Apoc2

Summary

Gene Symbol: Apoc2
Description: apolipoprotein C-II
Alias: apo-CII, apoC-II, apolipoprotein C-II, apolipoprotein C2
Species: mouse

Top Publications

  1. doi Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids
    Pierre R Provost
    Laboratory of Ontogeny and Reproduction, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, Canada
    J Endocrinol 200:321-30. 2009
  2. pmc Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide
    Toshihiro Sakurai
    Lipoprotein Metabolism Section, Cardio Pulmonary Branch, National Heart, Lung, and Blood Institute T S, A s, B L V, M J A, C L, S M G, M P, L A F, A T R, Transgenic Core Facility, National Heart, Lung, and Blood Institute C L, Department of Laboratory Medicine, Clinical Center M L S, A T R, Critical Care Medicine Department, Clinical Center S K D, and Laboratory of Obesity and Metabolic Diseases, National Heart, Lung, and Blood Institute L Y, National Institutes of Health, Bethesda, Maryland
    J Pharmacol Exp Ther 356:341-53. 2016
  3. pmc Role of the gut endoderm in relaying left-right patterning in mice
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 10:e1001276. 2012
  4. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  5. doi Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
  6. pmc Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth
    Melissa Cote
    Reproduction, Perinatal and Child Health Axis, Rm T 1 49, CHUQ Research Center, Centre de Recherche en Biologie de Reproduction, Laval University, Quebec City, Quebec, Canada
    BMC Dev Biol 10:111. 2010
  7. ncbi Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster
    Eungseok Kim
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 278:46919-26. 2003
  8. ncbi Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    Puiying A Mak
    Department of Biological Chemistry and Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 277:31900-8. 2002
  9. ncbi Transcriptional regulation of liver development
    S A Duncan
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 219:131-42. 2000
  10. ncbi Plasma lipoproteins: apolipoprotein structure and function
    R W Mahley
    J Lipid Res 25:1277-94. 1984

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  5. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

  • Hong Fu
  • S A Duncan
  • M C Jong
  • KLAUS KAESTNER
  • Pierre R Provost
  • Toshihiro Sakurai
  • Manuel Viotti
  • Sabine Pfister
  • Melissa Cote
  • Yves Tremblay
  • Naoki Ishimori
  • Eungseok Kim
  • Maureen L Sampson
  • Scott M Gordon
  • Chengyu Liu
  • Marcelo J Amar
  • Lita A Freeman
  • Akiko Sakurai
  • Steven K Drake
  • Milton Pryor
  • Alan T Remaley
  • Boris L Vaisman
  • Ling Yang
  • Puiying A Mak
  • M J Hoffer
  • Song Hai Shi
  • Lei Niu
  • Anna Katerina Hadjantonakis
  • Vanessa J Jones
  • Patrick P L Tam
  • David A F Loebel
  • Kirsten A Steiner
  • Melinda Power
  • Germaine L Truisi
  • Yoshiakira Kanai
  • Poh Lynn Khoo
  • Masami Kanai-Azuma
  • Marie Christine GĂ©rard-Hudon
  • Eric Boucher
  • K H Kaestner
  • M M van Eck
  • Peter M Kelmenson
  • Ron Korstanje
  • Gary A Churchill
  • Beverly Paigen
  • Kenneth A Walsh
  • Kristina Forsman-Semb
  • Renhua Li
  • Ning Chun Liu
  • Peng Hui Wang
  • Shauh Der Yeh
  • M H Hofker
  • Chawnshang Chang
  • Yueh Chiang Hu
  • Yen Ta Chen
  • Chih Rong Shyr
  • L M Havekes
  • R R Frants
  • Yi Fen Lee
  • Shaozhen Xie
  • Loretta L Collins
  • Xiao Min Mu
  • Peter Tontonoz
  • Catherine Desrumaux
  • Peter A Edwards
  • Sean B Joseph
  • Bryan A Laffitte
  • David J Mangelsdorf
  • Linda K Curtiss
  • D A Purcell-Huynh
  • J Palis
  • Y Liu
  • D J Drucker
  • J Katz
  • G Schutz
  • A J Lusis
  • C H Warden
  • L W Castellani
  • M H Doolittle
  • P D Kingsley
  • A Weinreb
  • M Mehrabian
  • M Y Yoon
  • Y R Xia
  • A Diep
  • K Svenson
  • R C Davis
  • D Y Hui
  • K Y He
  • R W Mahley

Detail Information

Publications19

  1. doi Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids
    Pierre R Provost
    Laboratory of Ontogeny and Reproduction, Centre Hospitalier Universitaire de Quebec, Pavillon CHUL, Quebec, Canada
    J Endocrinol 200:321-30. 2009
    ..Our results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis...
  2. pmc Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide
    Toshihiro Sakurai
    Lipoprotein Metabolism Section, Cardio Pulmonary Branch, National Heart, Lung, and Blood Institute T S, A s, B L V, M J A, C L, S M G, M P, L A F, A T R, Transgenic Core Facility, National Heart, Lung, and Blood Institute C L, Department of Laboratory Medicine, Clinical Center M L S, A T R, Critical Care Medicine Department, Clinical Center S K D, and Laboratory of Obesity and Metabolic Diseases, National Heart, Lung, and Blood Institute L Y, National Institutes of Health, Bethesda, Maryland
    J Pharmacol Exp Ther 356:341-53. 2016
    ..ApoC-II deficiency in humans results in hypertriglyceridemia. We used zinc finger nucleases to create Apoc2 mutant mice to investigate the use of C-II-a, a short apoC-II mimetic peptide, as a therapy for apoC-II deficiency...
  3. pmc Role of the gut endoderm in relaying left-right patterning in mice
    Manuel Viotti
    Developmental Biology Program, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Biol 10:e1001276. 2012
    ....
  4. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  5. doi Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal...
  6. pmc Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth
    Melissa Cote
    Reproduction, Perinatal and Child Health Axis, Rm T 1 49, CHUQ Research Center, Centre de Recherche en Biologie de Reproduction, Laval University, Quebec City, Quebec, Canada
    BMC Dev Biol 10:111. 2010
    ..thus according to the need in surfactant? Are LPL molecules translocated to the luminal surface of capillaries? Do the sites of apoC-II and LPL gene expression change according to the stage of lung development and to protein localization?..
  7. ncbi Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster
    Eungseok Kim
    George Whipple Laboratory for Cancer Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Biol Chem 278:46919-26. 2003
    ..Together our data show that loss of TR4 down-regulates expression of the apoE/C-I/C-II gene cluster in liver cells, demonstrating important roles of TR4 in the modulation of lipoprotein metabolism...
  8. ncbi Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
    Puiying A Mak
    Department of Biological Chemistry and Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 277:31900-8. 2002
    ..These results suggest an alternative mechanism by which lipids are removed from macrophage foam cells...
  9. ncbi Transcriptional regulation of liver development
    S A Duncan
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 219:131-42. 2000
    ..The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation...
  10. ncbi Plasma lipoproteins: apolipoprotein structure and function
    R W Mahley
    J Lipid Res 25:1277-94. 1984
    ....
  11. pmc Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Genes Dev 13:495-504. 1999
    ..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo...
  12. ncbi Differential gene expression during early murine yolk sac development
    J Palis
    University of Rochester, Department of Pediatrics, New York, USA
    Mol Reprod Dev 42:19-27. 1995
    ..One VYS endoderm-specific cDNA was identified as apolipoprotein C2. In situ hybridization studies confirmed the differential expression of these genes in E7.5 yolk sac tissues...
  13. ncbi The mouse apolipoprotein C1 gene: structure and expression
    M J Hoffer
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Genomics 18:37-42. 1993
    ..The delineation of the sequence and structural organization of the mouse Apoc1 gene is an essential step in enhancing the use of mouse models to study the function of apoC1 in the lipoprotein metabolism...
  14. ncbi Chromosomal localization of lipolytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase
    C H Warden
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles, 90024
    J Lipid Res 34:1451-5. 1993
    ..Comparison of chromosomal locations for these genes in mouse and humans shows that the previously observed interspecies syntenies are preserved...
  15. ncbi The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster
    M M van Eck
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Genomics 21:110-5. 1994
    ..study, we have shown that these 5' sequences represent a novel gene within the gene cluster designated the apolipoprotein C2-linked gene (Acl). The Acl gene is located 2 kb 5' to the Apoc2 gene...
  16. ncbi Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: structure and genetic variability in inbred mice
    M J Hoffer
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Genomics 15:62-7. 1993
    The human apolipoprotein E (APOE), APOC1, pseudo APOC1 (APOC1'), and APOC2 genes are clustered within 48 kb on the long arm of chromosome 19...
  17. ncbi Structure and expression of the mouse apolipoprotein C2 gene
    M J Hoffer
    MGC Department of Human Genetics, Leiden University, The Netherlands
    Genomics 17:45-51. 1993
    Three cDNA clones containing the mouse apolipoprotein C2 (Apoc2) gene were isolated from a mouse liver cDNA library...
  18. pmc Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach
    D A Purcell-Huynh
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024, USA
    J Clin Invest 96:1845-58. 1995
    ..0001), indicating that apoAII expression influences HDL cholesterol levels. Molecular studies suggested that structural differences in the apoAII polypeptide of the two strains may contribute to differences in clearance of the protein...
  19. ncbi Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice
    Naoki Ishimori
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Lipid Res 45:1624-32. 2004
    ..0) interacting with Obq18 (chromosome 9, cM 65). Knowing the genes for these QTL will enhance our understanding of obesity and lipid metabolism...

Research Grants5

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  5. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..