Genomes and Genes
Gene Symbol: HA
Species: Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
- Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 virusesTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
Virology 413:139-47. 2011..Here, we have introduced receptor binding domain mutations within the hemagglutinin (HA) gene of two H5N1 viruses and evaluated changes in receptor binding specificity by glycan microarray analysis...
- Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunityPierre Louis Hervé
Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, 25 28 Rue du Docteur Roux, F 75015 Paris, France CNRS UMR 3569, 25 28 Rue du Docteur Roux, F 75015 Paris, France Université Paris Diderot, Sorbonne, Paris Cité, EA 302, 25 28 Rue du Docteur Roux, Paris, France Electronic address
Virology 486:134-45. 2015..These viruses evolve regularly by substitutions in antigenic sites of the hemagglutinin (HA), which prevent neutralization by antibodies directed against previous strains (antigenic drift)...
- H5N1 influenza A virus with K193E and G225E double mutations in haemagglutinin is attenuated and immunogenic in micePeng Fei Han
Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China
J Gen Virol 96:2522-30. 2015..The receptor-binding domain (RBD) in haemagglutinin (HA) of influenza virus is responsible for viral binding to the avian-type 2,3-α-linked or human-type 2,6-α-linked ..
- The influenza hemagglutinin fusion domain is an amphipathic helical hairpin that functions by inducing membrane curvatureSean T Smrt
From the Department of Chemistry, University of Illinois, Chicago, Illinois 60607
J Biol Chem 290:228-38. 2015..The inverted wedge shape of HAfp23 is likely to play a crucial role in the initial stages of membrane fusion by stabilizing negative curvature in the fusion stalk. ..
- A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virusLikai Tan
Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, People s Republic of China
J Virol 88:14116-25. 2014..Amino acid substitutions in PB2 (E627K), PA (I38M), and hemagglutinin ([HA] L111F, H156N, and S263R) occurred in GDK6-MA...
- Mutagenesis studies of the H5 influenza hemagglutinin stem loop regionAleksandar Antanasijevic
From the Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60607
J Biol Chem 289:22237-45. 2014..and decreased sensitivities to MBX2329, which gives further insight into the binding site of the compound on HA and potential mechanisms of escape...
- [Construction and biological characteristics of H5N1 avian influenza viruses with different patterns of the glycosylation sites in HA protein]Xiao Jian Zhang
Key Laboratory of Animal Infectious Disease, Ministry of Agriculture, Yangzhou University, Yangzhou 225009, China
Bing Du Xue Bao 29:495-9. 2013The distribution of glycosylation sites in HA proteins was various among H5 subtype avian influenza viruses (AIVs), however, the role of glycosylation sites to the virus is still unclear...
- A unique and conserved neutralization epitope in H5N1 influenza viruses identified by an antibody against the A/Goose/Guangdong/1/96 hemagglutininXueyong Zhu
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA
J Virol 87:12619-35. 2013..Neutralizing antibodies against conserved epitopes on the viral hemagglutinin (HA) could confer immunity to the diverse H5N1 virus strains and provide information for effective vaccine design...
- Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong KongX Xu
Influenza Branch, Division of Viral Diseases, Center for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
Virology 261:15-9. 1999..from a sick goose during an outbreak in Guangdong province, China, in 1996, revealed that the hemagglutinin (HA) gene of the virus was genetically similar to those of the H5N1 viruses isolated in Hong Kong in 1997...
- Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferretsHassan Zaraket
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
J Virol 87:9911-22. 2013Influenza virus entry is mediated by the acidic-pH-induced activation of hemagglutinin (HA) protein...
- Efficacy of parainfluenza virus 5 mutants expressing hemagglutinin from H5N1 influenza A virus in miceZhuo Li
Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA
J Virol 87:9604-9. 2013..We have recently reported that PIV5 expressing the hemagglutinin (HA) from highly pathogenic avian influenza (HPAI) virus H5N1 (PIV5-H5) provides sterilizing immunity against lethal ..
- The antigenic architecture of the hemagglutinin of influenza H5N1 virusesTony Velkov
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia Electronic address
Mol Immunol 56:705-19. 2013..antibody (Ab) response against the major epitope regions of the viral surface glycoprotein, hemagglutinin (HA)...
- Attenuated influenza virus construct with enhanced hemagglutinin protein expressionJad Maamary
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA
J Virol 86:5782-90. 2012..H5N1 and H1N1 influenza viruses encoding a truncated NS1 protein expressed lower levels of hemagglutinin (HA) protein in infected cells than did wild-type viruses...
- Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibilityHolly Shelton
Division of Infectious Diseases, Imperial College London, St Mary s Campus, London, UK
J Gen Virol 94:1220-9. 2013..As well as mediating receptor interactions, the haemagglutinin (HA) protein of influenza facilitates fusion of the viral membrane and genome entry into the host cell; this process is ..
- The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in miceHassan Zaraket
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
J Virol 87:4826-34. 2013After receptor binding and internalization during influenza virus entry, the hemagglutinin (HA) protein is triggered by low pH to undergo irreversible conformational changes that mediate membrane fusion...
- The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidaseWentian Chen
Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi an, People s Republic of China
PLoS ONE 7:e49224. 2012Two glycoproteins, hemagglutinin (HA) and neuraminidase (NA), on the surface of influenza viruses play crucial roles in transfaunation, membrane fusion and the release of progeny virions...
- A single residue substitution in the receptor-binding domain of H5N1 hemagglutinin is critical for packaging into pseudotyped lentiviral particlesDong Jiang Tang
HKU Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
PLoS ONE 7:e43596. 2012..We have previously characterized lentiviral particles pseudotyped with H5-HA (H5pp) and validated an H5pp-based assay as a safe alternative for high-throughput serological studies in BSL-2 ..
- Permissible variation in the 3' non-coding region of the haemagglutinin genome segment of the H5N1 candidate influenza vaccine virus NIBRG-14 [corrected]Rachel E Johnson
Division of Virology, National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, Potters Bar, Hertfordshire, United Kingdom
PLoS ONE 7:e36241. 2012..NIBRG-14 was created by reverse genetics and is composed of the neuraminidase (NA) and modified haemagglutinin (HA) genes from A/Vietnam/1194/2004 and the internal genes of PR8, a high growing laboratory adapted influenza A(H1N1) ..
- A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity and neurovirulence of H5N1 influenza virus in miceYi Zhang
Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China
J Virol 86:6924-31. 2012H5 influenza viruses containing a motif of multiple basic amino acids at the hemagglutinin (HA) cleavage site (HACS) are highly pathogenic in chicken but display different virulence phenotypes in mammals...
- The difference in IL-1beta , MIP-1alpha, IL-8 and IL-18 production between the infection of PMA activated U937 cells with recombinant vaccinia viruses inserted 2004 H5N1 influenza HA genes and NS genesMolvibha Vongsakul
Department of Microbiology, Faculty of Science Mahidol University, Bangkok, Thailand
Asian Pac J Allergy Immunol 29:349-56. 2011..However, the role of each virus gene is unknown. To elaborate the function of each virus gene, the recombinant vaccinia virus inserted HA and NS gene from the 2004 H5N1 virus were used in the study.
- The multibasic cleavage site in H5N1 virus is critical for systemic spread along the olfactory and hematogenous routes in ferretsEefje J A Schrauwen
National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
J Virol 86:3975-84. 2012..Although the multibasic cleavage site (MBCS) in the hemagglutinin (HA) of HPAI H5N1 viruses is a major determinant of systemic spread in poultry, the association between the MBCS and ..
- The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammalsAmorsolo L Suguitan
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:2706-14. 2012..and H7 subtypes typically possess multiple basic amino acids around the cleavage site (MBS) of their hemagglutinin (HA) protein, a recognized virulence motif in poultry...
- Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virusKelly K Lee
Department of Medicinal Chemistry and Biomolecular Structure and Design Program, University ofWashington, Seattle, Washington 98195, USA
J Biol Chem 286:42141-9. 2011..Here we compare the activity of fusion-inhibitory peptides derived from the influenza hemagglutinin (HA) and show that although the unconjugated peptides are inactive, the cholesterol-conjugated compounds are effective ..
- Identification of amino acids in highly pathogenic avian influenza H5N1 virus hemagglutinin that determine avian influenza species specificityZheng Li
The Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, 5 Dong Dan San Tiao, Beijing 100005, China
Arch Virol 156:1803-12. 2011..virus, two H5N1 strains, isolated from human and avian hosts, with four amino acid differences in hemagglutinin (HA) and seven HA mutations were studied...
- Dendritic cell activation by recombinant hemagglutinin proteins of H1N1 and H5N1 influenza A virusesWen Chun Liu
Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan
J Virol 84:12011-7. 2010..play a key role in defense against influenza virus infection, we examined the effects of recombinant hemagglutinin (HA) proteins derived from mouse-adapted H1N1 (A/WSN/1933), swine-origin 2009 pandemic H1N1 (A/Texas/05/2009), and ..
- Genomic analysis of pandemic (H1N1) 2009 reveals association of increasing disease severity with emergence of novel hemagglutinin mutationsGennadi V Glinsky
Translational and Functional Genomics Laboratory, Department of Pathology and Laboratory Medicine, and Department of Surgery, Division of Urology, Albany Medical College, Ordway Cancer Center, Ordway Research Institute, Inc, Center for Medical Science, Albany, NY, USA
Cell Cycle 9:958-70. 2010..of individuals who died from laboratory-confirmed cases of the pandemic (H1N1) were infected with the hemagglutinin (HA) Q310H mutant virus...
- Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunityBaibaswata Nayak
Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland, USA
J Virol 84:2408-20. 2010..We evaluated the individual contributions of each of the three HPAIV surface proteins, namely, the hemagglutinin (HA), the neuraminidase (NA), and the M2 proteins, to the induction of HPAIV-neutralizing serum antibodies and ..
- Glycans on influenza hemagglutinin affect receptor binding and immune responseCheng Chi Wang
Genomics Research Center, Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan
Proc Natl Acad Sci U S A 106:18137-42. 2009..Viral transmission begins with a critical interaction between hemagglutinin (HA) glycoprotein, which is on the viral coat of influenza, and sialic acid (SA) containing glycans, which are on the ..
- Fine antigenic variation within H5N1 influenza virus hemagglutinin's antigenic sites defined by yeast cell surface displayJian Li
The Institute of Immunology, PLA, Third Military Medical University, Chongqing, P R China
Eur J Immunol 39:3498-510. 2009Fifteen strains of mAb specific for HA of the A/Hong Kong/482/97 (H5N1) influenza virus were generated...
- Free energy simulations reveal a double mutant avian H5N1 virus hemagglutinin with altered receptor binding specificityPayel Das
Computational Biology Center, IBM Thomas J Watson Research Center, Yorktown Heights, New York 10598, USA
J Comput Chem 30:1654-63. 2009..Most critically, the major surface glycoprotein hemagglutinin (HA) must adapt to the usage of human-like (alpha-2,6-linked) sialylated glycan receptors...
- [Identification of peptide mimotopes of an abroad-spectrum neutralizing epitope of highly pathogenic avian influenza hemagglutinin]Hui Juan Song
National Institute of Diagnostics and Vaccine Development in Infectious Diseases and School of Life Sciences, Xiamen University, Xiamen 361005, China
Bing Du Xue Bao 24:421-6. 2008..This result indicated the presence of highly conserved neutralizing site on hemagglutinin (HA) of various H5N1 subtypes...
- Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display libraryAngeline P C Lim
Defence Medical and Environmental Research Institute, DSO National Laboratories, 27 Medical Dr, 117510, Singapore
Virol J 5:130. 2008..In this study, we used a combination of panning strategies against the hemagglutinin (HA) of several antigenic distinct H5N1 isolates to bias selection of Fab-phage from a naïve human library away from ..