Genomes and Genes
Gene Symbol: Cacna1d
Description: calcium channel, voltage-dependent, L type, alpha 1D subunit
Alias: 8430418G19Rik, C79217, Cach3, Cacn4, Cacnl1a2, Cav1.3, Cchl1a, Cchl1a2, D-LTCC, voltage-dependent L-type calcium channel subunit alpha-1D, Cav1.3alpha1, alpha 1 E, calcium channel, L type, alpha-1 polypeptide, voltage-gated calcium channel subunit alpha Cav1.3
Publications102 found, 100 shown here
- CaV1.3 L-type Ca2+ channels modulate depression-like behaviour in mice independent of deaf phenotypePerrine Busquet
Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck CMBI, University of Innsbruck, Innsbruck, Austria
Int J Neuropsychopharmacol 13:499-513. 2010..The findings raise the possibility that selective modulation of CaV1.3 channels could be a promising new therapeutic concept for the treatment of mood disorders...
- Abundant L-type calcium channel Ca(v)1.3 (alpha1D) subunit mRNA is detected in rod photoreceptors of the mouse retina via in situ hybridizationHailian Xiao
Neuroscience Institute, Department of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
Mol Vis 13:764-71. 2007..In order to get around the innate complications of utilizing unproven antibodies and to shed light on this discussion, we investigated the mRNA expression profile for the Ca(v)1.3 (alpha1D) subunit in the mouse retina...
- [Mice lacking of voltage-gated L-type calcium channel alpha1D subunit have impaired sinoatrial node function and caused deafness]Hanqi Chu
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 21:468-72. 2007....
- Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP)Joanne E Driver
School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JP, UK
Eur J Neurosci 26:1280-8. 2007..These data suggest that deficits in network function in Alzheimer's disease occur early and are not directly correlated to amyloid load...
- Chronic morphine treatment decreases the Cav1.3 subunit of the L-type calcium channelVictoria L Haller
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0524, USA
Eur J Pharmacol 578:101-7. 2008..The Ca(v)2.2 subunit protein of the N-type channel of VOCs remained unchanged. The Ca(v)1.3 subunit modification may represent one of many potential adaptive changes in tolerance to morphine-induced changes in intracellular calcium...
- Structure and functional characterization of neuronal alpha 1E calcium channel subtypesM E Williams
SIBIA, Inc, La Jolla, California 92037
J Biol Chem 269:22347-57. 1994..Thus, alpha 1E-mediated Ca2+ channels appear to be a pharmacologically distinct class of voltage-activated Ca2+ channels...
- Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channelsJ Platzer
Institut fur Biochemische Pharmakologie, Innsbruck, Austria
Cell 102:89-97. 2000..We conclude that alpha1D can form LTCCs with negative activation thresholds essential for normal auditory function and control of cardiac pacemaker activity...
- Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generationY Namkung
National Creative Research Initiatives Center for Calcium and Learning, Pohang University of Science and Technology, Pohang, Korea
J Clin Invest 108:1015-22. 2001....
- Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activityMatteo E Mangoni
Unité Propre de Recherche 1142, Centre National de la Recherche Scientifique, Institut de Genetique Humaine, 141 rue de la Cardonille, Montpellier Cedex 5, France
Proc Natl Acad Sci U S A 100:5543-8. 2003..Taken together, our data demonstrate that Ca(v)1.3 channels play a major role in the generation of cardiac pacemaker activity by contributing to diastolic depolarization in SAN pacemaker cells...
- Neurological phenotype and synaptic function in mice lacking the CaV1.3 alpha subunit of neuronal L-type voltage-dependent Ca2+ channelsN C Clark
The Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK
Neuroscience 120:435-42. 2003..3 alpha 1 subunit expression there is sufficient residual activity of other Ca2+ channel subtypes to support NMDA receptor-independent long-term potentiation and some forms of sensory behavior/function...
- Cav1.3 (alpha1D) Ca2+ currents in neonatal outer hair cells of miceMarcus Michna
Institute of Physiology II and Department of Otolaryngology, Tuebingen Hearing Research Centre THRC, University of Tuebingen, Gmelinstrasse 5, D 72076 Tuebingen, Germany
J Physiol 553:747-58. 2003..Single cell RT-PCR revealed expression of Cav1.3 in OHCs. In OHCs from Cav1.3-/- mice, Ba2+ current density was reduced to 0.6 +/- 0.5 pA pF-1 (n = 9) indicating that > 97 % of the Ca2+ channel current in OHCs flows through Cav1.3...
- CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cellsAndreas Brandt
Department of Otolaryngology, Goettingen University Medical School, 37075 Goettingen, Germany
J Neurosci 23:10832-40. 2003..We conclude that CaV1.3 channels are essential for normal hair cell development and synaptic transmission...
- G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domainPatricia A Olson
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 25:1050-62. 2005..Together, these results suggest that Shank promotes the assembly of a signaling complex at corticostriatal synapses that enables key GPCRs to regulate L-type Ca2+ channels and the integration of glutamatergic synaptic events...
- Neuronal L-type calcium channels open quickly and are inhibited slowlyThomas D Helton
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 25:10247-51. 2005....
- Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREBHua Zhang
Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Eur J Neurosci 23:2297-310. 2006..3 channels play a more important role in pCREB signaling in striatal medium spiny neurons than in hippocampal neurons. Our results provide novel insights into the function of CaV1.2 and CaV1.3 L-type Ca2+ channels in the brain...
- Role of voltage-gated L-type Ca2+ channel isoforms for brain functionJ Striessnig
Department of Pharmacology and Toxicology, Institute for Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Peter Mayrstr 1 I, A 6020 Innsbruck, Austria
Biochem Soc Trans 34:903-9. 2006..The results described here also allow predictions about the pharmacotherapeutic potential of isoform-selective LTCC modulators...
- Erbin enhances voltage-dependent facilitation of Ca(v)1.3 Ca2+ channels through relief of an autoinhibitory domain in the Ca(v)1.3 alpha1 subunitIrina Calin-Jageman
Department of Pharmacology and Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 27:1374-85. 2007..Our findings reveal a novel mechanism by which PDZ interactions and alternative splicing of alpha1 1.3 may influence activity-dependent regulation of Ca(v)1.3 channels at the synapse...
- Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cellsAlexandra Koschak
Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, 35121 Padova, Italy
J Neurosci 27:3855-63. 2007..2005), we discuss the hypothesis that anomalous rather than cardiac-type Ca(v)1.2 channels are specifically involved in LTCC-dependent and gene transcription-dependent LTP...
- 'Rejuvenation' protects neurons in mouse models of Parkinson's diseaseC Savio Chan
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Nature 447:1081-6. 2007..Such blocking ('rejuvenation') protects these neurons in both in vitro and in vivo models of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease...
- Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domainAnamika Singh
Institute of Pharmacy, Pharmacology, and Toxicology, and Center for Molecular Biosciences, University of Innsbruck, Peter Mayr Strasse 1 I, Innsbruck, Austria
J Biol Chem 283:20733-44. 2008..3 channel activation at lower voltages expected to favor Ca(V)1.3 activity at threshold voltages as required for modulation of neuronal firing behavior and sinoatrial node pacemaking...
- Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of Ca(V)1.3 knockout miceBrandon C McKinney
Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109 5619, United States
Neurobiol Learn Mem 92:519-28. 2009..Together, these results demonstrate altered neuronal function in the BLA of Ca(V)1.3 knockout mice which may account for the impaired ability of these mice to consolidate contextually-conditioned fear...
- Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cellsAndrea Marcantoni
Department of Neuroscience, Nanostructured Interfaces and Surfaces Centre of Excellence, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, 10125 Torino, Italy
J Neurosci 30:491-504. 2010..2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress...
- Impact of gating modulation in CaV1.3 L-type calcium channelsAlexandra Koschak
Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
Channels (Austin) 4:523-5. 2010..This mechanism was elicited during analysis of human C-terminal splice variants that differ in the length of their C-terminus and that modulates the channel's negative activation range and slows calcium-dependent inactivation...
- Are Ca(v)1.3 pacemaker channels in chromaffin cells? Possible bias from resting cell conditions and DHP blockers usageSatyajit Mahapatra
Department of Neuroscience, NIS Center, CNISM Research Unit, Torino, Italy
Channels (Austin) 5:219-24. 2011..3 and Ca(v)1.2 as pacemaker channels in MCCs...
- The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's diseaseE Ilijic
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Neurobiol Dis 43:364-71. 2011..This analysis revealed that isradipine produced a dose-dependent sparing of DA fibers and cell bodies at concentrations achievable in humans, suggesting that isradipine is a potentially viable neuroprotective agent for PD...
- Functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channelsBao Zhen Tan
Department of Physiology, Yong Loo Lin School Medicine, National University of Singapore, Singapore
J Biol Chem 286:42725-35. 2011..Thus, alternative splicing in the C terminus of Ca(V)1.3 channels modulates its electrophysiological properties, which could in turn alter neuronal firing properties and functions...
- High levels of RNA-editing site conservation amongst 15 laboratory mouse strainsPetr Danecek
Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK
Genome Biol 13:26. 2012..Recently the Mouse Genomes Project generated genome sequences for 17 laboratory mouse strains and rich catalogues of variants. We also generated RNA-seq data from whole brain RNA from 15 of the sequenced strains...
- Structural determinants of CaV1.3 L-type calcium channel gatingAndreas Lieb
Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, Austria
Channels (Austin) 6:197-205. 2012..3(scg) mutations in rat superior cervical ganglion preparations. However, the rCa(v)1.3(scg) variant provided interesting insight into the structural machinery involved in Ca(v)1.3 gating...
- Ca(V)1.3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cellsDavid H F Vandael
Department of Drug Science, Laboratory of Cellular and Molecular Neuroscience, Nanostructured Interfaces and Surfaces Center, 10125 Torino, Italy
J Neurosci 32:16345-59. 2012..3 slows down MCC firing by activating SK channels that maintain Na(V) channel availability high enough to preserve stable AP waveforms, even upon high-frequency stimulation of chromaffin cells during stress responses...
- Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cellsFrederick D Gregory
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA
Nat Neurosci 14:1109-11. 2011..We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway...
- Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythmsMichael L Ko
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
J Biol Rhythms 26:412-22. 2011..Taken together, these results indicate that the cardiac core oscillators have an impact in regulating circadian rhythmicities and cardiac function...
- Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cellsFrederick D Gregory
Department of Molecular Physiology and Biophysics, University of Iowa, 5 610 Bowen Science Building, 51 Newton Rd, Iowa City, IA 52242, USA
J Physiol 591:3253-69. 2013..Collectively, our results indicate a multifaceted presynaptic role of harmonin in IHCs in regulating Cav1.3 Ca(2+) channels and exocytosis...
- Junctophilin-2 is necessary for T-tubule maturation during mouse heart developmentJulia O Reynolds
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, BCM 335, Houston, TX 77030, USA
Cardiovasc Res 100:44-53. 2013..This study aims to elucidate the role of junctophilin-2 (JPH2), a junctional membrane complex protein, in the maturation of TTs in cardiomyocytes...
- L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexinsRupalatha Maddala
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA
PLoS ONE 8:e64676. 2013....
- Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cellsAngela Scavone
Department of Biosciences, Universita degli Studi di Milano, Milano, Italy
Circ Res 113:389-98. 2013..So far, such selection has been hampered by the lack of proper markers. CD166 is specifically but transiently expressed in the mouse heart tube and sinus venosus, the prospective SAN...
- Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizuresDaniel Radzicki
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Neurosci 33:9920-31. 2013....
- Mapacalcine protects mouse neurons against hypoxia by blocking cell calcium overloadHamid Moha Ou Maati
Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique UMR7275, Universite de Nice Sophia Antipolis, Valbonne, France
PLoS ONE 8:e66194. 2013..The protective effect was confirmed by measuring the cell survival rate after Oxygen Glucose Deprivation condition. Our data indicate that mapacalcine is a promising molecule for stroke treatment. ..
- Gene-by-diet interactions influence calcium absorption and bone density in miceRebecca A Replogle
Department of Nutrition Science, Purdue University, West Lafayette, IN, USA
J Bone Miner Res 29:657-65. 2014..These observations lay the groundwork for discovery-focused initiatives to identify novel genetic factors controlling gene-by-diet interactions affecting Ca/bone metabolism...
- Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channelsSarah C Brennan
Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
PLoS ONE 8:e80294. 2013..Furthermore, rhythmic epithelial depolarisations evoked by airway peristalsis would allow for branching to match growth and distension within the developing lung...
- Co-localization of L-type voltage dependent calcium channel alpha 1D subunit (Ca(v)1.3) and calbindin (CB) in the mouse central nervous systemJie Hua Xu
Department of Anatomy and Histology, Xi an Jiaotong University College of Medicine, Xi an 710061, People s Republic of China
Neurosci Lett 561:80-5. 2014..3 with CB in the laminae II of the dorsal horn of the spinal cord indicate that the regulation mechanism of nociceptive transmission may be related with both VDCC and Ca(2+) binding protein...
- Short- and long-term treatment of mouse cortical primary astrocytes with β-amyloid differentially regulates the mRNA expression of L-type calcium channelsNina Daschil
Department of Psychiatry and Psychotherapy, University Clinic for General and Social Psychiatry, Innsbruck, Austria
Pharmacology 93:24-31. 2014..2 α1-subunit around β-amyloid (Aβ) plaques in an Alzheimer mouse model. The aim of the present study was to explore whether Aβ peptides may regulate the mRNA expression of all LTCC subunits in primary mouse astrocytes in culture...
- Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neuronsJulia Hasreiter
Center of Physiology and Pharmacology, Department of Neurophysiology and Pharmacology, Medical University of Vienna, Vienna, Austria
Am J Physiol Cell Physiol 306:C1200-13. 2014..Moreover, our findings suggest that Cav1.3 knockout mice together with Cav1.2DHP(-)-knockin mice provide valuable models for future investigation of hippocampal LTCC-dependent afterdepolarizations...
- Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neuronsPing Lv
University of California, Davis, School of Medicine, Center for Neuroscience, Program in Communication Science, Davis, California 95618, Department of Pharmacology, Hebei Medical University, Shijiazhuang, China 050017
J Neurosci 34:7383-93. 2014..2 currents in neurons. Finally, using shRNA gene knockdown methodology, and histological analyses of SGNs from Cav1.2(+/-) and Cav1.3(+/-) mice, we were able to establish the differential roles of Cav1.2 and Cav1.3 in SGNs. ..
- Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neuronsElena Dragicevic
1 Institute of Applied Physiology, University of Ulm, Ulm, Germany
Brain 137:2287-302. 2014..As it is accessible to pharmacological modulation, it provides a novel promising target for tuning substantia nigra dopamine neuron activity, and their vulnerability to degeneration. ..
- Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activatorsNadine J Ortner
1 Department of Pharmacology and Toxicology, Center for Molecular Biosciences, University of Innsbruck, Innrain 80 82, 6020 Innsbruck, Austria 2
Nat Commun 5:3897. 2014..Evidence for a weak and non-selective inhibition of Cav1.3 and Cav1.2 currents is only observed in a minority of cells using Ba(2+) as charge carrier. Therefore, our data identify pyrimidine-2,4,6-triones as Ca(2+) channel activators. ..
- CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serumGuang Yang
The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, 171 76, Stockholm, Sweden
Cell Mol Life Sci 72:1197-207. 2015..These data demonstrate that T1D serum hyperactivates both CaV1.2 and CaV1.3 channels by increasing their conductivity and number. These findings suggest CaV1.2 and CaV1.3 channels as potential targets for anti-diabetes therapy. ..
- The L-type calcium channel Cav1.3 is required for proper hippocampal neurogenesis and cognitive functionsJulia Marschallinger
Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria Spinal Cord Injury and Tissue Regeneration Center Salzburg SCI TReCS, Paracelsus Medical University, Salzburg, Austria
Cell Calcium 58:606-16. 2015..Thus, modulation of LTCC activities may have a crucial impact on neurogenic responses and cognition, which should be considered for future therapeutic administration of LTCCs modulators. ..
- A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cellsPhilippe Fy Vincent
Bordeaux Neurocampus, Equipe Neurophysiologie de la Synapse Auditive, Universite de Bordeaux, Bordeaux, France
elife 4:. 2015....
- Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5aMing Lei
University Laboratory of Physiology, University of Oxford, Oxford, OX1 3PT UK
J Physiol 567:387-400. 2005..The findings accordingly provide a basis for understanding of the role of cardiac-type Na+ channels in normal SAN function and the pathophysiology of sinus node dysfunction and suggest new potential targets for its clinical management...
- Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node diseaseSolena Le Scouarnec
Institut National de la Sante et de la Recherche Medicale, UMR 915, F 44000 Nantes, France
Proc Natl Acad Sci U S A 105:15617-22. 2008..Together, our findings associate abnormal channel targeting with human SND and highlight the critical role of local membrane organization for sinoatrial node excitability...
- Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillationShane R Cunha
Dorothy M Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, 43210, USA
Circulation 124:1212-22. 2011..ANK2 encodes ankyrin-B, a multifunctional adapter molecule implicated in membrane targeting of ion channels, transporters, and signaling molecules in excitable cells...
- Neurochemical characterization of the striatum and the nucleus accumbens in L-type Ca(v)1.3 channels knockout miceFerry S P Sagala
Department of Neurology, Campus Virchow, Charite University Medicine, Berlin, Germany
Neurochem Int 60:229-32. 2012..3 channel subunit (CACNA1D) and compared to those in wild-type mice. Striatal DA level did not differ between the two groups...
- Retrocochlear function of the peripheral deafness gene Cacna1dSomisetty V Satheesh
Department of Neurogenetics, Carl von Ossietzky University Oldenburg, 26111 Oldenburg, Germany
Hum Mol Genet 21:3896-909. 2012..Mostly, only malfunction of the ear is considered. Here, we assessed the role of the peripheral deafness gene Cacna1d, encoding the L-type channel Ca(v)1.3, in downstream processing of acoustic information...
- A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc waveSatoru Yamasaki
Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology RCAI, Yokohama, Kanagawa, Japan
PLoS ONE 7:e39654. 2012..These findings indicated that the LTCC α(1D) subunit located on the ER membrane has a novel function as a gatekeeper for the Zn wave, which is involved in regulating NF-κB signaling and the delayed-type allergic reaction...
- Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cellsSatyajit Mahapatra
Department of Neuroscience, Corso Raffaello 30, 10125 Torino, Italy
J Physiol 590:5053-73. 2012....
- Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial nodeCarl J Christel
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
J Physiol 590:6327-42. 2012..We conclude that strong VDF and colocalization with ryanodine receptors in mouse SAN cells are unique properties that may underlie a specific role for Ca(v)1.3 in opposing abnormal slowing of heart rate...
- Downregulation of Cav1.3 calcium channel expression in the cochlea is associated with age-related hearing loss in C57BL/6J miceJin Chen
Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji, People s Republic of China
Neuroreport 24:313-7. 2013..3.3 calcium channel expression in the cochlea is reduced in the ARHL mice and is associated with ARHL. The data also support a view that Ca(v)1.3.3 calcium channel is a good target for prevention and therapy of ARHL...
- Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequencesJ Hanley-Hyde
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
Genomics 13:1018-30. 1992..Cycb1-rs6 (on chromosome 13) is discussed as the most likely candidate for an expressed structural gene locus...
- A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3H M Chin
Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892
Genomics 11:914-9. 1991..blot analysis of an intersubspecies cross demonstrated that the calcium channel alpha 1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1...
- Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genesE Perez-Reyes
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 265:20430-6. 1990..These results demonstrate that calcium channel diversity is created by both the expression of distinct genes and the alternate splicing of these genes...
- Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7aM C Adamson
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
Genomics 24:9-13. 1994..Interspecific crosses were used to demonstrate close linkage between Wnt12 and Wnt1 on Chromosome (Chr) 15. Wnt7a was mapped to mouse Chr 6, Wnt5a to the centromeric region of Chr 14, and Wnt11 to Chr7...
- Genomic organization and chromosomal localization of the mouse synexin geneZ Y Zhang-Keck
Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
Biochem J 301:835-45. 1994..Finally, we have determined that the functional synexin gene (Anx7) is located on mouse chromosome 14 and that a pseudogene (Anx7-ps1) is located on chromosome 10...
- Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular systemT N Sato
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110
Proc Natl Acad Sci U S A 90:9355-8. 1993....
- Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cellsS N Yang
The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Karolinska Hospital, S 171 76 Stockholm, Sweden
Proc Natl Acad Sci U S A 96:10164-9. 1999..This suggests that there is a structure-function relationship between the alpha(1D) subunit of the L type Ca(2+) channel and the exocytotic machinery in the pancreatic beta cell...
- Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant miceZhao Zhang
Department of Internal Medicine, University of California, Davis 95616, USA
Circ Res 90:981-7. 2002..3 Ca(2+) channel. In summary, using gene-targeted deletion of the Ca(v)1.3 Ca(2+) channel, we were able to establish a role for Ca(v)1.3 Ca(2+) channels in the generation of the spontaneous action potential in SA node cells...
- Ligand-activated signal transduction in the 2-cell embryoDavid P Lu
Human Reproduction Unit, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, 2065 Australia
Biol Reprod 69:106-16. 2003..The activation of a voltage-gated L-type calcium channel in the 2-cell embryo is required for normal signal transduction to an embryonic trophic factor...
- Role of class D L-type Ca2+ channels for cochlear morphologyR Glueckert
Universitätsklinik für Hals, Nasen und Ohrenheilkunde, Anichstr 35, A 6020, Innsbruck, Austria
Hear Res 178:95-105. 2003..The observed pattern of degeneration involves afferent nerve fibres (P7) followed by cell bodies in the spiral ganglion (P15), OHCs (P15) and IHCs (after P15)...
- Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient miceMan Xu
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
J Biol Chem 278:40837-41. 2003..2 (-/-) cardiomyocytes. In summary, our results imply that calcium channel expression is dynamically regulated during heart development and that the Cav1.3 channel may substitute for Cav1.2 during early embryogenesis...
- Cloning of the Cav 1.3 (alpha1D) L-type Ca2+ channel from mouse and its expression in the liverToshihiro Okamoto
Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005, Japan
Int J Mol Med 13:573-6. 2004..The present results indicated that mouse Cav 1.3 exhibited 96% homology with human Cav 1.3 and was expressed in the liver. Thus, mouse hepatitis model seemed to be useful to screen DHP-CCB specific for Cav 1.3...
- Developmental expression of Ca(v)1.3 (alpha1d) calcium channels in the mouse inner earA Hafidi
Laboratoire de Biologie Cellulaire de l Audition, EA3665 Université Victor Segalen Bordeaux 2, Hopital Pellegrin, PQR3, INSERM EMI 99 27, 33076 Bordeaux, France
Brain Res Dev Brain Res 150:167-75. 2004..An early expression during development suggested that these calcium channels are in addition important in the development of the cochlear and vestibular sensory epithelium...
- Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in miceHongwei Dou
Department of Pediatric Otolaryngology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Assoc Res Otolaryngol 5:215-26. 2004....
- Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in miceManabu Murakami
Department of Pharmacology, Akita University School of Medicine, 1 1 1 Hondoh, Akita 010 8543, Japan
Brain Res 1024:122-9. 2004..The results of this study revealed the localization and functions of several calcium channels that are involved in nociceptive neurotransmission within the dorsal horn of the mouse spinal cord...
- Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant miceZhao Zhang
Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA
Circulation 112:1936-44. 2005..3 Ca2+ channel-deficient mice (Cav1.3(-/-)) demonstrate sinus bradycardia with a prolonged PR interval. In the present study, we extended our study to examine the role of the Cav1.3(alpha1D) Ca2+ channel in the atria of Cav1.3(-/-) mice...
- Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease modelsMichelle Day
Department of Physiology, 303 East Chicago Avenue, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Nat Neurosci 9:251-9. 2006..3 L-type Ca(2+) channels. The disconnection of striatopallidal neurons from motor command structures is likely to be a key step in the emergence of pathological activity that is responsible for symptoms in Parkinson disease...
- Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneuronsZhongfeng Wang
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Neuron 50:443-52. 2006..In addition to reconciling discordant tracts of the striatal literature, these findings point to cholinergic interneurons as key mediators of dopamine-dependent striatal plasticity and learning...
- Synaptic organization in cochlear inner hair cells deficient for the CaV1.3 (alpha1D) subunit of L-type Ca2+ channelsR M Nemzou N
Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Gottingen Medical School, D 37099 Göttingen, Germany
Neuroscience 141:1849-60. 2006..Ca(V)1.3 channels seem not to be essential for ribbon synapse formation, but are required for the maintenance of ribbon synapses and spiral ganglion neurons...
- Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fearMark Barad
Veterans Health Administration, West Los Angeles, California 90073, and Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
Learn Mem 13:560-1. 2006
- The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in miceBrandon C McKinney
Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan 48109, USA
Learn Mem 13:584-9. 2006..3 knockout mice is not likely the result of an inability to encode the context, but may reflect an inability to make the association between the context and the unconditioned stimulus...
- Up-regulation of dopamine D(2)L mRNA levels in the ventral tegmental area and dorsal striatum of amphetamine-sensitized C57BL/6 mice: role of Ca(v)1.3 L-type Ca(2+) channelsT P Giordano
Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
J Neurochem 99:1197-206. 2006..In conclusion, our results find that amphetamine increases D(2)L mRNA expression in the dStr and the VTA, an adaptation that correlates with expression of sensitized behavior and dependence on Ca(v)1.3 Ca(2+) channels...
- Two classes of outer hair cells along the tonotopic axis of the cochleaJ Engel
University of Tubingen, Institute of Physiology II and Department of Otolaryngology, THRC, Gmelinstrasse 5, 72076 Tubingen, Germany
Neuroscience 143:837-49. 2006..Our findings propose new mechanisms and candidate genes for explaining high and low frequency hearing loss...
- Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2Ling Lu
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, One Shields Avenue, GBSF 6315, Davis, CA 95616, USA
Circ Res 100:112-20. 2007....
- Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channelsJana Tchekalarova
Institute of Neurobiology, Acad G Bonchev Str, bl 23, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria
Neurosci Lett 415:68-72. 2007..The results support the view that angiotensins are involved in mechanisms of learning and memory including the plasticity changes in the LA...
- Voltage-dependent calcium channel CaV1.3 subunits regulate the light peak of the electroretinogramJiang Wu
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Neurophysiol 97:3731-5. 2007..3(-/-) littermates. Our results identify Ca(V)1.3 as the principal pore-forming subunit of VDCCs involved in stimulating the ERG LP...
- Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscleManuel F Navedo
Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
Am J Physiol Heart Circ Physiol 293:H1359-70. 2007..We conclude that although Ca(v)1.3 channels can produce Ca(2+) sparklets, Ca(v)1.2 channels underlie I(Ca), Ca(2+) sparklets, and hence dihydropyridine-sensitive Ca(2+) influx in mouse arterial myocytes...
- Impaired Ca2+ homeostasis is associated with atrial fibrillation in the alpha1D L-type Ca2+ channel KO mouseSalvatore Mancarella
Molecular and Cellular Cardiology Program, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY 11209, USA
Am J Physiol Heart Circ Physiol 295:H2017-24. 2008..These findings provide new insights into the mechanism leading to atrial electrical dysfunction in the alpha1D KO mice...
- NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowthVsevolod Bodrikov
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, 20246 Hamburg, Germany
J Cell Biol 182:1185-200. 2008..Thus, we reveal a novel function for a cell adhesion molecule in coordination of cell behavior with intracellular phosphatase activity...
- Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3Neeliyath A Ramakrishnan
Department of Otolaryngology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
J Biol Chem 284:1364-72. 2009..3 calcium channel, it is these interactions that may mediate regulation by otoferlin of hair cell synaptic exocytosis critical to inner ear hair cell function...
- Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cellsThomas Frank
InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Gottingen, 37099 Gottingen, Germany
Proc Natl Acad Sci U S A 106:4483-8. 2009..We propose that IHCs adjust the number and the gating of Ca(V)1.3 channels at their active zones to diversify their transmitter release rates...
- Miniature EPSCs in the lateral superior olive before hearing onset: regional and cell-type-specific differences and heterogeneous neuromodulatory effects of ATPMichael Kreinest
Animal Physiology Group, Department of Biology, University of Kaiserslautern, PO Box 3049, D 67653 Kaiserslautern, Germany
Brain Res 1295:21-36. 2009..Together, our results demonstrate specific, rather than stochastic, characteristics of mEPSCs in the neonatal LSO, in accordance with their potential developmental significance...
- Association of whirlin with Cav1.3 (alpha1D) channels in photoreceptors, defining a novel member of the usher protein networkFerry F J Kersten
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Invest Ophthalmol Vis Sci 51:2338-46. 2010..This study was undertaken to identify novel, Usher syndrome-associated, interacting partners of whirlin and thereby obtain more insights into the function of whirlin...
- Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neuronsB Schlick
Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria
Neuroscience 167:786-98. 2010..Developmental changes are likely determined by an intrinsic program and not regulated by changes in neuronal activity...
- Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting moleculeMathias Gebhart
Institute of Pharmacy, Pharmacology and Toxicology, University of Innsbruck, Peter Mayr Strasse 1 I, A 6020 Innsbruck, Austria Center of Molecular Biosciences Innsbruck CMBI, Innsbruck, Austria
Mol Cell Neurosci 44:246-59. 2010..3 currents which should allow these channels to carry a substantial window current during prolonged depolarizations. These data suggest that RIM2 contributes to the stabilization of Ca(v)1.3 gating kinetics in immature IHCs...
- Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteinsDaniel Fulton
Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, 90095, USA
Glia 58:1292-303. 2010..These data on L-type Ca(2+) channels and process development provide in situ evidence for the influence of golli on VOCCs, and offer an explanation for the hypomyelination observed in the brains of golli-KO mice...
- Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight responseMichelle A Emrick
Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
Proc Natl Acad Sci U S A 107:18712-7. 2010....
- Expression and roles of Cav1.3 (α1D) L-type Ca²+ channel in atrioventricular node automaticityQian Zhang
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA
J Mol Cell Cardiol 50:194-202. 2011..3 isoform in the AV node of Ca(v)1.3 null mutant mice. Thus, our study demonstrates that the distinct biophysical properties of Ca(v)1.3 Ca(2+) channel play critical roles in the firing frequency of AV node tissues...
- Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cellsAlberto Pérez-Alvarez
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain
J Neurochem 116:105-21. 2011..Our data reveal the key yet differential roles of Cav1.2 and Cav1.3 channels in mediating action potential firing and exocytotic events in the neuroendocrine chromaffin cell...
- Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neuronsMisty R Marshall
Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195 7280, USA
J Biol Chem 286:12627-39. 2011..2 channels in vivo: increased functional expression, anchoring of AKAP15 and PKA, and initiation of excitation-transcription coupling...
- Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birthKatrin Domes
From the Forschergruppe 923, Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802 Munchen, Germany
J Biol Chem 286:33863-71. 2011..2 expression. These findings indicate that absence of the carboxyl-terminal tail differentially determines the fate of the cardiac and smooth muscle splice variant of the CaV1.2 channel in the mouse...
- Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channelsM Ino
Tsukuba Research Laboratories, Eisai Co, 5 1 3 Tokodai, Tsukuba, Ibaraki 300 2635, Japan
Proc Natl Acad Sci U S A 98:5323-8. 2001....
- Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in miceWeon Young Son
Department of Life Science, Sogang University, Seoul 121 742, Korea
Dev Growth Differ 44:181-90. 2002..On E15, signals were detected throughout all organs of the embryo. These findings indicate that the expression of alpha1H T-type Ca2+ channels is spatio-temporally regulated during spermatogenesis and organogenesis...
- Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouseYoko Toba
Cellular and Developmental Neurobiology Section, NINDS, NIH, Bethesda, MD 20892, USA
Eur J Neurosci 22:79-92. 2005..These results indicate that extracellular calcium is required for initiating GnRH-1 neuronal migration and that these events are partially dependent on N-type VGCC signals...
- Rodent models of anxiety disorder treatmentMark Barad; Fiscal Year: 2004..abstract_text> ..
- Translating Extinction of Fear to Anxiety Disorder TreatmentMark Barad; Fiscal Year: 2006..These experiments should help establish the translational validity of the extinction model for anxiety disorder treatment and also may yield potential improvements in current anxiety disorder treatments. ..
- Conference on Childhood, Culture, and NeurodevelopmentMark Barad; Fiscal Year: 2008..abstract_text> ..