Ahsg

Summary

Gene Symbol: Ahsg
Description: alpha-2-HS-glycoprotein
Alias: alpha-2-HS-glycoprotein, countertrypin, fetuin-A
Species: mouse

Top Publications

  1. pmc The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    Cora Schafer
    Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
    J Clin Invest 112:357-66. 2003
  2. ncbi Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles
    Alexander Heiss
    IZKF BIOMAT, University Clinics, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 278:13333-41. 2003
  3. ncbi Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1537-46. 2007
  4. doi Fetuin-A regulation of calcified matrix metabolism
    Willi Jahnen-Dechent
    RWTH Aachen University Clinics, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circ Res 108:1494-509. 2011
  5. ncbi alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling
    Melanie Szweras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:19991-7. 2002
  6. ncbi Cloning and targeted deletion of the mouse fetuin gene
    W Jahnen-Dechent
    Institut für Physiologische Chemie und Pathobiochemie, Johannes Gutenberg Universitat, Duesbergweg 6, D 55099 Mainz, Federal Republic of Germany
    J Biol Chem 272:31496-503. 1997
  7. ncbi The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis
    T Schinke
    Institut für Physiologische Chemie und Pathobiochemie, Universitat Mainz, D 55099 Mainz, Duesbergweg 6, Federal Republic of Germany
    J Biol Chem 271:20789-96. 1996
  8. ncbi Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist
    M Demetriou
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 271:12755-61. 1996
  9. pmc Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages
    Priyajit Chatterjee
    From the Department of Zoology, School of Life Science, Visva Bharati University, Santiniketan 731235
    J Biol Chem 288:28324-30. 2013
  10. doi FGF23-regulated production of Fetuin-A (AHSG) in osteocytes
    D Mattinzoli
    Renal Research Laboratory, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Fondazione D Amico per la Ricerca sulle Malattie Renali, Via Pace 9, 20122 Milano, Italy Electronic address
    Bone 83:35-47. 2016

Scientific Experts

  • Ralf Westenfeld
  • Maria L Leite-Browning
  • Carol J Swallow
  • Bernd Denecke
  • Willi Jahnen-Dechent
  • W Jahnen Dechent
  • Suresh T Mathews
  • M W Merx
  • Scott W Altmann
  • Cora Schafer
  • Alexander Heiss
  • D Mattinzoli
  • Nathalie Piazzon
  • Wei Ling Lau
  • Laura Brylka
  • Priyajit Chatterjee
  • Violaine K Harris
  • Subeer S Majumdar
  • Sukanta Ray
  • Rakesh Kundu
  • Satinath Mukhopadhyay
  • Samir Bhattacharya
  • Irina M Bochkis
  • Durba Pal
  • Jong Seto
  • Horng Yih Ou
  • Marietta Herrmann
  • Wei Li
  • Bobby Guillory
  • Steffen Gräber
  • Diana Caballero-Hernández
  • Pan Zhang
  • Josiah Ochieng
  • Thorsten Schinke
  • Awadh Binhazim
  • Michael Wöltje
  • B Rittenberg
  • Deepa Jethwaney
  • Madappa N Kundranda
  • A Regalia
  • S Armelloni
  • M Ikehata
  • C M Alfieri
  • Andrea Jochheim
  • M Li
  • D Riccardi
  • L A Giardino
  • M P Rastaldi
  • P Messa
  • C Pignatari
  • Dorien J M Peters
  • Wouter N Leonhard
  • Daniel B Constam
  • Florian Bernet
  • Dmitri Firsov
  • Sophia Piergiovanni
  • Séverine Urfer
  • Linda Guihard
  • Bruno Vogt
  • Hassib Chehade
  • Olivier Bonny
  • Shuman Liu
  • Nosratola D Vaziri
  • Melanie Szweras
  • Soma Seal
  • Sandip Mukherjee
  • Qi Jiang Yan
  • Amir Touray
  • Kristi Clark
  • Nicola Donelan
  • Sutapa Mukherjee
  • Mustapha Rammal
  • Saud A Sadiq
  • Björn Busse
  • Paul Zaslansky
  • Jonathan Schug
  • Jörg Bornemann
  • Laura Helming
  • Hung Tsung Wu
  • Sudipta Maitra
  • Diana Z Ye
  • Yi Ching Yang
  • Stefanie Krauss
  • Admir Masic
  • Suman Dasgupta
  • Svitlana Kurinna
  • Klaus H Kaestner
  • Chih Jen Chang
  • Andrea Büscher
  • Peter Fratzl

Detail Information

Publications42

  1. pmc The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    Cora Schafer
    Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
    J Clin Invest 112:357-66. 2003
    ..Here we identify the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg, also known as fetuin-A) as an important inhibitor of ectopic calcification acting on the systemic level...
  2. ncbi Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles
    Alexander Heiss
    IZKF BIOMAT, University Clinics, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 278:13333-41. 2003
    Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification...
  3. ncbi Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in mice
    Ralf Westenfeld
    Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    Nephrol Dial Transplant 22:1537-46. 2007
    ..Chronic kidney disease (CKD) is associated with vascular and tissue calcification. The extent of vascular calcification has been identified as an independent risk factor of cardiovascular death in patients on haemodialysis...
  4. doi Fetuin-A regulation of calcified matrix metabolism
    Willi Jahnen-Dechent
    RWTH Aachen University Clinics, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circ Res 108:1494-509. 2011
    ..Fetuin-A deficiency is associated with soft tissue calcification in mice and humans...
  5. ncbi alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling
    Melanie Szweras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:19991-7. 2002
    ..Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg(-/-) mice appeared normal at birth, but abnormalities were observed in adult Ahsg(-/-) mice...
  6. ncbi Cloning and targeted deletion of the mouse fetuin gene
    W Jahnen-Dechent
    Institut für Physiologische Chemie und Pathobiochemie, Johannes Gutenberg Universitat, Duesbergweg 6, D 55099 Mainz, Federal Republic of Germany
    J Biol Chem 272:31496-503. 1997
    ..These results corroborate a role for fetuin in serum calcium homeostasis. The fact that generalized ectopic calcification did not occur in fetuin-deficient mice proves that additional inhibitors of phase separation exist in serum...
  7. ncbi The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis
    T Schinke
    Institut für Physiologische Chemie und Pathobiochemie, Universitat Mainz, D 55099 Mainz, Duesbergweg 6, Federal Republic of Germany
    J Biol Chem 271:20789-96. 1996
    ..Fetuins account for roughly half of the capacity of serum to inhibit salt precipitation. We propose that fetuins inhibit phase separation in serum and modulate apatite formation during mineralization...
  8. ncbi Fetuin/alpha2-HS glycoprotein is a transforming growth factor-beta type II receptor mimic and cytokine antagonist
    M Demetriou
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 271:12755-61. 1996
    ..In summary, these experiments define the TRH1 peptide loop as a cytokine-binding domain in both TbetaRII and fetuin and suggest that fetuin is a natural antagonist of TGF-beta and BMP activities...
  9. pmc Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages
    Priyajit Chatterjee
    From the Department of Zoology, School of Life Science, Visva Bharati University, Santiniketan 731235
    J Biol Chem 288:28324-30. 2013
    ..Taken together, lipid-induced FetA from adipocytes is an efficient chemokine for macrophage migration and polarization. These findings open a new dimension for understanding obesity-induced inflammation. ..
  10. doi FGF23-regulated production of Fetuin-A (AHSG) in osteocytes
    D Mattinzoli
    Renal Research Laboratory, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and Fondazione D Amico per la Ricerca sulle Malattie Renali, Via Pace 9, 20122 Milano, Italy Electronic address
    Bone 83:35-47. 2016
    b>AHSG, a serum glycoprotein with recognized anti-calcification activity, has also been suggested to modulate both bone formation and resorption...
  11. pmc Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression
    Nathalie Piazzon
    Ecole Polytechnique Federale de Lausanne EPFL, Bâtiment SV ISREC, Station 19, Lausanne, Switzerland
    J Transl Med 13:103. 2015
    ..While promising treatment options are in advanced clinical development, early diagnosis and follow-up remain a major challenge. We therefore evaluated the diagnostic value of Fetuin-A as a new biomarker of ADPKD in human urine...
  12. doi Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    Durba Pal
    Cellular and Molecular Endocrinology Laboratory, Centre for Advanced Studies in Zoology, School of Life Science, Visva Bharati A Central University, Santiniketan, West Bengal, India
    Nat Med 18:1279-85. 2012
    ..FetA (officially known as Ahsg) knockdown in mice with insulin resistance caused by a high-fat diet (HFD) resulted in downregulation of Tlr4-..
  13. doi The role of fetuin-A in physiological and pathological mineralization
    Laura Brylka
    Helmholtz Institute for Biomedical Engineering, BioInterface Group, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany
    Calcif Tissue Int 93:355-64. 2013
    ..Fetuin-A-deficient (Ahsg(-/-)) mice show impaired growth of their long bones and premature growth plate closure...
  14. doi Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification
    Wei Ling Lau
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Calif, USA
    Am J Nephrol 40:51-5. 2014
    ..Given the prevalence of arterial medial calcification in CKD, the present study was undertaken to test the hypothesis that CKD may lead to acquired ABCC6 deficiency...
  15. doi Cerebrospinal fluid fetuin-A is a biomarker of active multiple sclerosis
    Violaine K Harris
    Multiple Sclerosis Research Center of New York, USA
    Mult Scler 19:1462-72. 2013
    ..Fetuin-A was recently identified as a potential biomarker in MS cerebrospinal fluid (CSF). Fetuin-A has diverse functions, including a role in immune pathways...
  16. pmc Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice
    Jong Seto
    Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany
    PLoS ONE 7:e47338. 2012
    The plasma protein fetuin-A/alpha2-HS-glycoprotein (genetic symbol Ahsg) is a systemic inhibitor of extraskeletal mineralization, which is best underscored by the excessive mineral deposition found in various tissues of fetuin-A deficient ..
  17. doi Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A
    Marietta Herrmann
    Helmholtz Institute for Biomedical Engineering, BioInterface Group, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Circ Res 111:575-84. 2012
    ..Biochemical studies showed that fetuin-A is essential for the formation of protein-mineral complexes, called calciprotein particles (CPPs). CPPs must be cleared from circulation to prevent local deposition and pathological calcification...
  18. pmc Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2
    Irina M Bochkis
    Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1002770. 2012
    ..Thus, Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution...
  19. doi Endoplasmic reticulum stress induces the expression of fetuin-A to develop insulin resistance
    Horng Yih Ou
    Department of Internal Medicine, National Cheng Kung University Hospital, 138, Sheng Li Road, Tainan 70403, Taiwan
    Endocrinology 153:2974-84. 2012
    ..Moreover, ER stress induced by high glucose and palmitate increased the expression of fetuin-A and further contributed to the development of insulin resistance...
  20. pmc A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation
    Wei Li
    The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 6:e16945. 2011
    ....
  21. ncbi Myocardial stiffness, cardiac remodeling, and diastolic dysfunction in calcification-prone fetuin-A-deficient mice
    Marc W Merx
    Medical Clinic I, RWTH University Hospital, Aachen, Germany
    J Am Soc Nephrol 16:3357-64. 2005
    ....
  22. pmc Lack of fetuin-A (alpha2-HS-glycoprotein) reduces mammary tumor incidence and prolongs tumor latency via the transforming growth factor-beta signaling pathway in a mouse model of breast cancer
    Bobby Guillory
    Department of Biochemistry and Cancer Biology, Meharry Medical College, 1005 D B Todd Blvd, Nashville, TN 37208, USA
    Am J Pathol 177:2635-44. 2010
    ..The data indicate that Fet is a powerful modulator of breast tumorigenesis in this model system and has the potential to modulate breast cancer progression in humans...
  23. pmc Fetuin-A protects against atherosclerotic calcification in CKD
    Ralf Westenfeld
    Department of Nephrology, Rheinisch Westfälische Technische Hochschule RWTH Aachen University Hospital, Aachen, Germany
    J Am Soc Nephrol 20:1264-74. 2009
    ..In conclusion, fetuin-A inhibits pathologic calcification in both the soft tissue and vasculature, even in the setting of atherosclerosis...
  24. doi Role of immunogenic fetuin A on L5178Y-R lymphoma tumorigenesis
    Diana Caballero-Hernández
    Departamento de Microbiologia e Inmunologia, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico
    Cancer Invest 27:257-63. 2009
    ....
  25. ncbi [The expression of fetuin-A and its pathological significance in fulminant hepatic failure in mice]
    Pan Zhang
    Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Gan Zang Bing Za Zhi 16:440-4. 2008
    ..To explore the dynamic changes of fetuin-A expression and the influences of the changes on liver damage, hepatocyte apoptosis and inflammation in a mouse fulminant hepatic failure (FHF) model...
  26. pmc Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A
    Bernd Denecke
    Interdisciplinary Center for Clinical Research on Biomaterials IZKF BIOMAT, University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 376:135-45. 2003
    ..Therefore fetuin-B may have a function that is partly overlapping, if not identical, with the function of fetuin-A...
  27. pmc Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouse
    J P Salier
    INSERM U 78, Boisguillaume, France
    Biochem J 296:85-91. 1993
    ....
  28. ncbi Isolation and characterization of mouse countertrypin, a new trypsin inhibitor belonging to the mammalian fetuin family
    K Yamamoto
    Department of Biochemistry, Kinki University School of Medicine, Osaka, Japan
    J Biol Chem 268:17750-3. 1993
    A novel trypsin inhibitor, tentatively named countertrypin, was isolated from mouse plasma in an apparently homogeneous state...
  29. ncbi Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice
    T Tsujimura
    Department of Pathology, Medical School, Osaka University, Suita, Japan
    Blood 88:1225-33. 1996
    ..Thus, the involvement of (+)-MITF in the c-kit transactivation appeared to be specific to the mast cell lineage...
  30. pmc Fetuin-B, a second member of the fetuin family in mammals
    E Olivier
    INSERM Unit 519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculte de Medecine Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
    Biochem J 350:589-97. 2000
    ..However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat...
  31. pmc Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human alpha2-HS glycoprotein
    V J Cintron
    Department of Biological Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Int J Exp Diabetes Res 1:249-63. 2001
    ..In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor...
  32. ncbi The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption
    Scott W Altmann
    Department of CNS and Cardiovascular Research, Schering Plough Research Institute, Kenilworth, NJ 07033 0539, USA
    Biochim Biophys Acta 1580:77-93. 2002
    ..In contrast studies with SR-B1 knockout mice suggest that SR-B1 is not essential for intestinal cholesterol absorption or the activity of ezetimibe...
  33. ncbi Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene
    Suresh T Mathews
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Diabetes 51:2450-8. 2002
    ..The fetuin gene (AHSG) is located on human chromosome 3q27, recently identified as a susceptibility locus for type 2 diabetes and the ..
  34. ncbi Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays
    Andrea Jochheim
    Hannover Medical School, Centre of Internal Medicine, Department of Gastroenterology, Hepatology and Endocrinology, Carl Neubergstr 1, 30625 Hannover, Germany
    Differentiation 71:62-72. 2003
    ..Furthermore, the microarray approach led to the identification of a number of genes, which have not yet been associated with liver organogenesis and maturation...
  35. ncbi Fetuin-null mice are protected against obesity and insulin resistance associated with aging
    Suresh T Mathews
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Biochem Biophys Res Commun 350:437-43. 2006
    alpha2-HS glycoprotein (AHSG), also known as fetuin-A, inhibits insulin receptor autophosphorylation and tyrosine kinase activity in vitro and in vivo...
  36. ncbi Alpha 2-HS glycoprotein (fetuin-A) modulates murine skin tumorigenesis
    Maria L Leite-Browning
    Department of Cancer Biology, Meharry Medical College, Vanderbilt University, Nashville, TN 37208, USA
    Int J Oncol 25:319-24. 2004
    ..Our results suggest that fetuin-A contributes to early stages of skin tumorigenesis...
  37. ncbi alpha2HS-glycoprotein, an antagonist of transforming growth factor beta in vivo, inhibits intestinal tumor progression
    Carol J Swallow
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer Res 64:6402-9. 2004
    ..Here, we show that the serum glycoprotein alpha2-HS-glycoprotein (AHSG) blocks TGF-beta1 binding to cell surface receptors, suppresses TGF-beta signal transduction, and inhibits TGF-beta-..
  38. ncbi The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms
    Madappa N Kundranda
    Department of Biochemistry, Meharry Medical College, Nashville, TN 37208, USA
    Cancer Res 65:499-506. 2005
    ..These studies support the role of fetuin-A as a major growth promoter in serum that can influence tumor establishment and growth...
  39. ncbi Regulation of BMP-induced ectopic bone formation by Ahsg
    B Rittenberg
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Orthop Res 23:653-62. 2005
    alpha2-HS-glycoprotein (Ahsg), also known as fetuin is a serum and bone resident glycoprotein, which binds to TGF-beta superfamily members including bone morphogenetic proteins (BMP) and inhibits dexamethasone-induced osteogenesis in bone ..
  40. pmc Fetuin-A, a hepatocyte-specific protein that binds Plasmodium berghei thrombospondin-related adhesive protein: a potential role in infectivity
    Deepa Jethwaney
    Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115 6018, USA
    Infect Immun 73:5883-91. 2005
    ..These data demonstrate that the extracellular region of TRAP interacts with fetuin-A on hepatocyte membranes and that this interaction enhances the parasite's ability to invade hepatocytes...
  41. ncbi Human alpha 2-HS-glycoprotein/bovine fetuin homologue in mice: identification and developmental regulation of the gene
    F Yang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
    Biochim Biophys Acta 1130:149-56. 1992
    Human alpha 2-HS-glycoprotein (AHSG) is a plasma protein synthesized in liver and selectively concentrated in bone matrix. It has been reported to be involved in bone formation and resorption as well as immune responses...
  42. ncbi CCAAT enhancer binding protein beta and hepatocyte nuclear factor 3beta are necessary and sufficient to mediate dexamethasone-induced up-regulation of alpha2HS-glycoprotein/fetuin-A gene expression
    Michael Wöltje
    Interdisciplinary Center for Clinical Research IZKF BIOMAT, RWTH Aachen University Hospital, Pauwelsstr 30, D 52074 Aachen, Germany
    J Mol Endocrinol 36:261-77. 2006
    Alpha2HS-glycoprotein/fetuin-A (Ahsg) is a serum protein preventing soft tissue calcification. In trauma and inflammation, Ahsg is down-regulated and therefore considered a negative acute phase protein...