Camk2a

Summary

Gene Symbol: Camk2a
Description: calcium/calmodulin-dependent protein kinase II alpha
Alias: CaMKII, R74975, mKIAA0968, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaMK II, alpha-CaMKII, caM kinase II subunit alpha, caMK-II subunit alpha
Species: mouse
Products:     Camk2a

Top Publications

  1. Kourrich S, Klug J, Mayford M, Thomas M. AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward. J Neurosci. 2012;32:6578-86 pubmed publisher
    Changes in CaMKII-regulated synaptic excitability are a means through which experience may modify neuronal function and shape behavior...
  2. Cho Y, Giese K, Tanila H, Silva A, Eichenbaum H. Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice. Science. 1998;279:867-9 pubmed
    ..Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning. ..
  3. Giese K, Fedorov N, Filipkowski R, Silva A. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science. 1998;279:870-3 pubmed
    The calcium-calmodulin-dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning...
  4. Feng B, Raghavachari S, Lisman J. Quantitative estimates of the cytoplasmic, PSD, and NMDAR-bound pools of CaMKII in dendritic spines. Brain Res. 2011;1419:46-52 pubmed publisher
    b>CaMKII plays a critical role in long-term potentiation (LTP). The kinase is a major component of the postsynaptic density (PSD); however, it is also contained in the spine cytoplasm...
  5. Bayer K, Lohler J, Schulman H, Harbers K. Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system. Brain Res Mol Brain Res. 1999;70:147-54 pubmed
    ..Additionally, we describe the murine betaM-CaM kinase II, a variant of the 'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal muscle. ..
  6. Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci. 2011;31:346-58 pubmed publisher
    ..Interestingly, aberrant increased calcium/calmodulin-dependent protein kinase II (CaMKII) activity was observed in the mPFC of ATRX(ΔE2) mice...
  7. Chelu M, Sarma S, Sood S, Wang S, van Oort R, Skapura D, et al. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009;119:1940-51 pubmed
    ..Rapid atrial pacing resulted in increased Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2, while both pharmacologic and genetic inhibition of CaMKII prevented AF inducibility in ..
  8. Grueter C, Abiria S, Dzhura I, Wu Y, Ham A, Mohler P, et al. L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol Cell. 2006;23:641-50 pubmed
    ..Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is associated with cardiac LTCC complexes and increases channel open probability (P(O)) to dynamically increase ..
  9. Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, et al. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007;27:13843-53 pubmed
    ..several prominent proteins in the postsynaptic density, including calcium/calmodulin-dependent protein kinase II (CaMKII)...
  10. Collins M, Husi H, Yu L, Brandon J, Anderson C, Blackstock W, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem. 2006;97 Suppl 1:16-23 pubmed
    ..These synapse proteome data sets offer a basis for future research in synaptic biology and will provide useful information in brain disease and mental disorder studies. ..

Detail Information

Publications62

  1. Kourrich S, Klug J, Mayford M, Thomas M. AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward. J Neurosci. 2012;32:6578-86 pubmed publisher
    Changes in CaMKII-regulated synaptic excitability are a means through which experience may modify neuronal function and shape behavior...
  2. Cho Y, Giese K, Tanila H, Silva A, Eichenbaum H. Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice. Science. 1998;279:867-9 pubmed
    ..Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning. ..
  3. Giese K, Fedorov N, Filipkowski R, Silva A. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science. 1998;279:870-3 pubmed
    The calcium-calmodulin-dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning...
  4. Feng B, Raghavachari S, Lisman J. Quantitative estimates of the cytoplasmic, PSD, and NMDAR-bound pools of CaMKII in dendritic spines. Brain Res. 2011;1419:46-52 pubmed publisher
    b>CaMKII plays a critical role in long-term potentiation (LTP). The kinase is a major component of the postsynaptic density (PSD); however, it is also contained in the spine cytoplasm...
  5. Bayer K, Lohler J, Schulman H, Harbers K. Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system. Brain Res Mol Brain Res. 1999;70:147-54 pubmed
    ..Additionally, we describe the murine betaM-CaM kinase II, a variant of the 'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal muscle. ..
  6. Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci. 2011;31:346-58 pubmed publisher
    ..Interestingly, aberrant increased calcium/calmodulin-dependent protein kinase II (CaMKII) activity was observed in the mPFC of ATRX(ΔE2) mice...
  7. Chelu M, Sarma S, Sood S, Wang S, van Oort R, Skapura D, et al. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009;119:1940-51 pubmed
    ..Rapid atrial pacing resulted in increased Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2, while both pharmacologic and genetic inhibition of CaMKII prevented AF inducibility in ..
  8. Grueter C, Abiria S, Dzhura I, Wu Y, Ham A, Mohler P, et al. L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKII. Mol Cell. 2006;23:641-50 pubmed
    ..Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is associated with cardiac LTCC complexes and increases channel open probability (P(O)) to dynamically increase ..
  9. Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, et al. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007;27:13843-53 pubmed
    ..several prominent proteins in the postsynaptic density, including calcium/calmodulin-dependent protein kinase II (CaMKII)...
  10. Collins M, Husi H, Yu L, Brandon J, Anderson C, Blackstock W, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem. 2006;97 Suppl 1:16-23 pubmed
    ..These synapse proteome data sets offer a basis for future research in synaptic biology and will provide useful information in brain disease and mental disorder studies. ..
  11. Robison A, Bass M, Jiao Y, MacMillan L, Carmody L, Bartlett R, et al. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J Biol Chem. 2005;280:35329-36 pubmed
    Dendritic calcium/calmodulin-dependent protein kinase II (CaMKII) is dynamically targeted to the synapse...
  12. Tomita S, Stein V, Stocker T, Nicoll R, Bredt D. Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs. Neuron. 2005;45:269-77 pubmed
    ..Synaptic NMDA receptor activity can induce both stargazin phosphorylation, via activation of CaMKII and PKC, and stargazin dephosphorylation, by activation of PP1 downstream of PP2B...
  13. Jenkins M, Christel C, Jiao Y, Abiria S, Kim K, Usachev Y, et al. Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J Neurosci. 2010;30:5125-35 pubmed publisher
    Ca(v)1 (L-type) channels and calmodulin-dependent protein kinase II (CaMKII) are key regulators of Ca(2+) signaling in neurons. CaMKII directly potentiates the activity of Ca(v)1.2 and Ca(v)1...
  14. Elgersma Y, Fedorov N, Ikonen S, Choi E, Elgersma M, Carvalho O, et al. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002;36:493-505 pubmed
    ..Our data demonstrate that blocking inhibitory phosphorylation increases CaMKII in the postsynaptic density (PSD), lowers the threshold for hippocampal long-term potentiation (LTP), and results ..
  15. Baucum A, Strack S, Colbran R. Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum. PLoS ONE. 2012;7:e31554 pubmed publisher
    ..We found that calcium/calmodulin-dependent protein kinase II (CaMKII) directly and indirectly associates with N- and C-terminal domains of spinophilin, but F-actin can displace CaMKII ..
  16. Mayford M, Bach M, Huang Y, Wang L, Hawkins R, Kandel E. Control of memory formation through regulated expression of a CaMKII transgene. Science. 1996;274:1678-83 pubmed
    ..Expression of an activated calcium-independent form of calcium-calmodulin-dependent kinase II (CaMKII) resulted in a loss of hippocampal long-term potentiation in response to 10-hertz stimulation and a deficit in ..
  17. Kemi O, Ellingsen O, Ceci M, Grimaldi S, Smith G, Condorelli G, et al. Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. J Mol Cell Cardiol. 2007;43:354-61 pubmed
    ..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training. ..
  18. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, et al. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain. 2008;1:6 pubmed publisher
    ..heterozygous for a null mutation of the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha-CaMKII+/-) have profoundly dysregulated behaviours and impaired neuronal development in the dentate gyrus (DG)...
  19. Yang Y, Zhu W, Joiner M, Zhang R, Oddis C, Hou Y, et al. Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivo. Am J Physiol Heart Circ Physiol. 2006;291:H3065-75 pubmed
    Inhibition of the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) or depletion of sarcoplasmic reticulum (SR) Ca(2+) stores protects against apoptosis from excessive isoproterenol (Iso) stimulation in cultured ..
  20. Robison A, Bartlett R, Bass M, Colbran R. Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin. J Biol Chem. 2005;280:39316-23 pubmed
    Neuronal Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) interacts with several prominent dendritic spine proteins, which have been termed CaMKII-associated proteins...
  21. Jiao Y, Jalan Sakrikar N, Robison A, Baucum A, Bass M, Colbran R. Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J Biol Chem. 2011;286:24806-18 pubmed publisher
    The densin C-terminal domain can target Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) in cells...
  22. Frederick A, Yano H, Trifilieff P, Vishwasrao H, Biezonski D, Meszaros J, et al. Evidence against dopamine D1/D2 receptor heteromers. Mol Psychiatry. 2015;20:1373-85 pubmed publisher
    ..responses were intact in D2 receptor and Gαq KO mice, as well as in knock-in mice expressing a mutant Ala(286)-CaMKIIα that cannot autophosphorylate to become active...
  23. Zhu L, Klutho P, Scott J, Xie L, Luczak E, Dibbern M, et al. Oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis. Vascul Pharmacol. 2014;60:75-83 pubmed publisher
    Activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and reactive oxygen species (ROS) promote neointimal hyperplasia after vascular injury. CaMKII can be directly activated by ROS through oxidation...
  24. Scott J, Xie L, Li H, Li W, He J, Sanders P, et al. The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9. Am J Physiol Heart Circ Physiol. 2012;302:H1953-64 pubmed publisher
    The multifunctional CaMKII has been implicated in vascular smooth muscle cell (VSMC) migration, but little is known regarding its downstream targets that mediate migration...
  25. Hao Z, Pei D, Guan Q, Zhang G. Calcium/calmodulin-dependent protein kinase II (CaMKII), through NMDA receptors and L-Voltage-gated channels, modulates the serine phosphorylation of GluR6 during cerebral ischemia and early reperfusion period in rat hippocampus. Brain Res Mol Brain Res. 2005;140:55-62 pubmed
    ..On the other hand, KN-62, a selective inhibitor of rat brain Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), diminished the increase in serine phosphorylation of GluR6...
  26. Liu X, Yao M, Li N, Wang C, Zheng Y, Cao X. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood. 2008;112:4961-70 pubmed publisher
    Calcium and its major downstream effector, calcium/calmodulin-dependent protein kinase II (CaMKII), are found to be important for the functions of immune cells...