) mice...
  4. Cao X, Wang H, Mei B, An S, Yin L, Wang L, et al. Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulation. Neuron. 2008;60:353-66 pubmed publisher
    ..Therefore, our study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain. ..
  5. Bayer K, Lohler J, Schulman H, Harbers K. Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system. Brain Res Mol Brain Res. 1999;70:147-54 pubmed
    ..Additionally, we describe the murine betaM-CaM kinase II, a variant of the 'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal muscle. ..
  6. Feng B, Raghavachari S, Lisman J. Quantitative estimates of the cytoplasmic, PSD, and NMDAR-bound pools of CaMKII in dendritic spines. Brain Res. 2011;1419:46-52 pubmed publisher
    b>CaMKII plays a critical role in long-term potentiation (LTP). The kinase is a major component of the postsynaptic density (PSD); however, it is also contained in the spine cytoplasm...
  7. Giese K, Fedorov N, Filipkowski R, Silva A. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science. 1998;279:870-3 pubmed
    The calcium-calmodulin-dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning...
  8. Cho Y, Giese K, Tanila H, Silva A, Eichenbaum H. Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice. Science. 1998;279:867-9 pubmed
    ..Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning. ..
  9. Kee N, Teixeira C, Wang A, Frankland P. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci. 2007;10:355-62 pubmed
    ..This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus. ..
  10. Glazewski S, Chen C, Silva A, Fox K. Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortex. Science. 1996;272:421-3 pubmed
    ..The synaptic plasticity mechanism of long-term potentiation requiring calcium-calmodulin-dependent kinase type II (CaMKII) could underlie experience-dependent plasticity...
  11. Wiltgen B, Law M, Ostlund S, Mayford M, Balleine B. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci. 2007;25:2491-7 pubmed
    ..In the current experiments we examined the role of calcium calmodulin-dependent kinase II (CaMKII) by using transgenic mice that express a constitutively active form of this kinase...
  12. van Woerden G, Harris K, Hojjati M, Gustin R, Qiu S, de Avila Freire R, et al. Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation. Nat Neurosci. 2007;10:280-2 pubmed
    ..Moreover, these double mutants no longer show the behavioral deficits seen in AS mice, suggesting that these deficits are the direct result of increased inhibitory phosphorylation of alphaCaMKII. ..
  13. Hinds H, Tonegawa S, Malinow R. CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant mice. Learn Mem. 1998;5:344-54 pubmed
    ..Previous work has shown that mice missing the alpha-isoform of calcium-calmodulin-dependent protein kinase II (alpha-CaMKII) have a deficiency in CA1 hippocampal long-term potentiation (LTP)...
  14. Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, et al. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007;27:13843-53 pubmed
    ..several prominent proteins in the postsynaptic density, including calcium/calmodulin-dependent protein kinase II (CaMKII)...
  15. Miller S, Yasuda M, Coats J, Jones Y, Martone M, Mayford M. Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidation. Neuron. 2002;36:507-19 pubmed
    ..These results demonstrate that local translation is important for synaptic delivery of the kinase and that local translation contributes to synaptic and behavioral plasticity. ..
  16. Chen C, Rainnie D, Greene R, Tonegawa S. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science. 1994;266:291-4 pubmed
    Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion...
  17. Chelu M, Sarma S, Sood S, Wang S, van Oort R, Skapura D, et al. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009;119:1940-51 pubmed
    ..Rapid atrial pacing resulted in increased Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2, while both pharmacologic and genetic inhibition of CaMKII prevented AF inducibility in ..
  18. Collins M, Husi H, Yu L, Brandon J, Anderson C, Blackstock W, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem. 2006;97 Suppl 1:16-23 pubmed
    ..These synapse proteome data sets offer a basis for future research in synaptic biology and will provide useful information in brain disease and mental disorder studies. ..
  19. Robison A, Bass M, Jiao Y, MacMillan L, Carmody L, Bartlett R, et al. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J Biol Chem. 2005;280:35329-36 pubmed
    Dendritic calcium/calmodulin-dependent protein kinase II (CaMKII) is dynamically targeted to the synapse...
  20. Hardingham N, Glazewski S, Pakhotin P, Mizuno K, Chapman P, Giese K, et al. Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation. J Neurosci. 2003;23:4428-36 pubmed
  21. Tomita S, Stein V, Stocker T, Nicoll R, Bredt D. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron. 2005;45:269-77 pubmed
    ..Synaptic NMDA receptor activity can induce both stargazin phosphorylation, via activation of CaMKII and PKC, and stargazin dephosphorylation, by activation of PP1 downstream of PP2B...
  22. Thaler C, Koushik S, Puhl H, Blank P, Vogel S. Structural rearrangement of CaMKIIalpha catalytic domains encodes activation. Proc Natl Acad Sci U S A. 2009;106:6369-74 pubmed publisher
    ..Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J (2005) Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell 123:849-860]...
  23. Silva A, Rosahl T, Chapman P, Marowitz Z, Friedman E, Frankland P, et al. Impaired learning in mice with abnormal short-lived plasticity. Curr Biol. 1996;6:1509-18 pubmed
    ..abnormal SLP, but apparently normal LTP-mice heterozygous for a alpha-calcium calmodulin kinase II mutation (alpha CaMKII +/-) have lower paired-pulse facilitation (PPF) and increased post-tetanic potentiation (PTP); mice lacking ..
  24. Jenkins M, Christel C, Jiao Y, Abiria S, Kim K, Usachev Y, et al. Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J Neurosci. 2010;30:5125-35 pubmed publisher
    Ca(v)1 (L-type) channels and calmodulin-dependent protein kinase II (CaMKII) are key regulators of Ca(2+) signaling in neurons. CaMKII directly potentiates the activity of Ca(v)1.2 and Ca(v)1...
  25. Wang H, Shimizu E, Tang Y, Cho M, Kyin M, Zuo W, et al. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A. 2003;100:4287-92 pubmed
    ..stages of memory consolidation process and revealed the first postlearning week as the critical time window during which a precise level of CaMKII reactivation is essential for the consolidation of long-term memories in the brain.
  26. Baucum A, Strack S, Colbran R. Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum. PLoS ONE. 2012;7:e31554 pubmed publisher
    ..We found that calcium/calmodulin-dependent protein kinase II (CaMKII) directly and indirectly associates with N- and C-terminal domains of spinophilin, but F-actin can displace CaMKII ..
  27. Li J, Marionneau C, Koval O, Zingman L, Mohler P, Nerbonne J, et al. Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current. Channels (Austin). 2007;1:387-94 pubmed
    Mice with genetic inhibition (AC3-I) of the multifunctional Ca(2+)/calmodulin dependent protein kinase II (CaMKII) have improved cardiomyocyte survival after ischemia...
  28. Elgersma Y, Fedorov N, Ikonen S, Choi E, Elgersma M, Carvalho O, et al. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002;36:493-505 pubmed
    ..Our data demonstrate that blocking inhibitory phosphorylation increases CaMKII in the postsynaptic density (PSD), lowers the threshold for hippocampal long-term potentiation (LTP), and results ..
  29. Lamsa K, Irvine E, Giese K, Kullmann D. NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca(2+)/calmodulin-dependent kinases. J Physiol. 2007;584:885-94 pubmed
    ..influx triggers phosphorylation of several kinases, in particular Ca(2+)/calmodulin-dependent kinase type II (CaMKII)...
  30. Cooke S, Wu J, Plattner F, Errington M, Rowan M, Peters M, et al. Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse. J Physiol. 2006;574:805-18 pubmed
    ..Thus, the autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse. ..
  31. Frankland P, Bontempi B, Talton L, Kaczmarek L, Silva A. The involvement of the anterior cingulate cortex in remote contextual fear memory. Science. 2004;304:881-3 pubmed
    ..that the anterior cingulate is activated by remote memory and that this activation is impaired by a null alpha-CaMKII mutation that blocks remote memory...
  32. Mukherji S, Soderling T. Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase II. J Biol Chem. 1995;270:14062-7 pubmed
  33. Gustin R, Shonesy B, Robinson S, Rentz T, Baucum A, Jalan Sakrikar N, et al. Loss of Thr286 phosphorylation disrupts synaptic CaMKII? targeting, NMDAR activity and behavior in pre-adolescent mice. Mol Cell Neurosci. 2011;47:286-92 pubmed publisher
    In order to provide insight into in vivo roles of CaMKII? autophosphorylation at Thr286 during postnatal development, behavioral, biochemical, and electrophysiological phenotypes of pre-adolescent Thr286 to Ala CaMKII? knock-in (T286A-KI) ..
  34. Irvine E, Vernon J, Giese K. AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory. Nat Neurosci. 2005;8:411-2 pubmed
    ..We conclude that alphaCaMKII autophosphorylation contributes to single-trial learning but is dispensable for memory. ..
  35. Kemi O, Ellingsen O, Ceci M, Grimaldi S, Smith G, Condorelli G, et al. Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. J Mol Cell Cardiol. 2007;43:354-61 pubmed
    ..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training. ..
  36. Sametsky E, Disterhoft J, Ohno M. Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulation. Neurobiol Learn Mem. 2009;92:120-3 pubmed publisher
  37. Silva A, Stevens C, Tonegawa S, Wang Y. Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science. 1992;257:201-6 pubmed
    ..mechanisms, mutant mice were produced that do not express the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII)...
  38. Hojjati M, van Woerden G, Tyler W, Giese K, Silva A, Pozzo Miller L, et al. Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses. Nat Neurosci. 2007;10:1125-7 pubmed
    ..These results indicate that alphaCaMKII has a nonenzymatic role in short-term presynaptic plasticity at hippocampal CA3-CA1 synapses. ..
  39. Silva A, Paylor R, Wehner J, Tonegawa S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science. 1992;257:206-11 pubmed
    ..The mice with a mutation in the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII), a synaptic protein enriched in the hippocampus, are appropriate for addressing this issue because the ..
  40. Mayford M, Bach M, Huang Y, Wang L, Hawkins R, Kandel E. Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996;274:1678-83 pubmed
    ..Expression of an activated calcium-independent form of calcium-calmodulin-dependent kinase II (CaMKII) resulted in a loss of hippocampal long-term potentiation in response to 10-hertz stimulation and a deficit in ..
  41. Frankland P, O BRIEN C, Ohno M, Kirkwood A, Silva A. Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature. 2001;411:309-13 pubmed
    ..Here we show that mice heterozygous for a null mutation of alpha-calcium-calmodulin kinase II (alpha-CaMKII+/-) show normal learning and memory 1-3 days after training in two hippocampus-dependent tasks...
  42. Zeitz K, Giese K, Silva A, Basbaum A. The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent pain. Neuroscience. 2004;128:889-98 pubmed
    ..To assess the contribution of alpha-calcium-calmodulin kinase II (alpha-CaMKII) to injury-induced inflammation and pain, we evaluated nociceptive responses in mice that carry a point mutation ..
  43. Cacucci F, Wills T, Lever C, Giese K, O Keefe J. Experience-dependent increase in CA1 place cell spatial information, but not spatial reproducibility, is dependent on the autophosphorylation of the alpha-isoform of the calcium/calmodulin-dependent protein kinase II. J Neurosci. 2007;27:7854-9 pubmed
    ..Consequently, the progressive improvement in spatial coding in new hippocampal place cell maps depends on the existence of two molecularly dissociable, experience-dependent processes. ..
  44. Yang Y, Zhu W, Joiner M, Zhang R, Oddis C, Hou Y, et al. Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo. Am J Physiol Heart Circ Physiol. 2006;291:H3065-75 pubmed
    Inhibition of the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) or depletion of sarcoplasmic reticulum (SR) Ca(2+) stores protects against apoptosis from excessive isoproterenol (Iso) stimulation in cultured ..
  45. Kato I, Oya T, Suzuki H, Takasawa K, Ichsan A, Nakada S, et al. A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells. Diabetes Metab Res Rev. 2008;24:486-97 pubmed publisher
    The activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in pancreatic beta-cells has been thought to play a central role in Ca2+-mediated insulin secretion...
  46. Robison A, Bartlett R, Bass M, Colbran R. Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin. J Biol Chem. 2005;280:39316-23 pubmed
    Neuronal Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) interacts with several prominent dendritic spine proteins, which have been termed CaMKII-associated proteins...
  47. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, et al. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain. 2008;1:6 pubmed publisher
    ..heterozygous for a null mutation of the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha-CaMKII+/-) have profoundly dysregulated behaviours and impaired neuronal development in the dentate gyrus (DG)...
  48. Jiao Y, Jalan Sakrikar N, Robison A, Baucum A, Bass M, Colbran R. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J Biol Chem. 2011;286:24806-18 pubmed publisher
    The densin C-terminal domain can target Ca(2+)/calmodulin-dependent protein kinase II? (CaMKII?) in cells...
  49. Zhang R, Khoo M, Wu Y, Yang Y, Grueter C, Ni G, et al. Calmodulin kinase II inhibition protects against structural heart disease. Nat Med. 2005;11:409-17 pubmed
    ..The Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is a recently identified downstream element of the betaAR-initiated signaling cascade that is linked to ..
  50. Yamagata Y, Kobayashi S, Umeda T, Inoue A, Sakagami H, Fukaya M, et al. Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learning. J Neurosci. 2009;29:7607-18 pubmed publisher
    ..CaMKIIalpha (K42R) mice, kinase activity was reduced to the same level as in CaMKIIalpha-null mice, whereas CaMKII protein expression was well preserved...
  51. Weeber E, Jiang Y, Elgersma Y, Varga A, Carrasquillo Y, Brown S, et al. Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. J Neurosci. 2003;23:2634-44 pubmed
    ..animals exhibited a significant increase in hippocampal phospho-calcium/calmodulin-dependent protein kinase II (CaMKII), specifically at sites Thr(286) and Thr(305), with no corresponding change in the levels of total CaMKII...
  52. Deng G, Orfila J, Dietz R, Moreno Garcia M, Rodgers K, Coultrap S, et al. Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep. 2017;18:1109-1117 pubmed publisher
    The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a major mediator of physiological glutamate signaling, but its role in pathological glutamate signaling (excitotoxicity) remains less clear, with indications for both ..
  53. De Koning A, Walton N, Shin R, Chen Q, Miyake S, Tajinda K, et al. Derivation of neural stem cells from an animal model of psychiatric disease. Transl Psychiatry. 2013;3:e323 pubmed publisher
  54. Wagner S, Ruff H, Weber S, Bellmann S, Sowa T, Schulte T, et al. Reactive oxygen species-activated Ca/calmodulin kinase II? is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res. 2011;108:555-65 pubmed publisher
    ..Both ROS and CaMKII can increase late I(Na) leading to intracellular Na accumulation and arrhythmias...
  55. Hoelz A, Nairn A, Kuriyan J. Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II. Mol Cell. 2003;11:1241-51 pubmed
    ..the crystal structure of the 143 residue association domain of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)...
  56. Zhang L, Kirschstein T, Sommersberg B, Merkens M, Manahan Vaughan D, Elgersma Y, et al. Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II. J Neurosci. 2005;25:7697-707 pubmed
    ..Here, we show that inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II (CaMKII) is required for hippocampal metaplasticity at the lateral perforant path-dentate granule cell synapse...
  57. Wang N, Chen L, Cheng N, Zhang J, Tian T, Lu W. Active calcium/calmodulin-dependent protein kinase II (CaMKII) regulates NMDA receptor mediated postischemic long-term potentiation (i-LTP) by promoting the interaction between CaMKII and NMDA receptors in ischemia. Neural Plast. 2014;2014:827161 pubmed publisher
    Active calcium/calmodulin-dependent protein kinase II (CaMKII) has been reported to take a critical role in the induction of long-term potentiation (LTP). Changes in CaMKII activity were detected in various ischemia models...
  58. Rosenberg O, Deindl S, Comolli L, Hoelz A, Downing K, Nairn A, et al. Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J. 2006;273:682-94 pubmed
    Ca2+/calmodulin activated protein kinase II (CaMKII) is an oligomeric protein kinase with a unique holoenyzme architecture...
  59. Gao N, Luo J, Uray K, Qian A, Yin S, Wang G, et al. CaMKII is essential for the function of the enteric nervous system. PLoS ONE. 2012;7:e44426 pubmed publisher
    ..b>CaMKII, one of the key CaMKs, plays a significant role in mediating cellular responses to external signaling molecules...
  60. Frederick A, Yano H, Trifilieff P, Vishwasrao H, Biezonski D, Meszaros J, et al. Evidence against dopamine D1/D2 receptor heteromers. Mol Psychiatry. 2015;20:1373-85 pubmed publisher
    ..responses were intact in D2 receptor and G?q KO mice, as well as in knock-in mice expressing a mutant Ala(286)-CaMKII? that cannot autophosphorylate to become active...
  61. FREDERIKSE P, Nandanoor A, Kasinathan C. PTBP-dependent PSD-95 and CamKII? alternative splicing in the lens. Mol Vis. 2014;20:1660-7 pubmed
    ..Postsynaptic density protein 95 (PSD-95) and Ca(2+)/calmodulin-dependent protein kinase (CaMKII?) expression and functions illustrate the integration of aspects of neuronal molecular and cell biology and were ..
  62. Kawaai K, Mizutani A, Shoji H, Ogawa N, Ebisui E, Kuroda Y, et al. IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proc Natl Acad Sci U S A. 2015;112:5515-20 pubmed publisher
    ..Here we identified calcium calmodulin-dependent kinase II alpha (CaMKIIα) as an IRBIT-interacting molecule in the central nervous system...
  63. Afroze T, Yang L, Wang C, Gros R, Kalair W, Hoque A, et al. Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Am J Physiol Cell Physiol. 2003;285:C88-95 pubmed
    ..These data show that G1/S-specific PMCA4 repression in proliferating VSMC is brought about by c-Myb and CaMK-II and that calcineurin may regulate cell cycle-associated [Ca2+]i through alternate targets. ..
  64. Zhu L, Klutho P, Scott J, Xie L, Luczak E, Dibbern M, et al. Oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis. Vascul Pharmacol. 2014;60:75-83 pubmed publisher
    Activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and reactive oxygen species (ROS) promote neointimal hyperplasia after vascular injury. CaMKII can be directly activated by ROS through oxidation...
  65. Scott J, Xie L, Li H, Li W, He J, Sanders P, et al. The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9. Am J Physiol Heart Circ Physiol. 2012;302:H1953-64 pubmed publisher
    The multifunctional CaMKII has been implicated in vascular smooth muscle cell (VSMC) migration, but little is known regarding its downstream targets that mediate migration...
  66. Sola C, Tusell J, Serratosa J. Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures. J Neurochem. 1998;70:1600-8 pubmed
    The Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the phosphatase calcineurin (CaN) are especially abundant in the mammalian CNS, where they have been implicated repeatedly in different neuronal functions...
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