Genomes and Genes
Gene Symbol: Camk2a
Description: calcium/calmodulin-dependent protein kinase II alpha
Alias: CaMKII, R74975, mKIAA0968, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaMK II, alpha-CaMKII, caM kinase II subunit alpha, caMK-II subunit alpha
Publications124 found, 100 shown here
- Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoformsWen Xie
New York State Institute for Basic Research in Developmental Disabilities, Department of Molecular Biology, 1050 Forest Hill Road, Staten Island, NY 10314, USA
Neurobiol Dis 35:52-62. 2009..Altogether, the spatio-temporal plasticity of FMR1 mRNA is consistent with complex RNA processing that is mis-regulated in fragile X syndrome...
- The septin CDCrel-1 is dispensable for normal development and neurotransmitter releaseXiao Rong Peng
Programmes in Cell Biology Brain and Behavior, Hospital for Sick Children, Toronto, Ontario, Canada
Mol Cell Biol 22:378-87. 2002..Together, these data suggest that CDCrel-1 is not essential for neuronal development or function, and that changes in expression of other septins may account for its functional redundancy...
- The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent mannerRani Dhavan
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 22:7879-91. 2002..activation of glutamate receptors increases the association of p35 and p39 with CaMKIIalpha, and the inhibition of CaMKII activation diminishes this effect...
- Behavioral testing upregulates pCaMKII, BDNF, PSD-95 and egr-1 in hippocampus of FVB/N miceDaniela D Pollak
Department of Pediatrics, Division of Pediatric Neuroscience, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
Behav Brain Res 163:128-35. 2005..Levels of total and autophosphorylated (T286) alphacalcium-calmodulin dependent kinase II (CaMKII, pCaMKII), total and phosphorylated mitogen-activated protein kinase (MAPK, pMAPK), total and phosphorylated ..
- Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured regionMiles A Pufall
Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112 5550, USA
Science 309:142-5. 2005..Variable phosphorylation thus serves as a "rheostat" for cell signaling to fine-tune transcription at the level of DNA binding...
- IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanismMihai G Netea
Divisions of Infectious Diseases and Pulmonary Science and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 102:16309-14. 2005..The modulation of intracellular NOD2 pathways by IL-32, but not cell-surface TLRs, and the marked expression of IL-32 in colon mucosa suggest a role of IL-32 in the pathogenesis of Crohn's disease...
- Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant miceA J Silva
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA
Science 257:206-11. 1992..The mice with a mutation in the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII), a synaptic protein enriched in the hippocampus, are appropriate for addressing this issue because the ..
- Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant miceA J Silva
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA
Science 257:201-6. 1992..mechanisms, mutant mice were produced that do not express the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII)...
- Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase IIS Mukherji
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
J Biol Chem 270:14062-7. 1995....
- Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase IIC Chen
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA
Science 266:291-4. 1994Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion...
- Requirement for alpha-CaMKII in experience-dependent plasticity of the barrel cortexS Glazewski
Department of Physiology, University of Minnesota, Minneapolis 55455, USA
Science 272:421-3. 1996..The synaptic plasticity mechanism of long-term potentiation requiring calcium-calmodulin-dependent kinase type II (CaMKII) could underlie experience-dependent plasticity...
- Impaired learning in mice with abnormal short-lived plasticityA J Silva
Cold Spring Harbor Laboratory, New York 11724, USA
Curr Biol 6:1509-18. 1996..abnormal SLP, but apparently normal LTP-mice heterozygous for a alpha-calcium calmodulin kinase II mutation (alpha CaMKII +/-) have lower paired-pulse facilitation (PPF) and increased post-tetanic potentiation (PTP); mice lacking ..
- Control of memory formation through regulated expression of a CaMKII transgeneM Mayford
Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168 Street, New York, NY 10032, USA
Science 274:1678-83. 1996..Expression of an activated calcium-independent form of calcium-calmodulin-dependent kinase II (CaMKII) resulted in a loss of hippocampal long-term potentiation in response to 10-hertz stimulation and a deficit in ..
- Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learningK P Giese
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Science 279:870-3. 1998The calcium-calmodulin-dependent kinase II (CaMKII) is required for hippocampal long-term potentiation (LTP) and spatial learning...
- Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous systemK U Bayer
Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305 5125, USA
Brain Res Mol Brain Res 70:147-54. 1999..Additionally, we describe the murine betaM-CaM kinase II, a variant of the 'brain-specific' beta-CaM kinase II, which is highly expressed in skeletal muscle...
- CA1 long-term potentiation is diminished but present in hippocampal slices from alpha-CaMKII mutant miceH L Hinds
Cold Spring Harbor Laboratory, New York 11724, USA
Learn Mem 5:344-54. 1998..Previous work has shown that mice missing the alpha-isoform of calcium-calmodulin-dependent protein kinase II (alpha-CaMKII) have a deficiency in CA1 hippocampal long-term potentiation (LTP)...
- Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memoryP W Frankland
Departments of Neurobiology, Psychiatry and Psychology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
Nature 411:309-13. 2001..Here we show that mice heterozygous for a null mutation of alpha-calcium-calmodulin kinase II (alpha-CaMKII+/-) show normal learning and memory 1-3 days after training in two hippocampus-dependent tasks...
- Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learningYpe Elgersma
Department of Neurobiology, Department of Psychiatry, Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA
Neuron 36:493-505. 2002..Our data demonstrate that blocking inhibitory phosphorylation increases CaMKII in the postsynaptic density (PSD), lowers the threshold for hippocampal long-term potentiation (LTP), and results ..
- Disruption of dendritic translation of CaMKIIalpha impairs stabilization of synaptic plasticity and memory consolidationStephan Miller
Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 202, La Jolla, CA 92037, USA
Neuron 36:507-19. 2002..These results demonstrate that local translation is important for synaptic delivery of the kinase and that local translation contributes to synaptic and behavioral plasticity...
- Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndromeEdwin J Weeber
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:2634-44. 2003..animals exhibited a significant increase in hippocampal phospho-calcium/calmodulin-dependent protein kinase II (CaMKII), specifically at sites Thr(286) and Thr(305), with no corresponding change in the levels of total CaMKII...
- Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylationNeil Hardingham
School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
J Neurosci 23:4428-36. 2003....
- The involvement of the anterior cingulate cortex in remote contextual fear memoryPaul W Frankland
Departments of Neurobiology, Psychiatry, Psychology and Brain Research Institute, UCLA, 695 Charles Young Drive South, Los Angeles, CA 90095 1761, USA
Science 304:881-3. 2004..that the anterior cingulate is activated by remote memory and that this activation is impaired by a null alpha-CaMKII mutation that blocks remote memory...
- The contribution of autophosphorylated alpha-calcium-calmodulin kinase II to injury-induced persistent painK P Zeitz
Departments of Anatomy and Physiology and the W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94080, USA
Neuroscience 128:889-98. 2004..To assess the contribution of alpha-calcium-calmodulin kinase II (alpha-CaMKII) to injury-induced inflammation and pain, we evaluated nociceptive responses in mice that carry a point mutation ..
- Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPsSusumu Tomita
Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
Neuron 45:269-77. 2005..Synaptic NMDA receptor activity can induce both stargazin phosphorylation, via activation of CaMKII and PKC, and stargazin dephosphorylation, by activation of PP1 downstream of PP2B...
- AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memoryElaine E Irvine
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK
Nat Neurosci 8:411-2. 2005..We conclude that alphaCaMKII autophosphorylation contributes to single-trial learning but is dispensable for memory...
- Calmodulin kinase II inhibition protects against structural heart diseaseRong Zhang
Department of Medicine, Vanderbilt University School of Medicine, 2220 Pierce Avenue, Nashville, Tennessee 37232 6300, USA
Nat Med 11:409-17. 2005..The Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is a recently identified downstream element of the betaAR-initiated signaling cascade that is linked to ..
- Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2A J Robison
Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
J Biol Chem 280:35329-36. 2005Dendritic calcium/calmodulin-dependent protein kinase II (CaMKII) is dynamically targeted to the synapse...
- Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteomeMark O Collins
Genes to Cognition, The Wellcome Trust Sanger Institute, Hinxton, UK
J Neurochem 97:16-23. 2006..These synapse proteome data sets offer a basis for future research in synaptic biology and will provide useful information in brain disease and mental disorder studies...
- Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouseSam F Cooke
MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Physiol 574:805-18. 2006..Thus, the autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse...
- Calmodulin kinase II inhibition protects against myocardial cell apoptosis in vivoYingbo Yang
Dept of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Physiol Heart Circ Physiol 291:H3065-75. 2006Inhibition of the multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) or depletion of sarcoplasmic reticulum (SR) Ca(2+) stores protects against apoptosis from excessive isoproterenol (Iso) stimulation in cultured ..
- L-type Ca2+ channel facilitation mediated by phosphorylation of the beta subunit by CaMKIIChad E Grueter
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Mol Cell 23:641-50. 2006..Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is associated with cardiac LTCC complexes and increases channel open probability (P(O)) to dynamically increase ..
- Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylationGeeske M van Woerden
Erasmus MC, University Medical Centre, Department of Neuroscience, Dr Molewaterplein 50, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
Nat Neurosci 10:280-2. 2007..Moreover, these double mutants no longer show the behavioral deficits seen in AS mice, suggesting that these deficits are the direct result of increased inhibitory phosphorylation of alphaCaMKII...
- Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrusNohjin Kee
Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Nat Neurosci 10:355-62. 2007..This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus...
- The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatumBrian J Wiltgen
Department of Psychology and the Brain Research Institute, University of California, Los Angeles, CA 90095, USA
Eur J Neurosci 25:2491-7. 2007..In the current experiments we examined the role of calcium calmodulin-dependent kinase II (CaMKII) by using transgenic mice that express a constitutively active form of this kinase...
- Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapsesMohammad Reza Hojjati
Department of Neuroscience, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Nat Neurosci 10:1125-7. 2007..These results indicate that alphaCaMKII has a nonenzymatic role in short-term presynaptic plasticity at hippocampal CA3-CA1 synapses...
- Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholambanOle J Kemi
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
J Mol Cell Cardiol 43:354-61. 2007..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training...
- NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca(2+)/calmodulin-dependent kinasesKarri Lamsa
Institute of Neurology, University College London, Queen Square, London, UK
J Physiol 584:885-94. 2007..influx triggers phosphorylation of several kinases, in particular Ca(2+)/calmodulin-dependent kinase type II (CaMKII)...
- Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learningYu Zhou
Department of Neurobiology, Semel Institute, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
J Neurosci 27:13843-53. 2007..several prominent proteins in the postsynaptic density, including calcium/calmodulin-dependent protein kinase II (CaMKII)...
- A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cellsIchiro Kato
Department of Biochemistry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930 0194, Japan
Diabetes Metab Res Rev 24:486-97. 2008The activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in pancreatic beta-cells has been thought to play a central role in Ca2+-mediated insulin secretion...
- Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ currentJingdong Li
Departments of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1081, USA
Channels (Austin) 1:387-94. 2007Mice with genetic inhibition (AC3-I) of the multifunctional Ca(2+)/calmodulin dependent protein kinase II (CaMKII) have improved cardiomyocyte survival after ischemia...
- Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disordersNobuyuki Yamasaki
Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
Mol Brain 1:6. 2008..heterozygous for a null mutation of the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha-CaMKII+/-) have profoundly dysregulated behaviours and impaired neuronal development in the dentate gyrus (DG)...
- Inducible and selective erasure of memories in the mouse brain via chemical-genetic manipulationXiaohua Cao
Shanghai Institute of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, MOE and STCSM, East China Normal University, Shanghai, China
Neuron 60:353-66. 2008..Therefore, our study reveals a molecular genetic paradigm through which a given memory, such as new or old fear memory, can be rapidly and specifically erased in a controlled and inducible manner in the brain...
- Autophosphorylation of alphaCaMKII downregulates excitability of CA1 pyramidal neurons following synaptic stimulationEvgeny A Sametsky
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
Neurobiol Learn Mem 92:120-3. 2009....
- Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggressionShunsuke Hasegawa
Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
Mol Brain 2:6. 2009Previous studies have demonstrated essential roles for alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) in learning, memory and long-term potentiation (LTP)...
- Structural rearrangement of CaMKIIalpha catalytic domains encodes activationChristopher Thaler
National Institute on Alcohol Abuse and Alcoholism and Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 5625 Fishers Lane, Rockville, MD 20892, USA
Proc Natl Acad Sci U S A 106:6369-74. 2009..Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J (2005) Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell 123:849-860]...
- Kinase-dead knock-in mouse reveals an essential role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIalpha in dendritic spine enlargement, long-term potentiation, and learningYoko Yamagata
Department of Information Physiology, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
J Neurosci 29:7607-18. 2009..CaMKIIalpha (K42R) mice, kinase activity was reduced to the same level as in CaMKIIalpha-null mice, whereas CaMKII protein expression was well preserved...
- Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in miceMihail G Chelu
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
J Clin Invest 119:1940-51. 2009..Rapid atrial pacing resulted in increased Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2, while both pharmacologic and genetic inhibition of CaMKII prevented AF inducibility in ..
- Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase IIMeagan A Jenkins
Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 30:5125-35. 2010Ca(v)1 (L-type) channels and calmodulin-dependent protein kinase II (CaMKII) are key regulators of Ca(2+) signaling in neurons. CaMKII directly potentiates the activity of Ca(v)1.2 and Ca(v)1...
- Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brainNorifumi Shioda
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
J Neurosci 31:346-58. 2011..Interestingly, aberrant increased calcium/calmodulin-dependent protein kinase II (CaMKII) activity was observed in the mPFC of ATRX(ΔE2) mice...
- Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylationYuxia Jiao
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 286:24806-18. 2011The densin C-terminal domain can target Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) in cells...
- Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent miceRichard M Gustin
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States
Mol Cell Neurosci 47:286-92. 2011In order to provide insight into in vivo roles of CaMKIIα autophosphorylation at Thr286 during postnatal development, behavioral, biochemical, and electrophysiological phenotypes of pre-adolescent Thr286 to Ala CaMKIIα knock-in (T286A-..
- Quantitative estimates of the cytoplasmic, PSD, and NMDAR-bound pools of CaMKII in dendritic spinesBihua Feng
Biology Department and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454 9110, USA
Brain Res 1419:46-52. 2011b>CaMKII plays a critical role in long-term potentiation (LTP). The kinase is a major component of the postsynaptic density (PSD); however, it is also contained in the spine cytoplasm...
- Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatumAnthony J Baucum
Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 7:e31554. 2012..We found that calcium/calmodulin-dependent protein kinase II (CaMKII) directly and indirectly associates with N- and C-terminal domains of spinophilin, but F-actin can displace CaMKII ..
- AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine rewardSaid Kourrich
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
J Neurosci 32:6578-86. 2012Changes in CaMKII-regulated synaptic excitability are a means through which experience may modify neuronal function and shape behavior...
- Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- miceY H Cho
Department of Psychology, Boston University, Boston, MA 02215, USA
Science 279:867-9. 1998..Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning...
- Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brainHuimin Wang
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 100:4287-92. 2003..stages of memory consolidation process and revealed the first postlearning week as the critical time window during which a precise level of CaMKII reactivation is essential for the consolidation of long-term memories in the brain.
- Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actininA J Robison
Department of Molecular Physiology and Biophysics, Center for Molecular Neurosciences and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Biol Chem 280:39316-23. 2005Neuronal Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) interacts with several prominent dendritic spine proteins, which have been termed CaMKII-associated proteins...
- Experience-dependent increase in CA1 place cell spatial information, but not spatial reproducibility, is dependent on the autophosphorylation of the alpha-isoform of the calcium/calmodulin-dependent protein kinase IIFrancesca Cacucci
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 27:7854-9. 2007..Consequently, the progressive improvement in spatial coding in new hippocampal place cell maps depends on the existence of two molecularly dissociable, experience-dependent processes...
- Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytesJ DeSantiago
Department of Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
J Mol Cell Cardiol 36:67-74. 2004..This recovery in rat myocytes could be inhibited by KN-93 suggesting that CaMKII-dependent protein phosphorylation (and enhanced SR Ca uptake) may be responsible...
- Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggsSuzanne Madgwick
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle, Newcastle, NE2 4HH, UK
J Cell Sci 118:3849-59. 2005..pathway is not fully resolved but both protein kinase C (PKC) and calmodulin-dependent protein kinase II (CamKII) activities increase at fertilization and previous pharmacological studies have implicated both in cell-cycle ..
- Transgenic mice overexpressing nNOS in the adult nervous systemM A Packer
Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY 11724, USA
Cell Mol Biol (Noisy-le-grand) 51:269-77. 2005..Our experiments describe specific changes in cell division and gene activity in the CaMKII-nNOS transgenic model and demonstrate its utility for studying the action of NO in the adult brain.
- Regulation of kinesin light chain 1 level correlates with the development of morphine reward in the mouse brainWiktor Bilecki
Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Eur J Neurosci 30:1101-10. 2009..In the cortex, hippocampus and amygdala, KLC1 co-localized with calcium/calmodulin-dependent protein kinase II (CaMKII), suggesting that KLC1 was present in the cell bodies and dendrites of pyramidal neurons...
- CaMKII is essential for the proasthmatic effects of oxidationPhilip N Sanders
Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Sci Transl Med 5:195ra97. 2013..We show that enhanced oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase (ox-CaMKII) in bronchial epithelium positively correlates with asthma severity and that epithelial ox-CaMKII increases in ..
- Oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosisLinda J Zhu
Department of Medicine, Iowa City, IA, United States
Vascul Pharmacol 60:75-83. 2014Activation of the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and reactive oxygen species (ROS) promote neointimal hyperplasia after vascular injury. CaMKII can be directly activated by ROS through oxidation...
- Mechanism for long-term memory formation when synaptic strengthening is impairedKasia Radwanska
Institute of Psychiatry, King s College London, London SE5 9NU, United Kingdom
Proc Natl Acad Sci U S A 108:18471-5. 2011..Taken together, we suggest that activation of mTOR signaling, followed by overexpression of PSD95 protein and synaptogenesis, contributes to formation of invariant LTM when functional strengthening is impaired...
- Ca(2+)/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitisWenbin Yang
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Am J Physiol Renal Physiol 303:F350-6. 2012..of pain-signaling pathways at the dorsal horn suggested that Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) contributes to neurogenic cystitis pelvic pain...
- Interaction between αCaMKII and GluN2B controls ERK-dependent plasticityFarida El Gaamouch
Universite de Caen Basse Normandie, CNRS UMR 6232, CINAPS PSY, 14 000 Caen, France
J Neurosci 32:10767-79. 2012..We show that αCaMKII, but not βCaMKII, is critically involved in this GluN2B-dependent activation of ERK1/2 signaling, through a ..
- Studies of the regulatory mechanism of Ca2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartateY L Fong
Howard Hughes Medical Institute, Vanderbilt University, Nashville, Tennessee 37232
J Biol Chem 264:16759-63. 1989..These results establish that introduction of negative charge(s) at residue 286, either by autophosphorylation of Thr or by mutation to Asp, is sufficient and necessary to generate the partially Ca2+-independent form of CaM-kinase II...
- Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant miceJ A Gordon
Department of Physiology, University of California, San Francisco 94143 0444, USA
Neuron 17:491-9. 1996..visual cortical plasticity in mice lacking the alpha-isoform of calcium/calmodulin-dependent protein kinase II (alpha CaMKII)...
- Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggsJ Johnson
Molecular and Cellular Biology Program Biology, Arizona State University, Tempe, Arizona, 85287 1501, USA
Dev Biol 204:464-77. 1998..CaM kinase II appears localized on midzone microtubules as soon as they form and may have a role in specifying the position of the contractile ring of the second polar body...
- Photoreceptor regulated expression of Ca(2+)/calmodulin-dependent protein kinase II in the mouse retinaL O Liu
Department of Ophthalmology and Visual Sciences, School of Medicine University of Louisville, Louisville, KY 40202, USA
Brain Res Mol Brain Res 82:150-66. 2000The objective of this investigation is to determine mechanisms for regulation of retinal calmodulin kinase II (CaMKII)...
- [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]Hideyuki Yamamoto
Tanpakushitsu Kakusan Koso 47:241-7. 2002
- Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivoJosep M Colomer
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Endocrinol 17:183-92. 2003..On the other hand, TAC does increase both mRNA and protein levels of specific isoforms of CaMKII derived from both gamma and delta genes...
- Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapseHeather L Hinds
Howard Hughes Medical Institute, Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:4275-80. 2003A significant fraction of the total calciumcalmodulin-dependent protein kinase II (CaMKII) activity in neurons is associated with synaptic connections and is present in nerve terminals, thus suggesting a role for CaMKII in ..
- Oscillatory CaMKII activity in mouse egg activationStyliani Markoulaki
Sackler School of Biomedical Sciences, Program in Cell, Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA 02111, USA
Dev Biol 258:464-74. 2003..increases in Ca(2+) similar to those at fertilization stimulate oscillatory Ca(2+)/calmodulin-dependent kinase II (CaMKII) enzyme activity, incrementally driving the events of egg activation...
- Handling and environmental enrichment do not rescue learning and memory impairments in alphaCamKII(T286A) mutant miceA C Need
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
Genes Brain Behav 2:132-9. 2003..Furthermore, we have established that there are enrichment mechanisms that are independent of this autophosphorylation...
- Calmodulin and calmodulin-dependent kinase IIalpha regulate osteoblast differentiation by controlling c-fos expressionMajd Zayzafoon
Department of Pathology, University of Alabama at Birmingham, USA
J Biol Chem 280:7049-59. 2005Ca(2+)/calmodulin-dependent protein kinase IIalpha (alpha-CaMKII) was once thought to be exclusively expressed in neuronal tissue, but it is becoming increasingly evident that CaMKII is also expressed in various extraneural cells...
- Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase IILian Zhang
Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
J Neurosci 25:7697-707. 2005..Here, we show that inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II (CaMKII) is required for hippocampal metaplasticity at the lateral perforant path-dentate granule cell synapse...
- Neuronal cell type-specific promoter of the alpha CaM kinase II gene is activated by Zic2, a Zic family zinc finger proteinTakumi Sakurada
Department of Biochemistry, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770 8505, Japan
Neurosci Res 53:323-30. 2005..These results indicated that Zic2 was one of the proteins binding to, and regulating the activity of, the promoter of alpha CaM kinase II...
- CaMKII inactivation by extracellular Ca(2+) depletion in dorsal root ganglion neuronsJonathan E Cohen
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA
Cell Calcium 39:445-54. 2006A mechanism by which Ca(2+)/CaM-dependent protein kinase (CaMKII) is autophosphorylated by changes in extracellular calcium in the absence of detectable changes in cytoplasmic [Ca(2+)] has been identified...
- Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKIIShumin Liu
Department of Pathology, Taub Institute, Columbia University, New York, NY 10032, USA
Eur J Neurosci 25:3583-96. 2007..Thus, our results suggest that NO, cGMP, GMP-dependent protein kinase and calmodulin-dependent protein kinase II play a key role in the redistribution of alpha-synuclein during plasticity...
- Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKIIalpha mutant miceKa Wan Li
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
J Proteome Res 6:3127-33. 2007..g., receptors and ion channels, scaffolding proteins, cytoskeletal proteins, signaling proteins, adhesion molecules, and proteins of synaptic vesicles and those involved in membrane recycling...
- Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytesChristian Faul
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Mol Cell Biol 27:8215-27. 2007..myopodin forms a Z-disc signaling complex with alpha-actinin, calcineurin, Ca2+/calmodulin-dependent kinase II (CaMKII), muscle-specific A-kinase anchoring protein, and myomegalin...
- Spatiotemporal dynamics of cortical sensorimotor integration in behaving miceIsabelle Ferezou
Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
Neuron 56:907-23. 2007..Sensory processing in motor cortex may therefore contribute significantly to active tactile sensory perception...
- Disruption of KIF17-Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin-cargo releaseLaurent Guillaud
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nat Cell Biol 10:19-29. 2008..of protein-protein interaction by FRET and various in vitro and in vivo approaches we have demonstrated that CaMKII-dependent phosphorylation of KIF17 on Ser 1029 disrupts the KIF17-Mint1 association and results in the release of ..
- Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cellsAkihiro Mizutani
Laboratory for Developmental Neurobiology and Laboratory for Molecular Neurogenesis, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
J Neurosci 28:5369-82. 2008..the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo...
- Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failureYanggan Wang
Department of Internal Medicine Cardiology and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
J Biol Chem 283:25524-32. 2008Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) activity is increased in heart failure (HF), a syndrome characterized by markedly increased risk of arrhythmia...
- Activity-dependent modulation of limbic dopamine D3 receptors by CaMKIIXian Yu Liu
Department of Basic Medical Science, University of Missouri Kansas City, Kansas City, MO 64108, USA
Neuron 61:425-38. 2009Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is central to synaptic transmission. Here we show that synaptic CaMKIIalpha binds to the N-terminal region of the third intracellular loop of the limbic dopamine D3 receptor (D3R)...
- Improvement of depressive behaviors by nefiracetam is associated with activation of CaM kinases in olfactory bulbectomized miceFeng Han
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai, Japan
Brain Res 1265:205-14. 2009..J. Neurochem. 97, 22-29), decreased activities of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and extracellular signal-regulated kinase (ERK) in the hippocampal CA1 region and amygdala were observed in OBX ..
- Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized miceShigeki Moriguchi
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
J Neurochem 110:170-81. 2009..potentiation (LTP) of hippocampal CA1 regions from OBX mice was associated with down-regulation of CaM kinase II (CaMKII) and protein kinase C (PKC) activities...
- Enhanced CaMKII activity and spatial cognitive function in SAMP6 miceEiki Takahashi
Research Resources Center, RIKEN Brain Science Institute, Saitama, Japan
Behav Neurosci 123:527-32. 2009..The Thr286 phosphorylation of alpha calcium/calmodulin-dependent protein kinase II (CaMKII) has a crucial role in plasticity and learning among multiple downstream signaling pathways linked to the NMDA ..
- The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?Kenichi Okamoto
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Physiology (Bethesda) 24:357-66. 2009Ca2+/calmodulin-dependent protein kinase II (CaMKII) and actin are two crucial molecules involved in long-term potentiation (LTP)...
- Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase IIZhiping P Pang
Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California 94304 5543, USA
J Neurosci 30:4132-42. 2010..Viewed together, these data suggest that calmodulin performs a major function in boosting synaptic strength via direct activation of presynaptic calmodulin-dependent kinase II...
- A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in miceThomas J Hund
Department of Internal Medicine, Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Clin Invest 120:3508-19. 2010..for Na(+) channels, via direct phosphorylation by β(IV)-spectrin-targeted calcium/calmodulin-dependent kinase II (CaMKII)...
- Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overloadStefan Wagner
Department of Cardiology and Pneumology, Georg August University, Robert Koch Strasse 40, 37075 Gottingen, Germany
Circ Res 108:555-65. 2011..Both ROS and CaMKII can increase late I(Na) leading to intracellular Na accumulation and arrhythmias...
- Conformational changes underlying calcium/calmodulin-dependent protein kinase II activationLAUREL HOFFMAN
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
EMBO J 30:1251-62. 2011Calcium/calmodulin-dependent protein kinase II (CaMKII) interprets information conveyed by the amplitude and frequency of calcium transients by a controlled transition from an autoinhibited basal intermediate to an autonomously active ..
- Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gatingAnders S Kristensen
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
Nat Neurosci 14:727-35. 2011..Ca(2+)/calmodulin-dependent kinase II (CaMKII) phosphorylates the GluA1 AMPA receptor subunit at Ser831 to increase single-channel conductance...
- Oxidized CaMKII causes cardiac sinus node dysfunction in micePaari Dominic Swaminathan
Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
J Clin Invest 121:3277-88. 2011..Here, we show that oxidized calmodulin kinase II (ox-CaMKII) is a biomarker for SND in patients and dogs and a disease determinant in mice...
- Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase IIM Danciger
Jules Stein Eye Institute, UCLA School of Medicine 90024
Mamm Genome 3:122-5. 1992
- Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brainR M Hanley
Department of Cell Biology, Baylor College of Medicine, Houston, TX
Nucleic Acids Res 17:3992. 1989
- Calmodulin-dependent protein kinase II is activated transiently in ethanol-stimulated mouse oocytesN J Winston
Departement de Biologie du Developpement, Institut Jacques Monod, CNRS Université Paris VII, France
Dev Biol 170:350-2. 1995The activity of calmodulin-dependent protein kinase II (CaMKII) was measured in mouse oocytes arrested in metaphase II and following their activation parthenogenetically. In metaphase II-arrested oocytes CaMKII was inactive...
- FORM CELL APO (A)/LP(A) RECEPTOR--CLONING AND FUNCTIONIra Tabas; Fiscal Year: 2002..The studies in this proposal will lead to the molecular identification of a novel cholesterol-induced receptor on foam cells and should provide important insight into the role of foam cell-apo(a)/Lp(a) interactions in atherogenesis. ..
- Conference on Cellular Biology of AtherosclerosisIra Tabas; Fiscal Year: 2005....
- Macrophage Death in Plaque VulnerabilityIra Tabas; Fiscal Year: 2005..New insights in this area may suggest new therapeutic strategies to combat cardiovascular disease. ..
- INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGESIRA A TABAS; Fiscal Year: 2010..abstract_text> ..
- Role of JNK1 in Skeletal Muscle Glucose MetabolismCAROL WITCZAK; Fiscal Year: 2006..Also, these studies may uncover new pharmacological targets for the treatment of type 2 diabetes. ..