Aqp1

Summary

Gene Symbol: Aqp1
Description: aquaporin 1
Alias: CHIP28, aquaporin-1, AQP-1, DER2, aquaporin-CHIP, delayed early response protein 2, growth factor-induced delayed early response protein, water channel protein for red blood cells and kidney proximal tubule
Species: mouse
Products:     Aqp1

Top Publications

  1. Oshio K, Watanabe H, Yan D, Verkman A, Manley G. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006;341:1022-8 pubmed
    Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production...
  2. Saadoun S, Papadopoulos M, Hara Chikuma M, Verkman A. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92 pubmed
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  3. Moore M, Ma T, Yang B, Verkman A. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000;70:557-62 pubmed
    ..AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia...
  4. Larsen H, Ruus A, Galtung H. Aquaporin expression patterns in the developing mouse salivary gland. Eur J Oral Sci. 2009;117:655-62 pubmed publisher
    ..Overall, this study demonstrates that AQP presentation varies and has a specific expression pattern during the development of mouse SMG. This feature may be important for glandular anatomical and physiological development. ..
  5. Sohara E, Rai T, Miyazaki J, Verkman A, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005;289:F1195-200 pubmed
    ..0 +/- 0.3 x 10(-3) cm/s). Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, ..
  6. Chou C, Knepper M, Hoek A, Brown D, Yang B, Ma T, et al. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999;103:491-6 pubmed
    ..high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels...
  7. Shields S, Mazario J, Skinner K, Basbaum A. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007;131:8-20 pubmed
    b>Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues...
  8. Monzani E, Bazzotti R, Perego C, La Porta C. AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS ONE. 2009;4:e6167 pubmed publisher
    b>AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues...
  9. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..
  10. Verkman A, Yang B, Song Y, Manley G, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000;85 Spec No:233S-241S pubmed
    ..Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect...

Detail Information

Publications62

  1. Oshio K, Watanabe H, Yan D, Verkman A, Manley G. Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006;341:1022-8 pubmed
    Aquaporin-1 (AQP1), a membrane water channel, is expressed in choroid plexus where it contributes to cerebrospinal fluid production...
  2. Saadoun S, Papadopoulos M, Hara Chikuma M, Verkman A. Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature. 2005;434:786-92 pubmed
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  3. Moore M, Ma T, Yang B, Verkman A. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000;70:557-62 pubmed
    ..AQP5 in the apical membranes of acinar and duct cells, AQP4 in the basolateral membranes of acinar cells, and AQP1 in microvascular endothelia...
  4. Larsen H, Ruus A, Galtung H. Aquaporin expression patterns in the developing mouse salivary gland. Eur J Oral Sci. 2009;117:655-62 pubmed publisher
    ..Overall, this study demonstrates that AQP presentation varies and has a specific expression pattern during the development of mouse SMG. This feature may be important for glandular anatomical and physiological development. ..
  5. Sohara E, Rai T, Miyazaki J, Verkman A, Sasaki S, Uchida S. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005;289:F1195-200 pubmed
    ..0 +/- 0.3 x 10(-3) cm/s). Although AQP7 solo-knockout mice did not exhibit a urinary concentrating defect, AQP1/AQP7 double-knockout mice had a reduction in urinary concentrating ability compared with AQP1 solo-knockout mice, ..
  6. Chou C, Knepper M, Hoek A, Brown D, Yang B, Ma T, et al. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999;103:491-6 pubmed
    ..high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels...
  7. Shields S, Mazario J, Skinner K, Basbaum A. Anatomical and functional analysis of aquaporin 1, a water channel in primary afferent neurons. Pain. 2007;131:8-20 pubmed
    b>Aquaporin 1 (AQP1) is the archetypal member of a family of water channel proteins that contribute to water homeostasis in kidney, lung, and other tissues...
  8. Monzani E, Bazzotti R, Perego C, La Porta C. AQP1 is not only a water channel: it contributes to cell migration through Lin7/beta-catenin. PLoS ONE. 2009;4:e6167 pubmed publisher
    b>AQP1 belongs to aquaporins family, water-specific, membrane-channel proteins expressed in diverse tissues...
  9. Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, et al. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol. 2012;23:112-22 pubmed publisher
    ..Taken together, these data suggest that ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. ..
  10. Verkman A, Yang B, Song Y, Manley G, Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000;85 Spec No:233S-241S pubmed
    ..Multiple phenotype abnormalities were found in the null mice. For example, in kidney, deletion of AQP1 or AQP3 produced marked polyuria whereas AQP4 deletion produced only a mild concentrating defect...
  11. Verkman A. More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 2005;118:3225-32 pubmed
    ..AQPs facilitate cell migration, as manifested by reduced tumor angiogenesis in AQP1-knockout mice, by a mechanism that might involve facilitated water transport in lamellipodia of migrating cells...
  12. Song Y, Ma T, Matthay M, Verkman A. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000;115:17-27 pubmed
    The mammalian peripheral lung contains at least three aquaporin (AQP) water channels: AQP1 in microvascular endothelia, AQP4 in airway epithelia, and AQP5 in alveolar epithelia...
  13. Schnermann J, Chou C, Ma T, Traynor T, Knepper M, Verkman A. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A. 1998;95:9660-4 pubmed
    To investigate the role of aquaporin-1 (AQP1) water channels in proximal tubule function, in vitro proximal tubule microperfusion and in vivo micropuncture measurements were done on AQP1 knockout mice...
  14. Song Y, Fukuda N, Bai C, Ma T, Matthay M, Verkman A. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000;525 Pt 3:771-9 pubmed
    ..We used mice deficient in each of the three principal lung aquaporins, AQP1, AQP4 and AQP5, to test the hypothesis that aquaporins are important in neonatal lung fluid balance, adult lung ..
  15. Yang B, Ma T, Verkman A. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001;276:624-8 pubmed
    Aquaporin (AQP) water channel AQP3 has been proposed to be the major glycerol and non-AQP1 water transporter in erythrocytes...
  16. Shields S, Moore K, Phelps P, Basbaum A. Olfactory ensheathing glia express aquaporin 1. J Comp Neurol. 2010;518:4329-41 pubmed publisher
    ..Here we provide evidence through anatomical colocalization studies that OEG express the water channel aquaporin 1 (AQP1), both in vivo and in vitro...
  17. Bai C, Fukuda N, Song Y, Ma T, Matthay M, Verkman A. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999;103:555-61 pubmed
    The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia...
  18. Iandiev I, Pannicke T, Reichel M, Wiedemann P, Reichenbach A, Bringmann A. Expression of aquaporin-1 immunoreactivity by photoreceptor cells in the mouse retina. Neurosci Lett. 2005;388:96-9 pubmed
    ..The data suggest that photoreceptor cells, but not Müller cells, express aquaporin-1 in the murine retina. ..
  19. Zhang H, Verkman A. Aquaporin-1 tunes pain perception by interaction with Na(v)1.8 Na+ channels in dorsal root ganglion neurons. J Biol Chem. 2010;285:5896-906 pubmed publisher
    Aquaporin-1 (AQP1) water channels are expressed in the plasma membrane of dorsal root ganglion (DRG) neurons. We found reduced osmotic water permeability in freshly isolated DRG neurons from AQP1(-/-) versus AQP1(+/+) mice...
  20. Li J, Verkman A. Impaired hearing in mice lacking aquaporin-4 water channels. J Biol Chem. 2001;276:31233-7 pubmed
    ..Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus ..
  21. Jouret F, Igarashi T, Gofflot F, Wilson P, Karet F, Thakker R, et al. Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5. Kidney Int. 2004;65:198-208 pubmed
    ..mouse and human nephrogenesis, in comparison with H+-ATPase, type II carbonic anhydrase (CAII), and aquaporin-1 (AQP1). An early induction (E13.5-E14...
  22. Ma T, Yang B, Gillespie A, Carlson E, Epstein C, Verkman A. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998;273:4296-9 pubmed
    Water channel aquaporin-1 (AQP1) is strongly expressed in kidney in proximal tubule and descending limb of Henle epithelia and in vasa recta endothelia...
  23. Yang B, Fukuda N, van Hoek A, Matthay M, Ma T, Verkman A. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000;275:2686-92 pubmed
    Measurements of CO(2) permeability in oocytes and liposomes containing water channel aquaporin-1 (AQP1) have suggested that AQP1 is able to transport both water and CO(2)...
  24. Pallone T, Edwards A, Ma T, Silldorff E, Verkman A. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest. 2000;105:215-22 pubmed
    Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasa recta (OMDVR)...
  25. Ma T, Song Y, Gillespie A, Carlson E, Epstein C, Verkman A. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999;274:20071-4 pubmed
    ..Water channels AQP1 and AQP4 have also been localized to salivary gland; however, pilocarpine stimulation studies showed no defect in ..
  26. Ni J, Verbavatz J, Rippe A, Boisdé I, Moulin P, Rippe B, et al. Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis. Kidney Int. 2006;69:1518-25 pubmed
    The water channel aquaporin-1 (AQP1) is considered as the molecular counterpart of the ultrasmall pore predicted by the three-pore model of fluid transport across the peritoneal membrane...
  27. Kumari S, Gao J, Mathias R, Sun X, Eswaramoorthy A, Browne N, et al. Aquaporin 0 Modulates Lens Gap Junctions in the Presence of Lens-Specific Beaded Filament Proteins. Invest Ophthalmol Vis Sci. 2017;58:6006-6019 pubmed publisher
    ..type (WT), AQP0-Htz lenses showed decreased Pf (approximately 50%), which was restored by transgenic expression of AQP1 (TgAQP1/AQP0-Htz), but the opacities and differences between FVB and C57 persisted...
  28. Varadaraj K, Kumari S, Mathias R. Functional expression of aquaporins in embryonic, postnatal, and adult mouse lenses. Dev Dyn. 2007;236:1319-28 pubmed
    Aquaporin 0 (AQP0) and AQP1 are expressed in the lens, each in a different cell type, and their functional roles are not thoroughly understood. Our previous study showed that these two AQPs function as water transporters...
  29. Zheng Fischhöfer Q, Schnichels M, Dere E, Strotmann J, Loscher N, McCulloch F, et al. Characterization of connexin30.3-deficient mice suggests a possible role of connexin30.3 in olfaction. Eur J Cell Biol. 2007;86:683-700 pubmed
    ..Furthermore, they showed normal auditory thresholds as measured by brain stem evoked potentials. These mice did, however, exhibit reduced behavioural responses to a vanilla scent...
  30. Galán Cobo A, Ramirez Lorca R, Toledo Aral J, Echevarria M. Aquaporin-1 plays important role in proliferation by affecting cell cycle progression. J Cell Physiol. 2016;231:243-56 pubmed publisher
    Aquaporin-1 (AQP1) has been associated with tumor development. Here, we investigated how AQP1 may affect cell proliferation...
  31. Edashige K, Sakamoto M, Kasai M. Expression of mRNAs of the aquaporin family in mouse oocytes and embryos. Cryobiology. 2000;40:171-5 pubmed
    ..These aquaporins may play a role in water transport and conceivably also in cryoprotectant transport across the plasma membrane in these cells...
  32. Vallon V, Verkman A, Schnermann J. Luminal hypotonicity in proximal tubules of aquaporin-1-knockout mice. Am J Physiol Renal Physiol. 2000;278:F1030-3 pubmed
    To examine the role of aquaporin-1 (AQP1) in near-isosmolar fluid reabsorption in the proximal tubule, we compared osmolalities in micropuncture samples of late proximal tubular fluid and plasma in wild-type (+/+) and AQP1-knockout (-/-) ..
  33. Fotiadis D, Suda K, Tittmann P, Jeno P, Philippsen A, Muller D, et al. Identification and structure of a putative Ca2+-binding domain at the C terminus of AQP1. J Mol Biol. 2002;318:1381-94 pubmed
    Aquaporin-1 (AQP1) is the first functionally identified aquaporin of a growing family of membrane water channels found in all forms of life...
  34. Zhou Q, Clarke L, Nie R, Carnes K, Lai L, Lien Y, et al. Estrogen action and male fertility: roles of the sodium/hydrogen exchanger-3 and fluid reabsorption in reproductive tract function. Proc Natl Acad Sci U S A. 2001;98:14132-7 pubmed
    ..Immunohistochemical staining for NHE3, carbonic anhydrase II (CAII), and aquaporin-I (AQP1) was decreased in ER alpha knockout (alpha ERKO) efferent ductules...
  35. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..The C57Bl6 Wnt11 (-/-) mouse generated here provides a model for studying the mechanisms behind tubular anomalies and glomerular cyst formation. ..
  36. Dong C, Wang G, Li B, Xiao K, Ma Z, Huang H, et al. Anti-asthmatic agents alleviate pulmonary edema by upregulating AQP1 and AQP5 expression in the lungs of mice with OVA-induced asthma. Respir Physiol Neurobiol. 2012;181:21-8 pubmed publisher
    ..The influence of these agents on OVA-induced airway inflammation was also evaluated. The mRNA expression levels of AQP1, 4, and 5 were significantly reduced and that of AQP3 was significantly increased 24h after the last OVA exposure...
  37. Huang X, Ketova T, Fleming J, Wang H, Dey S, Litingtung Y, et al. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 2009;136:2535-43 pubmed publisher
    ....
  38. Zhang W, Freichel M, van der Hoeven F, Nawroth P, Katus H, Kälble F, et al. Novel Endothelial Cell-Specific AQP1 Knockout Mice Confirm the Crucial Role of Endothelial AQP1 in Ultrafiltration during Peritoneal Dialysis. PLoS ONE. 2016;11:e0145513 pubmed publisher
    The water channel aquaporin-1 (AQP1) mediates about 50% ultrafiltration during a 2-hour hypertonic dwell in global AQP1 knockout (AQP1-/-) mice...
  39. Lanaspa M, Andres Hernando A, Li N, Rivard C, Cicerchi C, Roncal Jimenez C, et al. The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. J Biol Chem. 2010;285:31694-703 pubmed publisher
    Expression of aquaporin-1 (AQP1) and -2 (AQP2) channels in the kidney are critical for the maintenance of water homeostasis and the operation of the urinary concentrating mechanism...
  40. Kumari S, Varadaraj K. Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration. Biochem Biophys Res Commun. 2014;452:986-91 pubmed publisher
    ..of wild type (WT) mouse, AQP0 knockout (heterozygous, AQP0(+/-)) and AQP0 knockout lens transgenically expressing AQP1 (heterozygous AQP0(+/)(-)/AQP1(+/)(-)) mouse models were used for the study...
  41. Verkman A. Aquaporins in endothelia. Kidney Int. 2006;69:1120-3 pubmed
    Aquaporin-1 (AQP1) water channels are expressed widely in microvascular endothelia outside of the central nervous system, including renal vasa recta and tumor microvessels, as well as in non-vascular endothelia in pleura, peritoneum, ..
  42. Felszeghy S, Modis L, Nemeth P, Nagy G, Zelles T, Agre P, et al. Expression of aquaporin isoforms during human and mouse tooth development. Arch Oral Biol. 2004;49:247-57 pubmed
    ..In the present study we have characterised the expression of six different aquaporin isoforms (AQP1-5, AQP-9) in developing human and mouse tooth germs by immunohistochemistry using isoform specific antibodies...
  43. Verkman A. Role of aquaporin water channels in eye function. Exp Eye Res. 2003;76:137-43 pubmed
    ..At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary ..
  44. Zhang J, Xie C, Zhu Z, Huang H, Zeng Z. Potential role of AQP1 and VEGF in the development of malignant pleural effusion in mice. Med Oncol. 2012;29:656-62 pubmed publisher
    Recent studies have revealed the important role of aquaporin-1 (AQP1) in tumor cell migration and angiogenesis. However, the function of AQP1 in malignant pleural effusion has not been well characterized...
  45. Downes G, Gilbert D, Copeland N, Gautam N, Jenkins N. Chromosomal mapping of five mouse G protein gamma subunits. Genomics. 1999;57:173-6 pubmed
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes. ..
  46. Schweitzer K, Li E, Sidhaye V, Leitch V, Kuznetsov S, King L. Accumulation of aquaporin-1 during hemolysin-induced necrotic cell death. Cell Mol Biol Lett. 2008;13:195-211 pubmed
    ..We observed induction of aquaporin-1 (AQP1) during Staphylococcus aureus infection of cultured cells indicating a potential mechanism underlying altered water ..
  47. Song Y, Jayaraman S, Yang B, Matthay M, Verkman A. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. J Gen Physiol. 2001;117:573-82 pubmed
    Several aquaporin-type water channels are expressed in mammalian airways and lung: AQP1 in microvascular endothelia, AQP3 in upper airway epithelia, AQP4 in upper and lower airway epithelia, and AQP5 in alveolar epithelia...
  48. Kim J, Lee Y, Park K, Lee W, Lee J. Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J Cereb Blood Flow Metab. 2010;30:943-9 pubmed publisher
    ..It can thus be suggested that agmatine could attenuate brain edema by limiting BBB disruption and blocking the accumulation of brain water content through lessening the expression of AQP-1 after cerebral ischemia. ..
  49. Yang B, Ma T, Dong J, Verkman A. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther. 2000;11:567-75 pubmed
    ..channel gene delivery to kidney tubules and microvessels was evaluated by delivery of an adenovirus encoding aquaporin 1 (AQP1-Ad5) to transgenic AQP1 null mice...
  50. Rutkovskiy A, Bliksøen M, Hillestad V, Amin M, Czibik G, Valen G, et al. Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia. J Mol Cell Cardiol. 2013;56:22-33 pubmed publisher
    Aquaporin-1 (AQP1) is expressed in human and mouse hearts, but little is known about its cellular and subcellular localization and regulation...
  51. Prows D, Leikauf G. Quantitative trait analysis of nickel-induced acute lung injury in mice. Am J Respir Cell Mol Biol. 2001;24:740-6 pubmed
    ....
  52. Kim W, Lee H, Han K, Nam S, Choi A, Kim Y, et al. Descending thin limb of the intermediate loop expresses both aquaporin 1 and urea transporter A2 in the mouse kidney. Histochem Cell Biol. 2016;146:1-12 pubmed publisher
    ..to identify the descending thin limb (DTL) of the intermediate loop in the adult C57Bl/6 mouse kidney using aquaporin 1 (AQP1) and urea transporter A2 (UT-A2) antibodies...
  53. Liu Z, Brunskill E, Boyle S, Chen S, Turkoz M, Guo Y, et al. Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity. Development. 2015;142:1193-202 pubmed publisher
    ....
  54. Georgas K, Rumballe B, Wilkinson L, Chiu H, Lesieur E, Gilbert T, et al. Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem Cell Biol. 2008;130:927-42 pubmed publisher
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
  55. Yang B, Zhao D, Verkman A. Evidence against functionally significant aquaporin expression in mitochondria. J Biol Chem. 2006;281:16202-6 pubmed
    ....
  56. Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode Shakked N, et al. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development. 2010;137:3835-45 pubmed publisher
    ..Together, our data provide evidence that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation. ..
  57. Nicchia G, Stigliano C, Sparaneo A, Rossi A, Frigeri A, Svelto M. Inhibition of aquaporin-1 dependent angiogenesis impairs tumour growth in a mouse model of melanoma. J Mol Med (Berl). 2013;91:613-23 pubmed publisher
    ..Aquaporin-1 (AQP1) is a water channel membrane protein that promotes tumour angiogenesis by allowing faster endothelial cell ..
  58. Radtke A, O Riordan M. Homeostatic maintenance of pathogen-containing vacuoles requires TBK1-dependent regulation of aquaporin-1. Cell Microbiol. 2008;10:2197-207 pubmed publisher
    ..We found that Aquaporin-1 (AQP1), a water channel that regulates swelling of secretory vesicles, associated with PCV...
  59. Buffoli B, Foglio E, Borsani E, Exley C, Rezzani R, Rodella L. Silicic acid in drinking water prevents age-related alterations in the endothelium-dependent vascular relaxation modulating eNOS and AQP1 expression in experimental mice: an immunohistochemical study. Acta Histochem. 2013;115:418-24 pubmed publisher
    ....
  60. Guo J, He H, Liu H, Liu Q, Zhang L, Liu B, et al. Aquaporin-1, a New Maternally Expressed Gene, Regulates Placental Development in the Mouse. Biol Reprod. 2016;95:40 pubmed publisher
    ..The imprinting state, expression, and function of aquaporin-1 (Aqp1) were explored in knockout mice by imprinting analysis, real-time PCR, and immunohistochemistry...
  61. Kao L, Kurtz L, Shao X, Papadopoulos M, Liu L, Bok D, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene). J Biol Chem. 2011;286:32563-74 pubmed publisher
    ..Our findings are the first demonstration of the fundamental importance of NBCe2 in the biology of the nervous system. ..
  62. Basta J, Robbins L, Denner D, Kolar G, Rauchman M. A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Development. 2017;144:3080-3094 pubmed publisher
    ..These global changes in gene expression were accompanied by a significant decrease in THP-, NKCC2- and AQP1-positive loop of Henle nephron segments in mutant ΔSRM kidneys...